Amino acid dipepetide frequency for Acaromyces ingoldii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.551AlaAla: 13.551 ± 0.114
1.052AlaCys: 1.052 ± 0.017
4.859AlaAsp: 4.859 ± 0.034
5.503AlaGlu: 5.503 ± 0.04
3.284AlaPhe: 3.284 ± 0.032
7.58AlaGly: 7.58 ± 0.053
2.21AlaHis: 2.21 ± 0.022
3.856AlaIle: 3.856 ± 0.035
4.908AlaLys: 4.908 ± 0.041
8.955AlaLeu: 8.955 ± 0.067
2.176AlaMet: 2.176 ± 0.023
2.979AlaAsn: 2.979 ± 0.026
5.923AlaPro: 5.923 ± 0.057
4.212AlaGln: 4.212 ± 0.039
6.872AlaArg: 6.872 ± 0.046
10.632AlaSer: 10.632 ± 0.078
6.195AlaThr: 6.195 ± 0.046
5.671AlaVal: 5.671 ± 0.039
1.276AlaTrp: 1.276 ± 0.021
2.095AlaTyr: 2.095 ± 0.025
0.0AlaXaa: 0.0 ± 0.0
Cys
0.944CysAla: 0.944 ± 0.018
0.218CysCys: 0.218 ± 0.008
0.593CysAsp: 0.593 ± 0.013
0.494CysGlu: 0.494 ± 0.011
0.454CysPhe: 0.454 ± 0.011
0.742CysGly: 0.742 ± 0.014
0.271CysHis: 0.271 ± 0.01
0.523CysIle: 0.523 ± 0.011
0.423CysLys: 0.423 ± 0.012
1.153CysLeu: 1.153 ± 0.018
0.199CysMet: 0.199 ± 0.007
0.325CysAsn: 0.325 ± 0.01
0.572CysPro: 0.572 ± 0.012
0.394CysGln: 0.394 ± 0.01
0.68CysArg: 0.68 ± 0.014
0.808CysSer: 0.808 ± 0.016
0.571CysThr: 0.571 ± 0.012
0.699CysVal: 0.699 ± 0.013
0.153CysTrp: 0.153 ± 0.007
0.27CysTyr: 0.27 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.856AspAla: 5.856 ± 0.04
0.531AspCys: 0.531 ± 0.013
5.604AspAsp: 5.604 ± 0.069
5.885AspGlu: 5.885 ± 0.057
1.912AspPhe: 1.912 ± 0.023
4.865AspGly: 4.865 ± 0.041
1.121AspHis: 1.121 ± 0.018
2.138AspIle: 2.138 ± 0.026
2.316AspLys: 2.316 ± 0.025
4.732AspLeu: 4.732 ± 0.039
1.079AspMet: 1.079 ± 0.016
1.466AspAsn: 1.466 ± 0.021
2.762AspPro: 2.762 ± 0.029
1.823AspGln: 1.823 ± 0.023
3.211AspArg: 3.211 ± 0.029
3.804AspSer: 3.804 ± 0.037
2.355AspThr: 2.355 ± 0.025
4.23AspVal: 4.23 ± 0.032
0.796AspTrp: 0.796 ± 0.013
1.284AspTyr: 1.284 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
7.046GluAla: 7.046 ± 0.046
0.495GluCys: 0.495 ± 0.011
4.447GluAsp: 4.447 ± 0.05
7.124GluGlu: 7.124 ± 0.084
1.256GluPhe: 1.256 ± 0.018
4.778GluGly: 4.778 ± 0.039
1.363GluHis: 1.363 ± 0.02
2.069GluIle: 2.069 ± 0.026
3.367GluLys: 3.367 ± 0.033
4.798GluLeu: 4.798 ± 0.041
1.378GluMet: 1.378 ± 0.02
1.512GluAsn: 1.512 ± 0.02
2.504GluPro: 2.504 ± 0.027
2.936GluGln: 2.936 ± 0.029
4.723GluArg: 4.723 ± 0.044
3.977GluSer: 3.977 ± 0.033
3.014GluThr: 3.014 ± 0.026
3.512GluVal: 3.512 ± 0.033
0.743GluTrp: 0.743 ± 0.014
1.147GluTyr: 1.147 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
3.186PheAla: 3.186 ± 0.029
0.465PheCys: 0.465 ± 0.012
2.205PheAsp: 2.205 ± 0.025
1.918PheGlu: 1.918 ± 0.022
1.455PhePhe: 1.455 ± 0.021
2.717PheGly: 2.717 ± 0.033
0.761PheHis: 0.761 ± 0.013
1.259PheIle: 1.259 ± 0.022
1.219PheLys: 1.219 ± 0.019
3.085PheLeu: 3.085 ± 0.032
0.58PheMet: 0.58 ± 0.014
1.059PheAsn: 1.059 ± 0.016
1.544PhePro: 1.544 ± 0.02
1.061PheGln: 1.061 ± 0.018
1.73PheArg: 1.73 ± 0.022
2.826PheSer: 2.826 ± 0.029
1.651PheThr: 1.651 ± 0.02
2.414PheVal: 2.414 ± 0.026
0.497PheTrp: 0.497 ± 0.011
0.891PheTyr: 0.891 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
7.719GlyAla: 7.719 ± 0.054
0.735GlyCys: 0.735 ± 0.015
4.121GlyAsp: 4.121 ± 0.031
4.267GlyGlu: 4.267 ± 0.032
2.465GlyPhe: 2.465 ± 0.031
8.303GlyGly: 8.303 ± 0.089
1.873GlyHis: 1.873 ± 0.025
2.933GlyIle: 2.933 ± 0.033
3.711GlyLys: 3.711 ± 0.04
6.316GlyLeu: 6.316 ± 0.048
1.467GlyMet: 1.467 ± 0.023
2.352GlyAsn: 2.352 ± 0.03
4.045GlyPro: 4.045 ± 0.039
3.417GlyGln: 3.417 ± 0.037
4.772GlyArg: 4.772 ± 0.047
7.015GlySer: 7.015 ± 0.056
4.069GlyThr: 4.069 ± 0.033
4.175GlyVal: 4.175 ± 0.041
1.035GlyTrp: 1.035 ± 0.015
1.685GlyTyr: 1.685 ± 0.023
0.0GlyXaa: 0.0 ± 0.0
His
2.196HisAla: 2.196 ± 0.023
0.283HisCys: 0.283 ± 0.008
1.317HisAsp: 1.317 ± 0.019
1.278HisGlu: 1.278 ± 0.017
0.91HisPhe: 0.91 ± 0.014
1.815HisGly: 1.815 ± 0.02
1.054HisHis: 1.054 ± 0.03
0.92HisIle: 0.92 ± 0.015
0.77HisLys: 0.77 ± 0.012
2.444HisLeu: 2.444 ± 0.025
0.425HisMet: 0.425 ± 0.01
0.685HisAsn: 0.685 ± 0.014
1.546HisPro: 1.546 ± 0.022
1.174HisGln: 1.174 ± 0.024
1.672HisArg: 1.672 ± 0.022
1.819HisSer: 1.819 ± 0.027
1.115HisThr: 1.115 ± 0.018
1.475HisVal: 1.475 ± 0.019
0.318HisTrp: 0.318 ± 0.009
0.589HisTyr: 0.589 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.624IleAla: 3.624 ± 0.036
0.515IleCys: 0.515 ± 0.011
2.61IleAsp: 2.61 ± 0.025
2.443IleGlu: 2.443 ± 0.025
1.49IlePhe: 1.49 ± 0.023
2.635IleGly: 2.635 ± 0.03
0.906IleHis: 0.906 ± 0.016
1.647IleIle: 1.647 ± 0.024
1.798IleLys: 1.798 ± 0.022
3.497IleLeu: 3.497 ± 0.038
0.695IleMet: 0.695 ± 0.012
1.302IleAsn: 1.302 ± 0.02
1.916IlePro: 1.916 ± 0.023
1.325IleGln: 1.325 ± 0.018
2.282IleArg: 2.282 ± 0.023
2.854IleSer: 2.854 ± 0.027
1.833IleThr: 1.833 ± 0.021
2.923IleVal: 2.923 ± 0.031
0.52IleTrp: 0.52 ± 0.011
0.952IleTyr: 0.952 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
4.721LysAla: 4.721 ± 0.043
0.365LysCys: 0.365 ± 0.011
2.613LysAsp: 2.613 ± 0.029
3.344LysGlu: 3.344 ± 0.039
0.989LysPhe: 0.989 ± 0.018
3.433LysGly: 3.433 ± 0.035
0.963LysHis: 0.963 ± 0.017
1.666LysIle: 1.666 ± 0.017
3.157LysLys: 3.157 ± 0.051
3.718LysLeu: 3.718 ± 0.031
0.951LysMet: 0.951 ± 0.016
1.235LysAsn: 1.235 ± 0.019
2.252LysPro: 2.252 ± 0.03
1.877LysGln: 1.877 ± 0.025
4.026LysArg: 4.026 ± 0.038
3.145LysSer: 3.145 ± 0.033
2.593LysThr: 2.593 ± 0.026
2.719LysVal: 2.719 ± 0.025
0.525LysTrp: 0.525 ± 0.011
0.858LysTyr: 0.858 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
9.342LeuAla: 9.342 ± 0.066
1.187LeuCys: 1.187 ± 0.019
5.423LeuAsp: 5.423 ± 0.042
5.121LeuGlu: 5.121 ± 0.046
3.298LeuPhe: 3.298 ± 0.036
6.245LeuGly: 6.245 ± 0.04
2.162LeuHis: 2.162 ± 0.023
3.197LeuIle: 3.197 ± 0.031
3.428LeuLys: 3.428 ± 0.034
8.645LeuLeu: 8.645 ± 0.066
1.584LeuMet: 1.584 ± 0.02
2.479LeuAsn: 2.479 ± 0.028
5.402LeuPro: 5.402 ± 0.041
3.693LeuGln: 3.693 ± 0.036
5.98LeuArg: 5.98 ± 0.043
7.755LeuSer: 7.755 ± 0.049
4.404LeuThr: 4.404 ± 0.032
5.924LeuVal: 5.924 ± 0.046
1.042LeuTrp: 1.042 ± 0.018
2.008LeuTyr: 2.008 ± 0.024
0.0LeuXaa: 0.0 ± 0.0
Met
2.364MetAla: 2.364 ± 0.025
0.203MetCys: 0.203 ± 0.007
1.126MetAsp: 1.126 ± 0.016
1.046MetGlu: 1.046 ± 0.016
0.515MetPhe: 0.515 ± 0.011
1.517MetGly: 1.517 ± 0.023
0.451MetHis: 0.451 ± 0.009
0.686MetIle: 0.686 ± 0.013
0.768MetLys: 0.768 ± 0.013
1.81MetLeu: 1.81 ± 0.02
0.534MetMet: 0.534 ± 0.013
0.564MetAsn: 0.564 ± 0.012
1.27MetPro: 1.27 ± 0.021
0.87MetGln: 0.87 ± 0.017
1.388MetArg: 1.388 ± 0.019
1.865MetSer: 1.865 ± 0.023
1.239MetThr: 1.239 ± 0.018
1.112MetVal: 1.112 ± 0.017
0.211MetTrp: 0.211 ± 0.007
0.387MetTyr: 0.387 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
2.959AsnAla: 2.959 ± 0.028
0.282AsnCys: 0.282 ± 0.009
1.739AsnAsp: 1.739 ± 0.022
1.796AsnGlu: 1.796 ± 0.021
0.999AsnPhe: 0.999 ± 0.017
2.806AsnGly: 2.806 ± 0.033
0.663AsnHis: 0.663 ± 0.013
1.259AsnIle: 1.259 ± 0.019
1.31AsnLys: 1.31 ± 0.018
2.577AsnLeu: 2.577 ± 0.028
0.564AsnMet: 0.564 ± 0.012
1.161AsnAsn: 1.161 ± 0.024
1.647AsnPro: 1.647 ± 0.021
1.013AsnGln: 1.013 ± 0.017
1.668AsnArg: 1.668 ± 0.022
2.23AsnSer: 2.23 ± 0.027
1.487AsnThr: 1.487 ± 0.017
2.131AsnVal: 2.131 ± 0.028
0.341AsnTrp: 0.341 ± 0.008
0.699AsnTyr: 0.699 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
5.753ProAla: 5.753 ± 0.053
0.458ProCys: 0.458 ± 0.011
2.673ProAsp: 2.673 ± 0.026
2.743ProGlu: 2.743 ± 0.029
1.949ProPhe: 1.949 ± 0.026
3.88ProGly: 3.88 ± 0.039
1.394ProHis: 1.394 ± 0.022
1.99ProIle: 1.99 ± 0.021
2.278ProLys: 2.278 ± 0.033
5.023ProLeu: 5.023 ± 0.038
1.09ProMet: 1.09 ± 0.019
1.644ProAsn: 1.644 ± 0.019
5.42ProPro: 5.42 ± 0.077
2.321ProGln: 2.321 ± 0.033
3.719ProArg: 3.719 ± 0.037
7.305ProSer: 7.305 ± 0.074
3.799ProThr: 3.799 ± 0.035
3.127ProVal: 3.127 ± 0.033
0.673ProTrp: 0.673 ± 0.013
1.246ProTyr: 1.246 ± 0.019
0.0ProXaa: 0.0 ± 0.0
Gln
4.34GlnAla: 4.34 ± 0.04
0.36GlnCys: 0.36 ± 0.01
2.109GlnAsp: 2.109 ± 0.025
2.662GlnGlu: 2.662 ± 0.029
0.928GlnPhe: 0.928 ± 0.016
3.157GlnGly: 3.157 ± 0.03
1.359GlnHis: 1.359 ± 0.026
1.401GlnIle: 1.401 ± 0.018
1.716GlnLys: 1.716 ± 0.024
3.464GlnLeu: 3.464 ± 0.029
0.868GlnMet: 0.868 ± 0.016
1.06GlnAsn: 1.06 ± 0.017
2.505GlnPro: 2.505 ± 0.036
4.967GlnGln: 4.967 ± 0.13
3.453GlnArg: 3.453 ± 0.031
3.219GlnSer: 3.219 ± 0.029
2.216GlnThr: 2.216 ± 0.025
2.154GlnVal: 2.154 ± 0.023
0.507GlnTrp: 0.507 ± 0.01
0.836GlnTyr: 0.836 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
6.307ArgAla: 6.307 ± 0.046
0.742ArgCys: 0.742 ± 0.015
3.506ArgAsp: 3.506 ± 0.03
4.173ArgGlu: 4.173 ± 0.041
2.244ArgPhe: 2.244 ± 0.026
4.659ArgGly: 4.659 ± 0.046
1.704ArgHis: 1.704 ± 0.023
2.696ArgIle: 2.696 ± 0.028
3.534ArgLys: 3.534 ± 0.037
6.156ArgLeu: 6.156 ± 0.042
1.388ArgMet: 1.388 ± 0.017
1.963ArgAsn: 1.963 ± 0.023
3.956ArgPro: 3.956 ± 0.036
3.162ArgGln: 3.162 ± 0.028
6.563ArgArg: 6.563 ± 0.057
5.871ArgSer: 5.871 ± 0.051
3.456ArgThr: 3.456 ± 0.031
3.317ArgVal: 3.317 ± 0.03
0.948ArgTrp: 0.948 ± 0.016
1.496ArgTyr: 1.496 ± 0.02
0.0ArgXaa: 0.0 ± 0.0
Ser
8.847SerAla: 8.847 ± 0.068
0.778SerCys: 0.778 ± 0.014
4.292SerAsp: 4.292 ± 0.037
3.96SerGlu: 3.96 ± 0.037
2.951SerPhe: 2.951 ± 0.028
6.426SerGly: 6.426 ± 0.053
2.079SerHis: 2.079 ± 0.026
3.425SerIle: 3.425 ± 0.034
3.896SerLys: 3.896 ± 0.037
8.0SerLeu: 8.0 ± 0.058
1.893SerMet: 1.893 ± 0.025
2.92SerAsn: 2.92 ± 0.033
6.113SerPro: 6.113 ± 0.078
3.466SerGln: 3.466 ± 0.038
5.676SerArg: 5.676 ± 0.051
14.635SerSer: 14.635 ± 0.152
6.198SerThr: 6.198 ± 0.06
4.638SerVal: 4.638 ± 0.036
1.004SerTrp: 1.004 ± 0.014
1.811SerTyr: 1.811 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
5.686ThrAla: 5.686 ± 0.038
0.594ThrCys: 0.594 ± 0.014
2.483ThrAsp: 2.483 ± 0.025
2.502ThrGlu: 2.502 ± 0.026
1.982ThrPhe: 1.982 ± 0.023
3.999ThrGly: 3.999 ± 0.035
1.137ThrHis: 1.137 ± 0.018
2.303ThrIle: 2.303 ± 0.027
2.412ThrLys: 2.412 ± 0.025
5.044ThrLeu: 5.044 ± 0.042
1.204ThrMet: 1.204 ± 0.018
1.643ThrAsn: 1.643 ± 0.021
3.923ThrPro: 3.923 ± 0.038
1.822ThrGln: 1.822 ± 0.023
3.223ThrArg: 3.223 ± 0.032
6.01ThrSer: 6.01 ± 0.053
4.152ThrThr: 4.152 ± 0.045
3.304ThrVal: 3.304 ± 0.033
0.675ThrTrp: 0.675 ± 0.014
1.261ThrTyr: 1.261 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
6.201ValAla: 6.201 ± 0.045
0.758ValCys: 0.758 ± 0.014
3.889ValAsp: 3.889 ± 0.029
3.986ValGlu: 3.986 ± 0.035
2.12ValPhe: 2.12 ± 0.025
4.388ValGly: 4.388 ± 0.038
1.412ValHis: 1.412 ± 0.02
2.296ValIle: 2.296 ± 0.027
2.64ValLys: 2.64 ± 0.027
5.53ValLeu: 5.53 ± 0.046
1.129ValMet: 1.129 ± 0.015
1.754ValAsn: 1.754 ± 0.022
3.491ValPro: 3.491 ± 0.032
2.347ValGln: 2.347 ± 0.024
3.839ValArg: 3.839 ± 0.032
4.557ValSer: 4.557 ± 0.037
3.031ValThr: 3.031 ± 0.032
4.454ValVal: 4.454 ± 0.047
0.807ValTrp: 0.807 ± 0.013
1.371ValTyr: 1.371 ± 0.02
0.0ValXaa: 0.0 ± 0.0
Trp
1.093TrpAla: 1.093 ± 0.016
0.171TrpCys: 0.171 ± 0.006
0.771TrpAsp: 0.771 ± 0.019
0.667TrpGlu: 0.667 ± 0.012
0.422TrpPhe: 0.422 ± 0.011
0.761TrpGly: 0.761 ± 0.016
0.32TrpHis: 0.32 ± 0.009
0.602TrpIle: 0.602 ± 0.012
0.629TrpLys: 0.629 ± 0.012
1.234TrpLeu: 1.234 ± 0.02
0.29TrpMet: 0.29 ± 0.009
0.475TrpAsn: 0.475 ± 0.011
0.58TrpPro: 0.58 ± 0.012
0.545TrpGln: 0.545 ± 0.012
0.953TrpArg: 0.953 ± 0.016
1.09TrpSer: 1.09 ± 0.019
0.852TrpThr: 0.852 ± 0.014
0.636TrpVal: 0.636 ± 0.012
0.236TrpTrp: 0.236 ± 0.008
0.306TrpTyr: 0.306 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.052TyrAla: 2.052 ± 0.025
0.296TyrCys: 0.296 ± 0.009
1.391TyrAsp: 1.391 ± 0.017
1.275TyrGlu: 1.275 ± 0.019
0.898TyrPhe: 0.898 ± 0.016
1.768TyrGly: 1.768 ± 0.028
0.599TyrHis: 0.599 ± 0.012
0.902TyrIle: 0.902 ± 0.014
0.87TyrLys: 0.87 ± 0.014
2.139TyrLeu: 2.139 ± 0.026
0.436TyrMet: 0.436 ± 0.012
0.754TyrAsn: 0.754 ± 0.016
1.115TyrPro: 1.115 ± 0.018
0.856TyrGln: 0.856 ± 0.018
1.412TyrArg: 1.412 ± 0.017
1.594TyrSer: 1.594 ± 0.022
1.128TyrThr: 1.128 ± 0.018
1.382TyrVal: 1.382 ± 0.02
0.325TyrTrp: 0.325 ± 0.009
0.661TyrTyr: 0.661 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.004
Statistics based on 8019 proteins (4210363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski