Amino acid dipepetide frequency for Tepidanaerobacter acetatoxydans (strain DSM 21804 / JCM 16047 / Re1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.474AlaAla: 6.474 ± 0.141
0.888AlaCys: 0.888 ± 0.033
3.828AlaAsp: 3.828 ± 0.07
4.81AlaGlu: 4.81 ± 0.073
2.873AlaPhe: 2.873 ± 0.068
5.455AlaGly: 5.455 ± 0.103
1.108AlaHis: 1.108 ± 0.04
6.166AlaIle: 6.166 ± 0.103
5.339AlaLys: 5.339 ± 0.083
7.343AlaLeu: 7.343 ± 0.115
2.088AlaMet: 2.088 ± 0.058
2.686AlaAsn: 2.686 ± 0.063
1.892AlaPro: 1.892 ± 0.052
2.267AlaGln: 2.267 ± 0.059
2.984AlaArg: 2.984 ± 0.064
3.617AlaSer: 3.617 ± 0.073
3.198AlaThr: 3.198 ± 0.075
5.783AlaVal: 5.783 ± 0.099
0.459AlaTrp: 0.459 ± 0.026
2.197AlaTyr: 2.197 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.738CysAla: 0.738 ± 0.032
0.175CysCys: 0.175 ± 0.015
0.629CysAsp: 0.629 ± 0.028
0.643CysGlu: 0.643 ± 0.027
0.461CysPhe: 0.461 ± 0.023
1.093CysGly: 1.093 ± 0.042
0.251CysHis: 0.251 ± 0.017
1.005CysIle: 1.005 ± 0.039
0.785CysLys: 0.785 ± 0.029
0.852CysLeu: 0.852 ± 0.032
0.296CysMet: 0.296 ± 0.021
0.536CysAsn: 0.536 ± 0.03
0.559CysPro: 0.559 ± 0.031
0.338CysGln: 0.338 ± 0.021
0.496CysArg: 0.496 ± 0.025
0.719CysSer: 0.719 ± 0.03
0.464CysThr: 0.464 ± 0.026
0.653CysVal: 0.653 ± 0.03
0.086CysTrp: 0.086 ± 0.01
0.46CysTyr: 0.46 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.598AspAla: 3.598 ± 0.066
0.566AspCys: 0.566 ± 0.026
2.848AspAsp: 2.848 ± 0.068
4.826AspGlu: 4.826 ± 0.087
2.805AspPhe: 2.805 ± 0.061
3.528AspGly: 3.528 ± 0.074
0.602AspHis: 0.602 ± 0.028
6.333AspIle: 6.333 ± 0.106
4.432AspLys: 4.432 ± 0.078
4.752AspLeu: 4.752 ± 0.079
1.663AspMet: 1.663 ± 0.047
2.411AspAsn: 2.411 ± 0.051
1.8AspPro: 1.8 ± 0.051
0.935AspGln: 0.935 ± 0.032
2.14AspArg: 2.14 ± 0.048
2.854AspSer: 2.854 ± 0.063
2.617AspThr: 2.617 ± 0.066
4.126AspVal: 4.126 ± 0.066
0.439AspTrp: 0.439 ± 0.025
2.379AspTyr: 2.379 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.953GluAla: 4.953 ± 0.091
0.551GluCys: 0.551 ± 0.027
4.142GluAsp: 4.142 ± 0.084
6.075GluGlu: 6.075 ± 0.116
2.597GluPhe: 2.597 ± 0.067
4.223GluGly: 4.223 ± 0.072
1.072GluHis: 1.072 ± 0.039
6.953GluIle: 6.953 ± 0.103
7.001GluLys: 7.001 ± 0.101
6.834GluLeu: 6.834 ± 0.095
2.087GluMet: 2.087 ± 0.046
4.038GluAsn: 4.038 ± 0.074
1.981GluPro: 1.981 ± 0.057
2.419GluGln: 2.419 ± 0.061
3.025GluArg: 3.025 ± 0.071
3.291GluSer: 3.291 ± 0.07
3.24GluThr: 3.24 ± 0.063
4.862GluVal: 4.862 ± 0.085
0.464GluTrp: 0.464 ± 0.026
2.526GluTyr: 2.526 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.741PheAla: 2.741 ± 0.061
0.531PheCys: 0.531 ± 0.03
2.604PheAsp: 2.604 ± 0.06
2.736PheGlu: 2.736 ± 0.056
1.895PhePhe: 1.895 ± 0.061
3.06PheGly: 3.06 ± 0.073
0.594PheHis: 0.594 ± 0.03
3.822PheIle: 3.822 ± 0.08
2.735PheLys: 2.735 ± 0.064
3.914PheLeu: 3.914 ± 0.083
1.107PheMet: 1.107 ± 0.036
1.958PheAsn: 1.958 ± 0.054
1.499PhePro: 1.499 ± 0.043
1.013PheGln: 1.013 ± 0.032
1.416PheArg: 1.416 ± 0.042
2.781PheSer: 2.781 ± 0.067
2.227PheThr: 2.227 ± 0.063
2.407PheVal: 2.407 ± 0.059
0.309PheTrp: 0.309 ± 0.021
1.568PheTyr: 1.568 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.95GlyAla: 4.95 ± 0.096
0.947GlyCys: 0.947 ± 0.039
3.353GlyAsp: 3.353 ± 0.06
4.331GlyGlu: 4.331 ± 0.079
3.25GlyPhe: 3.25 ± 0.063
5.017GlyGly: 5.017 ± 0.099
1.227GlyHis: 1.227 ± 0.043
7.243GlyIle: 7.243 ± 0.1
5.581GlyLys: 5.581 ± 0.095
6.345GlyLeu: 6.345 ± 0.112
2.026GlyMet: 2.026 ± 0.056
2.817GlyAsn: 2.817 ± 0.064
1.768GlyPro: 1.768 ± 0.045
1.951GlyGln: 1.951 ± 0.046
2.944GlyArg: 2.944 ± 0.061
3.808GlySer: 3.808 ± 0.074
3.603GlyThr: 3.603 ± 0.064
4.807GlyVal: 4.807 ± 0.089
0.558GlyTrp: 0.558 ± 0.027
2.795GlyTyr: 2.795 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.91HisAla: 0.91 ± 0.041
0.21HisCys: 0.21 ± 0.019
0.778HisAsp: 0.778 ± 0.029
0.948HisGlu: 0.948 ± 0.034
0.67HisPhe: 0.67 ± 0.033
1.184HisGly: 1.184 ± 0.037
0.334HisHis: 0.334 ± 0.022
1.514HisIle: 1.514 ± 0.049
1.01HisLys: 1.01 ± 0.032
1.369HisLeu: 1.369 ± 0.039
0.416HisMet: 0.416 ± 0.024
0.697HisAsn: 0.697 ± 0.032
0.768HisPro: 0.768 ± 0.031
0.5HisGln: 0.5 ± 0.024
0.672HisArg: 0.672 ± 0.031
0.814HisSer: 0.814 ± 0.034
0.752HisThr: 0.752 ± 0.026
0.943HisVal: 0.943 ± 0.031
0.139HisTrp: 0.139 ± 0.015
0.553HisTyr: 0.553 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.707IleAla: 6.707 ± 0.098
1.095IleCys: 1.095 ± 0.037
5.516IleAsp: 5.516 ± 0.094
6.463IleGlu: 6.463 ± 0.088
3.615IlePhe: 3.615 ± 0.082
5.955IleGly: 5.955 ± 0.097
1.308IleHis: 1.308 ± 0.039
8.391IleIle: 8.391 ± 0.127
7.421IleLys: 7.421 ± 0.102
8.684IleLeu: 8.684 ± 0.13
2.354IleMet: 2.354 ± 0.064
4.73IleAsn: 4.73 ± 0.079
3.952IlePro: 3.952 ± 0.079
2.342IleGln: 2.342 ± 0.056
3.435IleArg: 3.435 ± 0.07
6.338IleSer: 6.338 ± 0.091
4.921IleThr: 4.921 ± 0.083
5.91IleVal: 5.91 ± 0.092
0.564IleTrp: 0.564 ± 0.024
3.159IleTyr: 3.159 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
5.736LysAla: 5.736 ± 0.091
0.664LysCys: 0.664 ± 0.034
4.912LysAsp: 4.912 ± 0.088
6.575LysGlu: 6.575 ± 0.095
2.138LysPhe: 2.138 ± 0.047
4.646LysGly: 4.646 ± 0.069
1.146LysHis: 1.146 ± 0.031
7.178LysIle: 7.178 ± 0.103
6.625LysLys: 6.625 ± 0.099
6.768LysLeu: 6.768 ± 0.098
2.222LysMet: 2.222 ± 0.054
4.562LysAsn: 4.562 ± 0.082
2.766LysPro: 2.766 ± 0.061
2.592LysGln: 2.592 ± 0.065
3.094LysArg: 3.094 ± 0.066
4.296LysSer: 4.296 ± 0.07
4.139LysThr: 4.139 ± 0.075
5.45LysVal: 5.45 ± 0.086
0.518LysTrp: 0.518 ± 0.028
2.946LysTyr: 2.946 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
6.888LeuAla: 6.888 ± 0.11
1.064LeuCys: 1.064 ± 0.038
5.175LeuAsp: 5.175 ± 0.087
6.717LeuGlu: 6.717 ± 0.093
3.514LeuPhe: 3.514 ± 0.075
6.659LeuGly: 6.659 ± 0.093
1.284LeuHis: 1.284 ± 0.041
7.626LeuIle: 7.626 ± 0.134
8.194LeuLys: 8.194 ± 0.097
8.591LeuLeu: 8.591 ± 0.136
2.557LeuMet: 2.557 ± 0.062
4.588LeuAsn: 4.588 ± 0.074
3.677LeuPro: 3.677 ± 0.068
2.575LeuGln: 2.575 ± 0.062
3.65LeuArg: 3.65 ± 0.082
6.64LeuSer: 6.64 ± 0.092
4.878LeuThr: 4.878 ± 0.085
5.564LeuVal: 5.564 ± 0.083
0.63LeuTrp: 0.63 ± 0.028
2.889LeuTyr: 2.889 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.384MetAla: 2.384 ± 0.06
0.246MetCys: 0.246 ± 0.018
1.643MetAsp: 1.643 ± 0.048
1.956MetGlu: 1.956 ± 0.053
0.972MetPhe: 0.972 ± 0.036
2.143MetGly: 2.143 ± 0.056
0.376MetHis: 0.376 ± 0.021
2.197MetIle: 2.197 ± 0.057
2.098MetLys: 2.098 ± 0.05
2.644MetLeu: 2.644 ± 0.055
0.755MetMet: 0.755 ± 0.032
1.323MetAsn: 1.323 ± 0.04
1.182MetPro: 1.182 ± 0.038
0.933MetGln: 0.933 ± 0.034
1.099MetArg: 1.099 ± 0.038
1.642MetSer: 1.642 ± 0.045
1.403MetThr: 1.403 ± 0.047
1.896MetVal: 1.896 ± 0.058
0.169MetTrp: 0.169 ± 0.016
0.675MetTyr: 0.675 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.9AsnAla: 2.9 ± 0.056
0.584AsnCys: 0.584 ± 0.028
2.227AsnAsp: 2.227 ± 0.059
2.994AsnGlu: 2.994 ± 0.063
2.006AsnPhe: 2.006 ± 0.049
2.858AsnGly: 2.858 ± 0.066
0.707AsnHis: 0.707 ± 0.032
5.276AsnIle: 5.276 ± 0.088
3.508AsnLys: 3.508 ± 0.064
4.858AsnLeu: 4.858 ± 0.083
1.408AsnMet: 1.408 ± 0.038
2.325AsnAsn: 2.325 ± 0.066
2.446AsnPro: 2.446 ± 0.057
1.342AsnGln: 1.342 ± 0.04
1.925AsnArg: 1.925 ± 0.052
2.512AsnSer: 2.512 ± 0.061
2.4AsnThr: 2.4 ± 0.061
2.958AsnVal: 2.958 ± 0.067
0.395AsnTrp: 0.395 ± 0.022
1.822AsnTyr: 1.822 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.354ProAla: 2.354 ± 0.058
0.394ProCys: 0.394 ± 0.022
2.113ProAsp: 2.113 ± 0.054
3.119ProGlu: 3.119 ± 0.074
1.706ProPhe: 1.706 ± 0.053
2.724ProGly: 2.724 ± 0.057
0.665ProHis: 0.665 ± 0.028
3.164ProIle: 3.164 ± 0.068
2.354ProLys: 2.354 ± 0.058
3.236ProLeu: 3.236 ± 0.075
0.934ProMet: 0.934 ± 0.038
1.447ProAsn: 1.447 ± 0.048
1.137ProPro: 1.137 ± 0.041
1.118ProGln: 1.118 ± 0.038
1.206ProArg: 1.206 ± 0.039
2.013ProSer: 2.013 ± 0.051
1.84ProThr: 1.84 ± 0.039
2.836ProVal: 2.836 ± 0.06
0.321ProTrp: 0.321 ± 0.02
1.414ProTyr: 1.414 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.06GlnAla: 2.06 ± 0.054
0.271GlnCys: 0.271 ± 0.019
1.657GlnAsp: 1.657 ± 0.05
2.466GlnGlu: 2.466 ± 0.059
0.922GlnPhe: 0.922 ± 0.036
1.821GlnGly: 1.821 ± 0.051
0.431GlnHis: 0.431 ± 0.026
2.691GlnIle: 2.691 ± 0.054
2.594GlnLys: 2.594 ± 0.062
2.645GlnLeu: 2.645 ± 0.053
0.942GlnMet: 0.942 ± 0.032
1.561GlnAsn: 1.561 ± 0.048
0.824GlnPro: 0.824 ± 0.037
1.13GlnGln: 1.13 ± 0.052
1.294GlnArg: 1.294 ± 0.042
1.416GlnSer: 1.416 ± 0.043
1.369GlnThr: 1.369 ± 0.037
1.93GlnVal: 1.93 ± 0.052
0.265GlnTrp: 0.265 ± 0.023
0.899GlnTyr: 0.899 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.647ArgAla: 2.647 ± 0.065
0.488ArgCys: 0.488 ± 0.024
1.998ArgAsp: 1.998 ± 0.057
3.225ArgGlu: 3.225 ± 0.068
1.706ArgPhe: 1.706 ± 0.049
2.499ArgGly: 2.499 ± 0.065
0.653ArgHis: 0.653 ± 0.026
3.688ArgIle: 3.688 ± 0.07
3.076ArgLys: 3.076 ± 0.07
3.872ArgLeu: 3.872 ± 0.076
1.089ArgMet: 1.089 ± 0.036
1.858ArgAsn: 1.858 ± 0.048
1.403ArgPro: 1.403 ± 0.041
1.556ArgGln: 1.556 ± 0.043
1.962ArgArg: 1.962 ± 0.054
1.771ArgSer: 1.771 ± 0.042
1.798ArgThr: 1.798 ± 0.043
2.642ArgVal: 2.642 ± 0.057
0.334ArgTrp: 0.334 ± 0.02
1.581ArgTyr: 1.581 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
3.763SerAla: 3.763 ± 0.08
0.693SerCys: 0.693 ± 0.028
3.176SerAsp: 3.176 ± 0.066
3.708SerGlu: 3.708 ± 0.071
2.704SerPhe: 2.704 ± 0.061
4.519SerGly: 4.519 ± 0.082
0.925SerHis: 0.925 ± 0.04
5.201SerIle: 5.201 ± 0.08
4.448SerLys: 4.448 ± 0.078
5.621SerLeu: 5.621 ± 0.074
1.599SerMet: 1.599 ± 0.05
2.53SerAsn: 2.53 ± 0.057
2.066SerPro: 2.066 ± 0.056
1.855SerGln: 1.855 ± 0.051
2.405SerArg: 2.405 ± 0.052
3.55SerSer: 3.55 ± 0.073
2.8SerThr: 2.8 ± 0.056
3.673SerVal: 3.673 ± 0.064
0.434SerTrp: 0.434 ± 0.027
1.963SerTyr: 1.963 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.034ThrAla: 4.034 ± 0.073
0.544ThrCys: 0.544 ± 0.028
2.712ThrAsp: 2.712 ± 0.061
3.055ThrGlu: 3.055 ± 0.061
2.175ThrPhe: 2.175 ± 0.056
4.227ThrGly: 4.227 ± 0.071
0.865ThrHis: 0.865 ± 0.035
4.329ThrIle: 4.329 ± 0.083
3.214ThrLys: 3.214 ± 0.068
4.753ThrLeu: 4.753 ± 0.087
1.216ThrMet: 1.216 ± 0.041
2.075ThrAsn: 2.075 ± 0.052
2.138ThrPro: 2.138 ± 0.057
1.356ThrGln: 1.356 ± 0.039
1.857ThrArg: 1.857 ± 0.053
2.96ThrSer: 2.96 ± 0.062
2.612ThrThr: 2.612 ± 0.059
3.925ThrVal: 3.925 ± 0.079
0.314ThrTrp: 0.314 ± 0.017
1.684ThrTyr: 1.684 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.923ValAla: 4.923 ± 0.091
0.793ValCys: 0.793 ± 0.034
3.738ValAsp: 3.738 ± 0.065
4.747ValGlu: 4.747 ± 0.08
2.863ValPhe: 2.863 ± 0.061
4.68ValGly: 4.68 ± 0.096
0.883ValHis: 0.883 ± 0.037
6.355ValIle: 6.355 ± 0.099
5.465ValLys: 5.465 ± 0.077
6.287ValLeu: 6.287 ± 0.099
1.855ValMet: 1.855 ± 0.049
3.065ValAsn: 3.065 ± 0.061
2.587ValPro: 2.587 ± 0.066
1.646ValGln: 1.646 ± 0.044
2.534ValArg: 2.534 ± 0.048
4.123ValSer: 4.123 ± 0.074
3.674ValThr: 3.674 ± 0.08
5.063ValVal: 5.063 ± 0.09
0.416ValTrp: 0.416 ± 0.025
2.25ValTyr: 2.25 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.485TrpAla: 0.485 ± 0.026
0.071TrpCys: 0.071 ± 0.009
0.443TrpAsp: 0.443 ± 0.023
0.551TrpGlu: 0.551 ± 0.028
0.331TrpPhe: 0.331 ± 0.025
0.509TrpGly: 0.509 ± 0.028
0.135TrpHis: 0.135 ± 0.014
0.57TrpIle: 0.57 ± 0.027
0.461TrpLys: 0.461 ± 0.026
0.719TrpLeu: 0.719 ± 0.035
0.226TrpMet: 0.226 ± 0.015
0.364TrpAsn: 0.364 ± 0.021
0.244TrpPro: 0.244 ± 0.018
0.331TrpGln: 0.331 ± 0.02
0.269TrpArg: 0.269 ± 0.021
0.404TrpSer: 0.404 ± 0.022
0.308TrpThr: 0.308 ± 0.021
0.445TrpVal: 0.445 ± 0.026
0.094TrpTrp: 0.094 ± 0.011
0.251TrpTyr: 0.251 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.208TyrAla: 2.208 ± 0.053
0.464TyrCys: 0.464 ± 0.022
2.16TyrAsp: 2.16 ± 0.053
2.391TyrGlu: 2.391 ± 0.056
1.716TyrPhe: 1.716 ± 0.05
2.521TyrGly: 2.521 ± 0.058
0.615TyrHis: 0.615 ± 0.026
3.155TyrIle: 3.155 ± 0.07
2.634TyrLys: 2.634 ± 0.055
3.273TyrLeu: 3.273 ± 0.072
0.894TyrMet: 0.894 ± 0.034
1.88TyrAsn: 1.88 ± 0.052
1.406TyrPro: 1.406 ± 0.045
0.989TyrGln: 0.989 ± 0.034
1.441TyrArg: 1.441 ± 0.047
2.085TyrSer: 2.085 ± 0.053
1.803TyrThr: 1.803 ± 0.057
2.073TyrVal: 2.073 ± 0.047
0.305TyrTrp: 0.305 ± 0.019
1.533TyrTyr: 1.533 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2640 proteins (799649 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski