Amino acid dipepetide frequency for Planoprotostelium fungivorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.516AlaAla: 5.516 ± 0.045	0.98AlaCys: 0.98 ± 0.014	3.101AlaAsp: 3.101 ± 0.022	4.04AlaGlu: 4.04 ± 0.035	2.425AlaPhe: 2.425 ± 0.018	3.54AlaGly: 3.54 ± 0.027	1.33AlaHis: 1.33 ± 0.014	3.664AlaIle: 3.664 ± 0.023	3.479AlaLys: 3.479 ± 0.033	5.615AlaLeu: 5.615 ± 0.031	1.399AlaMet: 1.399 ± 0.015	2.462AlaAsn: 2.462 ± 0.018	3.141AlaPro: 3.141 ± 0.03	2.555AlaGln: 2.555 ± 0.025	3.103AlaArg: 3.103 ± 0.021	5.358AlaSer: 5.358 ± 0.033	4.068AlaThr: 4.068 ± 0.031	4.378AlaVal: 4.378 ± 0.026	0.689AlaTrp: 0.689 ± 0.009	1.728AlaTyr: 1.728 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.849CysAla: 0.849 ± 0.011	0.339CysCys: 0.339 ± 0.007	0.844CysAsp: 0.844 ± 0.012	0.694CysGlu: 0.694 ± 0.009	0.626CysPhe: 0.626 ± 0.01	1.161CysGly: 1.161 ± 0.015	0.438CysHis: 0.438 ± 0.008	0.969CysIle: 0.969 ± 0.013	0.737CysLys: 0.737 ± 0.01	1.524CysLeu: 1.524 ± 0.014	0.345CysMet: 0.345 ± 0.006	0.781CysAsn: 0.781 ± 0.012	0.817CysPro: 0.817 ± 0.015	0.693CysGln: 0.693 ± 0.011	0.875CysArg: 0.875 ± 0.011	1.388CysSer: 1.388 ± 0.015	1.081CysThr: 1.081 ± 0.016	0.982CysVal: 0.982 ± 0.012	0.256CysTrp: 0.256 ± 0.006	0.488CysTyr: 0.488 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.353AspAla: 3.353 ± 0.024	0.783AspCys: 0.783 ± 0.012	3.302AspAsp: 3.302 ± 0.029	3.734AspGlu: 3.734 ± 0.034	2.183AspPhe: 2.183 ± 0.02	3.339AspGly: 3.339 ± 0.023	1.427AspHis: 1.427 ± 0.016	3.421AspIle: 3.421 ± 0.022	2.679AspLys: 2.679 ± 0.022	5.081AspLeu: 5.081 ± 0.033	1.269AspMet: 1.269 ± 0.013	2.32AspAsn: 2.32 ± 0.02	2.629AspPro: 2.629 ± 0.022	1.904AspGln: 1.904 ± 0.015	3.026AspArg: 3.026 ± 0.021	3.793AspSer: 3.793 ± 0.023	2.995AspThr: 2.995 ± 0.028	3.85AspVal: 3.85 ± 0.024	0.7AspTrp: 0.7 ± 0.009	1.638AspTyr: 1.638 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	4.347GluAla: 4.347 ± 0.038	0.808GluCys: 0.808 ± 0.011	4.15GluAsp: 4.15 ± 0.035	8.403GluGlu: 8.403 ± 0.104	1.957GluPhe: 1.957 ± 0.019	3.926GluGly: 3.926 ± 0.028	1.3GluHis: 1.3 ± 0.015	3.488GluIle: 3.488 ± 0.025	5.404GluLys: 5.404 ± 0.056	5.093GluLeu: 5.093 ± 0.04	1.902GluMet: 1.902 ± 0.018	2.673GluAsn: 2.673 ± 0.02	2.142GluPro: 2.142 ± 0.018	2.561GluGln: 2.561 ± 0.022	4.232GluArg: 4.232 ± 0.044	4.139GluSer: 4.139 ± 0.03	3.663GluThr: 3.663 ± 0.031	3.615GluVal: 3.615 ± 0.026	0.822GluTrp: 0.822 ± 0.01	1.755GluTyr: 1.755 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.222PheAla: 2.222 ± 0.015	0.775PheCys: 0.775 ± 0.011	2.219PheAsp: 2.219 ± 0.018	2.057PheGlu: 2.057 ± 0.016	1.78PhePhe: 1.78 ± 0.018	2.664PheGly: 2.664 ± 0.024	1.102PheHis: 1.102 ± 0.011	2.305PheIle: 2.305 ± 0.02	1.721PheLys: 1.721 ± 0.016	3.708PheLeu: 3.708 ± 0.026	0.798PheMet: 0.798 ± 0.01	1.868PheAsn: 1.868 ± 0.018	1.665PhePro: 1.665 ± 0.014	1.517PheGln: 1.517 ± 0.014	1.929PheArg: 1.929 ± 0.015	3.676PheSer: 3.676 ± 0.027	2.512PheThr: 2.512 ± 0.023	2.635PheVal: 2.635 ± 0.018	0.54PheTrp: 0.54 ± 0.008	1.365PheTyr: 1.365 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	3.576GlyAla: 3.576 ± 0.035	1.029GlyCys: 1.029 ± 0.014	3.112GlyAsp: 3.112 ± 0.022	3.34GlyGlu: 3.34 ± 0.026	2.254GlyPhe: 2.254 ± 0.02	4.646GlyGly: 4.646 ± 0.051	1.492GlyHis: 1.492 ± 0.016	3.178GlyIle: 3.178 ± 0.021	3.389GlyLys: 3.389 ± 0.028	4.789GlyLeu: 4.789 ± 0.027	1.343GlyMet: 1.343 ± 0.015	2.859GlyAsn: 2.859 ± 0.028	2.164GlyPro: 2.164 ± 0.021	2.439GlyGln: 2.439 ± 0.025	3.316GlyArg: 3.316 ± 0.027	5.023GlySer: 5.023 ± 0.039	3.622GlyThr: 3.622 ± 0.034	3.738GlyVal: 3.738 ± 0.025	0.845GlyTrp: 0.845 ± 0.012	1.902GlyTyr: 1.902 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.25HisAla: 1.25 ± 0.012	0.437HisCys: 0.437 ± 0.007	1.043HisAsp: 1.043 ± 0.012	1.187HisGlu: 1.187 ± 0.013	1.092HisPhe: 1.092 ± 0.011	1.238HisGly: 1.238 ± 0.015	0.995HisHis: 0.995 ± 0.013	1.452HisIle: 1.452 ± 0.013	1.234HisLys: 1.234 ± 0.014	2.745HisLeu: 2.745 ± 0.023	0.58HisMet: 0.58 ± 0.009	1.127HisAsn: 1.127 ± 0.012	1.479HisPro: 1.479 ± 0.015	1.065HisGln: 1.065 ± 0.011	1.574HisArg: 1.574 ± 0.015	1.995HisSer: 1.995 ± 0.018	1.481HisThr: 1.481 ± 0.013	1.45HisVal: 1.45 ± 0.013	0.356HisTrp: 0.356 ± 0.007	0.794HisTyr: 0.794 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.47IleAla: 3.47 ± 0.022	0.939IleCys: 0.939 ± 0.011	3.317IleAsp: 3.317 ± 0.021	3.601IleGlu: 3.601 ± 0.021	2.337IlePhe: 2.337 ± 0.019	2.955IleGly: 2.955 ± 0.024	1.543IleHis: 1.543 ± 0.014	3.446IleIle: 3.446 ± 0.024	2.712IleLys: 2.712 ± 0.022	5.174IleLeu: 5.174 ± 0.031	1.231IleMet: 1.231 ± 0.013	2.538IleAsn: 2.538 ± 0.021	2.997IlePro: 2.997 ± 0.027	2.591IleGln: 2.591 ± 0.02	3.092IleArg: 3.092 ± 0.021	5.009IleSer: 5.009 ± 0.035	3.903IleThr: 3.903 ± 0.04	3.822IleVal: 3.822 ± 0.022	0.661IleTrp: 0.661 ± 0.01	1.827IleTyr: 1.827 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.482LysAla: 3.482 ± 0.032	0.745LysCys: 0.745 ± 0.011	2.98LysAsp: 2.98 ± 0.027	5.115LysGlu: 5.115 ± 0.051	1.744LysPhe: 1.744 ± 0.017	3.103LysGly: 3.103 ± 0.027	1.145LysHis: 1.145 ± 0.013	3.223LysIle: 3.223 ± 0.023	5.461LysLys: 5.461 ± 0.061	4.634LysLeu: 4.634 ± 0.032	1.857LysMet: 1.857 ± 0.014	2.636LysAsn: 2.636 ± 0.018	2.324LysPro: 2.324 ± 0.022	2.274LysGln: 2.274 ± 0.02	4.113LysArg: 4.113 ± 0.036	4.229LysSer: 4.229 ± 0.03	3.528LysThr: 3.528 ± 0.026	3.095LysVal: 3.095 ± 0.023	0.697LysTrp: 0.697 ± 0.01	1.581LysTyr: 1.581 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	5.272LeuAla: 5.272 ± 0.031	1.621LeuCys: 1.621 ± 0.015	4.774LeuAsp: 4.774 ± 0.027	5.193LeuGlu: 5.193 ± 0.035	3.933LeuPhe: 3.933 ± 0.026	4.556LeuGly: 4.556 ± 0.024	2.314LeuHis: 2.314 ± 0.019	4.668LeuIle: 4.668 ± 0.028	5.186LeuLys: 5.186 ± 0.034	9.148LeuLeu: 9.148 ± 0.044	2.107LeuMet: 2.107 ± 0.017	4.296LeuAsn: 4.296 ± 0.029	4.579LeuPro: 4.579 ± 0.034	4.055LeuGln: 4.055 ± 0.026	5.371LeuArg: 5.371 ± 0.033	8.996LeuSer: 8.996 ± 0.048	5.637LeuThr: 5.637 ± 0.036	5.139LeuVal: 5.139 ± 0.029	1.187LeuTrp: 1.187 ± 0.012	2.949LeuTyr: 2.949 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.501MetAla: 1.501 ± 0.015	0.313MetCys: 0.313 ± 0.007	1.465MetAsp: 1.465 ± 0.014	1.838MetGlu: 1.838 ± 0.018	0.759MetPhe: 0.759 ± 0.01	1.348MetGly: 1.348 ± 0.013	0.506MetHis: 0.506 ± 0.007	1.376MetIle: 1.376 ± 0.014	1.717MetLys: 1.717 ± 0.016	1.83MetLeu: 1.83 ± 0.015	0.846MetMet: 0.846 ± 0.011	1.287MetAsn: 1.287 ± 0.012	0.884MetPro: 0.884 ± 0.012	0.999MetGln: 0.999 ± 0.01	1.495MetArg: 1.495 ± 0.015	2.275MetSer: 2.275 ± 0.019	1.576MetThr: 1.576 ± 0.014	1.407MetVal: 1.407 ± 0.013	0.317MetTrp: 0.317 ± 0.006	0.663MetTyr: 0.663 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.781AsnAla: 2.781 ± 0.021	0.772AsnCys: 0.772 ± 0.011	2.235AsnAsp: 2.235 ± 0.02	2.548AsnGlu: 2.548 ± 0.019	1.859AsnPhe: 1.859 ± 0.019	3.196AsnGly: 3.196 ± 0.033	1.22AsnHis: 1.22 ± 0.013	2.862AsnIle: 2.862 ± 0.025	2.245AsnLys: 2.245 ± 0.018	4.32AsnLeu: 4.32 ± 0.033	1.135AsnMet: 1.135 ± 0.012	2.713AsnAsn: 2.713 ± 0.032	2.18AsnPro: 2.18 ± 0.019	2.005AsnGln: 2.005 ± 0.02	2.607AsnArg: 2.607 ± 0.018	3.764AsnSer: 3.764 ± 0.032	2.908AsnThr: 2.908 ± 0.026	3.047AsnVal: 3.047 ± 0.03	0.581AsnTrp: 0.581 ± 0.008	1.484AsnTyr: 1.484 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	3.168ProAla: 3.168 ± 0.028	0.583ProCys: 0.583 ± 0.009	2.298ProAsp: 2.298 ± 0.016	2.801ProGlu: 2.801 ± 0.022	1.901ProPhe: 1.901 ± 0.017	2.203ProGly: 2.203 ± 0.026	1.174ProHis: 1.174 ± 0.015	2.594ProIle: 2.594 ± 0.021	2.515ProLys: 2.515 ± 0.023	4.236ProLeu: 4.236 ± 0.026	0.905ProMet: 0.905 ± 0.012	2.235ProAsn: 2.235 ± 0.021	3.614ProPro: 3.614 ± 0.048	2.074ProGln: 2.074 ± 0.018	2.303ProArg: 2.303 ± 0.019	5.078ProSer: 5.078 ± 0.035	3.541ProThr: 3.541 ± 0.03	2.915ProVal: 2.915 ± 0.026	0.507ProTrp: 0.507 ± 0.008	1.325ProTyr: 1.325 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.374GlnAla: 2.374 ± 0.019	0.674GlnCys: 0.674 ± 0.011	1.751GlnAsp: 1.751 ± 0.015	2.557GlnGlu: 2.557 ± 0.023	1.612GlnPhe: 1.612 ± 0.014	2.077GlnGly: 2.077 ± 0.021	1.004GlnHis: 1.004 ± 0.011	2.429GlnIle: 2.429 ± 0.018	2.693GlnLys: 2.693 ± 0.023	4.443GlnLeu: 4.443 ± 0.03	1.343GlnMet: 1.343 ± 0.013	1.948GlnAsn: 1.948 ± 0.016	2.053GlnPro: 2.053 ± 0.022	2.283GlnGln: 2.283 ± 0.03	2.634GlnArg: 2.634 ± 0.023	3.104GlnSer: 3.104 ± 0.022	2.553GlnThr: 2.553 ± 0.02	2.408GlnVal: 2.408 ± 0.02	0.625GlnTrp: 0.625 ± 0.009	1.353GlnTyr: 1.353 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.303ArgAla: 3.303 ± 0.024	0.919ArgCys: 0.919 ± 0.012	3.26ArgAsp: 3.26 ± 0.027	4.605ArgGlu: 4.605 ± 0.05	2.044ArgPhe: 2.044 ± 0.019	3.435ArgGly: 3.435 ± 0.027	1.365ArgHis: 1.365 ± 0.013	2.986ArgIle: 2.986 ± 0.022	3.465ArgLys: 3.465 ± 0.028	5.123ArgLeu: 5.123 ± 0.028	1.485ArgMet: 1.485 ± 0.015	2.467ArgAsn: 2.467 ± 0.018	2.38ArgPro: 2.38 ± 0.021	2.388ArgGln: 2.388 ± 0.02	3.872ArgArg: 3.872 ± 0.035	4.415ArgSer: 4.415 ± 0.025	3.024ArgThr: 3.024 ± 0.02	3.42ArgVal: 3.42 ± 0.025	0.824ArgTrp: 0.824 ± 0.01	1.706ArgTyr: 1.706 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	5.383SerAla: 5.383 ± 0.043	1.317SerCys: 1.317 ± 0.016	4.408SerAsp: 4.408 ± 0.026	4.416SerGlu: 4.416 ± 0.03	3.635SerPhe: 3.635 ± 0.03	5.17SerGly: 5.17 ± 0.042	2.19SerHis: 2.19 ± 0.021	5.233SerIle: 5.233 ± 0.035	4.0SerLys: 4.0 ± 0.027	8.148SerLeu: 8.148 ± 0.046	1.833SerMet: 1.833 ± 0.016	3.98SerAsn: 3.98 ± 0.032	4.477SerPro: 4.477 ± 0.03	3.611SerGln: 3.611 ± 0.026	4.201SerArg: 4.201 ± 0.024	9.291SerSer: 9.291 ± 0.1	6.342SerThr: 6.342 ± 0.085	5.454SerVal: 5.454 ± 0.038	1.031SerTrp: 1.031 ± 0.012	2.415SerTyr: 2.415 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	4.189ThrAla: 4.189 ± 0.034	1.027ThrCys: 1.027 ± 0.015	3.08ThrAsp: 3.08 ± 0.022	3.937ThrGlu: 3.937 ± 0.037	2.717ThrPhe: 2.717 ± 0.024	3.575ThrGly: 3.575 ± 0.036	1.384ThrHis: 1.384 ± 0.014	3.802ThrIle: 3.802 ± 0.03	3.381ThrLys: 3.381 ± 0.023	5.785ThrLeu: 5.785 ± 0.033	1.474ThrMet: 1.474 ± 0.018	2.838ThrAsn: 2.838 ± 0.026	3.736ThrPro: 3.736 ± 0.032	2.498ThrGln: 2.498 ± 0.02	3.001ThrArg: 3.001 ± 0.021	6.346ThrSer: 6.346 ± 0.085	4.944ThrThr: 4.944 ± 0.08	4.231ThrVal: 4.231 ± 0.041	0.722ThrTrp: 0.722 ± 0.011	1.753ThrTyr: 1.753 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.045ValAla: 4.045 ± 0.025	1.046ValCys: 1.046 ± 0.013	3.731ValAsp: 3.731 ± 0.025	4.045ValGlu: 4.045 ± 0.027	2.409ValPhe: 2.409 ± 0.017	3.335ValGly: 3.335 ± 0.025	1.503ValHis: 1.503 ± 0.014	3.592ValIle: 3.592 ± 0.023	3.479ValLys: 3.479 ± 0.025	5.465ValLeu: 5.465 ± 0.029	1.474ValMet: 1.474 ± 0.015	2.761ValAsn: 2.761 ± 0.024	2.947ValPro: 2.947 ± 0.021	2.722ValGln: 2.722 ± 0.023	3.253ValArg: 3.253 ± 0.025	5.168ValSer: 5.168 ± 0.032	4.306ValThr: 4.306 ± 0.041	4.439ValVal: 4.439 ± 0.029	0.868ValTrp: 0.868 ± 0.011	2.045ValTyr: 2.045 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.771TrpAla: 0.771 ± 0.01	0.213TrpCys: 0.213 ± 0.005	0.685TrpAsp: 0.685 ± 0.008	0.688TrpGlu: 0.688 ± 0.01	0.524TrpPhe: 0.524 ± 0.009	0.646TrpGly: 0.646 ± 0.01	0.254TrpHis: 0.254 ± 0.006	0.779TrpIle: 0.779 ± 0.009	0.951TrpLys: 0.951 ± 0.012	1.186TrpLeu: 1.186 ± 0.014	0.469TrpMet: 0.469 ± 0.008	0.786TrpAsn: 0.786 ± 0.011	0.436TrpPro: 0.436 ± 0.007	0.413TrpGln: 0.413 ± 0.007	0.776TrpArg: 0.776 ± 0.01	1.15TrpSer: 1.15 ± 0.014	0.891TrpThr: 0.891 ± 0.011	0.67TrpVal: 0.67 ± 0.01	0.238TrpTrp: 0.238 ± 0.007	0.383TrpTyr: 0.383 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.72TyrAla: 1.72 ± 0.016	0.566TyrCys: 0.566 ± 0.008	1.671TyrAsp: 1.671 ± 0.015	1.58TyrGlu: 1.58 ± 0.014	1.266TyrPhe: 1.266 ± 0.015	1.944TyrGly: 1.944 ± 0.018	0.888TyrHis: 0.888 ± 0.011	1.697TyrIle: 1.697 ± 0.016	1.516TyrLys: 1.516 ± 0.014	2.936TyrLeu: 2.936 ± 0.024	0.607TyrMet: 0.607 ± 0.009	1.889TyrAsn: 1.889 ± 0.019	1.324TyrPro: 1.324 ± 0.017	1.272TyrGln: 1.272 ± 0.014	1.713TyrArg: 1.713 ± 0.015	2.338TyrSer: 2.338 ± 0.021	1.846TyrThr: 1.846 ± 0.022	1.938TyrVal: 1.938 ± 0.015	0.442TyrTrp: 0.442 ± 0.007	1.047TyrTyr: 1.047 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 16856 proteins (8545775 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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