Amino acid dipepetide frequency for Fasciola gigantica (Giant liver fluke)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.788AlaAla: 5.788 ± 0.062	1.365AlaCys: 1.365 ± 0.018	3.525AlaAsp: 3.525 ± 0.029	3.935AlaGlu: 3.935 ± 0.035	2.426AlaPhe: 2.426 ± 0.026	3.601AlaGly: 3.601 ± 0.032	1.776AlaHis: 1.776 ± 0.019	3.123AlaIle: 3.123 ± 0.025	2.879AlaLys: 2.879 ± 0.028	6.263AlaLeu: 6.263 ± 0.041	1.411AlaMet: 1.411 ± 0.015	2.851AlaAsn: 2.851 ± 0.024	3.387AlaPro: 3.387 ± 0.029	2.808AlaGln: 2.808 ± 0.028	3.982AlaArg: 3.982 ± 0.031	6.296AlaSer: 6.296 ± 0.048	4.337AlaThr: 4.337 ± 0.032	4.731AlaVal: 4.731 ± 0.033	0.666AlaTrp: 0.666 ± 0.012	1.82AlaTyr: 1.82 ± 0.019	0.001AlaXaa: 0.001 ± 0.0
Cys	1.394CysAla: 1.394 ± 0.016	0.557CysCys: 0.557 ± 0.015	1.068CysAsp: 1.068 ± 0.016	1.085CysGlu: 1.085 ± 0.015	0.858CysPhe: 0.858 ± 0.014	1.298CysGly: 1.298 ± 0.022	0.609CysHis: 0.609 ± 0.009	0.985CysIle: 0.985 ± 0.016	0.755CysLys: 0.755 ± 0.013	2.27CysLeu: 2.27 ± 0.023	0.422CysMet: 0.422 ± 0.009	0.702CysAsn: 0.702 ± 0.012	1.302CysPro: 1.302 ± 0.022	0.848CysGln: 0.848 ± 0.016	1.34CysArg: 1.34 ± 0.019	1.996CysSer: 1.996 ± 0.022	1.254CysThr: 1.254 ± 0.016	1.396CysVal: 1.396 ± 0.019	0.251CysTrp: 0.251 ± 0.008	0.562CysTyr: 0.562 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.413AspAla: 3.413 ± 0.028	1.041AspCys: 1.041 ± 0.014	3.197AspAsp: 3.197 ± 0.041	3.799AspGlu: 3.799 ± 0.03	1.891AspPhe: 1.891 ± 0.02	3.08AspGly: 3.08 ± 0.037	1.335AspHis: 1.335 ± 0.016	2.198AspIle: 2.198 ± 0.02	2.047AspLys: 2.047 ± 0.022	5.102AspLeu: 5.102 ± 0.034	1.027AspMet: 1.027 ± 0.012	1.874AspAsn: 1.874 ± 0.018	3.065AspPro: 3.065 ± 0.023	2.314AspGln: 2.314 ± 0.023	3.371AspArg: 3.371 ± 0.024	4.923AspSer: 4.923 ± 0.034	2.818AspThr: 2.818 ± 0.022	3.228AspVal: 3.228 ± 0.027	0.703AspTrp: 0.703 ± 0.013	1.445AspTyr: 1.445 ± 0.018	0.001AspXaa: 0.001 ± 0.0
Glu	4.095GluAla: 4.095 ± 0.033	1.054GluCys: 1.054 ± 0.015	3.13GluAsp: 3.13 ± 0.03	4.225GluGlu: 4.225 ± 0.045	2.093GluPhe: 2.093 ± 0.023	2.211GluGly: 2.211 ± 0.022	1.49GluHis: 1.49 ± 0.016	2.801GluIle: 2.801 ± 0.024	3.113GluLys: 3.113 ± 0.036	5.997GluLeu: 5.997 ± 0.041	1.385GluMet: 1.385 ± 0.019	2.735GluAsn: 2.735 ± 0.025	2.808GluPro: 2.808 ± 0.032	2.806GluGln: 2.806 ± 0.026	3.696GluArg: 3.696 ± 0.034	4.782GluSer: 4.782 ± 0.037	3.502GluThr: 3.502 ± 0.031	3.391GluVal: 3.391 ± 0.036	0.618GluTrp: 0.618 ± 0.012	1.446GluTyr: 1.446 ± 0.02	0.001GluXaa: 0.001 ± 0.0
Phe	2.344PheAla: 2.344 ± 0.024	0.901PheCys: 0.901 ± 0.015	2.066PheAsp: 2.066 ± 0.022	1.942PheGlu: 1.942 ± 0.02	1.457PhePhe: 1.457 ± 0.022	2.375PheGly: 2.375 ± 0.023	1.126PheHis: 1.126 ± 0.013	1.835PheIle: 1.835 ± 0.023	1.322PheLys: 1.322 ± 0.018	3.564PheLeu: 3.564 ± 0.029	0.738PheMet: 0.738 ± 0.012	1.377PheAsn: 1.377 ± 0.017	1.95PhePro: 1.95 ± 0.02	1.431PheGln: 1.431 ± 0.019	2.341PheArg: 2.341 ± 0.022	3.388PheSer: 3.388 ± 0.03	2.343PheThr: 2.343 ± 0.022	2.58PheVal: 2.58 ± 0.026	0.47PheTrp: 0.47 ± 0.01	1.149PheTyr: 1.149 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	3.416GlyAla: 3.416 ± 0.033	1.137GlyCys: 1.137 ± 0.017	2.818GlyAsp: 2.818 ± 0.038	2.79GlyGlu: 2.79 ± 0.043	2.125GlyPhe: 2.125 ± 0.023	3.475GlyGly: 3.475 ± 0.041	1.5GlyHis: 1.5 ± 0.016	2.635GlyIle: 2.635 ± 0.025	2.418GlyLys: 2.418 ± 0.026	5.395GlyLeu: 5.395 ± 0.038	1.189GlyMet: 1.189 ± 0.016	2.179GlyAsn: 2.179 ± 0.02	3.096GlyPro: 3.096 ± 0.065	2.301GlyGln: 2.301 ± 0.024	3.533GlyArg: 3.533 ± 0.037	5.74GlySer: 5.74 ± 0.045	3.643GlyThr: 3.643 ± 0.03	3.241GlyVal: 3.241 ± 0.031	0.639GlyTrp: 0.639 ± 0.014	1.571GlyTyr: 1.571 ± 0.019	0.002GlyXaa: 0.002 ± 0.001
His	1.645HisAla: 1.645 ± 0.016	0.674HisCys: 0.674 ± 0.012	1.084HisAsp: 1.084 ± 0.015	1.403HisGlu: 1.403 ± 0.017	1.101HisPhe: 1.101 ± 0.016	1.524HisGly: 1.524 ± 0.017	1.013HisHis: 1.013 ± 0.017	1.224HisIle: 1.224 ± 0.014	0.99HisLys: 0.99 ± 0.014	2.987HisLeu: 2.987 ± 0.022	0.61HisMet: 0.61 ± 0.012	1.009HisAsn: 1.009 ± 0.015	1.859HisPro: 1.859 ± 0.022	1.281HisGln: 1.281 ± 0.016	1.939HisArg: 1.939 ± 0.018	2.879HisSer: 2.879 ± 0.027	1.664HisThr: 1.664 ± 0.019	1.721HisVal: 1.721 ± 0.018	0.386HisTrp: 0.386 ± 0.009	0.742HisTyr: 0.742 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	2.951IleAla: 2.951 ± 0.027	1.148IleCys: 1.148 ± 0.015	2.451IleAsp: 2.451 ± 0.022	2.582IleGlu: 2.582 ± 0.024	1.736IlePhe: 1.736 ± 0.02	2.666IleGly: 2.666 ± 0.023	1.421IleHis: 1.421 ± 0.016	2.142IleIle: 2.142 ± 0.024	2.006IleLys: 2.006 ± 0.02	4.443IleLeu: 4.443 ± 0.033	0.915IleMet: 0.915 ± 0.012	1.989IleAsn: 1.989 ± 0.021	3.161IlePro: 3.161 ± 0.028	2.228IleGln: 2.228 ± 0.021	3.421IleArg: 3.421 ± 0.026	4.418IleSer: 4.418 ± 0.031	3.014IleThr: 3.014 ± 0.026	2.854IleVal: 2.854 ± 0.025	0.571IleTrp: 0.571 ± 0.009	1.4IleTyr: 1.4 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.706LysAla: 2.706 ± 0.03	0.867LysCys: 0.867 ± 0.015	1.926LysAsp: 1.926 ± 0.018	2.596LysGlu: 2.596 ± 0.033	1.492LysPhe: 1.492 ± 0.018	1.702LysGly: 1.702 ± 0.037	1.263LysHis: 1.263 ± 0.016	2.07LysIle: 2.07 ± 0.021	2.44LysLys: 2.44 ± 0.035	4.413LysLeu: 4.413 ± 0.036	1.031LysMet: 1.031 ± 0.015	1.86LysAsn: 1.86 ± 0.022	2.752LysPro: 2.752 ± 0.03	2.22LysGln: 2.22 ± 0.025	3.378LysArg: 3.378 ± 0.03	3.999LysSer: 3.999 ± 0.033	2.761LysThr: 2.761 ± 0.026	2.348LysVal: 2.348 ± 0.023	0.491LysTrp: 0.491 ± 0.01	1.15LysTyr: 1.15 ± 0.017	0.001LysXaa: 0.001 ± 0.0
Leu	6.55LeuAla: 6.55 ± 0.042	2.161LeuCys: 2.161 ± 0.025	5.222LeuAsp: 5.222 ± 0.037	5.362LeuGlu: 5.362 ± 0.041	3.842LeuPhe: 3.842 ± 0.033	4.821LeuGly: 4.821 ± 0.033	2.684LeuHis: 2.684 ± 0.023	5.095LeuIle: 5.095 ± 0.035	4.183LeuLys: 4.183 ± 0.038	9.79LeuLeu: 9.79 ± 0.067	1.96LeuMet: 1.96 ± 0.018	4.275LeuAsn: 4.275 ± 0.025	5.605LeuPro: 5.605 ± 0.035	3.973LeuGln: 3.973 ± 0.029	6.427LeuArg: 6.427 ± 0.034	9.091LeuSer: 9.091 ± 0.052	6.176LeuThr: 6.176 ± 0.033	6.012LeuVal: 6.012 ± 0.042	1.052LeuTrp: 1.052 ± 0.015	2.377LeuTyr: 2.377 ± 0.023	0.002LeuXaa: 0.002 ± 0.001
Met	1.475MetAla: 1.475 ± 0.016	0.411MetCys: 0.411 ± 0.009	1.315MetAsp: 1.315 ± 0.016	1.386MetGlu: 1.386 ± 0.018	0.765MetPhe: 0.765 ± 0.013	1.085MetGly: 1.085 ± 0.017	0.629MetHis: 0.629 ± 0.011	1.049MetIle: 1.049 ± 0.014	1.039MetLys: 1.039 ± 0.016	1.964MetLeu: 1.964 ± 0.02	0.502MetMet: 0.502 ± 0.012	1.145MetAsn: 1.145 ± 0.015	1.11MetPro: 1.11 ± 0.016	0.917MetGln: 0.917 ± 0.012	1.35MetArg: 1.35 ± 0.019	1.786MetSer: 1.786 ± 0.019	1.346MetThr: 1.346 ± 0.016	1.233MetVal: 1.233 ± 0.014	0.228MetTrp: 0.228 ± 0.007	0.491MetTyr: 0.491 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	2.912AsnAla: 2.912 ± 0.025	0.866AsnCys: 0.866 ± 0.013	1.974AsnAsp: 1.974 ± 0.022	2.608AsnGlu: 2.608 ± 0.021	1.475AsnPhe: 1.475 ± 0.016	2.72AsnGly: 2.72 ± 0.03	1.107AsnHis: 1.107 ± 0.014	1.851AsnIle: 1.851 ± 0.021	1.839AsnLys: 1.839 ± 0.019	4.145AsnLeu: 4.145 ± 0.031	0.924AsnMet: 0.924 ± 0.013	1.879AsnAsn: 1.879 ± 0.024	2.727AsnPro: 2.727 ± 0.024	2.059AsnGln: 2.059 ± 0.017	2.822AsnArg: 2.822 ± 0.022	4.15AsnSer: 4.15 ± 0.035	2.792AsnThr: 2.792 ± 0.025	2.623AsnVal: 2.623 ± 0.019	0.53AsnTrp: 0.53 ± 0.01	1.16AsnTyr: 1.16 ± 0.016	0.001AsnXaa: 0.001 ± 0.0
Pro	3.596ProAla: 3.596 ± 0.028	1.043ProCys: 1.043 ± 0.016	3.136ProAsp: 3.136 ± 0.03	3.332ProGlu: 3.332 ± 0.028	1.977ProPhe: 1.977 ± 0.022	3.624ProGly: 3.624 ± 0.072	1.501ProHis: 1.501 ± 0.017	2.92ProIle: 2.92 ± 0.024	2.482ProLys: 2.482 ± 0.025	4.84ProLeu: 4.84 ± 0.029	1.159ProMet: 1.159 ± 0.014	2.866ProAsn: 2.866 ± 0.023	4.421ProPro: 4.421 ± 0.06	2.229ProGln: 2.229 ± 0.025	3.239ProArg: 3.239 ± 0.031	6.157ProSer: 6.157 ± 0.04	4.285ProThr: 4.285 ± 0.034	4.464ProVal: 4.464 ± 0.035	0.587ProTrp: 0.587 ± 0.01	1.39ProTyr: 1.39 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	2.741GlnAla: 2.741 ± 0.027	0.876GlnCys: 0.876 ± 0.015	1.553GlnAsp: 1.553 ± 0.018	2.037GlnGlu: 2.037 ± 0.027	1.682GlnPhe: 1.682 ± 0.018	1.57GlnGly: 1.57 ± 0.024	1.182GlnHis: 1.182 ± 0.017	2.22GlnIle: 2.22 ± 0.022	1.948GlnLys: 1.948 ± 0.019	5.167GlnLeu: 5.167 ± 0.04	1.102GlnMet: 1.102 ± 0.015	1.942GlnAsn: 1.942 ± 0.02	2.741GlnPro: 2.741 ± 0.026	2.712GlnGln: 2.712 ± 0.065	2.728GlnArg: 2.728 ± 0.023	4.371GlnSer: 4.371 ± 0.035	3.048GlnThr: 3.048 ± 0.028	2.342GlnVal: 2.342 ± 0.021	0.57GlnTrp: 0.57 ± 0.01	1.092GlnTyr: 1.092 ± 0.014	0.001GlnXaa: 0.001 ± 0.0
Arg	3.962ArgAla: 3.962 ± 0.033	1.362ArgCys: 1.362 ± 0.02	2.897ArgAsp: 2.897 ± 0.024	3.442ArgGlu: 3.442 ± 0.033	2.577ArgPhe: 2.577 ± 0.022	3.125ArgGly: 3.125 ± 0.036	1.795ArgHis: 1.795 ± 0.019	3.405ArgIle: 3.405 ± 0.026	3.144ArgLys: 3.144 ± 0.029	7.148ArgLeu: 7.148 ± 0.046	1.506ArgMet: 1.506 ± 0.016	2.614ArgAsn: 2.614 ± 0.023	3.591ArgPro: 3.591 ± 0.031	2.833ArgGln: 2.833 ± 0.024	5.301ArgArg: 5.301 ± 0.041	6.023ArgSer: 6.023 ± 0.041	3.918ArgThr: 3.918 ± 0.026	3.756ArgVal: 3.756 ± 0.034	0.81ArgTrp: 0.81 ± 0.014	1.723ArgTyr: 1.723 ± 0.018	0.001ArgXaa: 0.001 ± 0.0
Ser	6.661SerAla: 6.661 ± 0.042	1.826SerCys: 1.826 ± 0.021	5.214SerAsp: 5.214 ± 0.033	5.18SerGlu: 5.18 ± 0.033	3.121SerPhe: 3.121 ± 0.025	6.244SerGly: 6.244 ± 0.046	2.551SerHis: 2.551 ± 0.031	4.04SerIle: 4.04 ± 0.027	3.856SerLys: 3.856 ± 0.029	8.31SerLeu: 8.31 ± 0.045	1.93SerMet: 1.93 ± 0.022	4.232SerAsn: 4.232 ± 0.039	5.903SerPro: 5.903 ± 0.047	3.795SerGln: 3.795 ± 0.031	5.784SerArg: 5.784 ± 0.039	11.477SerSer: 11.477 ± 0.089	7.038SerThr: 7.038 ± 0.054	6.778SerVal: 6.778 ± 0.037	0.963SerTrp: 0.963 ± 0.016	2.058SerTyr: 2.058 ± 0.021	0.003SerXaa: 0.003 ± 0.001
Thr	4.672ThrAla: 4.672 ± 0.033	1.252ThrCys: 1.252 ± 0.017	3.644ThrAsp: 3.644 ± 0.029	4.153ThrGlu: 4.153 ± 0.038	2.054ThrPhe: 2.054 ± 0.022	4.309ThrGly: 4.309 ± 0.034	1.656ThrHis: 1.656 ± 0.018	2.858ThrIle: 2.858 ± 0.026	2.85ThrLys: 2.85 ± 0.023	5.229ThrLeu: 5.229 ± 0.03	1.306ThrMet: 1.306 ± 0.016	3.179ThrAsn: 3.179 ± 0.026	3.827ThrPro: 3.827 ± 0.032	2.586ThrGln: 2.586 ± 0.025	3.672ThrArg: 3.672 ± 0.026	6.346ThrSer: 6.346 ± 0.051	5.092ThrThr: 5.092 ± 0.053	4.69ThrVal: 4.69 ± 0.034	0.642ThrTrp: 0.642 ± 0.012	1.528ThrTyr: 1.528 ± 0.016	0.001ThrXaa: 0.001 ± 0.0
Val	4.275ValAla: 4.275 ± 0.031	1.527ValCys: 1.527 ± 0.021	3.741ValAsp: 3.741 ± 0.027	3.538ValGlu: 3.538 ± 0.033	2.341ValPhe: 2.341 ± 0.025	3.429ValGly: 3.429 ± 0.03	1.987ValHis: 1.987 ± 0.021	3.179ValIle: 3.179 ± 0.026	2.6ValLys: 2.6 ± 0.026	5.687ValLeu: 5.687 ± 0.033	1.23ValMet: 1.23 ± 0.015	2.875ValAsn: 2.875 ± 0.023	3.812ValPro: 3.812 ± 0.034	2.725ValGln: 2.725 ± 0.026	4.001ValArg: 4.001 ± 0.033	5.871ValSer: 5.871 ± 0.044	4.218ValThr: 4.218 ± 0.03	4.108ValVal: 4.108 ± 0.037	0.699ValTrp: 0.699 ± 0.011	1.807ValTyr: 1.807 ± 0.019	0.001ValXaa: 0.001 ± 0.0
Trp	0.622TrpAla: 0.622 ± 0.011	0.258TrpCys: 0.258 ± 0.007	0.583TrpAsp: 0.583 ± 0.011	0.507TrpGlu: 0.507 ± 0.011	0.528TrpPhe: 0.528 ± 0.011	0.413TrpGly: 0.413 ± 0.008	0.316TrpHis: 0.316 ± 0.008	0.746TrpIle: 0.746 ± 0.014	0.566TrpLys: 0.566 ± 0.011	1.234TrpLeu: 1.234 ± 0.016	0.291TrpMet: 0.291 ± 0.008	0.597TrpAsn: 0.597 ± 0.012	0.623TrpPro: 0.623 ± 0.013	0.42TrpGln: 0.42 ± 0.009	0.765TrpArg: 0.765 ± 0.012	1.11TrpSer: 1.11 ± 0.015	0.77TrpThr: 0.77 ± 0.013	0.544TrpVal: 0.544 ± 0.009	0.162TrpTrp: 0.162 ± 0.006	0.335TrpTyr: 0.335 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.749TyrAla: 1.749 ± 0.02	0.627TyrCys: 0.627 ± 0.011	1.327TyrAsp: 1.327 ± 0.018	1.477TyrGlu: 1.477 ± 0.017	1.158TyrPhe: 1.158 ± 0.016	1.571TyrGly: 1.571 ± 0.02	0.794TyrHis: 0.794 ± 0.012	1.141TyrIle: 1.141 ± 0.015	0.987TyrLys: 0.987 ± 0.014	2.707TyrLeu: 2.707 ± 0.03	0.586TyrMet: 0.586 ± 0.01	0.983TyrAsn: 0.983 ± 0.014	1.51TyrPro: 1.51 ± 0.019	1.14TyrGln: 1.14 ± 0.014	1.843TyrArg: 1.843 ± 0.02	2.161TyrSer: 2.161 ± 0.023	1.524TyrThr: 1.524 ± 0.018	1.607TyrVal: 1.607 ± 0.018	0.354TyrTrp: 0.354 ± 0.008	0.848TyrTyr: 0.848 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.048XaaXaa: 0.048 ± 0.01

Statistics based on 12643 proteins (5783738 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---