Amino acid dipepetide frequency for Dictyocaulus viviparus (Bovine lungworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.843AlaAla: 4.843 ± 0.052
1.199AlaCys: 1.199 ± 0.016
3.1AlaAsp: 3.1 ± 0.025
3.87AlaGlu: 3.87 ± 0.036
2.615AlaPhe: 2.615 ± 0.024
3.136AlaGly: 3.136 ± 0.035
1.437AlaHis: 1.437 ± 0.018
4.047AlaIle: 4.047 ± 0.031
3.492AlaLys: 3.492 ± 0.031
5.939AlaLeu: 5.939 ± 0.042
1.642AlaMet: 1.642 ± 0.02
2.653AlaAsn: 2.653 ± 0.024
2.588AlaPro: 2.588 ± 0.025
2.285AlaGln: 2.285 ± 0.026
3.36AlaArg: 3.36 ± 0.031
4.673AlaSer: 4.673 ± 0.032
3.44AlaThr: 3.44 ± 0.028
4.696AlaVal: 4.696 ± 0.036
0.576AlaTrp: 0.576 ± 0.011
1.774AlaTyr: 1.774 ± 0.02
0.0AlaXaa: 0.0 ± 0.0
Cys
1.305CysAla: 1.305 ± 0.02
0.651CysCys: 0.651 ± 0.016
1.356CysAsp: 1.356 ± 0.02
1.39CysGlu: 1.39 ± 0.023
1.031CysPhe: 1.031 ± 0.015
1.477CysGly: 1.477 ± 0.021
0.598CysHis: 0.598 ± 0.013
1.329CysIle: 1.329 ± 0.023
1.111CysLys: 1.111 ± 0.018
1.938CysLeu: 1.938 ± 0.025
0.531CysMet: 0.531 ± 0.012
0.981CysAsn: 0.981 ± 0.015
1.092CysPro: 1.092 ± 0.022
0.827CysGln: 0.827 ± 0.016
1.363CysArg: 1.363 ± 0.02
2.044CysSer: 2.044 ± 0.027
1.158CysThr: 1.158 ± 0.016
1.474CysVal: 1.474 ± 0.021
0.235CysTrp: 0.235 ± 0.007
0.711CysTyr: 0.711 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.139AspAla: 3.139 ± 0.029
1.133AspCys: 1.133 ± 0.021
3.934AspAsp: 3.934 ± 0.036
4.425AspGlu: 4.425 ± 0.044
2.395AspPhe: 2.395 ± 0.026
3.373AspGly: 3.373 ± 0.041
1.228AspHis: 1.228 ± 0.015
3.497AspIle: 3.497 ± 0.026
2.756AspLys: 2.756 ± 0.028
4.62AspLeu: 4.62 ± 0.035
1.348AspMet: 1.348 ± 0.018
2.28AspAsn: 2.28 ± 0.024
2.188AspPro: 2.188 ± 0.024
1.811AspGln: 1.811 ± 0.019
3.017AspArg: 3.017 ± 0.032
4.187AspSer: 4.187 ± 0.039
2.442AspThr: 2.442 ± 0.023
4.031AspVal: 4.031 ± 0.032
0.652AspTrp: 0.652 ± 0.013
1.816AspTyr: 1.816 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
3.909GluAla: 3.909 ± 0.038
1.319GluCys: 1.319 ± 0.024
3.494GluAsp: 3.494 ± 0.032
5.207GluGlu: 5.207 ± 0.054
2.412GluPhe: 2.412 ± 0.023
2.764GluGly: 2.764 ± 0.028
1.516GluHis: 1.516 ± 0.018
3.995GluIle: 3.995 ± 0.034
4.992GluLys: 4.992 ± 0.045
5.678GluLeu: 5.678 ± 0.044
1.91GluMet: 1.91 ± 0.021
3.476GluAsn: 3.476 ± 0.031
2.061GluPro: 2.061 ± 0.025
2.733GluGln: 2.733 ± 0.029
4.065GluArg: 4.065 ± 0.036
4.359GluSer: 4.359 ± 0.038
3.209GluThr: 3.209 ± 0.034
3.8GluVal: 3.8 ± 0.028
0.779GluTrp: 0.779 ± 0.015
1.94GluTyr: 1.94 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.637PheAla: 2.637 ± 0.027
1.116PheCys: 1.116 ± 0.016
2.556PheAsp: 2.556 ± 0.025
2.523PheGlu: 2.523 ± 0.022
2.209PhePhe: 2.209 ± 0.025
2.624PheGly: 2.624 ± 0.029
1.17PheHis: 1.17 ± 0.016
2.862PheIle: 2.862 ± 0.029
1.973PheLys: 1.973 ± 0.022
4.236PheLeu: 4.236 ± 0.038
1.107PheMet: 1.107 ± 0.015
1.922PheAsn: 1.922 ± 0.021
1.824PhePro: 1.824 ± 0.023
1.44PheGln: 1.44 ± 0.018
2.337PheArg: 2.337 ± 0.024
3.593PheSer: 3.593 ± 0.029
2.368PheThr: 2.368 ± 0.023
3.168PheVal: 3.168 ± 0.028
0.514PheTrp: 0.514 ± 0.011
1.593PheTyr: 1.593 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
3.089GlyAla: 3.089 ± 0.03
1.219GlyCys: 1.219 ± 0.02
2.91GlyAsp: 2.91 ± 0.03
3.162GlyGlu: 3.162 ± 0.036
2.432GlyPhe: 2.432 ± 0.028
3.5GlyGly: 3.5 ± 0.047
1.266GlyHis: 1.266 ± 0.016
3.354GlyIle: 3.354 ± 0.03
3.235GlyLys: 3.235 ± 0.031
4.257GlyLeu: 4.257 ± 0.04
1.367GlyMet: 1.367 ± 0.02
2.486GlyAsn: 2.486 ± 0.023
2.159GlyPro: 2.159 ± 0.04
1.901GlyGln: 1.901 ± 0.028
3.251GlyArg: 3.251 ± 0.034
4.25GlySer: 4.25 ± 0.038
2.943GlyThr: 2.943 ± 0.028
3.605GlyVal: 3.605 ± 0.028
0.63GlyTrp: 0.63 ± 0.012
1.894GlyTyr: 1.894 ± 0.025
0.0GlyXaa: 0.0 ± 0.0
His
1.326HisAla: 1.326 ± 0.017
0.648HisCys: 0.648 ± 0.011
1.243HisAsp: 1.243 ± 0.018
1.458HisGlu: 1.458 ± 0.019
1.197HisPhe: 1.197 ± 0.015
1.384HisGly: 1.384 ± 0.019
0.815HisHis: 0.815 ± 0.016
1.528HisIle: 1.528 ± 0.019
1.174HisLys: 1.174 ± 0.016
2.442HisLeu: 2.442 ± 0.023
0.65HisMet: 0.65 ± 0.012
1.092HisAsn: 1.092 ± 0.016
1.237HisPro: 1.237 ± 0.017
0.96HisGln: 0.96 ± 0.015
1.545HisArg: 1.545 ± 0.019
2.08HisSer: 2.08 ± 0.023
1.203HisThr: 1.203 ± 0.015
1.616HisVal: 1.616 ± 0.022
0.292HisTrp: 0.292 ± 0.008
0.917HisTyr: 0.917 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
4.107IleAla: 4.107 ± 0.03
1.559IleCys: 1.559 ± 0.023
3.717IleAsp: 3.717 ± 0.033
3.949IleGlu: 3.949 ± 0.03
2.784IlePhe: 2.784 ± 0.027
3.525IleGly: 3.525 ± 0.029
1.582IleHis: 1.582 ± 0.019
3.791IleIle: 3.791 ± 0.032
3.08IleLys: 3.08 ± 0.026
5.526IleLeu: 5.526 ± 0.042
1.483IleMet: 1.483 ± 0.018
2.763IleAsn: 2.763 ± 0.027
3.03IlePro: 3.03 ± 0.026
2.222IleGln: 2.222 ± 0.021
3.735IleArg: 3.735 ± 0.028
5.268IleSer: 5.268 ± 0.037
3.593IleThr: 3.593 ± 0.028
4.303IleVal: 4.303 ± 0.036
0.674IleTrp: 0.674 ± 0.014
1.981IleTyr: 1.981 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.447LysAla: 3.447 ± 0.032
1.294LysCys: 1.294 ± 0.019
2.997LysAsp: 2.997 ± 0.03
4.174LysGlu: 4.174 ± 0.042
2.165LysPhe: 2.165 ± 0.021
2.612LysGly: 2.612 ± 0.026
1.392LysHis: 1.392 ± 0.018
3.6LysIle: 3.6 ± 0.033
4.789LysLys: 4.789 ± 0.049
5.265LysLeu: 5.265 ± 0.04
1.676LysMet: 1.676 ± 0.019
2.956LysAsn: 2.956 ± 0.024
2.353LysPro: 2.353 ± 0.027
2.413LysGln: 2.413 ± 0.024
3.84LysArg: 3.84 ± 0.037
4.326LysSer: 4.326 ± 0.037
3.156LysThr: 3.156 ± 0.029
3.374LysVal: 3.374 ± 0.031
0.696LysTrp: 0.696 ± 0.011
1.919LysTyr: 1.919 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
5.725LeuAla: 5.725 ± 0.034
2.153LeuCys: 2.153 ± 0.027
4.645LeuAsp: 4.645 ± 0.036
5.445LeuGlu: 5.445 ± 0.047
4.217LeuPhe: 4.217 ± 0.038
4.071LeuGly: 4.071 ± 0.033
2.445LeuHis: 2.445 ± 0.027
5.54LeuIle: 5.54 ± 0.043
5.364LeuLys: 5.364 ± 0.038
9.363LeuLeu: 9.363 ± 0.066
2.41LeuMet: 2.41 ± 0.024
4.305LeuAsn: 4.305 ± 0.035
4.64LeuPro: 4.64 ± 0.038
3.754LeuGln: 3.754 ± 0.035
5.729LeuArg: 5.729 ± 0.041
7.85LeuSer: 7.85 ± 0.051
4.957LeuThr: 4.957 ± 0.033
5.453LeuVal: 5.453 ± 0.04
1.025LeuTrp: 1.025 ± 0.019
2.845LeuTyr: 2.845 ± 0.028
0.0LeuXaa: 0.0 ± 0.0
Met
1.739MetAla: 1.739 ± 0.021
0.548MetCys: 0.548 ± 0.011
1.417MetAsp: 1.417 ± 0.018
1.718MetGlu: 1.718 ± 0.019
1.148MetPhe: 1.148 ± 0.016
1.243MetGly: 1.243 ± 0.018
0.602MetHis: 0.602 ± 0.012
1.574MetIle: 1.574 ± 0.017
1.81MetLys: 1.81 ± 0.02
2.446MetLeu: 2.446 ± 0.024
0.804MetMet: 0.804 ± 0.015
1.356MetAsn: 1.356 ± 0.018
1.078MetPro: 1.078 ± 0.016
1.013MetGln: 1.013 ± 0.016
1.574MetArg: 1.574 ± 0.021
2.162MetSer: 2.162 ± 0.019
1.534MetThr: 1.534 ± 0.022
1.617MetVal: 1.617 ± 0.019
0.284MetTrp: 0.284 ± 0.008
0.738MetTyr: 0.738 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.852AsnAla: 2.852 ± 0.026
1.035AsnCys: 1.035 ± 0.017
2.756AsnAsp: 2.756 ± 0.027
3.342AsnGlu: 3.342 ± 0.029
1.937AsnPhe: 1.937 ± 0.023
2.947AsnGly: 2.947 ± 0.029
1.091AsnHis: 1.091 ± 0.016
3.077AsnIle: 3.077 ± 0.025
2.502AsnLys: 2.502 ± 0.024
3.962AsnLeu: 3.962 ± 0.034
1.222AsnMet: 1.222 ± 0.016
2.297AsnAsn: 2.297 ± 0.025
2.072AsnPro: 2.072 ± 0.025
1.621AsnGln: 1.621 ± 0.02
2.689AsnArg: 2.689 ± 0.023
3.735AsnSer: 3.735 ± 0.032
2.529AsnThr: 2.529 ± 0.023
3.359AsnVal: 3.359 ± 0.027
0.49AsnTrp: 0.49 ± 0.011
1.545AsnTyr: 1.545 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
2.437ProAla: 2.437 ± 0.027
0.851ProCys: 0.851 ± 0.017
2.164ProAsp: 2.164 ± 0.022
2.594ProGlu: 2.594 ± 0.028
1.968ProPhe: 1.968 ± 0.024
2.707ProGly: 2.707 ± 0.083
1.143ProHis: 1.143 ± 0.019
2.764ProIle: 2.764 ± 0.028
2.278ProLys: 2.278 ± 0.026
4.06ProLeu: 4.06 ± 0.033
1.016ProMet: 1.016 ± 0.017
2.034ProAsn: 2.034 ± 0.022
3.255ProPro: 3.255 ± 0.047
1.798ProGln: 1.798 ± 0.029
2.327ProArg: 2.327 ± 0.027
4.254ProSer: 4.254 ± 0.039
2.772ProThr: 2.772 ± 0.027
2.832ProVal: 2.832 ± 0.028
0.442ProTrp: 0.442 ± 0.011
1.477ProTyr: 1.477 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
2.249GlnAla: 2.249 ± 0.028
0.957GlnCys: 0.957 ± 0.021
1.402GlnAsp: 1.402 ± 0.019
2.071GlnGlu: 2.071 ± 0.024
1.663GlnPhe: 1.663 ± 0.018
1.538GlnGly: 1.538 ± 0.023
1.065GlnHis: 1.065 ± 0.017
2.43GlnIle: 2.43 ± 0.025
2.396GlnLys: 2.396 ± 0.025
4.133GlnLeu: 4.133 ± 0.037
1.226GlnMet: 1.226 ± 0.018
1.844GlnAsn: 1.844 ± 0.018
1.792GlnPro: 1.792 ± 0.028
2.257GlnGln: 2.257 ± 0.041
2.471GlnArg: 2.471 ± 0.025
2.936GlnSer: 2.936 ± 0.029
2.004GlnThr: 2.004 ± 0.022
2.105GlnVal: 2.105 ± 0.021
0.502GlnTrp: 0.502 ± 0.011
1.291GlnTyr: 1.291 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
3.289ArgAla: 3.289 ± 0.03
1.345ArgCys: 1.345 ± 0.023
2.942ArgAsp: 2.942 ± 0.031
3.598ArgGlu: 3.598 ± 0.036
2.586ArgPhe: 2.586 ± 0.025
2.821ArgGly: 2.821 ± 0.034
1.541ArgHis: 1.541 ± 0.017
3.764ArgIle: 3.764 ± 0.026
4.15ArgLys: 4.15 ± 0.033
5.566ArgLeu: 5.566 ± 0.034
1.593ArgMet: 1.593 ± 0.02
3.063ArgAsn: 3.063 ± 0.029
2.419ArgPro: 2.419 ± 0.026
2.383ArgGln: 2.383 ± 0.025
4.668ArgArg: 4.668 ± 0.04
4.781ArgSer: 4.781 ± 0.043
3.102ArgThr: 3.102 ± 0.031
3.394ArgVal: 3.394 ± 0.026
0.657ArgTrp: 0.657 ± 0.013
1.893ArgTyr: 1.893 ± 0.023
0.0ArgXaa: 0.0 ± 0.0
Ser
4.878SerAla: 4.878 ± 0.037
1.77SerCys: 1.77 ± 0.025
4.548SerAsp: 4.548 ± 0.041
4.701SerGlu: 4.701 ± 0.032
3.564SerPhe: 3.564 ± 0.031
4.477SerGly: 4.477 ± 0.034
1.944SerHis: 1.944 ± 0.022
5.069SerIle: 5.069 ± 0.036
4.353SerLys: 4.353 ± 0.036
7.401SerLeu: 7.401 ± 0.046
2.044SerMet: 2.044 ± 0.024
3.847SerAsn: 3.847 ± 0.034
3.801SerPro: 3.801 ± 0.042
2.983SerGln: 2.983 ± 0.03
4.653SerArg: 4.653 ± 0.038
8.789SerSer: 8.789 ± 0.087
5.443SerThr: 5.443 ± 0.05
5.251SerVal: 5.251 ± 0.037
0.799SerTrp: 0.799 ± 0.012
2.438SerTyr: 2.438 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
3.66ThrAla: 3.66 ± 0.035
1.188ThrCys: 1.188 ± 0.018
2.74ThrAsp: 2.74 ± 0.028
3.131ThrGlu: 3.131 ± 0.028
2.364ThrPhe: 2.364 ± 0.025
2.895ThrGly: 2.895 ± 0.031
1.222ThrHis: 1.222 ± 0.016
3.661ThrIle: 3.661 ± 0.031
3.026ThrLys: 3.026 ± 0.027
4.986ThrLeu: 4.986 ± 0.036
1.44ThrMet: 1.44 ± 0.024
2.611ThrAsn: 2.611 ± 0.026
2.825ThrPro: 2.825 ± 0.028
1.911ThrGln: 1.911 ± 0.02
2.738ThrArg: 2.738 ± 0.025
5.071ThrSer: 5.071 ± 0.044
3.89ThrThr: 3.89 ± 0.044
4.081ThrVal: 4.081 ± 0.034
0.556ThrTrp: 0.556 ± 0.013
1.607ThrTyr: 1.607 ± 0.017
0.0ThrXaa: 0.0 ± 0.0
Val
4.265ValAla: 4.265 ± 0.035
1.524ValCys: 1.524 ± 0.021
3.982ValAsp: 3.982 ± 0.03
4.259ValGlu: 4.259 ± 0.034
3.029ValPhe: 3.029 ± 0.032
3.313ValGly: 3.313 ± 0.032
1.616ValHis: 1.616 ± 0.019
4.145ValIle: 4.145 ± 0.034
3.58ValLys: 3.58 ± 0.03
6.165ValLeu: 6.165 ± 0.04
1.706ValMet: 1.706 ± 0.019
3.013ValAsn: 3.013 ± 0.029
2.963ValPro: 2.963 ± 0.027
2.407ValGln: 2.407 ± 0.028
3.504ValArg: 3.504 ± 0.029
4.982ValSer: 4.982 ± 0.036
3.608ValThr: 3.608 ± 0.03
4.901ValVal: 4.901 ± 0.037
0.684ValTrp: 0.684 ± 0.013
2.019ValTyr: 2.019 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
0.592TrpAla: 0.592 ± 0.013
0.247TrpCys: 0.247 ± 0.008
0.545TrpAsp: 0.545 ± 0.013
0.606TrpGlu: 0.606 ± 0.012
0.501TrpPhe: 0.501 ± 0.011
0.444TrpGly: 0.444 ± 0.011
0.267TrpHis: 0.267 ± 0.008
0.784TrpIle: 0.784 ± 0.012
0.763TrpLys: 0.763 ± 0.014
1.1TrpLeu: 1.1 ± 0.017
0.397TrpMet: 0.397 ± 0.009
0.602TrpAsn: 0.602 ± 0.012
0.411TrpPro: 0.411 ± 0.01
0.448TrpGln: 0.448 ± 0.01
0.721TrpArg: 0.721 ± 0.012
0.885TrpSer: 0.885 ± 0.015
0.646TrpThr: 0.646 ± 0.013
0.554TrpVal: 0.554 ± 0.011
0.171TrpTrp: 0.171 ± 0.007
0.371TrpTyr: 0.371 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.877TyrAla: 1.877 ± 0.02
0.849TyrCys: 0.849 ± 0.014
1.822TyrAsp: 1.822 ± 0.022
1.994TyrGlu: 1.994 ± 0.021
1.554TyrPhe: 1.554 ± 0.019
2.059TyrGly: 2.059 ± 0.024
0.868TyrHis: 0.868 ± 0.014
1.861TyrIle: 1.861 ± 0.023
1.617TyrLys: 1.617 ± 0.017
2.854TyrLeu: 2.854 ± 0.033
0.834TyrMet: 0.834 ± 0.013
1.478TyrAsn: 1.478 ± 0.017
1.384TyrPro: 1.384 ± 0.023
1.167TyrGln: 1.167 ± 0.017
1.97TyrArg: 1.97 ± 0.021
2.526TyrSer: 2.526 ± 0.024
1.604TyrThr: 1.604 ± 0.021
2.053TyrVal: 2.053 ± 0.024
0.397TyrTrp: 0.397 ± 0.01
1.238TyrTyr: 1.238 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14161 proteins (4630289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski