Amino acid dipepetide frequency for Tobacco necrosis virus (strain D) (TNV-D)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.373AlaAla: 9.373 ± 3.707
2.884AlaCys: 2.884 ± 1.574
2.163AlaAsp: 2.163 ± 0.738
5.047AlaGlu: 5.047 ± 1.211
5.768AlaPhe: 5.768 ± 1.434
3.605AlaGly: 3.605 ± 2.847
2.884AlaHis: 2.884 ± 1.574
2.884AlaIle: 2.884 ± 1.814
2.884AlaLys: 2.884 ± 1.126
5.047AlaLeu: 5.047 ± 1.512
0.721AlaMet: 0.721 ± 0.413
3.605AlaAsn: 3.605 ± 1.005
0.721AlaPro: 0.721 ± 0.445
2.884AlaGln: 2.884 ± 0.537
2.884AlaArg: 2.884 ± 1.135
5.768AlaSer: 5.768 ± 1.941
2.884AlaThr: 2.884 ± 2.088
7.931AlaVal: 7.931 ± 2.087
1.442AlaTrp: 1.442 ± 0.891
0.721AlaTyr: 0.721 ± 0.445
0.0AlaXaa: 0.0 ± 0.0
Cys
0.721CysAla: 0.721 ± 0.445
0.0CysCys: 0.0 ± 0.0
0.721CysAsp: 0.721 ± 0.445
0.0CysGlu: 0.0 ± 0.0
1.442CysPhe: 1.442 ± 0.787
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
2.884CysIle: 2.884 ± 1.574
0.0CysLys: 0.0 ± 0.0
0.721CysLeu: 0.721 ± 1.247
2.884CysMet: 2.884 ± 1.126
0.0CysAsn: 0.0 ± 0.0
2.163CysPro: 2.163 ± 1.339
0.721CysGln: 0.721 ± 0.445
2.163CysArg: 2.163 ± 0.863
2.884CysSer: 2.884 ± 0.537
0.0CysThr: 0.0 ± 0.0
0.721CysVal: 0.721 ± 1.247
0.0CysTrp: 0.0 ± 0.0
2.884CysTyr: 2.884 ± 0.537
0.0CysXaa: 0.0 ± 0.0
Asp
4.326AspAla: 4.326 ± 0.982
0.721AspCys: 0.721 ± 0.445
0.721AspAsp: 0.721 ± 0.445
2.163AspGlu: 2.163 ± 1.336
1.442AspPhe: 1.442 ± 0.787
3.605AspGly: 3.605 ± 0.654
0.721AspHis: 0.721 ± 0.445
2.884AspIle: 2.884 ± 0.537
2.884AspLys: 2.884 ± 1.285
3.605AspLeu: 3.605 ± 0.654
2.163AspMet: 2.163 ± 1.073
0.721AspAsn: 0.721 ± 1.084
5.047AspPro: 5.047 ± 1.664
1.442AspGln: 1.442 ± 0.891
0.721AspArg: 0.721 ± 1.064
2.163AspSer: 2.163 ± 0.863
1.442AspThr: 1.442 ± 1.536
2.163AspVal: 2.163 ± 1.073
0.721AspTrp: 0.721 ± 0.445
0.721AspTyr: 0.721 ± 0.445
0.0AspXaa: 0.0 ± 0.0
Glu
1.442GluAla: 1.442 ± 0.637
0.0GluCys: 0.0 ± 0.0
2.884GluAsp: 2.884 ± 1.17
5.047GluGlu: 5.047 ± 1.956
4.326GluPhe: 4.326 ± 1.369
2.884GluGly: 2.884 ± 1.943
0.721GluHis: 0.721 ± 0.445
2.163GluIle: 2.163 ± 1.101
4.326GluLys: 4.326 ± 0.798
4.326GluLeu: 4.326 ± 0.982
3.605GluMet: 3.605 ± 1.479
2.163GluAsn: 2.163 ± 1.989
1.442GluPro: 1.442 ± 0.637
1.442GluGln: 1.442 ± 0.891
6.489GluArg: 6.489 ± 1.42
7.21GluSer: 7.21 ± 2.282
5.047GluThr: 5.047 ± 2.357
2.884GluVal: 2.884 ± 1.781
0.0GluTrp: 0.0 ± 0.0
2.163GluTyr: 2.163 ± 1.101
0.0GluXaa: 0.0 ± 0.0
Phe
1.442PheAla: 1.442 ± 0.787
1.442PheCys: 1.442 ± 0.637
0.721PheAsp: 0.721 ± 0.445
2.163PheGlu: 2.163 ± 0.863
0.721PhePhe: 0.721 ± 0.445
2.884PheGly: 2.884 ± 1.107
1.442PheHis: 1.442 ± 1.762
2.163PheIle: 2.163 ± 0.738
5.047PheLys: 5.047 ± 1.664
3.605PheLeu: 3.605 ± 1.591
1.442PheMet: 1.442 ± 1.231
1.442PheAsn: 1.442 ± 0.891
2.163PhePro: 2.163 ± 0.786
3.605PheGln: 3.605 ± 1.005
2.884PheArg: 2.884 ± 0.537
2.163PheSer: 2.163 ± 0.786
4.326PheThr: 4.326 ± 1.392
1.442PheVal: 1.442 ± 0.637
0.721PheTrp: 0.721 ± 0.445
0.721PheTyr: 0.721 ± 0.445
0.0PheXaa: 0.0 ± 0.0
Gly
5.047GlyAla: 5.047 ± 0.959
0.721GlyCys: 0.721 ± 0.445
7.21GlyAsp: 7.21 ± 0.951
2.884GlyGlu: 2.884 ± 1.018
2.884GlyPhe: 2.884 ± 1.781
5.047GlyGly: 5.047 ± 1.6
0.0GlyHis: 0.0 ± 0.0
2.163GlyIle: 2.163 ± 1.098
0.721GlyLys: 0.721 ± 1.247
7.21GlyLeu: 7.21 ± 1.814
4.326GlyMet: 4.326 ± 0.982
2.163GlyAsn: 2.163 ± 0.786
2.884GlyPro: 2.884 ± 1.662
0.721GlyGln: 0.721 ± 0.445
4.326GlyArg: 4.326 ± 1.369
5.047GlySer: 5.047 ± 3.912
1.442GlyThr: 1.442 ± 0.891
5.047GlyVal: 5.047 ± 1.664
0.0GlyTrp: 0.0 ± 0.0
1.442GlyTyr: 1.442 ± 1.335
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
1.442HisAsp: 1.442 ± 0.891
0.0HisGlu: 0.0 ± 0.0
2.163HisPhe: 2.163 ± 1.989
1.442HisGly: 1.442 ± 0.787
0.0HisHis: 0.0 ± 0.0
2.884HisIle: 2.884 ± 1.126
1.442HisLys: 1.442 ± 0.637
1.442HisLeu: 1.442 ± 1.088
1.442HisMet: 1.442 ± 0.787
0.721HisAsn: 0.721 ± 0.445
2.163HisPro: 2.163 ± 0.863
2.163HisGln: 2.163 ± 2.298
0.0HisArg: 0.0 ± 0.0
2.163HisSer: 2.163 ± 1.336
0.0HisThr: 0.0 ± 0.0
1.442HisVal: 1.442 ± 0.787
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.326IleAla: 4.326 ± 1.26
1.442IleCys: 1.442 ± 0.787
1.442IleAsp: 1.442 ± 0.637
2.884IleGlu: 2.884 ± 1.814
1.442IlePhe: 1.442 ± 0.637
5.047IleGly: 5.047 ± 2.562
1.442IleHis: 1.442 ± 0.787
6.489IleIle: 6.489 ± 5.178
2.884IleLys: 2.884 ± 1.574
1.442IleLeu: 1.442 ± 1.088
0.721IleMet: 0.721 ± 0.59
2.163IleAsn: 2.163 ± 0.786
4.326IlePro: 4.326 ± 1.476
3.605IleGln: 3.605 ± 1.2
3.605IleArg: 3.605 ± 1.205
3.605IleSer: 3.605 ± 0.94
2.884IleThr: 2.884 ± 1.571
5.768IleVal: 5.768 ± 3.011
2.163IleTrp: 2.163 ± 1.395
0.721IleTyr: 0.721 ± 0.768
0.0IleXaa: 0.0 ± 0.0
Lys
3.605LysAla: 3.605 ± 1.19
0.721LysCys: 0.721 ± 0.768
4.326LysAsp: 4.326 ± 1.871
5.768LysGlu: 5.768 ± 2.197
2.163LysPhe: 2.163 ± 0.863
3.605LysGly: 3.605 ± 1.359
2.163LysHis: 2.163 ± 0.863
5.768LysIle: 5.768 ± 4.319
2.884LysLys: 2.884 ± 1.273
5.047LysLeu: 5.047 ± 2.295
2.884LysMet: 2.884 ± 1.447
1.442LysAsn: 1.442 ± 0.637
2.884LysPro: 2.884 ± 1.781
2.163LysGln: 2.163 ± 1.101
1.442LysArg: 1.442 ± 1.55
2.163LysSer: 2.163 ± 0.738
4.326LysThr: 4.326 ± 2.179
3.605LysVal: 3.605 ± 1.66
1.442LysTrp: 1.442 ± 1.536
0.721LysTyr: 0.721 ± 1.084
0.721LysXaa: 0.721 ± 0.445
Leu
9.373LeuAla: 9.373 ± 1.143
4.326LeuCys: 4.326 ± 2.361
2.163LeuAsp: 2.163 ± 0.738
3.605LeuGlu: 3.605 ± 2.226
0.721LeuPhe: 0.721 ± 0.445
5.047LeuGly: 5.047 ± 2.366
2.163LeuHis: 2.163 ± 1.336
5.768LeuIle: 5.768 ± 1.941
4.326LeuLys: 4.326 ± 2.197
7.931LeuLeu: 7.931 ± 2.846
0.721LeuMet: 0.721 ± 1.058
2.163LeuAsn: 2.163 ± 1.052
5.768LeuPro: 5.768 ± 1.966
0.721LeuGln: 0.721 ± 0.445
1.442LeuArg: 1.442 ± 0.891
5.768LeuSer: 5.768 ± 1.92
5.768LeuThr: 5.768 ± 1.073
7.21LeuVal: 7.21 ± 1.669
0.721LeuTrp: 0.721 ± 0.445
2.163LeuTyr: 2.163 ± 0.786
0.0LeuXaa: 0.0 ± 0.0
Met
2.884MetAla: 2.884 ± 0.537
0.721MetCys: 0.721 ± 0.445
0.721MetAsp: 0.721 ± 0.445
2.884MetGlu: 2.884 ± 1.237
2.163MetPhe: 2.163 ± 0.863
1.442MetGly: 1.442 ± 0.971
0.721MetHis: 0.721 ± 0.445
0.0MetIle: 0.0 ± 0.0
2.884MetLys: 2.884 ± 1.527
2.163MetLeu: 2.163 ± 1.336
0.0MetMet: 0.0 ± 0.0
1.442MetAsn: 1.442 ± 0.891
0.721MetPro: 0.721 ± 0.768
0.0MetGln: 0.0 ± 0.0
2.163MetArg: 2.163 ± 0.738
3.605MetSer: 3.605 ± 1.597
0.721MetThr: 0.721 ± 1.064
5.768MetVal: 5.768 ± 2.436
0.721MetTrp: 0.721 ± 0.445
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.163AsnAla: 2.163 ± 2.304
0.721AsnCys: 0.721 ± 0.445
1.442AsnAsp: 1.442 ± 0.96
1.442AsnGlu: 1.442 ± 0.787
0.0AsnPhe: 0.0 ± 0.0
2.163AsnGly: 2.163 ± 1.336
0.721AsnHis: 0.721 ± 0.768
2.884AsnIle: 2.884 ± 2.088
0.721AsnLys: 0.721 ± 0.445
1.442AsnLeu: 1.442 ± 0.891
0.721AsnMet: 0.721 ± 0.995
2.163AsnAsn: 2.163 ± 0.786
0.721AsnPro: 0.721 ± 0.768
2.163AsnGln: 2.163 ± 1.868
3.605AsnArg: 3.605 ± 1.121
5.047AsnSer: 5.047 ± 2.057
1.442AsnThr: 1.442 ± 0.637
2.163AsnVal: 2.163 ± 1.073
0.721AsnTrp: 0.721 ± 0.445
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.884ProAla: 2.884 ± 0.537
2.163ProCys: 2.163 ± 1.395
4.326ProAsp: 4.326 ± 1.871
0.721ProGlu: 0.721 ± 1.084
0.0ProPhe: 0.0 ± 0.0
0.721ProGly: 0.721 ± 0.445
0.0ProHis: 0.0 ± 0.0
0.0ProIle: 0.0 ± 0.0
3.605ProLys: 3.605 ± 1.359
7.21ProLeu: 7.21 ± 1.886
0.0ProMet: 0.0 ± 0.0
1.442ProAsn: 1.442 ± 0.787
2.163ProPro: 2.163 ± 1.052
2.163ProGln: 2.163 ± 0.738
4.326ProArg: 4.326 ± 1.906
3.605ProSer: 3.605 ± 0.94
5.768ProThr: 5.768 ± 1.784
8.652ProVal: 8.652 ± 1.513
0.0ProTrp: 0.0 ± 0.0
1.442ProTyr: 1.442 ± 1.32
0.0ProXaa: 0.0 ± 0.0
Gln
2.163GlnAla: 2.163 ± 0.863
1.442GlnCys: 1.442 ± 1.55
2.163GlnAsp: 2.163 ± 1.101
2.163GlnGlu: 2.163 ± 1.073
2.884GlnPhe: 2.884 ± 1.135
2.163GlnGly: 2.163 ± 0.738
1.442GlnHis: 1.442 ± 0.971
2.163GlnIle: 2.163 ± 1.336
1.442GlnLys: 1.442 ± 0.637
0.721GlnLeu: 0.721 ± 0.445
0.721GlnMet: 0.721 ± 0.768
2.884GlnAsn: 2.884 ± 1.863
1.442GlnPro: 1.442 ± 0.637
1.442GlnGln: 1.442 ± 1.777
2.884GlnArg: 2.884 ± 0.537
2.884GlnSer: 2.884 ± 1.571
1.442GlnThr: 1.442 ± 0.96
2.884GlnVal: 2.884 ± 1.285
0.0GlnTrp: 0.0 ± 0.0
0.721GlnTyr: 0.721 ± 1.084
0.0GlnXaa: 0.0 ± 0.0
Arg
5.047ArgAla: 5.047 ± 1.482
2.163ArgCys: 2.163 ± 1.336
1.442ArgAsp: 1.442 ± 0.971
7.931ArgGlu: 7.931 ± 1.886
2.163ArgPhe: 2.163 ± 1.336
3.605ArgGly: 3.605 ± 1.493
0.721ArgHis: 0.721 ± 0.445
0.0ArgIle: 0.0 ± 0.0
6.489ArgLys: 6.489 ± 1.024
5.047ArgLeu: 5.047 ± 1.595
1.442ArgMet: 1.442 ± 0.891
0.721ArgAsn: 0.721 ± 0.445
4.326ArgPro: 4.326 ± 1.26
2.884ArgGln: 2.884 ± 2.175
4.326ArgArg: 4.326 ± 1.749
0.721ArgSer: 0.721 ± 1.064
2.884ArgThr: 2.884 ± 1.273
9.373ArgVal: 9.373 ± 1.143
1.442ArgTrp: 1.442 ± 1.55
7.21ArgTyr: 7.21 ± 2.659
0.0ArgXaa: 0.0 ± 0.0
Ser
1.442SerAla: 1.442 ± 0.637
0.721SerCys: 0.721 ± 0.768
2.884SerAsp: 2.884 ± 1.126
2.884SerGlu: 2.884 ± 1.325
5.768SerPhe: 5.768 ± 2.233
5.047SerGly: 5.047 ± 1.474
1.442SerHis: 1.442 ± 0.787
3.605SerIle: 3.605 ± 1.869
7.21SerLys: 7.21 ± 2.408
6.489SerLeu: 6.489 ± 1.673
3.605SerMet: 3.605 ± 1.19
0.0SerAsn: 0.0 ± 0.0
1.442SerPro: 1.442 ± 0.96
1.442SerGln: 1.442 ± 0.637
10.094SerArg: 10.094 ± 2.365
3.605SerSer: 3.605 ± 0.654
5.768SerThr: 5.768 ± 2.555
5.768SerVal: 5.768 ± 2.362
4.326SerTrp: 4.326 ± 1.187
1.442SerTyr: 1.442 ± 0.787
0.0SerXaa: 0.0 ± 0.0
Thr
5.768ThrAla: 5.768 ± 2.233
0.0ThrCys: 0.0 ± 0.0
0.0ThrAsp: 0.0 ± 0.0
2.163ThrGlu: 2.163 ± 1.283
5.047ThrPhe: 5.047 ± 0.945
2.163ThrGly: 2.163 ± 1.336
1.442ThrHis: 1.442 ± 1.088
7.21ThrIle: 7.21 ± 1.882
1.442ThrLys: 1.442 ± 0.96
4.326ThrLeu: 4.326 ± 1.511
2.163ThrMet: 2.163 ± 0.863
2.163ThrAsn: 2.163 ± 1.868
5.047ThrPro: 5.047 ± 2.283
2.884ThrGln: 2.884 ± 2.574
2.884ThrArg: 2.884 ± 1.107
3.605ThrSer: 3.605 ± 1.359
5.047ThrThr: 5.047 ± 1.935
3.605ThrVal: 3.605 ± 1.449
0.721ThrTrp: 0.721 ± 0.445
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
7.931ValAla: 7.931 ± 2.692
0.0ValCys: 0.0 ± 0.0
2.163ValAsp: 2.163 ± 0.786
8.652ValGlu: 8.652 ± 3.669
1.442ValPhe: 1.442 ± 0.787
8.652ValGly: 8.652 ± 2.157
2.884ValHis: 2.884 ± 1.275
2.884ValIle: 2.884 ± 2.039
6.489ValLys: 6.489 ± 1.784
5.047ValLeu: 5.047 ± 1.956
0.721ValMet: 0.721 ± 0.768
2.884ValAsn: 2.884 ± 2.088
4.326ValPro: 4.326 ± 1.707
0.721ValGln: 0.721 ± 1.084
9.373ValArg: 9.373 ± 2.289
7.931ValSer: 7.931 ± 1.153
5.047ValThr: 5.047 ± 1.595
6.489ValVal: 6.489 ± 3.261
0.721ValTrp: 0.721 ± 1.084
2.884ValTyr: 2.884 ± 1.285
0.0ValXaa: 0.0 ± 0.0
Trp
1.442TrpAla: 1.442 ± 0.787
0.721TrpCys: 0.721 ± 0.445
0.721TrpAsp: 0.721 ± 0.445
1.442TrpGlu: 1.442 ± 0.787
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.442TrpIle: 1.442 ± 1.32
0.721TrpLys: 0.721 ± 1.247
4.326TrpLeu: 4.326 ± 0.982
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.721TrpGln: 0.721 ± 0.445
2.163TrpArg: 2.163 ± 0.786
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
1.442TrpVal: 1.442 ± 1.088
0.0TrpTrp: 0.0 ± 0.0
0.721TrpTyr: 0.721 ± 0.768
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.721TyrAla: 0.721 ± 0.768
0.0TyrCys: 0.0 ± 0.0
0.721TyrAsp: 0.721 ± 0.768
0.721TyrGlu: 0.721 ± 0.768
0.0TyrPhe: 0.0 ± 0.0
1.442TyrGly: 1.442 ± 0.637
0.0TyrHis: 0.0 ± 0.0
2.884TyrIle: 2.884 ± 2.039
1.442TyrLys: 1.442 ± 0.971
0.721TyrLeu: 0.721 ± 0.445
0.721TyrMet: 0.721 ± 0.445
2.163TyrAsn: 2.163 ± 0.786
1.442TyrPro: 1.442 ± 0.787
2.163TyrGln: 2.163 ± 1.052
2.163TyrArg: 2.163 ± 1.336
5.047TyrSer: 5.047 ± 1.905
1.442TyrThr: 1.442 ± 0.891
2.884TyrVal: 2.884 ± 1.574
0.0TyrTrp: 0.0 ± 0.0
0.721TyrTyr: 0.721 ± 0.445
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.721XaaGly: 0.721 ± 0.445
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1388 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski