Amino acid dipepetide frequency for Thermodesulfatator indicus (strain DSM 15286 / JCM 11887 / CIR29812)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.965AlaAla: 5.965 ± 0.098	0.996AlaCys: 0.996 ± 0.048	2.981AlaAsp: 2.981 ± 0.071	5.588AlaGlu: 5.588 ± 0.104	3.65AlaPhe: 3.65 ± 0.075	5.487AlaGly: 5.487 ± 0.1	1.47AlaHis: 1.47 ± 0.048	5.591AlaIle: 5.591 ± 0.103	5.743AlaLys: 5.743 ± 0.094	9.486AlaLeu: 9.486 ± 0.142	1.714AlaMet: 1.714 ± 0.056	2.07AlaAsn: 2.07 ± 0.056	2.577AlaPro: 2.577 ± 0.059	2.834AlaGln: 2.834 ± 0.062	4.828AlaArg: 4.828 ± 0.097	3.787AlaSer: 3.787 ± 0.077	3.198AlaThr: 3.198 ± 0.076	4.897AlaVal: 4.897 ± 0.096	0.74AlaTrp: 0.74 ± 0.035	2.651AlaTyr: 2.651 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	0.843CysAla: 0.843 ± 0.041	0.181CysCys: 0.181 ± 0.02	0.435CysAsp: 0.435 ± 0.025	0.73CysGlu: 0.73 ± 0.037	0.61CysPhe: 0.61 ± 0.03	1.228CysGly: 1.228 ± 0.043	0.574CysHis: 0.574 ± 0.069	0.548CysIle: 0.548 ± 0.031	0.535CysLys: 0.535 ± 0.031	1.176CysLeu: 1.176 ± 0.044	0.18CysMet: 0.18 ± 0.016	0.281CysAsn: 0.281 ± 0.021	0.951CysPro: 0.951 ± 0.049	0.456CysGln: 0.456 ± 0.026	0.6CysArg: 0.6 ± 0.028	0.558CysSer: 0.558 ± 0.034	0.449CysThr: 0.449 ± 0.033	0.659CysVal: 0.659 ± 0.032	0.107CysTrp: 0.107 ± 0.012	0.419CysTyr: 0.419 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	2.444AspAla: 2.444 ± 0.064	0.458AspCys: 0.458 ± 0.026	1.716AspAsp: 1.716 ± 0.055	3.573AspGlu: 3.573 ± 0.08	2.781AspPhe: 2.781 ± 0.075	2.595AspGly: 2.595 ± 0.077	0.805AspHis: 0.805 ± 0.037	3.676AspIle: 3.676 ± 0.083	2.945AspLys: 2.945 ± 0.068	5.851AspLeu: 5.851 ± 0.099	0.884AspMet: 0.884 ± 0.037	1.287AspAsn: 1.287 ± 0.048	2.735AspPro: 2.735 ± 0.058	1.101AspGln: 1.101 ± 0.043	2.148AspArg: 2.148 ± 0.059	1.637AspSer: 1.637 ± 0.051	1.742AspThr: 1.742 ± 0.048	2.938AspVal: 2.938 ± 0.073	0.623AspTrp: 0.623 ± 0.031	1.688AspTyr: 1.688 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.196GluAla: 7.196 ± 0.13	0.583GluCys: 0.583 ± 0.034	3.781GluAsp: 3.781 ± 0.076	8.724GluGlu: 8.724 ± 0.171	3.014GluPhe: 3.014 ± 0.064	4.914GluGly: 4.914 ± 0.088	1.187GluHis: 1.187 ± 0.044	7.341GluIle: 7.341 ± 0.124	8.787GluLys: 8.787 ± 0.131	8.124GluLeu: 8.124 ± 0.114	1.552GluMet: 1.552 ± 0.054	3.341GluAsn: 3.341 ± 0.073	2.729GluPro: 2.729 ± 0.062	1.729GluGln: 1.729 ± 0.059	4.38GluArg: 4.38 ± 0.103	2.653GluSer: 2.653 ± 0.059	3.567GluThr: 3.567 ± 0.072	5.992GluVal: 5.992 ± 0.099	0.658GluTrp: 0.658 ± 0.032	1.844GluTyr: 1.844 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.072PheAla: 3.072 ± 0.078	0.717PheCys: 0.717 ± 0.031	2.378PheAsp: 2.378 ± 0.06	3.524PheGlu: 3.524 ± 0.081	2.91PhePhe: 2.91 ± 0.086	3.306PheGly: 3.306 ± 0.073	0.913PheHis: 0.913 ± 0.04	3.224PheIle: 3.224 ± 0.076	3.394PheLys: 3.394 ± 0.07	6.696PheLeu: 6.696 ± 0.121	1.023PheMet: 1.023 ± 0.044	1.547PheAsn: 1.547 ± 0.045	2.309PhePro: 2.309 ± 0.064	1.205PheGln: 1.205 ± 0.047	2.391PheArg: 2.391 ± 0.056	3.347PheSer: 3.347 ± 0.075	2.106PheThr: 2.106 ± 0.056	3.118PheVal: 3.118 ± 0.07	0.851PheTrp: 0.851 ± 0.038	1.998PheTyr: 1.998 ± 0.061	0.0PheXaa: 0.0 ± 0.0
Gly	4.904GlyAla: 4.904 ± 0.09	0.887GlyCys: 0.887 ± 0.044	2.88GlyAsp: 2.88 ± 0.067	4.887GlyGlu: 4.887 ± 0.079	3.623GlyPhe: 3.623 ± 0.078	4.576GlyGly: 4.576 ± 0.109	1.462GlyHis: 1.462 ± 0.051	4.944GlyIle: 4.944 ± 0.089	5.424GlyLys: 5.424 ± 0.086	8.311GlyLeu: 8.311 ± 0.134	1.219GlyMet: 1.219 ± 0.044	1.886GlyAsn: 1.886 ± 0.058	2.578GlyPro: 2.578 ± 0.06	2.068GlyGln: 2.068 ± 0.055	3.781GlyArg: 3.781 ± 0.078	3.098GlySer: 3.098 ± 0.071	3.234GlyThr: 3.234 ± 0.081	4.762GlyVal: 4.762 ± 0.088	0.727GlyTrp: 0.727 ± 0.033	2.398GlyTyr: 2.398 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.084HisAla: 1.084 ± 0.039	0.235HisCys: 0.235 ± 0.018	0.671HisAsp: 0.671 ± 0.033	1.252HisGlu: 1.252 ± 0.047	1.038HisPhe: 1.038 ± 0.042	1.265HisGly: 1.265 ± 0.045	0.51HisHis: 0.51 ± 0.033	1.271HisIle: 1.271 ± 0.038	0.973HisLys: 0.973 ± 0.044	2.428HisLeu: 2.428 ± 0.065	0.304HisMet: 0.304 ± 0.023	0.564HisAsn: 0.564 ± 0.033	1.244HisPro: 1.244 ± 0.045	0.602HisGln: 0.602 ± 0.031	1.022HisArg: 1.022 ± 0.037	0.809HisSer: 0.809 ± 0.038	0.807HisThr: 0.807 ± 0.034	1.084HisVal: 1.084 ± 0.045	0.207HisTrp: 0.207 ± 0.016	0.746HisTyr: 0.746 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.265IleAla: 5.265 ± 0.092	0.954IleCys: 0.954 ± 0.041	3.529IleAsp: 3.529 ± 0.079	5.498IleGlu: 5.498 ± 0.097	3.987IlePhe: 3.987 ± 0.094	4.351IleGly: 4.351 ± 0.085	1.116IleHis: 1.116 ± 0.041	5.16IleIle: 5.16 ± 0.107	6.274IleLys: 6.274 ± 0.097	8.009IleLeu: 8.009 ± 0.124	1.278IleMet: 1.278 ± 0.044	2.673IleAsn: 2.673 ± 0.068	3.745IlePro: 3.745 ± 0.077	1.634IleGln: 1.634 ± 0.045	3.289IleArg: 3.289 ± 0.065	4.566IleSer: 4.566 ± 0.084	3.467IleThr: 3.467 ± 0.072	4.612IleVal: 4.612 ± 0.096	0.724IleTrp: 0.724 ± 0.033	2.363IleTyr: 2.363 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	6.492LysAla: 6.492 ± 0.111	0.584LysCys: 0.584 ± 0.034	4.079LysAsp: 4.079 ± 0.073	8.495LysGlu: 8.495 ± 0.144	2.828LysPhe: 2.828 ± 0.066	5.199LysGly: 5.199 ± 0.089	1.252LysHis: 1.252 ± 0.045	6.778LysIle: 6.778 ± 0.108	7.328LysLys: 7.328 ± 0.125	7.554LysLeu: 7.554 ± 0.118	1.35LysMet: 1.35 ± 0.045	3.306LysAsn: 3.306 ± 0.071	3.429LysPro: 3.429 ± 0.075	1.884LysGln: 1.884 ± 0.059	4.386LysArg: 4.386 ± 0.087	2.961LysSer: 2.961 ± 0.071	3.65LysThr: 3.65 ± 0.067	5.568LysVal: 5.568 ± 0.093	0.655LysTrp: 0.655 ± 0.032	2.148LysTyr: 2.148 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	10.876LeuAla: 10.876 ± 0.142	1.331LeuCys: 1.331 ± 0.056	4.838LeuAsp: 4.838 ± 0.076	9.078LeuGlu: 9.078 ± 0.144	5.307LeuPhe: 5.307 ± 0.102	7.852LeuGly: 7.852 ± 0.107	1.66LeuHis: 1.66 ± 0.051	7.305LeuIle: 7.305 ± 0.11	10.328LeuLys: 10.328 ± 0.156	11.81LeuLeu: 11.81 ± 0.189	1.955LeuMet: 1.955 ± 0.054	3.763LeuAsn: 3.763 ± 0.077	5.791LeuPro: 5.791 ± 0.093	2.319LeuGln: 2.319 ± 0.063	5.841LeuArg: 5.841 ± 0.09	7.406LeuSer: 7.406 ± 0.113	4.96LeuThr: 4.96 ± 0.092	7.328LeuVal: 7.328 ± 0.117	1.17LeuTrp: 1.17 ± 0.043	3.331LeuTyr: 3.331 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.172MetAla: 2.172 ± 0.054	0.163MetCys: 0.163 ± 0.017	0.727MetAsp: 0.727 ± 0.033	1.3MetGlu: 1.3 ± 0.045	0.704MetPhe: 0.704 ± 0.03	1.451MetGly: 1.451 ± 0.044	0.24MetHis: 0.24 ± 0.019	1.267MetIle: 1.267 ± 0.043	1.642MetLys: 1.642 ± 0.042	1.799MetLeu: 1.799 ± 0.056	0.347MetMet: 0.347 ± 0.023	0.606MetAsn: 0.606 ± 0.027	0.973MetPro: 0.973 ± 0.038	0.417MetGln: 0.417 ± 0.025	1.033MetArg: 1.033 ± 0.037	0.944MetSer: 0.944 ± 0.039	0.769MetThr: 0.769 ± 0.035	1.298MetVal: 1.298 ± 0.04	0.148MetTrp: 0.148 ± 0.016	0.311MetTyr: 0.311 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	1.84AsnAla: 1.84 ± 0.056	0.453AsnCys: 0.453 ± 0.027	1.159AsnAsp: 1.159 ± 0.047	1.981AsnGlu: 1.981 ± 0.059	2.066AsnPhe: 2.066 ± 0.063	1.802AsnGly: 1.802 ± 0.055	0.573AsnHis: 0.573 ± 0.03	2.869AsnIle: 2.869 ± 0.07	2.256AsnLys: 2.256 ± 0.066	4.631AsnLeu: 4.631 ± 0.09	0.664AsnMet: 0.664 ± 0.028	1.172AsnAsn: 1.172 ± 0.057	2.231AsnPro: 2.231 ± 0.057	1.061AsnGln: 1.061 ± 0.042	1.631AsnArg: 1.631 ± 0.051	1.37AsnSer: 1.37 ± 0.046	1.321AsnThr: 1.321 ± 0.05	2.078AsnVal: 2.078 ± 0.056	0.404AsnTrp: 0.404 ± 0.023	1.209AsnTyr: 1.209 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.921ProAla: 2.921 ± 0.07	0.507ProCys: 0.507 ± 0.028	2.446ProAsp: 2.446 ± 0.066	5.454ProGlu: 5.454 ± 0.083	2.474ProPhe: 2.474 ± 0.058	3.542ProGly: 3.542 ± 0.078	0.996ProHis: 0.996 ± 0.039	2.733ProIle: 2.733 ± 0.066	3.488ProLys: 3.488 ± 0.079	4.894ProLeu: 4.894 ± 0.083	0.744ProMet: 0.744 ± 0.036	1.329ProAsn: 1.329 ± 0.05	2.443ProPro: 2.443 ± 0.084	1.578ProGln: 1.578 ± 0.046	2.256ProArg: 2.256 ± 0.064	2.46ProSer: 2.46 ± 0.058	1.848ProThr: 1.848 ± 0.053	3.561ProVal: 3.561 ± 0.074	0.648ProTrp: 0.648 ± 0.029	1.801ProTyr: 1.801 ± 0.057	0.0ProXaa: 0.0 ± 0.0
Gln	2.644GlnAla: 2.644 ± 0.062	0.255GlnCys: 0.255 ± 0.02	1.1GlnAsp: 1.1 ± 0.043	3.001GlnGlu: 3.001 ± 0.068	0.969GlnPhe: 0.969 ± 0.035	1.982GlnGly: 1.982 ± 0.059	0.354GlnHis: 0.354 ± 0.023	2.195GlnIle: 2.195 ± 0.059	3.325GlnLys: 3.325 ± 0.079	2.166GlnLeu: 2.166 ± 0.062	0.583GlnMet: 0.583 ± 0.029	1.095GlnAsn: 1.095 ± 0.047	0.891GlnPro: 0.891 ± 0.037	0.772GlnGln: 0.772 ± 0.038	1.422GlnArg: 1.422 ± 0.051	0.989GlnSer: 0.989 ± 0.041	1.195GlnThr: 1.195 ± 0.046	2.274GlnVal: 2.274 ± 0.065	0.23GlnTrp: 0.23 ± 0.015	0.671GlnTyr: 0.671 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.837ArgAla: 3.837 ± 0.078	0.586ArgCys: 0.586 ± 0.032	2.217ArgAsp: 2.217 ± 0.06	4.97ArgGlu: 4.97 ± 0.11	2.718ArgPhe: 2.718 ± 0.071	3.165ArgGly: 3.165 ± 0.077	1.042ArgHis: 1.042 ± 0.035	3.541ArgIle: 3.541 ± 0.083	4.128ArgLys: 4.128 ± 0.094	6.948ArgLeu: 6.948 ± 0.112	0.99ArgMet: 0.99 ± 0.038	1.544ArgAsn: 1.544 ± 0.049	2.446ArgPro: 2.446 ± 0.065	1.821ArgGln: 1.821 ± 0.047	3.381ArgArg: 3.381 ± 0.086	1.958ArgSer: 1.958 ± 0.048	2.096ArgThr: 2.096 ± 0.054	3.404ArgVal: 3.404 ± 0.071	0.642ArgTrp: 0.642 ± 0.033	2.017ArgTyr: 2.017 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	3.226SerAla: 3.226 ± 0.068	0.62SerCys: 0.62 ± 0.038	1.91SerAsp: 1.91 ± 0.046	3.208SerGlu: 3.208 ± 0.07	3.178SerPhe: 3.178 ± 0.084	3.78SerGly: 3.78 ± 0.078	0.917SerHis: 0.917 ± 0.038	3.026SerIle: 3.026 ± 0.069	2.921SerLys: 2.921 ± 0.072	6.869SerLeu: 6.869 ± 0.121	0.898SerMet: 0.898 ± 0.033	1.336SerAsn: 1.336 ± 0.053	2.968SerPro: 2.968 ± 0.059	1.835SerGln: 1.835 ± 0.054	2.762SerArg: 2.762 ± 0.068	2.843SerSer: 2.843 ± 0.069	1.848SerThr: 1.848 ± 0.042	2.932SerVal: 2.932 ± 0.07	0.723SerTrp: 0.723 ± 0.037	1.726SerTyr: 1.726 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.021ThrAla: 3.021 ± 0.066	0.584ThrCys: 0.584 ± 0.036	1.755ThrAsp: 1.755 ± 0.052	2.746ThrGlu: 2.746 ± 0.065	2.222ThrPhe: 2.222 ± 0.061	3.921ThrGly: 3.921 ± 0.078	0.841ThrHis: 0.841 ± 0.032	3.03ThrIle: 3.03 ± 0.073	2.718ThrLys: 2.718 ± 0.065	4.789ThrLeu: 4.789 ± 0.094	0.748ThrMet: 0.748 ± 0.039	1.46ThrAsn: 1.46 ± 0.045	2.551ThrPro: 2.551 ± 0.058	1.206ThrGln: 1.206 ± 0.044	2.142ThrArg: 2.142 ± 0.059	2.312ThrSer: 2.312 ± 0.064	2.086ThrThr: 2.086 ± 0.068	2.867ThrVal: 2.867 ± 0.075	0.461ThrTrp: 0.461 ± 0.027	1.533ThrTyr: 1.533 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.504ValAla: 5.504 ± 0.099	0.9ValCys: 0.9 ± 0.044	2.981ValAsp: 2.981 ± 0.066	4.756ValGlu: 4.756 ± 0.086	3.424ValPhe: 3.424 ± 0.081	4.18ValGly: 4.18 ± 0.08	1.146ValHis: 1.146 ± 0.045	5.355ValIle: 5.355 ± 0.094	5.316ValLys: 5.316 ± 0.089	7.22ValLeu: 7.22 ± 0.106	1.206ValMet: 1.206 ± 0.046	2.129ValAsn: 2.129 ± 0.051	3.168ValPro: 3.168 ± 0.078	1.504ValGln: 1.504 ± 0.048	3.329ValArg: 3.329 ± 0.075	3.968ValSer: 3.968 ± 0.081	3.072ValThr: 3.072 ± 0.064	5.011ValVal: 5.011 ± 0.111	0.645ValTrp: 0.645 ± 0.031	2.253ValTyr: 2.253 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.855TrpAla: 0.855 ± 0.034	0.145TrpCys: 0.145 ± 0.016	0.491TrpAsp: 0.491 ± 0.024	0.89TrpGlu: 0.89 ± 0.04	0.507TrpPhe: 0.507 ± 0.03	0.77TrpGly: 0.77 ± 0.038	0.255TrpHis: 0.255 ± 0.02	0.662TrpIle: 0.662 ± 0.029	0.626TrpLys: 0.626 ± 0.032	1.353TrpLeu: 1.353 ± 0.047	0.194TrpMet: 0.194 ± 0.019	0.334TrpAsn: 0.334 ± 0.023	0.58TrpPro: 0.58 ± 0.033	0.628TrpGln: 0.628 ± 0.029	0.741TrpArg: 0.741 ± 0.031	0.387TrpSer: 0.387 ± 0.023	0.33TrpThr: 0.33 ± 0.024	0.684TrpVal: 0.684 ± 0.033	0.214TrpTrp: 0.214 ± 0.02	0.337TrpTyr: 0.337 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.091TyrAla: 2.091 ± 0.057	0.383TyrCys: 0.383 ± 0.024	1.553TyrAsp: 1.553 ± 0.051	2.441TyrGlu: 2.441 ± 0.056	2.017TyrPhe: 2.017 ± 0.064	2.281TyrGly: 2.281 ± 0.054	0.803TyrHis: 0.803 ± 0.034	1.981TyrIle: 1.981 ± 0.052	1.778TyrLys: 1.778 ± 0.048	4.134TyrLeu: 4.134 ± 0.086	0.476TyrMet: 0.476 ± 0.028	1.048TyrAsn: 1.048 ± 0.04	1.783TyrPro: 1.783 ± 0.05	1.46TyrGln: 1.46 ± 0.048	2.087TyrArg: 2.087 ± 0.069	1.474TyrSer: 1.474 ± 0.052	1.247TyrThr: 1.247 ± 0.043	1.999TyrVal: 1.999 ± 0.055	0.406TyrTrp: 0.406 ± 0.021	1.274TyrTyr: 1.274 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2184 proteins (694740 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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