Amino acid dipepetide frequency for Thioflexothrix psekupsii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.962AlaAla: 7.962 ± 0.124
1.043AlaCys: 1.043 ± 0.035
4.56AlaAsp: 4.56 ± 0.063
5.642AlaGlu: 5.642 ± 0.094
3.113AlaPhe: 3.113 ± 0.051
5.361AlaGly: 5.361 ± 0.09
2.287AlaHis: 2.287 ± 0.05
5.645AlaIle: 5.645 ± 0.08
3.704AlaLys: 3.704 ± 0.063
9.868AlaLeu: 9.868 ± 0.112
2.044AlaMet: 2.044 ± 0.051
3.28AlaAsn: 3.28 ± 0.059
2.951AlaPro: 2.951 ± 0.059
4.972AlaGln: 4.972 ± 0.085
4.553AlaArg: 4.553 ± 0.068
4.329AlaSer: 4.329 ± 0.078
4.26AlaThr: 4.26 ± 0.087
5.845AlaVal: 5.845 ± 0.082
1.112AlaTrp: 1.112 ± 0.036
2.559AlaTyr: 2.559 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.777CysAla: 0.777 ± 0.028
0.152CysCys: 0.152 ± 0.012
0.556CysAsp: 0.556 ± 0.025
0.627CysGlu: 0.627 ± 0.025
0.456CysPhe: 0.456 ± 0.025
0.851CysGly: 0.851 ± 0.031
0.4CysHis: 0.4 ± 0.022
0.519CysIle: 0.519 ± 0.022
0.314CysLys: 0.314 ± 0.016
1.091CysLeu: 1.091 ± 0.03
0.154CysMet: 0.154 ± 0.011
0.321CysAsn: 0.321 ± 0.016
0.531CysPro: 0.531 ± 0.024
0.66CysGln: 0.66 ± 0.029
0.603CysArg: 0.603 ± 0.025
0.519CysSer: 0.519 ± 0.023
0.457CysThr: 0.457 ± 0.021
0.72CysVal: 0.72 ± 0.028
0.124CysTrp: 0.124 ± 0.01
0.346CysTyr: 0.346 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.911AspAla: 3.911 ± 0.071
0.519AspCys: 0.519 ± 0.022
2.792AspAsp: 2.792 ± 0.123
3.175AspGlu: 3.175 ± 0.071
2.485AspPhe: 2.485 ± 0.053
3.216AspGly: 3.216 ± 0.089
1.13AspHis: 1.13 ± 0.037
3.639AspIle: 3.639 ± 0.056
2.402AspLys: 2.402 ± 0.049
5.811AspLeu: 5.811 ± 0.093
1.149AspMet: 1.149 ± 0.033
2.3AspAsn: 2.3 ± 0.047
2.314AspPro: 2.314 ± 0.05
2.01AspGln: 2.01 ± 0.041
2.493AspArg: 2.493 ± 0.057
2.932AspSer: 2.932 ± 0.077
2.775AspThr: 2.775 ± 0.072
3.54AspVal: 3.54 ± 0.062
0.831AspTrp: 0.831 ± 0.03
2.173AspTyr: 2.173 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.244GluAla: 5.244 ± 0.079
0.463GluCys: 0.463 ± 0.02
2.552GluAsp: 2.552 ± 0.067
3.97GluGlu: 3.97 ± 0.085
2.312GluPhe: 2.312 ± 0.051
3.158GluGly: 3.158 ± 0.06
1.413GluHis: 1.413 ± 0.035
4.165GluIle: 4.165 ± 0.06
3.956GluLys: 3.956 ± 0.073
7.576GluLeu: 7.576 ± 0.123
1.741GluMet: 1.741 ± 0.044
2.935GluAsn: 2.935 ± 0.055
1.947GluPro: 1.947 ± 0.042
4.392GluGln: 4.392 ± 0.073
3.615GluArg: 3.615 ± 0.064
3.444GluSer: 3.444 ± 0.07
3.774GluThr: 3.774 ± 0.09
3.654GluVal: 3.654 ± 0.064
0.959GluTrp: 0.959 ± 0.033
1.686GluTyr: 1.686 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.27PheAla: 3.27 ± 0.054
0.449PheCys: 0.449 ± 0.022
2.432PheAsp: 2.432 ± 0.048
2.309PheGlu: 2.309 ± 0.05
2.034PhePhe: 2.034 ± 0.058
2.559PheGly: 2.559 ± 0.052
0.94PheHis: 0.94 ± 0.031
3.005PheIle: 3.005 ± 0.069
1.833PheLys: 1.833 ± 0.046
4.342PheLeu: 4.342 ± 0.08
0.966PheMet: 0.966 ± 0.032
2.027PheAsn: 2.027 ± 0.049
1.564PhePro: 1.564 ± 0.034
1.465PheGln: 1.465 ± 0.038
1.705PheArg: 1.705 ± 0.043
3.194PheSer: 3.194 ± 0.062
2.456PheThr: 2.456 ± 0.048
2.393PheVal: 2.393 ± 0.054
0.584PheTrp: 0.584 ± 0.023
1.631PheTyr: 1.631 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.321GlyAla: 4.321 ± 0.074
0.786GlyCys: 0.786 ± 0.029
3.323GlyAsp: 3.323 ± 0.078
4.167GlyGlu: 4.167 ± 0.063
2.964GlyPhe: 2.964 ± 0.064
4.256GlyGly: 4.256 ± 0.084
1.704GlyHis: 1.704 ± 0.04
4.311GlyIle: 4.311 ± 0.07
3.097GlyLys: 3.097 ± 0.056
6.985GlyLeu: 6.985 ± 0.092
1.642GlyMet: 1.642 ± 0.042
2.196GlyAsn: 2.196 ± 0.055
1.125GlyPro: 1.125 ± 0.035
3.284GlyGln: 3.284 ± 0.064
3.179GlyArg: 3.179 ± 0.061
3.236GlySer: 3.236 ± 0.066
3.266GlyThr: 3.266 ± 0.085
4.557GlyVal: 4.557 ± 0.077
0.87GlyTrp: 0.87 ± 0.038
2.394GlyTyr: 2.394 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.094HisAla: 2.094 ± 0.047
0.424HisCys: 0.424 ± 0.022
1.232HisAsp: 1.232 ± 0.035
1.345HisGlu: 1.345 ± 0.041
1.386HisPhe: 1.386 ± 0.037
1.532HisGly: 1.532 ± 0.036
1.023HisHis: 1.023 ± 0.033
1.599HisIle: 1.599 ± 0.038
0.832HisLys: 0.832 ± 0.031
3.502HisLeu: 3.502 ± 0.06
0.289HisMet: 0.289 ± 0.016
0.799HisAsn: 0.799 ± 0.025
1.398HisPro: 1.398 ± 0.034
1.471HisGln: 1.471 ± 0.04
1.472HisArg: 1.472 ± 0.036
1.653HisSer: 1.653 ± 0.039
1.259HisThr: 1.259 ± 0.035
1.594HisVal: 1.594 ± 0.039
0.495HisTrp: 0.495 ± 0.022
1.397HisTyr: 1.397 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.899IleAla: 5.899 ± 0.069
0.682IleCys: 0.682 ± 0.024
3.826IleAsp: 3.826 ± 0.063
4.507IleGlu: 4.507 ± 0.068
2.502IlePhe: 2.502 ± 0.055
4.065IleGly: 4.065 ± 0.063
1.545IleHis: 1.545 ± 0.046
3.821IleIle: 3.821 ± 0.071
2.905IleLys: 2.905 ± 0.066
6.336IleLeu: 6.336 ± 0.1
1.239IleMet: 1.239 ± 0.035
2.771IleAsn: 2.771 ± 0.054
3.005IlePro: 3.005 ± 0.055
2.644IleGln: 2.644 ± 0.051
3.206IleArg: 3.206 ± 0.058
3.772IleSer: 3.772 ± 0.063
3.628IleThr: 3.628 ± 0.064
3.869IleVal: 3.869 ± 0.064
0.731IleTrp: 0.731 ± 0.024
1.984IleTyr: 1.984 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
3.656LysAla: 3.656 ± 0.07
0.287LysCys: 0.287 ± 0.017
1.904LysAsp: 1.904 ± 0.05
2.934LysGlu: 2.934 ± 0.062
1.23LysPhe: 1.23 ± 0.039
2.427LysGly: 2.427 ± 0.049
0.996LysHis: 0.996 ± 0.035
3.261LysIle: 3.261 ± 0.062
2.697LysLys: 2.697 ± 0.068
4.167LysLeu: 4.167 ± 0.07
1.201LysMet: 1.201 ± 0.034
2.419LysAsn: 2.419 ± 0.06
2.071LysPro: 2.071 ± 0.044
2.78LysGln: 2.78 ± 0.055
2.476LysArg: 2.476 ± 0.047
2.291LysSer: 2.291 ± 0.047
3.122LysThr: 3.122 ± 0.059
2.591LysVal: 2.591 ± 0.055
0.493LysTrp: 0.493 ± 0.022
1.138LysTyr: 1.138 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
10.065LeuAla: 10.065 ± 0.104
1.05LeuCys: 1.05 ± 0.032
5.736LeuAsp: 5.736 ± 0.086
6.615LeuGlu: 6.615 ± 0.089
4.816LeuPhe: 4.816 ± 0.091
6.841LeuGly: 6.841 ± 0.098
2.917LeuHis: 2.917 ± 0.061
6.977LeuIle: 6.977 ± 0.092
5.46LeuLys: 5.46 ± 0.081
13.631LeuLeu: 13.631 ± 0.187
2.774LeuMet: 2.774 ± 0.047
5.12LeuAsn: 5.12 ± 0.082
5.806LeuPro: 5.806 ± 0.098
5.912LeuGln: 5.912 ± 0.099
6.231LeuArg: 6.231 ± 0.09
8.218LeuSer: 8.218 ± 0.097
6.949LeuThr: 6.949 ± 0.084
5.946LeuVal: 5.946 ± 0.086
1.384LeuTrp: 1.384 ± 0.043
2.966LeuTyr: 2.966 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.205MetAla: 2.205 ± 0.041
0.142MetCys: 0.142 ± 0.011
1.112MetAsp: 1.112 ± 0.029
1.112MetGlu: 1.112 ± 0.029
0.645MetPhe: 0.645 ± 0.025
1.623MetGly: 1.623 ± 0.037
0.408MetHis: 0.408 ± 0.021
1.275MetIle: 1.275 ± 0.035
0.936MetLys: 0.936 ± 0.03
2.266MetLeu: 2.266 ± 0.048
0.633MetMet: 0.633 ± 0.025
0.981MetAsn: 0.981 ± 0.03
1.284MetPro: 1.284 ± 0.036
1.325MetGln: 1.325 ± 0.03
1.315MetArg: 1.315 ± 0.033
1.598MetSer: 1.598 ± 0.045
1.53MetThr: 1.53 ± 0.036
1.461MetVal: 1.461 ± 0.037
0.204MetTrp: 0.204 ± 0.016
0.437MetTyr: 0.437 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.492AsnAla: 3.492 ± 0.057
0.369AsnCys: 0.369 ± 0.018
2.061AsnAsp: 2.061 ± 0.049
2.339AsnGlu: 2.339 ± 0.048
1.457AsnPhe: 1.457 ± 0.035
2.587AsnGly: 2.587 ± 0.05
1.066AsnHis: 1.066 ± 0.028
2.453AsnIle: 2.453 ± 0.051
1.773AsnLys: 1.773 ± 0.048
4.066AsnLeu: 4.066 ± 0.079
0.905AsnMet: 0.905 ± 0.03
1.763AsnAsn: 1.763 ± 0.051
2.451AsnPro: 2.451 ± 0.05
2.206AsnGln: 2.206 ± 0.051
2.188AsnArg: 2.188 ± 0.044
2.254AsnSer: 2.254 ± 0.05
2.347AsnThr: 2.347 ± 0.051
2.53AsnVal: 2.53 ± 0.051
0.598AsnTrp: 0.598 ± 0.029
1.543AsnTyr: 1.543 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
3.427ProAla: 3.427 ± 0.068
0.4ProCys: 0.4 ± 0.02
2.791ProAsp: 2.791 ± 0.055
3.639ProGlu: 3.639 ± 0.064
1.823ProPhe: 1.823 ± 0.045
1.914ProGly: 1.914 ± 0.058
1.216ProHis: 1.216 ± 0.034
2.823ProIle: 2.823 ± 0.059
1.737ProLys: 1.737 ± 0.046
5.012ProLeu: 5.012 ± 0.069
0.933ProMet: 0.933 ± 0.033
1.933ProAsn: 1.933 ± 0.046
2.251ProPro: 2.251 ± 0.082
1.91ProGln: 1.91 ± 0.042
1.825ProArg: 1.825 ± 0.047
2.574ProSer: 2.574 ± 0.063
2.303ProThr: 2.303 ± 0.051
3.319ProVal: 3.319 ± 0.07
0.463ProTrp: 0.463 ± 0.018
1.415ProTyr: 1.415 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
5.5GlnAla: 5.5 ± 0.086
0.46GlnCys: 0.46 ± 0.026
2.127GlnAsp: 2.127 ± 0.052
3.158GlnGlu: 3.158 ± 0.059
2.137GlnPhe: 2.137 ± 0.05
3.132GlnGly: 3.132 ± 0.06
1.92GlnHis: 1.92 ± 0.049
3.015GlnIle: 3.015 ± 0.056
2.256GlnLys: 2.256 ± 0.047
6.992GlnLeu: 6.992 ± 0.124
1.136GlnMet: 1.136 ± 0.034
1.923GlnAsn: 1.923 ± 0.051
2.015GlnPro: 2.015 ± 0.042
4.683GlnGln: 4.683 ± 0.116
3.607GlnArg: 3.607 ± 0.068
2.576GlnSer: 2.576 ± 0.057
2.696GlnThr: 2.696 ± 0.055
3.411GlnVal: 3.411 ± 0.058
0.972GlnTrp: 0.972 ± 0.034
1.355GlnTyr: 1.355 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
4.091ArgAla: 4.091 ± 0.063
0.6ArgCys: 0.6 ± 0.025
2.816ArgAsp: 2.816 ± 0.054
3.605ArgGlu: 3.605 ± 0.07
2.62ArgPhe: 2.62 ± 0.053
2.958ArgGly: 2.958 ± 0.055
1.748ArgHis: 1.748 ± 0.041
3.314ArgIle: 3.314 ± 0.055
1.97ArgLys: 1.97 ± 0.055
6.985ArgLeu: 6.985 ± 0.084
1.232ArgMet: 1.232 ± 0.036
1.8ArgAsn: 1.8 ± 0.037
1.966ArgPro: 1.966 ± 0.049
3.193ArgGln: 3.193 ± 0.06
2.957ArgArg: 2.957 ± 0.055
2.53ArgSer: 2.53 ± 0.054
2.379ArgThr: 2.379 ± 0.05
3.569ArgVal: 3.569 ± 0.059
0.897ArgTrp: 0.897 ± 0.033
2.316ArgTyr: 2.316 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
4.865SerAla: 4.865 ± 0.079
0.568SerCys: 0.568 ± 0.022
3.242SerAsp: 3.242 ± 0.064
3.823SerGlu: 3.823 ± 0.068
2.406SerPhe: 2.406 ± 0.048
4.342SerGly: 4.342 ± 0.084
1.691SerHis: 1.691 ± 0.037
3.315SerIle: 3.315 ± 0.059
2.093SerLys: 2.093 ± 0.043
6.486SerLeu: 6.486 ± 0.08
1.19SerMet: 1.19 ± 0.039
2.142SerAsn: 2.142 ± 0.052
2.99SerPro: 2.99 ± 0.058
2.866SerGln: 2.866 ± 0.058
2.945SerArg: 2.945 ± 0.054
3.544SerSer: 3.544 ± 0.068
2.91SerThr: 2.91 ± 0.066
4.068SerVal: 4.068 ± 0.073
0.644SerTrp: 0.644 ± 0.026
1.786SerTyr: 1.786 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
5.179ThrAla: 5.179 ± 0.092
0.519ThrCys: 0.519 ± 0.023
2.902ThrAsp: 2.902 ± 0.068
3.526ThrGlu: 3.526 ± 0.071
1.95ThrPhe: 1.95 ± 0.043
4.026ThrGly: 4.026 ± 0.083
1.582ThrHis: 1.582 ± 0.033
3.077ThrIle: 3.077 ± 0.057
1.648ThrLys: 1.648 ± 0.034
7.01ThrLeu: 7.01 ± 0.09
0.867ThrMet: 0.867 ± 0.034
1.509ThrAsn: 1.509 ± 0.048
3.414ThrPro: 3.414 ± 0.08
3.037ThrGln: 3.037 ± 0.066
2.76ThrArg: 2.76 ± 0.045
2.584ThrSer: 2.584 ± 0.061
2.95ThrThr: 2.95 ± 0.087
4.118ThrVal: 4.118 ± 0.088
0.706ThrTrp: 0.706 ± 0.024
1.451ThrTyr: 1.451 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
5.724ValAla: 5.724 ± 0.087
0.656ValCys: 0.656 ± 0.027
3.406ValAsp: 3.406 ± 0.067
4.09ValGlu: 4.09 ± 0.073
2.68ValPhe: 2.68 ± 0.059
3.894ValGly: 3.894 ± 0.065
1.334ValHis: 1.334 ± 0.037
4.498ValIle: 4.498 ± 0.07
3.005ValLys: 3.005 ± 0.058
7.312ValLeu: 7.312 ± 0.092
1.627ValMet: 1.627 ± 0.042
2.746ValAsn: 2.746 ± 0.052
2.49ValPro: 2.49 ± 0.056
2.728ValGln: 2.728 ± 0.048
3.377ValArg: 3.377 ± 0.064
4.024ValSer: 4.024 ± 0.069
3.71ValThr: 3.71 ± 0.093
4.474ValVal: 4.474 ± 0.089
0.862ValTrp: 0.862 ± 0.036
1.813ValTyr: 1.813 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.841TrpAla: 0.841 ± 0.032
0.152TrpCys: 0.152 ± 0.011
0.622TrpAsp: 0.622 ± 0.027
0.679TrpGlu: 0.679 ± 0.028
0.611TrpPhe: 0.611 ± 0.03
0.82TrpGly: 0.82 ± 0.032
0.439TrpHis: 0.439 ± 0.021
0.755TrpIle: 0.755 ± 0.025
0.487TrpLys: 0.487 ± 0.021
2.033TrpLeu: 2.033 ± 0.053
0.288TrpMet: 0.288 ± 0.015
0.424TrpAsn: 0.424 ± 0.019
0.505TrpPro: 0.505 ± 0.021
1.297TrpGln: 1.297 ± 0.041
0.895TrpArg: 0.895 ± 0.029
0.734TrpSer: 0.734 ± 0.028
0.559TrpThr: 0.559 ± 0.025
0.924TrpVal: 0.924 ± 0.028
0.222TrpTrp: 0.222 ± 0.015
0.373TrpTyr: 0.373 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.567TyrAla: 2.567 ± 0.051
0.457TyrCys: 0.457 ± 0.02
1.606TyrAsp: 1.606 ± 0.037
1.696TyrGlu: 1.696 ± 0.04
1.531TyrPhe: 1.531 ± 0.038
2.101TyrGly: 2.101 ± 0.046
1.035TyrHis: 1.035 ± 0.032
1.469TyrIle: 1.469 ± 0.041
1.034TyrLys: 1.034 ± 0.035
3.944TyrLeu: 3.944 ± 0.067
0.484TyrMet: 0.484 ± 0.019
1.06TyrAsn: 1.06 ± 0.03
1.63TyrPro: 1.63 ± 0.039
2.235TyrGln: 2.235 ± 0.051
2.146TyrArg: 2.146 ± 0.05
1.908TyrSer: 1.908 ± 0.043
1.48TyrThr: 1.48 ± 0.039
1.869TyrVal: 1.869 ± 0.048
0.51TyrTrp: 0.51 ± 0.021
1.203TyrTyr: 1.203 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3187 proteins (1126285 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski