Amino acid dipepetide frequency for Thermosporothrix hazakensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.015AlaAla: 9.015 ± 0.092	1.235AlaCys: 1.235 ± 0.026	3.933AlaAsp: 3.933 ± 0.046	5.826AlaGlu: 5.826 ± 0.059	3.624AlaPhe: 3.624 ± 0.046	6.404AlaGly: 6.404 ± 0.059	2.341AlaHis: 2.341 ± 0.036	5.5AlaIle: 5.5 ± 0.058	2.645AlaLys: 2.645 ± 0.044	12.399AlaLeu: 12.399 ± 0.107	2.164AlaMet: 2.164 ± 0.03	2.452AlaAsn: 2.452 ± 0.038	4.056AlaPro: 4.056 ± 0.058	4.493AlaGln: 4.493 ± 0.049	6.503AlaArg: 6.503 ± 0.06	5.45AlaSer: 5.45 ± 0.058	5.014AlaThr: 5.014 ± 0.051	5.956AlaVal: 5.956 ± 0.063	1.307AlaTrp: 1.307 ± 0.025	2.824AlaTyr: 2.824 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.953CysAla: 0.953 ± 0.023	0.204CysCys: 0.204 ± 0.011	0.476CysAsp: 0.476 ± 0.015	0.597CysGlu: 0.597 ± 0.02	0.489CysPhe: 0.489 ± 0.016	1.02CysGly: 1.02 ± 0.022	0.278CysHis: 0.278 ± 0.012	0.652CysIle: 0.652 ± 0.02	0.321CysLys: 0.321 ± 0.012	1.224CysLeu: 1.224 ± 0.028	0.246CysMet: 0.246 ± 0.01	0.334CysAsn: 0.334 ± 0.011	0.601CysPro: 0.601 ± 0.018	0.483CysGln: 0.483 ± 0.016	0.67CysArg: 0.67 ± 0.018	0.709CysSer: 0.709 ± 0.019	0.67CysThr: 0.67 ± 0.022	0.675CysVal: 0.675 ± 0.021	0.209CysTrp: 0.209 ± 0.009	0.4CysTyr: 0.4 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.202AspAla: 4.202 ± 0.051	0.416AspCys: 0.416 ± 0.014	2.06AspAsp: 2.06 ± 0.035	3.556AspGlu: 3.556 ± 0.045	1.717AspPhe: 1.717 ± 0.029	3.204AspGly: 3.204 ± 0.047	0.96AspHis: 0.96 ± 0.02	3.012AspIle: 3.012 ± 0.042	1.386AspLys: 1.386 ± 0.032	4.789AspLeu: 4.789 ± 0.049	1.099AspMet: 1.099 ± 0.026	1.166AspAsn: 1.166 ± 0.029	2.84AspPro: 2.84 ± 0.039	1.738AspGln: 1.738 ± 0.03	2.646AspArg: 2.646 ± 0.038	2.027AspSer: 2.027 ± 0.032	2.536AspThr: 2.536 ± 0.036	3.246AspVal: 3.246 ± 0.046	0.71AspTrp: 0.71 ± 0.019	1.482AspTyr: 1.482 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.919GluAla: 6.919 ± 0.065	0.523GluCys: 0.523 ± 0.017	2.587GluAsp: 2.587 ± 0.037	5.471GluGlu: 5.471 ± 0.078	1.566GluPhe: 1.566 ± 0.03	3.972GluGly: 3.972 ± 0.045	1.961GluHis: 1.961 ± 0.033	3.523GluIle: 3.523 ± 0.049	3.168GluLys: 3.168 ± 0.042	6.817GluLeu: 6.817 ± 0.056	1.619GluMet: 1.619 ± 0.029	1.885GluAsn: 1.885 ± 0.032	2.812GluPro: 2.812 ± 0.044	5.016GluGln: 5.016 ± 0.066	5.596GluArg: 5.596 ± 0.067	2.541GluSer: 2.541 ± 0.031	3.501GluThr: 3.501 ± 0.039	4.127GluVal: 4.127 ± 0.045	0.778GluTrp: 0.778 ± 0.02	1.746GluTyr: 1.746 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.328PheAla: 3.328 ± 0.045	0.561PheCys: 0.561 ± 0.019	1.826PheAsp: 1.826 ± 0.03	2.085PheGlu: 2.085 ± 0.036	1.781PhePhe: 1.781 ± 0.034	2.807PheGly: 2.807 ± 0.041	0.974PheHis: 0.974 ± 0.023	1.862PheIle: 1.862 ± 0.029	0.974PheLys: 0.974 ± 0.024	4.596PheLeu: 4.596 ± 0.052	0.688PheMet: 0.688 ± 0.02	0.967PheAsn: 0.967 ± 0.022	1.887PhePro: 1.887 ± 0.035	1.692PheGln: 1.692 ± 0.032	2.039PheArg: 2.039 ± 0.038	2.518PheSer: 2.518 ± 0.038	2.124PheThr: 2.124 ± 0.037	2.567PheVal: 2.567 ± 0.038	0.654PheTrp: 0.654 ± 0.018	1.22PheTyr: 1.22 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.766GlyAla: 5.766 ± 0.063	0.846GlyCys: 0.846 ± 0.021	2.935GlyAsp: 2.935 ± 0.042	4.128GlyGlu: 4.128 ± 0.048	2.692GlyPhe: 2.692 ± 0.041	5.053GlyGly: 5.053 ± 0.064	1.581GlyHis: 1.581 ± 0.031	4.531GlyIle: 4.531 ± 0.049	3.476GlyLys: 3.476 ± 0.045	7.209GlyLeu: 7.209 ± 0.071	1.839GlyMet: 1.839 ± 0.036	2.206GlyAsn: 2.206 ± 0.038	2.643GlyPro: 2.643 ± 0.04	2.976GlyGln: 2.976 ± 0.04	4.156GlyArg: 4.156 ± 0.049	4.28GlySer: 4.28 ± 0.05	4.069GlyThr: 4.069 ± 0.053	4.977GlyVal: 4.977 ± 0.063	1.177GlyTrp: 1.177 ± 0.022	2.518GlyTyr: 2.518 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.144HisAla: 2.144 ± 0.031	0.365HisCys: 0.365 ± 0.012	1.108HisAsp: 1.108 ± 0.026	1.471HisGlu: 1.471 ± 0.028	1.147HisPhe: 1.147 ± 0.026	1.642HisGly: 1.642 ± 0.027	0.759HisHis: 0.759 ± 0.023	1.656HisIle: 1.656 ± 0.03	0.689HisLys: 0.689 ± 0.019	2.973HisLeu: 2.973 ± 0.043	0.598HisMet: 0.598 ± 0.017	0.691HisAsn: 0.691 ± 0.017	1.724HisPro: 1.724 ± 0.03	1.1HisGln: 1.1 ± 0.024	1.492HisArg: 1.492 ± 0.025	1.347HisSer: 1.347 ± 0.026	1.491HisThr: 1.491 ± 0.028	1.569HisVal: 1.569 ± 0.029	0.43HisTrp: 0.43 ± 0.015	0.938HisTyr: 0.938 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.831IleAla: 5.831 ± 0.057	0.699IleCys: 0.699 ± 0.018	2.82IleAsp: 2.82 ± 0.042	3.952IleGlu: 3.952 ± 0.043	2.006IlePhe: 2.006 ± 0.034	4.274IleGly: 4.274 ± 0.051	1.285IleHis: 1.285 ± 0.027	2.97IleIle: 2.97 ± 0.039	1.775IleLys: 1.775 ± 0.031	5.63IleLeu: 5.63 ± 0.062	1.03IleMet: 1.03 ± 0.022	1.514IleAsn: 1.514 ± 0.027	3.074IlePro: 3.074 ± 0.036	2.558IleGln: 2.558 ± 0.035	3.245IleArg: 3.245 ± 0.042	3.528IleSer: 3.528 ± 0.044	3.349IleThr: 3.349 ± 0.044	4.126IleVal: 4.126 ± 0.049	0.769IleTrp: 0.769 ± 0.023	1.661IleTyr: 1.661 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.459LysAla: 3.459 ± 0.039	0.241LysCys: 0.241 ± 0.011	1.635LysAsp: 1.635 ± 0.031	2.793LysGlu: 2.793 ± 0.038	0.684LysPhe: 0.684 ± 0.019	2.483LysGly: 2.483 ± 0.044	0.895LysHis: 0.895 ± 0.022	1.671LysIle: 1.671 ± 0.033	1.912LysLys: 1.912 ± 0.038	3.451LysLeu: 3.451 ± 0.048	0.85LysMet: 0.85 ± 0.019	1.095LysAsn: 1.095 ± 0.026	2.033LysPro: 2.033 ± 0.036	2.486LysGln: 2.486 ± 0.034	2.923LysArg: 2.923 ± 0.042	1.609LysSer: 1.609 ± 0.03	1.988LysThr: 1.988 ± 0.034	2.272LysVal: 2.272 ± 0.037	0.377LysTrp: 0.377 ± 0.012	0.938LysTyr: 0.938 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.37LeuAla: 11.37 ± 0.091	1.42LeuCys: 1.42 ± 0.029	5.37LeuAsp: 5.37 ± 0.051	6.716LeuGlu: 6.716 ± 0.07	4.723LeuPhe: 4.723 ± 0.059	7.153LeuGly: 7.153 ± 0.076	3.188LeuHis: 3.188 ± 0.042	5.913LeuIle: 5.913 ± 0.064	3.971LeuLys: 3.971 ± 0.046	14.918LeuLeu: 14.918 ± 0.142	2.163LeuMet: 2.163 ± 0.035	3.185LeuAsn: 3.185 ± 0.044	6.455LeuPro: 6.455 ± 0.062	5.893LeuGln: 5.893 ± 0.07	7.263LeuArg: 7.263 ± 0.064	7.193LeuSer: 7.193 ± 0.071	6.153LeuThr: 6.153 ± 0.065	7.373LeuVal: 7.373 ± 0.08	1.498LeuTrp: 1.498 ± 0.027	3.432LeuTyr: 3.432 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.995MetAla: 1.995 ± 0.033	0.178MetCys: 0.178 ± 0.009	0.865MetAsp: 0.865 ± 0.024	1.259MetGlu: 1.259 ± 0.026	0.608MetPhe: 0.608 ± 0.02	1.414MetGly: 1.414 ± 0.028	0.589MetHis: 0.589 ± 0.018	1.194MetIle: 1.194 ± 0.029	1.0MetLys: 1.0 ± 0.022	2.849MetLeu: 2.849 ± 0.041	0.504MetMet: 0.504 ± 0.019	0.754MetAsn: 0.754 ± 0.022	1.229MetPro: 1.229 ± 0.027	1.424MetGln: 1.424 ± 0.026	1.621MetArg: 1.621 ± 0.03	1.345MetSer: 1.345 ± 0.025	1.344MetThr: 1.344 ± 0.028	1.434MetVal: 1.434 ± 0.026	0.191MetTrp: 0.191 ± 0.011	0.539MetTyr: 0.539 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.733AsnAla: 2.733 ± 0.04	0.289AsnCys: 0.289 ± 0.012	1.315AsnAsp: 1.315 ± 0.026	1.837AsnGlu: 1.837 ± 0.03	0.868AsnPhe: 0.868 ± 0.022	2.32AsnGly: 2.32 ± 0.04	0.604AsnHis: 0.604 ± 0.018	1.752AsnIle: 1.752 ± 0.03	1.015AsnLys: 1.015 ± 0.022	2.71AsnLeu: 2.71 ± 0.042	0.69AsnMet: 0.69 ± 0.018	0.974AsnAsn: 0.974 ± 0.023	1.795AsnPro: 1.795 ± 0.031	1.219AsnGln: 1.219 ± 0.025	1.751AsnArg: 1.751 ± 0.035	1.453AsnSer: 1.453 ± 0.028	1.782AsnThr: 1.782 ± 0.028	1.878AsnVal: 1.878 ± 0.033	0.494AsnTrp: 0.494 ± 0.017	0.9AsnTyr: 0.9 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.93ProAla: 4.93 ± 0.057	0.442ProCys: 0.442 ± 0.015	3.118ProAsp: 3.118 ± 0.044	4.479ProGlu: 4.479 ± 0.052	2.249ProPhe: 2.249 ± 0.034	3.909ProGly: 3.909 ± 0.06	1.323ProHis: 1.323 ± 0.026	2.386ProIle: 2.386 ± 0.034	1.397ProLys: 1.397 ± 0.03	5.855ProLeu: 5.855 ± 0.07	0.997ProMet: 0.997 ± 0.02	1.33ProAsn: 1.33 ± 0.028	2.829ProPro: 2.829 ± 0.057	2.456ProGln: 2.456 ± 0.045	2.796ProArg: 2.796 ± 0.037	3.001ProSer: 3.001 ± 0.042	2.999ProThr: 2.999 ± 0.053	3.786ProVal: 3.786 ± 0.045	0.718ProTrp: 0.718 ± 0.02	1.587ProTyr: 1.587 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.459GlnAla: 5.459 ± 0.063	0.415GlnCys: 0.415 ± 0.015	1.971GlnAsp: 1.971 ± 0.034	3.888GlnGlu: 3.888 ± 0.048	1.376GlnPhe: 1.376 ± 0.027	3.35GlnGly: 3.35 ± 0.037	1.511GlnHis: 1.511 ± 0.029	2.572GlnIle: 2.572 ± 0.035	2.326GlnLys: 2.326 ± 0.036	5.09GlnLeu: 5.09 ± 0.061	1.161GlnMet: 1.161 ± 0.026	1.42GlnAsn: 1.42 ± 0.029	2.812GlnPro: 2.812 ± 0.053	4.1GlnGln: 4.1 ± 0.055	4.024GlnArg: 4.024 ± 0.049	2.292GlnSer: 2.292 ± 0.036	2.614GlnThr: 2.614 ± 0.044	3.192GlnVal: 3.192 ± 0.043	0.702GlnTrp: 0.702 ± 0.021	1.313GlnTyr: 1.313 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.406ArgAla: 5.406 ± 0.061	0.735ArgCys: 0.735 ± 0.019	2.914ArgAsp: 2.914 ± 0.044	4.847ArgGlu: 4.847 ± 0.049	2.746ArgPhe: 2.746 ± 0.038	3.804ArgGly: 3.804 ± 0.045	1.587ArgHis: 1.587 ± 0.029	3.703ArgIle: 3.703 ± 0.05	2.73ArgLys: 2.73 ± 0.038	7.889ArgLeu: 7.889 ± 0.069	1.642ArgMet: 1.642 ± 0.029	1.832ArgAsn: 1.832 ± 0.03	3.025ArgPro: 3.025 ± 0.043	3.414ArgGln: 3.414 ± 0.044	4.747ArgArg: 4.747 ± 0.056	3.722ArgSer: 3.722 ± 0.046	3.354ArgThr: 3.354 ± 0.039	4.369ArgVal: 4.369 ± 0.046	1.102ArgTrp: 1.102 ± 0.023	2.478ArgTyr: 2.478 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.721SerAla: 4.721 ± 0.048	0.645SerCys: 0.645 ± 0.019	2.437SerAsp: 2.437 ± 0.037	3.096SerGlu: 3.096 ± 0.041	2.492SerPhe: 2.492 ± 0.038	4.451SerGly: 4.451 ± 0.049	1.304SerHis: 1.304 ± 0.024	3.365SerIle: 3.365 ± 0.043	1.787SerLys: 1.787 ± 0.03	6.808SerLeu: 6.808 ± 0.071	1.451SerMet: 1.451 ± 0.027	1.622SerAsn: 1.622 ± 0.031	3.153SerPro: 3.153 ± 0.048	2.417SerGln: 2.417 ± 0.038	3.464SerArg: 3.464 ± 0.042	3.783SerSer: 3.783 ± 0.054	3.269SerThr: 3.269 ± 0.042	3.663SerVal: 3.663 ± 0.044	0.924SerTrp: 0.924 ± 0.023	1.813SerTyr: 1.813 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	4.957ThrAla: 4.957 ± 0.05	0.606ThrCys: 0.606 ± 0.018	2.337ThrAsp: 2.337 ± 0.036	3.116ThrGlu: 3.116 ± 0.037	2.242ThrPhe: 2.242 ± 0.039	4.299ThrGly: 4.299 ± 0.045	1.329ThrHis: 1.329 ± 0.024	3.652ThrIle: 3.652 ± 0.05	1.499ThrLys: 1.499 ± 0.032	6.922ThrLeu: 6.922 ± 0.064	1.112ThrMet: 1.112 ± 0.024	1.568ThrAsn: 1.568 ± 0.029	3.775ThrPro: 3.775 ± 0.056	2.296ThrGln: 2.296 ± 0.039	3.408ThrArg: 3.408 ± 0.038	3.184ThrSer: 3.184 ± 0.046	3.428ThrThr: 3.428 ± 0.049	4.035ThrVal: 4.035 ± 0.057	0.72ThrTrp: 0.72 ± 0.019	1.726ThrTyr: 1.726 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	6.322ValAla: 6.322 ± 0.067	0.773ValCys: 0.773 ± 0.021	2.967ValAsp: 2.967 ± 0.043	4.291ValGlu: 4.291 ± 0.048	2.393ValPhe: 2.393 ± 0.041	4.343ValGly: 4.343 ± 0.051	1.568ValHis: 1.568 ± 0.028	3.921ValIle: 3.921 ± 0.051	2.176ValLys: 2.176 ± 0.038	7.901ValLeu: 7.901 ± 0.076	1.506ValMet: 1.506 ± 0.029	1.853ValAsn: 1.853 ± 0.032	3.593ValPro: 3.593 ± 0.043	3.21ValGln: 3.21 ± 0.044	4.313ValArg: 4.313 ± 0.048	4.1ValSer: 4.1 ± 0.049	3.876ValThr: 3.876 ± 0.04	4.918ValVal: 4.918 ± 0.061	0.836ValTrp: 0.836 ± 0.022	1.914ValTyr: 1.914 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.934TrpAla: 0.934 ± 0.024	0.188TrpCys: 0.188 ± 0.01	0.624TrpAsp: 0.624 ± 0.021	0.812TrpGlu: 0.812 ± 0.021	0.577TrpPhe: 0.577 ± 0.018	0.886TrpGly: 0.886 ± 0.022	0.405TrpHis: 0.405 ± 0.016	0.717TrpIle: 0.717 ± 0.021	0.632TrpLys: 0.632 ± 0.018	1.984TrpLeu: 1.984 ± 0.035	0.359TrpMet: 0.359 ± 0.013	0.575TrpAsn: 0.575 ± 0.016	0.611TrpPro: 0.611 ± 0.017	0.9TrpGln: 0.9 ± 0.02	1.028TrpArg: 1.028 ± 0.024	0.912TrpSer: 0.912 ± 0.026	0.714TrpThr: 0.714 ± 0.02	0.764TrpVal: 0.764 ± 0.02	0.27TrpTrp: 0.27 ± 0.012	0.489TrpTyr: 0.489 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.7TyrAla: 2.7 ± 0.037	0.432TyrCys: 0.432 ± 0.015	1.494TyrAsp: 1.494 ± 0.033	1.907TyrGlu: 1.907 ± 0.031	1.172TyrPhe: 1.172 ± 0.026	2.269TyrGly: 2.269 ± 0.037	0.893TyrHis: 0.893 ± 0.021	1.544TyrIle: 1.544 ± 0.029	0.918TyrLys: 0.918 ± 0.022	3.335TyrLeu: 3.335 ± 0.041	0.619TyrMet: 0.619 ± 0.016	0.956TyrAsn: 0.956 ± 0.022	1.637TyrPro: 1.637 ± 0.033	1.717TyrGln: 1.717 ± 0.033	2.359TyrArg: 2.359 ± 0.033	1.669TyrSer: 1.669 ± 0.026	1.936TyrThr: 1.936 ± 0.031	1.847TyrVal: 1.847 ± 0.033	0.515TyrTrp: 0.515 ± 0.017	1.058TyrTyr: 1.058 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 6382 proteins (2033648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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