Amino acid dipepetide frequency for Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.674AlaAla: 4.674 ± 0.053
1.239AlaCys: 1.239 ± 0.019
2.99AlaAsp: 2.99 ± 0.026
3.919AlaGlu: 3.919 ± 0.043
2.653AlaPhe: 2.653 ± 0.029
2.867AlaGly: 2.867 ± 0.035
1.383AlaHis: 1.383 ± 0.018
3.845AlaIle: 3.845 ± 0.03
3.602AlaLys: 3.602 ± 0.03
5.973AlaLeu: 5.973 ± 0.045
1.437AlaMet: 1.437 ± 0.02
2.821AlaAsn: 2.821 ± 0.028
2.257AlaPro: 2.257 ± 0.029
2.333AlaGln: 2.333 ± 0.03
3.041AlaArg: 3.041 ± 0.032
4.869AlaSer: 4.869 ± 0.039
3.321AlaThr: 3.321 ± 0.029
4.645AlaVal: 4.645 ± 0.033
0.567AlaTrp: 0.567 ± 0.013
1.823AlaTyr: 1.823 ± 0.024
0.001AlaXaa: 0.001 ± 0.0
Cys
1.343CysAla: 1.343 ± 0.021
0.681CysCys: 0.681 ± 0.018
1.358CysAsp: 1.358 ± 0.029
1.39CysGlu: 1.39 ± 0.024
1.069CysPhe: 1.069 ± 0.018
1.371CysGly: 1.371 ± 0.023
0.594CysHis: 0.594 ± 0.015
1.515CysIle: 1.515 ± 0.027
1.356CysLys: 1.356 ± 0.024
2.065CysLeu: 2.065 ± 0.026
0.522CysMet: 0.522 ± 0.011
1.156CysAsn: 1.156 ± 0.019
1.073CysPro: 1.073 ± 0.03
0.877CysGln: 0.877 ± 0.017
1.312CysArg: 1.312 ± 0.022
2.143CysSer: 2.143 ± 0.029
1.211CysThr: 1.211 ± 0.017
1.337CysVal: 1.337 ± 0.022
0.263CysTrp: 0.263 ± 0.008
0.771CysTyr: 0.771 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.09AspAla: 3.09 ± 0.029
1.182AspCys: 1.182 ± 0.022
3.736AspAsp: 3.736 ± 0.044
4.361AspGlu: 4.361 ± 0.04
2.477AspPhe: 2.477 ± 0.022
3.144AspGly: 3.144 ± 0.043
1.175AspHis: 1.175 ± 0.017
3.492AspIle: 3.492 ± 0.03
2.888AspLys: 2.888 ± 0.026
4.897AspLeu: 4.897 ± 0.04
1.219AspMet: 1.219 ± 0.02
2.448AspAsn: 2.448 ± 0.026
1.978AspPro: 1.978 ± 0.021
1.898AspGln: 1.898 ± 0.021
2.685AspArg: 2.685 ± 0.029
4.232AspSer: 4.232 ± 0.035
2.29AspThr: 2.29 ± 0.023
3.48AspVal: 3.48 ± 0.031
0.652AspTrp: 0.652 ± 0.014
1.841AspTyr: 1.841 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
3.784GluAla: 3.784 ± 0.043
1.371GluCys: 1.371 ± 0.025
3.313GluAsp: 3.313 ± 0.03
5.263GluGlu: 5.263 ± 0.06
2.307GluPhe: 2.307 ± 0.022
2.669GluGly: 2.669 ± 0.026
1.456GluHis: 1.456 ± 0.019
4.351GluIle: 4.351 ± 0.035
5.272GluLys: 5.272 ± 0.052
5.854GluLeu: 5.854 ± 0.054
1.861GluMet: 1.861 ± 0.02
3.898GluAsn: 3.898 ± 0.035
1.964GluPro: 1.964 ± 0.023
2.95GluGln: 2.95 ± 0.034
3.852GluArg: 3.852 ± 0.039
4.641GluSer: 4.641 ± 0.04
3.337GluThr: 3.337 ± 0.029
3.676GluVal: 3.676 ± 0.034
0.736GluTrp: 0.736 ± 0.016
2.005GluTyr: 2.005 ± 0.024
0.001GluXaa: 0.001 ± 0.0
Phe
2.767PheAla: 2.767 ± 0.026
1.199PheCys: 1.199 ± 0.017
2.549PheAsp: 2.549 ± 0.021
2.594PheGlu: 2.594 ± 0.024
2.108PhePhe: 2.108 ± 0.029
2.681PheGly: 2.681 ± 0.031
1.17PheHis: 1.17 ± 0.018
2.997PheIle: 2.997 ± 0.031
2.121PheLys: 2.121 ± 0.023
4.311PheLeu: 4.311 ± 0.042
1.076PheMet: 1.076 ± 0.015
1.903PheAsn: 1.903 ± 0.022
1.778PhePro: 1.778 ± 0.025
1.62PheGln: 1.62 ± 0.021
2.327PheArg: 2.327 ± 0.027
3.714PheSer: 3.714 ± 0.032
2.419PheThr: 2.419 ± 0.021
2.909PheVal: 2.909 ± 0.031
0.57PheTrp: 0.57 ± 0.012
1.633PheTyr: 1.633 ± 0.019
0.001PheXaa: 0.001 ± 0.0
Gly
2.788GlyAla: 2.788 ± 0.035
1.097GlyCys: 1.097 ± 0.02
2.593GlyAsp: 2.593 ± 0.028
2.837GlyGlu: 2.837 ± 0.032
2.306GlyPhe: 2.306 ± 0.026
2.897GlyGly: 2.897 ± 0.047
1.227GlyHis: 1.227 ± 0.019
3.44GlyIle: 3.44 ± 0.032
3.168GlyLys: 3.168 ± 0.03
4.078GlyLeu: 4.078 ± 0.045
1.195GlyMet: 1.195 ± 0.021
2.567GlyAsn: 2.567 ± 0.024
1.782GlyPro: 1.782 ± 0.035
1.854GlyGln: 1.854 ± 0.025
2.923GlyArg: 2.923 ± 0.034
4.159GlySer: 4.159 ± 0.036
2.851GlyThr: 2.851 ± 0.028
2.893GlyVal: 2.893 ± 0.031
0.605GlyTrp: 0.605 ± 0.014
1.798GlyTyr: 1.798 ± 0.028
0.001GlyXaa: 0.001 ± 0.0
His
1.345HisAla: 1.345 ± 0.017
0.705HisCys: 0.705 ± 0.013
1.157HisAsp: 1.157 ± 0.015
1.454HisGlu: 1.454 ± 0.021
1.316HisPhe: 1.316 ± 0.018
1.221HisGly: 1.221 ± 0.017
0.758HisHis: 0.758 ± 0.017
1.626HisIle: 1.626 ± 0.022
1.245HisLys: 1.245 ± 0.02
2.539HisLeu: 2.539 ± 0.028
0.568HisMet: 0.568 ± 0.012
1.105HisAsn: 1.105 ± 0.017
1.13HisPro: 1.13 ± 0.016
1.056HisGln: 1.056 ± 0.019
1.456HisArg: 1.456 ± 0.019
2.119HisSer: 2.119 ± 0.025
1.153HisThr: 1.153 ± 0.018
1.445HisVal: 1.445 ± 0.02
0.321HisTrp: 0.321 ± 0.008
0.956HisTyr: 0.956 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.256IleAla: 4.256 ± 0.031
1.709IleCys: 1.709 ± 0.026
3.674IleAsp: 3.674 ± 0.031
3.972IleGlu: 3.972 ± 0.036
3.096IlePhe: 3.096 ± 0.032
3.241IleGly: 3.241 ± 0.03
1.592IleHis: 1.592 ± 0.02
4.243IleIle: 4.243 ± 0.039
3.54IleLys: 3.54 ± 0.032
5.822IleLeu: 5.822 ± 0.042
1.41IleMet: 1.41 ± 0.019
3.172IleAsn: 3.172 ± 0.026
2.981IlePro: 2.981 ± 0.028
2.338IleGln: 2.338 ± 0.026
3.571IleArg: 3.571 ± 0.03
5.803IleSer: 5.803 ± 0.041
3.663IleThr: 3.663 ± 0.036
3.964IleVal: 3.964 ± 0.033
0.745IleTrp: 0.745 ± 0.015
2.145IleTyr: 2.145 ± 0.025
0.001IleXaa: 0.001 ± 0.0
Lys
3.417LysAla: 3.417 ± 0.034
1.475LysCys: 1.475 ± 0.025
2.959LysAsp: 2.959 ± 0.032
4.318LysGlu: 4.318 ± 0.048
2.523LysPhe: 2.523 ± 0.025
2.541LysGly: 2.541 ± 0.033
1.531LysHis: 1.531 ± 0.021
4.179LysIle: 4.179 ± 0.034
5.243LysLys: 5.243 ± 0.054
6.047LysLeu: 6.047 ± 0.048
1.689LysMet: 1.689 ± 0.021
3.575LysAsn: 3.575 ± 0.037
2.317LysPro: 2.317 ± 0.026
2.766LysGln: 2.766 ± 0.029
3.916LysArg: 3.916 ± 0.033
4.608LysSer: 4.608 ± 0.043
3.212LysThr: 3.212 ± 0.03
3.543LysVal: 3.543 ± 0.03
0.748LysTrp: 0.748 ± 0.013
2.186LysTyr: 2.186 ± 0.025
0.001LysXaa: 0.001 ± 0.0
Leu
5.713LeuAla: 5.713 ± 0.047
2.211LeuCys: 2.211 ± 0.028
4.659LeuAsp: 4.659 ± 0.036
5.792LeuGlu: 5.792 ± 0.05
4.197LeuPhe: 4.197 ± 0.04
3.806LeuGly: 3.806 ± 0.032
2.63LeuHis: 2.63 ± 0.029
5.978LeuIle: 5.978 ± 0.041
6.231LeuLys: 6.231 ± 0.044
9.989LeuLeu: 9.989 ± 0.074
2.308LeuMet: 2.308 ± 0.022
4.734LeuAsn: 4.734 ± 0.038
4.621LeuPro: 4.621 ± 0.04
4.348LeuGln: 4.348 ± 0.036
5.6LeuArg: 5.6 ± 0.041
8.08LeuSer: 8.08 ± 0.055
4.912LeuThr: 4.912 ± 0.042
5.041LeuVal: 5.041 ± 0.036
1.001LeuTrp: 1.001 ± 0.014
2.951LeuTyr: 2.951 ± 0.026
0.001LeuXaa: 0.001 ± 0.0
Met
1.512MetAla: 1.512 ± 0.018
0.49MetCys: 0.49 ± 0.011
1.343MetAsp: 1.343 ± 0.022
1.681MetGlu: 1.681 ± 0.022
0.938MetPhe: 0.938 ± 0.017
1.022MetGly: 1.022 ± 0.015
0.635MetHis: 0.635 ± 0.012
1.512MetIle: 1.512 ± 0.019
1.792MetLys: 1.792 ± 0.02
2.335MetLeu: 2.335 ± 0.023
0.641MetMet: 0.641 ± 0.014
1.324MetAsn: 1.324 ± 0.018
0.998MetPro: 0.998 ± 0.018
1.196MetGln: 1.196 ± 0.017
1.331MetArg: 1.331 ± 0.017
1.81MetSer: 1.81 ± 0.021
1.271MetThr: 1.271 ± 0.016
1.374MetVal: 1.374 ± 0.019
0.245MetTrp: 0.245 ± 0.008
0.681MetTyr: 0.681 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.083AsnAla: 3.083 ± 0.031
1.216AsnCys: 1.216 ± 0.021
3.092AsnAsp: 3.092 ± 0.029
3.723AsnGlu: 3.723 ± 0.034
2.432AsnPhe: 2.432 ± 0.023
2.946AsnGly: 2.946 ± 0.035
1.152AsnHis: 1.152 ± 0.016
3.487AsnIle: 3.487 ± 0.029
2.786AsnLys: 2.786 ± 0.025
4.566AsnLeu: 4.566 ± 0.04
1.207AsnMet: 1.207 ± 0.017
2.76AsnAsn: 2.76 ± 0.036
1.932AsnPro: 1.932 ± 0.024
1.852AsnGln: 1.852 ± 0.025
2.574AsnArg: 2.574 ± 0.024
4.279AsnSer: 4.279 ± 0.043
2.514AsnThr: 2.514 ± 0.028
3.196AsnVal: 3.196 ± 0.027
0.572AsnTrp: 0.572 ± 0.011
1.822AsnTyr: 1.822 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
2.219ProAla: 2.219 ± 0.026
0.819ProCys: 0.819 ± 0.02
2.019ProAsp: 2.019 ± 0.027
2.595ProGlu: 2.595 ± 0.027
1.903ProPhe: 1.903 ± 0.021
2.194ProGly: 2.194 ± 0.081
0.947ProHis: 0.947 ± 0.013
2.4ProIle: 2.4 ± 0.023
2.357ProLys: 2.357 ± 0.025
3.841ProLeu: 3.841 ± 0.03
0.805ProMet: 0.805 ± 0.014
2.038ProAsn: 2.038 ± 0.021
2.819ProPro: 2.819 ± 0.058
1.663ProGln: 1.663 ± 0.026
1.959ProArg: 1.959 ± 0.024
4.015ProSer: 4.015 ± 0.043
2.323ProThr: 2.323 ± 0.023
2.836ProVal: 2.836 ± 0.028
0.416ProTrp: 0.416 ± 0.01
1.437ProTyr: 1.437 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
2.244GlnAla: 2.244 ± 0.027
1.004GlnCys: 1.004 ± 0.022
1.469GlnAsp: 1.469 ± 0.021
2.38GlnGlu: 2.38 ± 0.029
1.747GlnPhe: 1.747 ± 0.019
1.474GlnGly: 1.474 ± 0.021
1.096GlnHis: 1.096 ± 0.021
2.855GlnIle: 2.855 ± 0.028
2.981GlnLys: 2.981 ± 0.035
4.241GlnLeu: 4.241 ± 0.036
1.191GlnMet: 1.191 ± 0.017
2.27GlnAsn: 2.27 ± 0.025
1.657GlnPro: 1.657 ± 0.024
2.755GlnGln: 2.755 ± 0.066
2.41GlnArg: 2.41 ± 0.023
3.066GlnSer: 3.066 ± 0.025
2.076GlnThr: 2.076 ± 0.023
2.213GlnVal: 2.213 ± 0.023
0.509GlnTrp: 0.509 ± 0.01
1.355GlnTyr: 1.355 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
2.89ArgAla: 2.89 ± 0.028
1.354ArgCys: 1.354 ± 0.026
2.661ArgAsp: 2.661 ± 0.031
3.405ArgGlu: 3.405 ± 0.033
2.49ArgPhe: 2.49 ± 0.027
2.48ArgGly: 2.48 ± 0.034
1.439ArgHis: 1.439 ± 0.018
3.764ArgIle: 3.764 ± 0.031
4.118ArgLys: 4.118 ± 0.04
5.318ArgLeu: 5.318 ± 0.04
1.367ArgMet: 1.367 ± 0.016
3.147ArgAsn: 3.147 ± 0.023
2.069ArgPro: 2.069 ± 0.023
2.345ArgGln: 2.345 ± 0.026
4.119ArgArg: 4.119 ± 0.045
4.508ArgSer: 4.508 ± 0.043
2.856ArgThr: 2.856 ± 0.028
2.893ArgVal: 2.893 ± 0.029
0.649ArgTrp: 0.649 ± 0.014
1.888ArgTyr: 1.888 ± 0.023
0.0ArgXaa: 0.0 ± 0.0
Ser
5.139SerAla: 5.139 ± 0.038
1.86SerCys: 1.86 ± 0.026
4.7SerAsp: 4.7 ± 0.036
5.055SerGlu: 5.055 ± 0.045
3.641SerPhe: 3.641 ± 0.033
4.399SerGly: 4.399 ± 0.042
1.931SerHis: 1.931 ± 0.023
4.882SerIle: 4.882 ± 0.036
4.889SerLys: 4.889 ± 0.041
7.806SerLeu: 7.806 ± 0.057
1.809SerMet: 1.809 ± 0.021
4.409SerAsn: 4.409 ± 0.043
3.363SerPro: 3.363 ± 0.039
3.158SerGln: 3.158 ± 0.033
4.373SerArg: 4.373 ± 0.042
9.449SerSer: 9.449 ± 0.086
5.16SerThr: 5.16 ± 0.043
5.569SerVal: 5.569 ± 0.034
0.847SerTrp: 0.847 ± 0.013
2.421SerTyr: 2.421 ± 0.025
0.001SerXaa: 0.001 ± 0.0
Thr
3.611ThrAla: 3.611 ± 0.034
1.207ThrCys: 1.207 ± 0.025
2.888ThrAsp: 2.888 ± 0.029
3.238ThrGlu: 3.238 ± 0.036
2.417ThrPhe: 2.417 ± 0.022
2.766ThrGly: 2.766 ± 0.03
1.156ThrHis: 1.156 ± 0.016
3.322ThrIle: 3.322 ± 0.029
3.034ThrLys: 3.034 ± 0.032
4.945ThrLeu: 4.945 ± 0.034
1.183ThrMet: 1.183 ± 0.015
2.649ThrAsn: 2.649 ± 0.028
2.346ThrPro: 2.346 ± 0.024
1.784ThrGln: 1.784 ± 0.021
2.42ThrArg: 2.42 ± 0.025
5.037ThrSer: 5.037 ± 0.048
3.471ThrThr: 3.471 ± 0.039
3.948ThrVal: 3.948 ± 0.031
0.531ThrTrp: 0.531 ± 0.012
1.626ThrTyr: 1.626 ± 0.02
0.001ThrXaa: 0.001 ± 0.0
Val
3.927ValAla: 3.927 ± 0.032
1.437ValCys: 1.437 ± 0.024
3.561ValAsp: 3.561 ± 0.033
4.029ValGlu: 4.029 ± 0.038
2.603ValPhe: 2.603 ± 0.024
2.947ValGly: 2.947 ± 0.031
1.57ValHis: 1.57 ± 0.019
4.227ValIle: 4.227 ± 0.038
3.619ValLys: 3.619 ± 0.032
5.817ValLeu: 5.817 ± 0.043
1.493ValMet: 1.493 ± 0.02
2.996ValAsn: 2.996 ± 0.026
2.761ValPro: 2.761 ± 0.031
2.42ValGln: 2.42 ± 0.024
3.239ValArg: 3.239 ± 0.029
4.863ValSer: 4.863 ± 0.038
3.4ValThr: 3.4 ± 0.029
4.114ValVal: 4.114 ± 0.048
0.639ValTrp: 0.639 ± 0.013
1.887ValTyr: 1.887 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
0.559TrpAla: 0.559 ± 0.011
0.243TrpCys: 0.243 ± 0.008
0.565TrpAsp: 0.565 ± 0.012
0.582TrpGlu: 0.582 ± 0.012
0.512TrpPhe: 0.512 ± 0.01
0.418TrpGly: 0.418 ± 0.011
0.299TrpHis: 0.299 ± 0.01
0.805TrpIle: 0.805 ± 0.016
0.845TrpLys: 0.845 ± 0.015
1.154TrpLeu: 1.154 ± 0.018
0.343TrpMet: 0.343 ± 0.01
0.706TrpAsn: 0.706 ± 0.014
0.448TrpPro: 0.448 ± 0.012
0.485TrpGln: 0.485 ± 0.012
0.675TrpArg: 0.675 ± 0.012
0.889TrpSer: 0.889 ± 0.017
0.62TrpThr: 0.62 ± 0.011
0.507TrpVal: 0.507 ± 0.01
0.163TrpTrp: 0.163 ± 0.007
0.391TrpTyr: 0.391 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.896TyrAla: 1.896 ± 0.023
0.908TyrCys: 0.908 ± 0.016
1.881TyrAsp: 1.881 ± 0.023
1.972TyrGlu: 1.972 ± 0.024
1.709TyrPhe: 1.709 ± 0.02
1.976TyrGly: 1.976 ± 0.026
0.934TyrHis: 0.934 ± 0.017
2.021TyrIle: 2.021 ± 0.025
1.708TyrLys: 1.708 ± 0.023
3.205TyrLeu: 3.205 ± 0.032
0.807TyrMet: 0.807 ± 0.014
1.511TyrAsn: 1.511 ± 0.022
1.33TyrPro: 1.33 ± 0.021
1.296TyrGln: 1.296 ± 0.018
1.978TyrArg: 1.978 ± 0.022
2.574TyrSer: 2.574 ± 0.029
1.517TyrThr: 1.517 ± 0.019
1.965TyrVal: 1.965 ± 0.022
0.429TyrTrp: 0.429 ± 0.012
1.321TyrTyr: 1.321 ± 0.019
0.001TyrXaa: 0.001 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.001XaaCys: 0.001 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.001XaaPhe: 0.001 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.001XaaLys: 0.001 ± 0.001
0.001XaaLeu: 0.001 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.057XaaXaa: 0.057 ± 0.012
Statistics based on 10885 proteins (4428208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski