Human herpesvirus 8 (HHV-8) (Kaposi s sarcoma-associated herpesvirus)

Taxonomy: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

Average proteome isoelectric point is 6.88

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 87 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    

Protein with the lowest isoelectric point:
>tr|D0UZU4|D0UZU4_HHV8 ORF75 OS=Human herpesvirus 8 OX=37296 GN=ORF75 PE=2 SV=1
MM1 pKa = 7.75APPGMRR7 pKa = 11.84LRR9 pKa = 11.84SGRR12 pKa = 11.84STGAPLTRR20 pKa = 11.84GSCRR24 pKa = 11.84KK25 pKa = 9.62RR26 pKa = 11.84NRR28 pKa = 11.84SPEE31 pKa = 3.97RR32 pKa = 11.84CDD34 pKa = 5.09LGDD37 pKa = 4.86DD38 pKa = 3.78LHH40 pKa = 6.35LQPRR44 pKa = 11.84RR45 pKa = 11.84KK46 pKa = 9.5HH47 pKa = 5.62VADD50 pKa = 3.58SVDD53 pKa = 3.17GRR55 pKa = 11.84EE56 pKa = 4.62CGPHH60 pKa = 5.99TLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHH118 pKa = 6.71PVSPGTTDD126 pKa = 2.91THH128 pKa = 6.78SPSPALPPTQSPEE141 pKa = 3.81SSQRR145 pKa = 11.84PPLSSPTGRR154 pKa = 11.84PDD156 pKa = 2.63SSTPMRR162 pKa = 11.84PPPSQQTTPPHH173 pKa = 6.63SPTTPPPEE181 pKa = 4.72PPSKK185 pKa = 10.64SSPDD189 pKa = 3.28SLAPSTLRR197 pKa = 11.84SLRR200 pKa = 11.84KK201 pKa = 9.2RR202 pKa = 11.84RR203 pKa = 11.84LSSPQGPSTLNPICQSPPVSPPRR226 pKa = 11.84CDD228 pKa = 3.09FANRR232 pKa = 11.84SVYY235 pKa = 10.06PPWATEE241 pKa = 3.69SPIYY245 pKa = 10.41VGSSSDD251 pKa = 3.01GDD253 pKa = 3.85TPPRR257 pKa = 11.84QPPTSPISIGSSSPSEE273 pKa = 4.18GSWGDD278 pKa = 3.52DD279 pKa = 2.79TAMLVLLAEE288 pKa = 4.45IAEE291 pKa = 4.14EE292 pKa = 3.7ASKK295 pKa = 11.3NEE297 pKa = 4.25KK298 pKa = 9.88EE299 pKa = 4.32CSEE302 pKa = 4.02NNQAGEE308 pKa = 4.28DD309 pKa = 3.65NGDD312 pKa = 3.55NEE314 pKa = 4.33ISKK317 pKa = 10.3EE318 pKa = 4.18SQVDD322 pKa = 3.67KK323 pKa = 11.19DD324 pKa = 4.68DD325 pKa = 4.5NDD327 pKa = 3.72NKK329 pKa = 10.87DD330 pKa = 3.69DD331 pKa = 4.22EE332 pKa = 4.92EE333 pKa = 4.21EE334 pKa = 4.3QEE336 pKa = 3.97TDD338 pKa = 4.05EE339 pKa = 4.96EE340 pKa = 4.57DD341 pKa = 3.94EE342 pKa = 4.7EE343 pKa = 6.24DD344 pKa = 5.14DD345 pKa = 5.21EE346 pKa = 6.18EE347 pKa = 6.72DD348 pKa = 5.0DD349 pKa = 5.25EE350 pKa = 6.16EE351 pKa = 6.7DD352 pKa = 5.0DD353 pKa = 5.25EE354 pKa = 6.16EE355 pKa = 6.7DD356 pKa = 5.0DD357 pKa = 5.25EE358 pKa = 6.16EE359 pKa = 6.7DD360 pKa = 5.0DD361 pKa = 5.25EE362 pKa = 6.16EE363 pKa = 6.7DD364 pKa = 5.0DD365 pKa = 5.25EE366 pKa = 6.16EE367 pKa = 6.7DD368 pKa = 5.0DD369 pKa = 4.88EE370 pKa = 6.06EE371 pKa = 6.43DD372 pKa = 5.02DD373 pKa = 4.1EE374 pKa = 5.75EE375 pKa = 4.55EE376 pKa = 5.15DD377 pKa = 3.76EE378 pKa = 5.3EE379 pKa = 4.38EE380 pKa = 5.36DD381 pKa = 3.77EE382 pKa = 5.16EE383 pKa = 4.41EE384 pKa = 4.92DD385 pKa = 4.21EE386 pKa = 4.38EE387 pKa = 5.04EE388 pKa = 3.96EE389 pKa = 4.88DD390 pKa = 3.95EE391 pKa = 4.88EE392 pKa = 4.59EE393 pKa = 5.03EE394 pKa = 4.72EE395 pKa = 5.79DD396 pKa = 5.51EE397 pKa = 5.53EE398 pKa = 6.97DD399 pKa = 6.31DD400 pKa = 5.53DD401 pKa = 7.12DD402 pKa = 5.49EE403 pKa = 6.88DD404 pKa = 5.88NEE406 pKa = 4.97DD407 pKa = 3.85EE408 pKa = 4.7EE409 pKa = 6.42DD410 pKa = 5.51DD411 pKa = 3.92EE412 pKa = 5.88EE413 pKa = 4.28EE414 pKa = 4.41DD415 pKa = 4.01KK416 pKa = 11.62KK417 pKa = 11.23EE418 pKa = 4.03DD419 pKa = 3.96EE420 pKa = 4.45EE421 pKa = 6.55DD422 pKa = 3.72GGDD425 pKa = 3.74GNKK428 pKa = 8.77TLSIQSSQQQQEE440 pKa = 4.2PQQQEE445 pKa = 4.09PQQQEE450 pKa = 4.09PQQQEE455 pKa = 4.09PQQQEE460 pKa = 4.09PQQQEE465 pKa = 4.09PQQQEE470 pKa = 4.09PQQQEE475 pKa = 3.9PQQRR479 pKa = 11.84EE480 pKa = 3.91PQQRR484 pKa = 11.84EE485 pKa = 3.78PQQRR489 pKa = 11.84EE490 pKa = 3.78PQQRR494 pKa = 11.84EE495 pKa = 3.78PQQRR499 pKa = 11.84EE500 pKa = 3.78PQQRR504 pKa = 11.84EE505 pKa = 3.94PQQQEE510 pKa = 3.96PQQQEE515 pKa = 4.09PQQQEE520 pKa = 4.09PQQQEE525 pKa = 4.09PQQQEE530 pKa = 4.09PQQQEE535 pKa = 4.09PQQQEE540 pKa = 4.09PQQQEE545 pKa = 4.09PQQQEE550 pKa = 4.09PQQQEE555 pKa = 4.09PQQQEE560 pKa = 4.09PQQQEE565 pKa = 4.09PQQQEE570 pKa = 4.09PQQQEE575 pKa = 4.09PQQQEE580 pKa = 3.99PQQQDD585 pKa = 3.2EE586 pKa = 4.35QQQDD590 pKa = 3.38EE591 pKa = 4.34QQQDD595 pKa = 3.38EE596 pKa = 4.34QQQDD600 pKa = 3.38EE601 pKa = 4.34QQQDD605 pKa = 3.38EE606 pKa = 4.37QQQDD610 pKa = 3.42EE611 pKa = 4.55QEE613 pKa = 4.31QQDD616 pKa = 3.86EE617 pKa = 4.34QQQDD621 pKa = 3.34EE622 pKa = 4.35QQQQDD627 pKa = 3.49EE628 pKa = 4.51QEE630 pKa = 4.15QQEE633 pKa = 4.3EE634 pKa = 4.39QEE636 pKa = 4.16QQEE639 pKa = 4.29EE640 pKa = 4.38QEE642 pKa = 4.16QQEE645 pKa = 4.29EE646 pKa = 4.38QEE648 pKa = 4.16QQEE651 pKa = 4.35EE652 pKa = 4.41QEE654 pKa = 4.38QEE656 pKa = 4.17LEE658 pKa = 4.15EE659 pKa = 4.07QEE661 pKa = 4.42QEE663 pKa = 4.69LEE665 pKa = 4.15EE666 pKa = 4.07QEE668 pKa = 4.42QEE670 pKa = 4.69LEE672 pKa = 4.15EE673 pKa = 4.07QEE675 pKa = 4.42QEE677 pKa = 4.69LEE679 pKa = 4.15EE680 pKa = 4.07QEE682 pKa = 4.42QEE684 pKa = 4.69LEE686 pKa = 4.15EE687 pKa = 4.07QEE689 pKa = 4.42QEE691 pKa = 4.69LEE693 pKa = 4.15EE694 pKa = 4.07QEE696 pKa = 4.42QEE698 pKa = 4.69LEE700 pKa = 4.15EE701 pKa = 4.07QEE703 pKa = 4.42QEE705 pKa = 4.69LEE707 pKa = 4.15EE708 pKa = 4.07QEE710 pKa = 4.42QEE712 pKa = 4.69LEE714 pKa = 4.15EE715 pKa = 4.07QEE717 pKa = 4.42QEE719 pKa = 4.69LEE721 pKa = 4.15EE722 pKa = 4.07QEE724 pKa = 4.42QEE726 pKa = 4.69LEE728 pKa = 4.15EE729 pKa = 4.07QEE731 pKa = 4.42QEE733 pKa = 4.69LEE735 pKa = 4.15EE736 pKa = 4.07QEE738 pKa = 4.42QEE740 pKa = 4.69LEE742 pKa = 4.15EE743 pKa = 4.07QEE745 pKa = 4.42QEE747 pKa = 4.69LEE749 pKa = 4.15EE750 pKa = 4.07QEE752 pKa = 4.42QEE754 pKa = 4.69LEE756 pKa = 4.15EE757 pKa = 4.07QEE759 pKa = 4.42QEE761 pKa = 4.69LEE763 pKa = 4.15EE764 pKa = 4.07QEE766 pKa = 4.42QEE768 pKa = 4.69LEE770 pKa = 4.15EE771 pKa = 4.07QEE773 pKa = 4.42QEE775 pKa = 4.69LEE777 pKa = 4.15EE778 pKa = 4.07QEE780 pKa = 4.42QEE782 pKa = 4.69LEE784 pKa = 4.15EE785 pKa = 4.07QEE787 pKa = 4.42QEE789 pKa = 4.69LEE791 pKa = 4.15EE792 pKa = 4.07QEE794 pKa = 4.42QEE796 pKa = 4.69LEE798 pKa = 4.15EE799 pKa = 4.07QEE801 pKa = 4.42QEE803 pKa = 4.69LEE805 pKa = 4.15EE806 pKa = 4.07QEE808 pKa = 4.42QEE810 pKa = 4.69LEE812 pKa = 4.17EE813 pKa = 4.1QEE815 pKa = 4.24QEE817 pKa = 4.08QEE819 pKa = 4.07LEE821 pKa = 4.06EE822 pKa = 4.42VEE824 pKa = 4.38EE825 pKa = 4.22QEE827 pKa = 4.93QEE829 pKa = 4.04QEE831 pKa = 4.12EE832 pKa = 4.52QEE834 pKa = 4.18LEE836 pKa = 4.06EE837 pKa = 4.61VEE839 pKa = 4.38EE840 pKa = 4.22QEE842 pKa = 4.93QEE844 pKa = 3.97QEE846 pKa = 4.09EE847 pKa = 4.39QEE849 pKa = 4.2EE850 pKa = 4.48QEE852 pKa = 4.15LEE854 pKa = 4.05EE855 pKa = 4.34VEE857 pKa = 4.21EE858 pKa = 4.21QEE860 pKa = 4.18EE861 pKa = 4.43QEE863 pKa = 4.13LEE865 pKa = 4.05EE866 pKa = 4.34VEE868 pKa = 4.21EE869 pKa = 4.21QEE871 pKa = 4.18EE872 pKa = 4.43QEE874 pKa = 4.13LEE876 pKa = 4.06EE877 pKa = 4.74VEE879 pKa = 4.41EE880 pKa = 4.22QEE882 pKa = 4.27QQGVEE887 pKa = 4.0QQEE890 pKa = 4.31QEE892 pKa = 4.47TVEE895 pKa = 4.17EE896 pKa = 4.66PIILHH901 pKa = 6.37GSSSEE906 pKa = 4.27DD907 pKa = 3.39EE908 pKa = 4.5MEE910 pKa = 3.4VDD912 pKa = 3.84YY913 pKa = 10.89PVVSTHH919 pKa = 5.49EE920 pKa = 4.56QIASSPPGDD929 pKa = 3.92NTPDD933 pKa = 5.1DD934 pKa = 4.93DD935 pKa = 4.49PQPGPSRR942 pKa = 11.84EE943 pKa = 3.78YY944 pKa = 10.3RR945 pKa = 11.84YY946 pKa = 10.66VLRR949 pKa = 11.84TSPPHH954 pKa = 5.87RR955 pKa = 11.84PGVRR959 pKa = 11.84MRR961 pKa = 11.84RR962 pKa = 11.84VPVTHH967 pKa = 7.12PKK969 pKa = 10.05KK970 pKa = 9.84PHH972 pKa = 6.45PRR974 pKa = 11.84YY975 pKa = 8.97QQPPVPYY982 pKa = 9.64RR983 pKa = 11.84QIDD986 pKa = 3.68DD987 pKa = 4.36CPAKK991 pKa = 10.46ARR993 pKa = 11.84PQHH996 pKa = 4.69IFYY999 pKa = 10.7RR1000 pKa = 11.84RR1001 pKa = 11.84FLGKK1005 pKa = 10.01DD1006 pKa = 2.94GRR1008 pKa = 11.84RR1009 pKa = 11.84DD1010 pKa = 3.68PKK1012 pKa = 10.69CQWKK1016 pKa = 9.05FAVIFWGNDD1025 pKa = 2.98PYY1027 pKa = 11.57GLKK1030 pKa = 10.41KK1031 pKa = 10.79LSQAFQFGGVKK1042 pKa = 10.3AGPVSCLPHH1051 pKa = 6.94PGPDD1055 pKa = 3.33QSPITYY1061 pKa = 9.65CVYY1064 pKa = 10.48VYY1066 pKa = 10.17CQNKK1070 pKa = 8.21DD1071 pKa = 3.17TSKK1074 pKa = 10.09KK1075 pKa = 9.13VQMARR1080 pKa = 11.84LAWEE1084 pKa = 4.34ASHH1087 pKa = 7.2PLAGNLQSSIVKK1099 pKa = 9.82FKK1101 pKa = 11.13KK1102 pKa = 9.77PLPLTQPGEE1111 pKa = 4.15NQGPGDD1117 pKa = 4.34SPQEE1121 pKa = 3.99MTT1123 pKa = 4.75

Molecular weight:
130.48 kDa
Isoelectric point according different methods:






Protein with the highest isoelectric point:
>tr|Q76RG8|Q76RG8_HHV8 Uracil-DNA glycosylase OS=Human herpesvirus 8 OX=37296 GN=ORF46 PE=3 SV=1
MM1 pKa = 7.87GIFALFAVLWTTLLVTSHH19 pKa = 6.98AYY21 pKa = 9.38VALPCCAIQASAASTLPLFFAVHH44 pKa = 6.91SIHH47 pKa = 6.77FADD50 pKa = 4.69PNHH53 pKa = 6.68CNGVCIAKK61 pKa = 9.92LRR63 pKa = 11.84SKK65 pKa = 9.72TGDD68 pKa = 3.01ITVEE72 pKa = 3.89TCVNGFNLRR81 pKa = 11.84SFLVAVVRR89 pKa = 11.84RR90 pKa = 11.84LGSWASQEE98 pKa = 3.94NLRR101 pKa = 11.84LLWYY105 pKa = 9.38LQRR108 pKa = 11.84SLTAYY113 pKa = 8.81TVGFNATTADD123 pKa = 3.69SSIHH127 pKa = 5.66NVNIIIISVGKK138 pKa = 10.46AMNRR142 pKa = 11.84TGSVSGSQTRR152 pKa = 11.84AKK154 pKa = 10.17SSSRR158 pKa = 11.84RR159 pKa = 11.84AHH161 pKa = 6.74AGQKK165 pKa = 10.08GKK167 pKa = 10.65

Molecular weight:
18.0 kDa
Isoelectric point according different methods:






Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

86

1

87

38936

60

2635

447.5

49.67

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

7.589 ± 0.311

2.537 ± 0.171

4.664 ± 0.143

5.607 ± 0.528

4.148 ± 0.162

6.161 ± 0.235

2.761 ± 0.098

4.531 ± 0.152

3.745 ± 0.164

10.379 ± 0.27

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.06 ± 0.116

3.218 ± 0.164

6.968 ± 0.336

4.389 ± 0.436

5.858 ± 0.16

7.664 ± 0.218

6.58 ± 0.208

6.963 ± 0.24

1.22 ± 0.085

2.959 ± 0.126

Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski