Amino acid dipepetide frequency for Ignicoccus islandicus DSM 13165

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.831AlaAla: 4.831 ± 0.123
0.675AlaCys: 0.675 ± 0.044
2.34AlaAsp: 2.34 ± 0.076
4.029AlaGlu: 4.029 ± 0.097
3.14AlaPhe: 3.14 ± 0.093
3.776AlaGly: 3.776 ± 0.097
1.06AlaHis: 1.06 ± 0.048
5.886AlaIle: 5.886 ± 0.121
5.25AlaLys: 5.25 ± 0.127
9.633AlaLeu: 9.633 ± 0.178
1.718AlaMet: 1.718 ± 0.066
1.949AlaAsn: 1.949 ± 0.059
2.4AlaPro: 2.4 ± 0.081
1.39AlaGln: 1.39 ± 0.055
3.838AlaArg: 3.838 ± 0.101
4.626AlaSer: 4.626 ± 0.123
3.154AlaThr: 3.154 ± 0.104
5.368AlaVal: 5.368 ± 0.135
0.957AlaTrp: 0.957 ± 0.054
2.735AlaTyr: 2.735 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.463CysAla: 0.463 ± 0.037
0.157CysCys: 0.157 ± 0.017
0.463CysAsp: 0.463 ± 0.033
0.785CysGlu: 0.785 ± 0.051
0.316CysPhe: 0.316 ± 0.028
1.07CysGly: 1.07 ± 0.062
0.243CysHis: 0.243 ± 0.042
0.6CysIle: 0.6 ± 0.041
0.829CysLys: 0.829 ± 0.047
0.764CysLeu: 0.764 ± 0.043
0.193CysMet: 0.193 ± 0.021
0.52CysAsn: 0.52 ± 0.034
0.969CysPro: 0.969 ± 0.058
0.137CysGln: 0.137 ± 0.018
0.359CysArg: 0.359 ± 0.029
0.679CysSer: 0.679 ± 0.044
0.467CysThr: 0.467 ± 0.039
0.718CysVal: 0.718 ± 0.046
0.159CysTrp: 0.159 ± 0.021
0.386CysTyr: 0.386 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
2.966AspAla: 2.966 ± 0.09
0.424AspCys: 0.424 ± 0.037
1.771AspAsp: 1.771 ± 0.072
4.152AspGlu: 4.152 ± 0.095
1.831AspPhe: 1.831 ± 0.073
2.997AspGly: 2.997 ± 0.168
0.636AspHis: 0.636 ± 0.04
2.853AspIle: 2.853 ± 0.085
2.838AspLys: 2.838 ± 0.092
5.648AspLeu: 5.648 ± 0.138
0.995AspMet: 0.995 ± 0.051
1.246AspAsn: 1.246 ± 0.056
2.93AspPro: 2.93 ± 0.102
0.802AspGln: 0.802 ± 0.042
1.875AspArg: 1.875 ± 0.071
2.164AspSer: 2.164 ± 0.076
1.708AspThr: 1.708 ± 0.084
5.031AspVal: 5.031 ± 0.129
0.667AspTrp: 0.667 ± 0.045
2.041AspTyr: 2.041 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
6.077GluAla: 6.077 ± 0.141
0.819GluCys: 0.819 ± 0.056
3.325GluAsp: 3.325 ± 0.083
8.373GluGlu: 8.373 ± 0.178
2.508GluPhe: 2.508 ± 0.091
5.568GluGly: 5.568 ± 0.111
0.901GluHis: 0.901 ± 0.047
6.38GluIle: 6.38 ± 0.147
6.289GluLys: 6.289 ± 0.162
9.619GluLeu: 9.619 ± 0.19
2.142GluMet: 2.142 ± 0.074
2.694GluAsn: 2.694 ± 0.086
2.665GluPro: 2.665 ± 0.076
1.06GluGln: 1.06 ± 0.05
4.725GluArg: 4.725 ± 0.106
3.501GluSer: 3.501 ± 0.097
2.99GluThr: 2.99 ± 0.084
8.467GluVal: 8.467 ± 0.164
0.988GluTrp: 0.988 ± 0.054
2.677GluTyr: 2.677 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.349PheAla: 2.349 ± 0.072
0.333PheCys: 0.333 ± 0.03
1.976PheAsp: 1.976 ± 0.074
2.841PheGlu: 2.841 ± 0.082
1.198PhePhe: 1.198 ± 0.064
2.424PheGly: 2.424 ± 0.078
0.663PheHis: 0.663 ± 0.04
2.176PheIle: 2.176 ± 0.061
2.696PheLys: 2.696 ± 0.085
3.812PheLeu: 3.812 ± 0.106
0.81PheMet: 0.81 ± 0.042
1.467PheAsn: 1.467 ± 0.066
1.499PhePro: 1.499 ± 0.052
0.778PheGln: 0.778 ± 0.04
1.557PheArg: 1.557 ± 0.064
2.515PheSer: 2.515 ± 0.081
1.67PheThr: 1.67 ± 0.066
3.021PheVal: 3.021 ± 0.089
0.431PheTrp: 0.431 ± 0.034
1.499PheTyr: 1.499 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.373GlyAla: 4.373 ± 0.103
0.778GlyCys: 0.778 ± 0.046
3.234GlyAsp: 3.234 ± 0.105
4.894GlyGlu: 4.894 ± 0.112
2.903GlyPhe: 2.903 ± 0.084
4.279GlyGly: 4.279 ± 0.114
1.034GlyHis: 1.034 ± 0.042
5.66GlyIle: 5.66 ± 0.11
5.698GlyLys: 5.698 ± 0.12
6.631GlyLeu: 6.631 ± 0.142
1.757GlyMet: 1.757 ± 0.071
2.597GlyAsn: 2.597 ± 0.095
2.458GlyPro: 2.458 ± 0.085
1.026GlyGln: 1.026 ± 0.053
3.684GlyArg: 3.684 ± 0.109
4.161GlySer: 4.161 ± 0.101
3.474GlyThr: 3.474 ± 0.094
5.33GlyVal: 5.33 ± 0.145
0.998GlyTrp: 0.998 ± 0.051
2.783GlyTyr: 2.783 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.978HisAla: 0.978 ± 0.047
0.181HisCys: 0.181 ± 0.021
0.554HisAsp: 0.554 ± 0.036
0.942HisGlu: 0.942 ± 0.048
0.564HisPhe: 0.564 ± 0.038
1.152HisGly: 1.152 ± 0.055
0.361HisHis: 0.361 ± 0.031
0.843HisIle: 0.843 ± 0.041
0.814HisLys: 0.814 ± 0.05
1.617HisLeu: 1.617 ± 0.072
0.33HisMet: 0.33 ± 0.028
0.354HisAsn: 0.354 ± 0.028
1.0HisPro: 1.0 ± 0.05
0.34HisGln: 0.34 ± 0.026
0.689HisArg: 0.689 ± 0.038
0.817HisSer: 0.817 ± 0.045
0.67HisThr: 0.67 ± 0.051
1.487HisVal: 1.487 ± 0.06
0.229HisTrp: 0.229 ± 0.024
0.679HisTyr: 0.679 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.421IleAla: 6.421 ± 0.141
0.581IleCys: 0.581 ± 0.042
4.171IleAsp: 4.171 ± 0.111
7.199IleGlu: 7.199 ± 0.155
1.94IlePhe: 1.94 ± 0.069
5.325IleGly: 5.325 ± 0.114
1.046IleHis: 1.046 ± 0.052
4.388IleIle: 4.388 ± 0.128
4.547IleLys: 4.547 ± 0.107
6.554IleLeu: 6.554 ± 0.138
1.296IleMet: 1.296 ± 0.06
2.303IleAsn: 2.303 ± 0.087
3.479IlePro: 3.479 ± 0.102
1.058IleGln: 1.058 ± 0.048
3.971IleArg: 3.971 ± 0.102
4.633IleSer: 4.633 ± 0.114
3.361IleThr: 3.361 ± 0.131
6.303IleVal: 6.303 ± 0.138
0.713IleTrp: 0.713 ± 0.04
2.624IleTyr: 2.624 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
5.457LysAla: 5.457 ± 0.117
1.053LysCys: 1.053 ± 0.062
3.474LysAsp: 3.474 ± 0.087
7.368LysGlu: 7.368 ± 0.177
2.436LysPhe: 2.436 ± 0.076
5.773LysGly: 5.773 ± 0.113
0.836LysHis: 0.836 ± 0.042
4.742LysIle: 4.742 ± 0.134
5.05LysLys: 5.05 ± 0.122
7.992LysLeu: 7.992 ± 0.128
1.624LysMet: 1.624 ± 0.058
2.05LysAsn: 2.05 ± 0.074
3.007LysPro: 3.007 ± 0.089
0.904LysGln: 0.904 ± 0.046
4.927LysArg: 4.927 ± 0.124
3.626LysSer: 3.626 ± 0.1
2.576LysThr: 2.576 ± 0.089
8.151LysVal: 8.151 ± 0.134
1.173LysTrp: 1.173 ± 0.055
3.161LysTyr: 3.161 ± 0.099
0.0LysXaa: 0.0 ± 0.0
Leu
7.802LeuAla: 7.802 ± 0.153
0.798LeuCys: 0.798 ± 0.053
4.923LeuAsp: 4.923 ± 0.111
8.587LeuGlu: 8.587 ± 0.196
3.127LeuPhe: 3.127 ± 0.096
7.628LeuGly: 7.628 ± 0.146
1.53LeuHis: 1.53 ± 0.065
7.698LeuIle: 7.698 ± 0.129
9.108LeuLys: 9.108 ± 0.171
10.823LeuLeu: 10.823 ± 0.21
2.566LeuMet: 2.566 ± 0.083
4.395LeuAsn: 4.395 ± 0.093
4.723LeuPro: 4.723 ± 0.099
2.043LeuGln: 2.043 ± 0.08
6.604LeuArg: 6.604 ± 0.151
7.686LeuSer: 7.686 ± 0.147
4.985LeuThr: 4.985 ± 0.15
7.949LeuVal: 7.949 ± 0.136
1.217LeuTrp: 1.217 ± 0.06
3.699LeuTyr: 3.699 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.655MetAla: 1.655 ± 0.058
0.173MetCys: 0.173 ± 0.018
1.154MetAsp: 1.154 ± 0.055
1.973MetGlu: 1.973 ± 0.076
0.639MetPhe: 0.639 ± 0.04
1.641MetGly: 1.641 ± 0.075
0.308MetHis: 0.308 ± 0.028
1.508MetIle: 1.508 ± 0.064
2.171MetLys: 2.171 ± 0.073
1.997MetLeu: 1.997 ± 0.077
0.458MetMet: 0.458 ± 0.037
0.879MetAsn: 0.879 ± 0.046
0.92MetPro: 0.92 ± 0.052
0.347MetGln: 0.347 ± 0.025
1.426MetArg: 1.426 ± 0.058
1.52MetSer: 1.52 ± 0.068
0.947MetThr: 0.947 ± 0.055
1.993MetVal: 1.993 ± 0.067
0.188MetTrp: 0.188 ± 0.019
0.679MetTyr: 0.679 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.487AsnAla: 2.487 ± 0.082
0.518AsnCys: 0.518 ± 0.038
1.547AsnAsp: 1.547 ± 0.058
3.111AsnGlu: 3.111 ± 0.089
1.313AsnPhe: 1.313 ± 0.051
2.696AsnGly: 2.696 ± 0.097
0.378AsnHis: 0.378 ± 0.028
1.925AsnIle: 1.925 ± 0.073
2.32AsnLys: 2.32 ± 0.085
3.843AsnLeu: 3.843 ± 0.099
0.689AsnMet: 0.689 ± 0.039
1.077AsnAsn: 1.077 ± 0.062
2.111AsnPro: 2.111 ± 0.071
0.571AsnGln: 0.571 ± 0.04
1.424AsnArg: 1.424 ± 0.063
2.046AsnSer: 2.046 ± 0.08
1.222AsnThr: 1.222 ± 0.06
4.019AsnVal: 4.019 ± 0.1
0.443AsnTrp: 0.443 ± 0.045
1.436AsnTyr: 1.436 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
2.156ProAla: 2.156 ± 0.073
0.549ProCys: 0.549 ± 0.04
1.985ProAsp: 1.985 ± 0.081
3.436ProGlu: 3.436 ± 0.092
2.019ProPhe: 2.019 ± 0.068
2.778ProGly: 2.778 ± 0.092
0.836ProHis: 0.836 ± 0.041
3.323ProIle: 3.323 ± 0.092
3.306ProLys: 3.306 ± 0.092
5.012ProLeu: 5.012 ± 0.127
0.913ProMet: 0.913 ± 0.048
1.667ProAsn: 1.667 ± 0.069
2.597ProPro: 2.597 ± 0.092
1.144ProGln: 1.144 ± 0.052
2.32ProArg: 2.32 ± 0.069
3.39ProSer: 3.39 ± 0.098
2.101ProThr: 2.101 ± 0.067
3.229ProVal: 3.229 ± 0.097
0.817ProTrp: 0.817 ± 0.049
2.002ProTyr: 2.002 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
1.306GlnAla: 1.306 ± 0.056
0.234GlnCys: 0.234 ± 0.024
0.53GlnAsp: 0.53 ± 0.032
1.229GlnGlu: 1.229 ± 0.063
0.598GlnPhe: 0.598 ± 0.035
1.164GlnGly: 1.164 ± 0.057
0.212GlnHis: 0.212 ± 0.022
1.284GlnIle: 1.284 ± 0.048
1.087GlnLys: 1.087 ± 0.048
2.25GlnLeu: 2.25 ± 0.083
0.61GlnMet: 0.61 ± 0.037
0.532GlnAsn: 0.532 ± 0.049
0.699GlnPro: 0.699 ± 0.049
0.441GlnGln: 0.441 ± 0.039
1.248GlnArg: 1.248 ± 0.058
0.87GlnSer: 0.87 ± 0.043
0.829GlnThr: 0.829 ± 0.052
1.448GlnVal: 1.448 ± 0.056
0.287GlnTrp: 0.287 ± 0.027
0.663GlnTyr: 0.663 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.66ArgAla: 3.66 ± 0.096
0.612ArgCys: 0.612 ± 0.046
2.829ArgAsp: 2.829 ± 0.075
5.185ArgGlu: 5.185 ± 0.134
1.711ArgPhe: 1.711 ± 0.071
4.082ArgGly: 4.082 ± 0.112
0.73ArgHis: 0.73 ± 0.046
3.944ArgIle: 3.944 ± 0.1
4.768ArgLys: 4.768 ± 0.122
5.123ArgLeu: 5.123 ± 0.105
1.224ArgMet: 1.224 ± 0.058
2.084ArgAsn: 2.084 ± 0.077
2.159ArgPro: 2.159 ± 0.067
0.72ArgGln: 0.72 ± 0.044
3.303ArgArg: 3.303 ± 0.099
2.966ArgSer: 2.966 ± 0.091
2.154ArgThr: 2.154 ± 0.08
4.238ArgVal: 4.238 ± 0.107
0.663ArgTrp: 0.663 ± 0.041
2.026ArgTyr: 2.026 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
3.325SerAla: 3.325 ± 0.081
0.593SerCys: 0.593 ± 0.04
2.761SerAsp: 2.761 ± 0.087
4.344SerGlu: 4.344 ± 0.12
2.564SerPhe: 2.564 ± 0.093
3.954SerGly: 3.954 ± 0.104
0.913SerHis: 0.913 ± 0.044
4.949SerIle: 4.949 ± 0.135
5.272SerLys: 5.272 ± 0.11
7.057SerLeu: 7.057 ± 0.15
1.463SerMet: 1.463 ± 0.058
2.47SerAsn: 2.47 ± 0.088
2.747SerPro: 2.747 ± 0.082
1.289SerGln: 1.289 ± 0.057
2.776SerArg: 2.776 ± 0.083
4.421SerSer: 4.421 ± 0.145
2.841SerThr: 2.841 ± 0.091
4.759SerVal: 4.759 ± 0.097
0.795SerTrp: 0.795 ± 0.043
2.313SerTyr: 2.313 ± 0.081
0.0SerXaa: 0.0 ± 0.0
Thr
2.744ThrAla: 2.744 ± 0.09
0.516ThrCys: 0.516 ± 0.04
1.836ThrAsp: 1.836 ± 0.115
2.771ThrGlu: 2.771 ± 0.09
1.858ThrPhe: 1.858 ± 0.076
2.918ThrGly: 2.918 ± 0.076
0.711ThrHis: 0.711 ± 0.041
3.421ThrIle: 3.421 ± 0.142
2.865ThrLys: 2.865 ± 0.093
5.306ThrLeu: 5.306 ± 0.131
0.925ThrMet: 0.925 ± 0.054
1.622ThrAsn: 1.622 ± 0.065
2.496ThrPro: 2.496 ± 0.084
1.01ThrGln: 1.01 ± 0.058
1.889ThrArg: 1.889 ± 0.075
3.046ThrSer: 3.046 ± 0.098
2.453ThrThr: 2.453 ± 0.194
3.756ThrVal: 3.756 ± 0.113
0.564ThrTrp: 0.564 ± 0.037
1.812ThrTyr: 1.812 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
6.375ValAla: 6.375 ± 0.116
0.728ValCys: 0.728 ± 0.048
4.13ValAsp: 4.13 ± 0.106
6.595ValGlu: 6.595 ± 0.152
2.954ValPhe: 2.954 ± 0.082
4.886ValGly: 4.886 ± 0.111
1.383ValHis: 1.383 ± 0.06
7.315ValIle: 7.315 ± 0.119
6.828ValLys: 6.828 ± 0.133
8.558ValLeu: 8.558 ± 0.142
1.797ValMet: 1.797 ± 0.075
3.356ValAsn: 3.356 ± 0.087
4.332ValPro: 4.332 ± 0.105
1.431ValGln: 1.431 ± 0.064
4.978ValArg: 4.978 ± 0.12
5.404ValSer: 5.404 ± 0.119
4.795ValThr: 4.795 ± 0.146
7.674ValVal: 7.674 ± 0.134
0.884ValTrp: 0.884 ± 0.048
3.212ValTyr: 3.212 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.689TrpAla: 0.689 ± 0.038
0.133TrpCys: 0.133 ± 0.019
0.653TrpAsp: 0.653 ± 0.037
1.053TrpGlu: 1.053 ± 0.061
0.525TrpPhe: 0.525 ± 0.035
0.776TrpGly: 0.776 ± 0.045
0.19TrpHis: 0.19 ± 0.027
1.017TrpIle: 1.017 ± 0.052
1.258TrpLys: 1.258 ± 0.053
1.236TrpLeu: 1.236 ± 0.053
0.342TrpMet: 0.342 ± 0.033
0.598TrpAsn: 0.598 ± 0.045
0.451TrpPro: 0.451 ± 0.03
0.222TrpGln: 0.222 ± 0.021
0.892TrpArg: 0.892 ± 0.044
0.798TrpSer: 0.798 ± 0.05
0.545TrpThr: 0.545 ± 0.04
0.887TrpVal: 0.887 ± 0.044
0.267TrpTrp: 0.267 ± 0.03
0.489TrpTyr: 0.489 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.638TyrAla: 2.638 ± 0.074
0.424TyrCys: 0.424 ± 0.032
1.92TyrAsp: 1.92 ± 0.088
2.901TyrGlu: 2.901 ± 0.081
1.571TyrPhe: 1.571 ± 0.065
2.865TyrGly: 2.865 ± 0.072
0.629TyrHis: 0.629 ± 0.046
2.0TyrIle: 2.0 ± 0.071
2.388TyrLys: 2.388 ± 0.08
4.417TyrLeu: 4.417 ± 0.107
0.725TyrMet: 0.725 ± 0.041
1.313TyrAsn: 1.313 ± 0.063
1.942TyrPro: 1.942 ± 0.055
0.805TyrGln: 0.805 ± 0.048
1.696TyrArg: 1.696 ± 0.062
2.735TyrSer: 2.735 ± 0.087
1.578TyrThr: 1.578 ± 0.069
3.79TyrVal: 3.79 ± 0.093
0.578TyrTrp: 0.578 ± 0.042
1.66TyrTyr: 1.66 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1510 proteins (415030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski