Amino acid dipepetide frequency for Aspergillus calidoustus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.07AlaAla: 9.07 ± 0.058
1.185AlaCys: 1.185 ± 0.015
4.276AlaAsp: 4.276 ± 0.026
5.147AlaGlu: 5.147 ± 0.03
3.224AlaPhe: 3.224 ± 0.025
5.932AlaGly: 5.932 ± 0.033
1.851AlaHis: 1.851 ± 0.015
4.481AlaIle: 4.481 ± 0.028
3.623AlaLys: 3.623 ± 0.026
8.314AlaLeu: 8.314 ± 0.043
1.932AlaMet: 1.932 ± 0.02
2.84AlaAsn: 2.84 ± 0.022
4.57AlaPro: 4.57 ± 0.041
3.389AlaGln: 3.389 ± 0.028
5.181AlaArg: 5.181 ± 0.031
7.028AlaSer: 7.028 ± 0.037
5.314AlaThr: 5.314 ± 0.028
5.596AlaVal: 5.596 ± 0.03
1.236AlaTrp: 1.236 ± 0.015
2.267AlaTyr: 2.267 ± 0.019
0.0AlaXaa: 0.0 ± 0.0
Cys
1.06CysAla: 1.06 ± 0.015
0.275CysCys: 0.275 ± 0.008
0.73CysAsp: 0.73 ± 0.012
0.643CysGlu: 0.643 ± 0.01
0.58CysPhe: 0.58 ± 0.01
0.972CysGly: 0.972 ± 0.014
0.355CysHis: 0.355 ± 0.007
0.725CysIle: 0.725 ± 0.012
0.475CysLys: 0.475 ± 0.008
1.392CysLeu: 1.392 ± 0.016
0.286CysMet: 0.286 ± 0.007
0.436CysAsn: 0.436 ± 0.007
0.73CysPro: 0.73 ± 0.013
0.481CysGln: 0.481 ± 0.009
0.86CysArg: 0.86 ± 0.012
0.989CysSer: 0.989 ± 0.013
0.756CysThr: 0.756 ± 0.011
0.86CysVal: 0.86 ± 0.012
0.215CysTrp: 0.215 ± 0.006
0.39CysTyr: 0.39 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
4.632AspAla: 4.632 ± 0.03
0.669AspCys: 0.669 ± 0.009
3.802AspAsp: 3.802 ± 0.031
4.229AspGlu: 4.229 ± 0.028
2.151AspPhe: 2.151 ± 0.018
3.989AspGly: 3.989 ± 0.025
1.263AspHis: 1.263 ± 0.014
3.152AspIle: 3.152 ± 0.025
2.131AspLys: 2.131 ± 0.021
5.178AspLeu: 5.178 ± 0.026
1.162AspMet: 1.162 ± 0.013
1.831AspAsn: 1.831 ± 0.017
3.396AspPro: 3.396 ± 0.026
1.863AspGln: 1.863 ± 0.018
3.106AspArg: 3.106 ± 0.027
4.062AspSer: 4.062 ± 0.025
3.046AspThr: 3.046 ± 0.024
3.568AspVal: 3.568 ± 0.022
0.92AspTrp: 0.92 ± 0.011
1.638AspTyr: 1.638 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
5.251GluAla: 5.251 ± 0.035
0.692GluCys: 0.692 ± 0.011
3.926GluAsp: 3.926 ± 0.029
5.132GluGlu: 5.132 ± 0.045
2.001GluPhe: 2.001 ± 0.017
3.827GluGly: 3.827 ± 0.028
1.407GluHis: 1.407 ± 0.015
3.163GluIle: 3.163 ± 0.023
3.316GluLys: 3.316 ± 0.025
5.2GluLeu: 5.2 ± 0.032
1.392GluMet: 1.392 ± 0.015
2.244GluAsn: 2.244 ± 0.018
2.865GluPro: 2.865 ± 0.03
2.455GluGln: 2.455 ± 0.023
3.998GluArg: 3.998 ± 0.059
4.326GluSer: 4.326 ± 0.03
3.669GluThr: 3.669 ± 0.024
3.548GluVal: 3.548 ± 0.023
0.892GluTrp: 0.892 ± 0.012
1.744GluTyr: 1.744 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.154PheAla: 3.154 ± 0.025
0.589PheCys: 0.589 ± 0.009
2.275PheAsp: 2.275 ± 0.018
2.142PheGlu: 2.142 ± 0.019
1.714PhePhe: 1.714 ± 0.02
2.891PheGly: 2.891 ± 0.025
0.933PheHis: 0.933 ± 0.011
1.871PheIle: 1.871 ± 0.019
1.352PheLys: 1.352 ± 0.015
3.68PheLeu: 3.68 ± 0.026
0.756PheMet: 0.756 ± 0.011
1.372PheAsn: 1.372 ± 0.015
2.066PhePro: 2.066 ± 0.018
1.397PheGln: 1.397 ± 0.016
2.089PheArg: 2.089 ± 0.019
2.992PheSer: 2.992 ± 0.023
2.187PheThr: 2.187 ± 0.02
2.414PheVal: 2.414 ± 0.021
0.696PheTrp: 0.696 ± 0.01
1.153PheTyr: 1.153 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
5.473GlyAla: 5.473 ± 0.034
0.945GlyCys: 0.945 ± 0.012
3.657GlyAsp: 3.657 ± 0.026
3.74GlyGlu: 3.74 ± 0.027
2.906GlyPhe: 2.906 ± 0.026
5.554GlyGly: 5.554 ± 0.043
1.747GlyHis: 1.747 ± 0.019
3.667GlyIle: 3.667 ± 0.03
3.182GlyLys: 3.182 ± 0.057
6.403GlyLeu: 6.403 ± 0.033
1.545GlyMet: 1.545 ± 0.016
2.469GlyAsn: 2.469 ± 0.02
3.356GlyPro: 3.356 ± 0.026
2.536GlyGln: 2.536 ± 0.02
4.152GlyArg: 4.152 ± 0.026
5.628GlySer: 5.628 ± 0.036
3.959GlyThr: 3.959 ± 0.024
4.624GlyVal: 4.624 ± 0.029
1.239GlyTrp: 1.239 ± 0.014
2.222GlyTyr: 2.222 ± 0.02
0.0GlyXaa: 0.0 ± 0.0
His
1.931HisAla: 1.931 ± 0.017
0.362HisCys: 0.362 ± 0.008
1.315HisAsp: 1.315 ± 0.012
1.365HisGlu: 1.365 ± 0.015
0.94HisPhe: 0.94 ± 0.012
1.801HisGly: 1.801 ± 0.02
0.847HisHis: 0.847 ± 0.014
1.268HisIle: 1.268 ± 0.011
0.846HisLys: 0.846 ± 0.011
2.418HisLeu: 2.418 ± 0.021
0.476HisMet: 0.476 ± 0.009
0.841HisAsn: 0.841 ± 0.011
1.723HisPro: 1.723 ± 0.015
0.968HisGln: 0.968 ± 0.012
1.617HisArg: 1.617 ± 0.017
1.881HisSer: 1.881 ± 0.018
1.372HisThr: 1.372 ± 0.014
1.457HisVal: 1.457 ± 0.014
0.396HisTrp: 0.396 ± 0.008
0.736HisTyr: 0.736 ± 0.009
0.0HisXaa: 0.0 ± 0.0
Ile
4.433IleAla: 4.433 ± 0.026
0.816IleCys: 0.816 ± 0.013
2.829IleAsp: 2.829 ± 0.022
2.873IleGlu: 2.873 ± 0.022
2.042IlePhe: 2.042 ± 0.021
3.247IleGly: 3.247 ± 0.026
1.284IleHis: 1.284 ± 0.014
2.594IleIle: 2.594 ± 0.023
1.929IleLys: 1.929 ± 0.016
4.907IleLeu: 4.907 ± 0.03
0.999IleMet: 0.999 ± 0.013
1.775IleAsn: 1.775 ± 0.016
3.233IlePro: 3.233 ± 0.024
1.983IleGln: 1.983 ± 0.018
2.974IleArg: 2.974 ± 0.025
3.939IleSer: 3.939 ± 0.022
2.927IleThr: 2.927 ± 0.021
3.202IleVal: 3.202 ± 0.024
0.775IleTrp: 0.775 ± 0.011
1.487IleTyr: 1.487 ± 0.015
0.001IleXaa: 0.001 ± 0.0
Lys
3.751LysAla: 3.751 ± 0.023
0.499LysCys: 0.499 ± 0.009
2.426LysAsp: 2.426 ± 0.02
3.026LysGlu: 3.026 ± 0.057
1.276LysPhe: 1.276 ± 0.013
2.762LysGly: 2.762 ± 0.02
1.049LysHis: 1.049 ± 0.011
2.038LysIle: 2.038 ± 0.018
2.641LysLys: 2.641 ± 0.035
3.76LysLeu: 3.76 ± 0.027
0.864LysMet: 0.864 ± 0.012
1.498LysAsn: 1.498 ± 0.015
2.475LysPro: 2.475 ± 0.024
1.663LysGln: 1.663 ± 0.017
3.158LysArg: 3.158 ± 0.028
3.078LysSer: 3.078 ± 0.026
2.53LysThr: 2.53 ± 0.021
2.557LysVal: 2.557 ± 0.022
0.642LysTrp: 0.642 ± 0.01
1.29LysTyr: 1.29 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
8.312LeuAla: 8.312 ± 0.038
1.287LeuCys: 1.287 ± 0.013
5.455LeuAsp: 5.455 ± 0.029
5.723LeuGlu: 5.723 ± 0.038
3.515LeuPhe: 3.515 ± 0.029
6.306LeuGly: 6.306 ± 0.039
2.445LeuHis: 2.445 ± 0.022
4.159LeuIle: 4.159 ± 0.028
3.883LeuLys: 3.883 ± 0.028
9.139LeuLeu: 9.139 ± 0.049
1.799LeuMet: 1.799 ± 0.015
3.208LeuAsn: 3.208 ± 0.02
5.684LeuPro: 5.684 ± 0.03
3.969LeuGln: 3.969 ± 0.03
6.047LeuArg: 6.047 ± 0.034
7.59LeuSer: 7.59 ± 0.031
5.013LeuThr: 5.013 ± 0.03
5.784LeuVal: 5.784 ± 0.035
1.309LeuTrp: 1.309 ± 0.015
2.586LeuTyr: 2.586 ± 0.02
0.0LeuXaa: 0.0 ± 0.0
Met
2.11MetAla: 2.11 ± 0.02
0.24MetCys: 0.24 ± 0.006
1.159MetAsp: 1.159 ± 0.014
1.218MetGlu: 1.218 ± 0.014
0.716MetPhe: 0.716 ± 0.011
1.417MetGly: 1.417 ± 0.014
0.486MetHis: 0.486 ± 0.008
0.992MetIle: 0.992 ± 0.012
0.88MetLys: 0.88 ± 0.012
1.829MetLeu: 1.829 ± 0.017
0.508MetMet: 0.508 ± 0.008
0.743MetAsn: 0.743 ± 0.012
1.22MetPro: 1.22 ± 0.057
0.812MetGln: 0.812 ± 0.01
1.227MetArg: 1.227 ± 0.015
1.742MetSer: 1.742 ± 0.016
1.257MetThr: 1.257 ± 0.013
1.322MetVal: 1.322 ± 0.015
0.267MetTrp: 0.267 ± 0.007
0.523MetTyr: 0.523 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
3.07AsnAla: 3.07 ± 0.023
0.469AsnCys: 0.469 ± 0.009
1.816AsnAsp: 1.816 ± 0.015
1.935AsnGlu: 1.935 ± 0.017
1.272AsnPhe: 1.272 ± 0.013
2.821AsnGly: 2.821 ± 0.022
0.856AsnHis: 0.856 ± 0.011
1.984AsnIle: 1.984 ± 0.017
1.348AsnLys: 1.348 ± 0.014
3.254AsnLeu: 3.254 ± 0.023
0.757AsnMet: 0.757 ± 0.01
1.374AsnAsn: 1.374 ± 0.017
2.484AsnPro: 2.484 ± 0.02
1.311AsnGln: 1.311 ± 0.016
1.988AsnArg: 1.988 ± 0.016
2.566AsnSer: 2.566 ± 0.023
2.147AsnThr: 2.147 ± 0.018
2.231AsnVal: 2.231 ± 0.018
0.565AsnTrp: 0.565 ± 0.01
1.045AsnTyr: 1.045 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
5.127ProAla: 5.127 ± 0.033
0.602ProCys: 0.602 ± 0.011
3.291ProAsp: 3.291 ± 0.023
3.875ProGlu: 3.875 ± 0.027
2.129ProPhe: 2.129 ± 0.018
4.033ProGly: 4.033 ± 0.03
1.367ProHis: 1.367 ± 0.016
2.603ProIle: 2.603 ± 0.02
2.335ProLys: 2.335 ± 0.024
5.013ProLeu: 5.013 ± 0.032
0.991ProMet: 0.991 ± 0.013
2.165ProAsn: 2.165 ± 0.018
4.767ProPro: 4.767 ± 0.057
2.464ProGln: 2.464 ± 0.057
3.495ProArg: 3.495 ± 0.026
5.969ProSer: 5.969 ± 0.048
4.013ProThr: 4.013 ± 0.028
3.658ProVal: 3.658 ± 0.028
0.823ProTrp: 0.823 ± 0.011
1.532ProTyr: 1.532 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
3.434GlnAla: 3.434 ± 0.027
0.483GlnCys: 0.483 ± 0.008
1.981GlnAsp: 1.981 ± 0.015
2.326GlnGlu: 2.326 ± 0.022
1.307GlnPhe: 1.307 ± 0.017
2.508GlnGly: 2.508 ± 0.059
1.074GlnHis: 1.074 ± 0.014
1.895GlnIle: 1.895 ± 0.016
1.765GlnLys: 1.765 ± 0.02
3.537GlnLeu: 3.537 ± 0.031
0.835GlnMet: 0.835 ± 0.012
1.477GlnAsn: 1.477 ± 0.017
2.482GlnPro: 2.482 ± 0.027
2.199GlnGln: 2.199 ± 0.036
2.688GlnArg: 2.688 ± 0.024
3.104GlnSer: 3.104 ± 0.027
2.364GlnThr: 2.364 ± 0.019
2.21GlnVal: 2.21 ± 0.02
0.596GlnTrp: 0.596 ± 0.01
1.152GlnTyr: 1.152 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
4.909ArgAla: 4.909 ± 0.029
0.801ArgCys: 0.801 ± 0.012
3.492ArgAsp: 3.492 ± 0.03
3.927ArgGlu: 3.927 ± 0.031
2.273ArgPhe: 2.273 ± 0.017
3.912ArgGly: 3.912 ± 0.029
1.631ArgHis: 1.631 ± 0.018
3.032ArgIle: 3.032 ± 0.02
3.209ArgLys: 3.209 ± 0.024
5.889ArgLeu: 5.889 ± 0.034
1.341ArgMet: 1.341 ± 0.053
2.246ArgAsn: 2.246 ± 0.018
3.474ArgPro: 3.474 ± 0.029
2.543ArgGln: 2.543 ± 0.023
5.151ArgArg: 5.151 ± 0.036
4.743ArgSer: 4.743 ± 0.033
3.491ArgThr: 3.491 ± 0.023
3.663ArgVal: 3.663 ± 0.02
1.008ArgTrp: 1.008 ± 0.012
1.793ArgTyr: 1.793 ± 0.016
0.0ArgXaa: 0.0 ± 0.0
Ser
6.613SerAla: 6.613 ± 0.04
0.963SerCys: 0.963 ± 0.014
4.152SerAsp: 4.152 ± 0.029
4.201SerGlu: 4.201 ± 0.029
3.049SerPhe: 3.049 ± 0.021
5.515SerGly: 5.515 ± 0.031
1.973SerHis: 1.973 ± 0.019
4.05SerIle: 4.05 ± 0.026
3.245SerLys: 3.245 ± 0.025
7.553SerLeu: 7.553 ± 0.038
1.605SerMet: 1.605 ± 0.016
2.801SerAsn: 2.801 ± 0.022
5.424SerPro: 5.424 ± 0.042
3.192SerGln: 3.192 ± 0.024
5.071SerArg: 5.071 ± 0.034
8.318SerSer: 8.318 ± 0.06
5.564SerThr: 5.564 ± 0.041
4.574SerVal: 4.574 ± 0.024
1.184SerTrp: 1.184 ± 0.013
2.097SerTyr: 2.097 ± 0.017
0.0SerXaa: 0.0 ± 0.0
Thr
5.308ThrAla: 5.308 ± 0.031
0.813ThrCys: 0.813 ± 0.012
2.915ThrAsp: 2.915 ± 0.02
3.214ThrGlu: 3.214 ± 0.025
2.289ThrPhe: 2.289 ± 0.021
4.295ThrGly: 4.295 ± 0.027
1.365ThrHis: 1.365 ± 0.014
3.167ThrIle: 3.167 ± 0.026
2.368ThrLys: 2.368 ± 0.019
5.574ThrLeu: 5.574 ± 0.03
1.15ThrMet: 1.15 ± 0.013
2.03ThrAsn: 2.03 ± 0.019
4.379ThrPro: 4.379 ± 0.033
2.1ThrGln: 2.1 ± 0.022
3.242ThrArg: 3.242 ± 0.023
5.256ThrSer: 5.256 ± 0.036
4.479ThrThr: 4.479 ± 0.045
3.874ThrVal: 3.874 ± 0.025
0.912ThrTrp: 0.912 ± 0.013
1.645ThrTyr: 1.645 ± 0.016
0.0ThrXaa: 0.0 ± 0.0
Val
5.299ValAla: 5.299 ± 0.031
0.886ValCys: 0.886 ± 0.011
3.742ValAsp: 3.742 ± 0.023
3.877ValGlu: 3.877 ± 0.025
2.531ValPhe: 2.531 ± 0.023
4.109ValGly: 4.109 ± 0.03
1.452ValHis: 1.452 ± 0.013
3.073ValIle: 3.073 ± 0.023
2.645ValLys: 2.645 ± 0.021
5.882ValLeu: 5.882 ± 0.03
1.253ValMet: 1.253 ± 0.016
2.172ValAsn: 2.172 ± 0.018
3.62ValPro: 3.62 ± 0.023
2.415ValGln: 2.415 ± 0.023
3.661ValArg: 3.661 ± 0.027
4.76ValSer: 4.76 ± 0.029
3.56ValThr: 3.56 ± 0.026
4.358ValVal: 4.358 ± 0.03
0.913ValTrp: 0.913 ± 0.013
1.876ValTyr: 1.876 ± 0.017
0.0ValXaa: 0.0 ± 0.0
Trp
1.207TrpAla: 1.207 ± 0.014
0.207TrpCys: 0.207 ± 0.005
0.93TrpAsp: 0.93 ± 0.013
0.91TrpGlu: 0.91 ± 0.012
0.575TrpPhe: 0.575 ± 0.009
0.975TrpGly: 0.975 ± 0.014
0.367TrpHis: 0.367 ± 0.009
0.823TrpIle: 0.823 ± 0.012
0.792TrpLys: 0.792 ± 0.009
1.473TrpLeu: 1.473 ± 0.017
0.377TrpMet: 0.377 ± 0.008
0.642TrpAsn: 0.642 ± 0.009
0.668TrpPro: 0.668 ± 0.01
0.566TrpGln: 0.566 ± 0.009
1.052TrpArg: 1.052 ± 0.014
1.098TrpSer: 1.098 ± 0.012
0.973TrpThr: 0.973 ± 0.014
0.962TrpVal: 0.962 ± 0.013
0.295TrpTrp: 0.295 ± 0.006
0.468TrpTyr: 0.468 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.31TyrAla: 2.31 ± 0.016
0.427TyrCys: 0.427 ± 0.008
1.62TyrAsp: 1.62 ± 0.016
1.547TyrGlu: 1.547 ± 0.017
1.233TyrPhe: 1.233 ± 0.015
2.138TyrGly: 2.138 ± 0.021
0.805TyrHis: 0.805 ± 0.011
1.51TyrIle: 1.51 ± 0.016
1.02TyrLys: 1.02 ± 0.013
2.819TyrLeu: 2.819 ± 0.022
0.641TyrMet: 0.641 ± 0.009
1.127TyrAsn: 1.127 ± 0.013
1.634TyrPro: 1.634 ± 0.019
1.11TyrGln: 1.11 ± 0.013
1.772TyrArg: 1.772 ± 0.016
2.075TyrSer: 2.075 ± 0.019
1.755TyrThr: 1.755 ± 0.017
1.62TyrVal: 1.62 ± 0.015
0.478TyrTrp: 0.478 ± 0.008
0.998TyrTyr: 0.998 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15359 proteins (7021788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski