Amino acid dipepetide frequency for Rodentolepis nana (Dwarf tapeworm) (Hymenolepis nana)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.449AlaAla: 5.449 ± 0.054
1.269AlaCys: 1.269 ± 0.017
3.263AlaAsp: 3.263 ± 0.028
4.014AlaGlu: 4.014 ± 0.035
2.833AlaPhe: 2.833 ± 0.028
3.31AlaGly: 3.31 ± 0.033
1.319AlaHis: 1.319 ± 0.017
3.801AlaIle: 3.801 ± 0.028
3.561AlaLys: 3.561 ± 0.032
6.299AlaLeu: 6.299 ± 0.047
1.433AlaMet: 1.433 ± 0.017
3.095AlaAsn: 3.095 ± 0.025
3.148AlaPro: 3.148 ± 0.03
2.324AlaGln: 2.324 ± 0.023
3.218AlaArg: 3.218 ± 0.027
6.163AlaSer: 6.163 ± 0.044
3.893AlaThr: 3.893 ± 0.026
4.136AlaVal: 4.136 ± 0.035
0.622AlaTrp: 0.622 ± 0.012
1.776AlaTyr: 1.776 ± 0.021
0.001AlaXaa: 0.001 ± 0.0
Cys
1.156CysAla: 1.156 ± 0.016
0.575CysCys: 0.575 ± 0.013
1.033CysAsp: 1.033 ± 0.019
1.175CysGlu: 1.175 ± 0.025
0.901CysPhe: 0.901 ± 0.013
1.266CysGly: 1.266 ± 0.018
0.525CysHis: 0.525 ± 0.01
1.168CysIle: 1.168 ± 0.018
0.971CysLys: 0.971 ± 0.018
2.315CysLeu: 2.315 ± 0.028
0.397CysMet: 0.397 ± 0.009
0.834CysAsn: 0.834 ± 0.014
1.162CysPro: 1.162 ± 0.019
0.863CysGln: 0.863 ± 0.016
1.225CysArg: 1.225 ± 0.019
1.719CysSer: 1.719 ± 0.024
0.981CysThr: 0.981 ± 0.014
1.213CysVal: 1.213 ± 0.019
0.207CysTrp: 0.207 ± 0.007
0.572CysTyr: 0.572 ± 0.013
0.001CysXaa: 0.001 ± 0.0
Asp
3.276AspAla: 3.276 ± 0.024
1.03AspCys: 1.03 ± 0.017
3.475AspAsp: 3.475 ± 0.053
3.983AspGlu: 3.983 ± 0.038
2.455AspPhe: 2.455 ± 0.023
3.126AspGly: 3.126 ± 0.039
1.018AspHis: 1.018 ± 0.014
3.112AspIle: 3.112 ± 0.029
2.456AspLys: 2.456 ± 0.026
5.11AspLeu: 5.11 ± 0.038
1.046AspMet: 1.046 ± 0.015
2.167AspAsn: 2.167 ± 0.021
2.676AspPro: 2.676 ± 0.028
1.775AspGln: 1.775 ± 0.018
2.592AspArg: 2.592 ± 0.022
4.507AspSer: 4.507 ± 0.037
2.449AspThr: 2.449 ± 0.022
3.227AspVal: 3.227 ± 0.027
0.652AspTrp: 0.652 ± 0.012
1.652AspTyr: 1.652 ± 0.021
0.001AspXaa: 0.001 ± 0.0
Glu
4.442GluAla: 4.442 ± 0.035
1.164GluCys: 1.164 ± 0.021
3.741GluAsp: 3.741 ± 0.037
5.825GluGlu: 5.825 ± 0.058
2.437GluPhe: 2.437 ± 0.021
3.146GluGly: 3.146 ± 0.034
1.246GluHis: 1.246 ± 0.017
3.903GluIle: 3.903 ± 0.03
4.081GluLys: 4.081 ± 0.039
5.609GluLeu: 5.609 ± 0.05
1.65GluMet: 1.65 ± 0.021
3.351GluAsn: 3.351 ± 0.032
2.447GluPro: 2.447 ± 0.031
2.225GluGln: 2.225 ± 0.025
3.467GluArg: 3.467 ± 0.032
5.156GluSer: 5.156 ± 0.043
3.382GluThr: 3.382 ± 0.033
3.99GluVal: 3.99 ± 0.035
0.609GluTrp: 0.609 ± 0.011
1.712GluTyr: 1.712 ± 0.021
0.002GluXaa: 0.002 ± 0.001
Phe
2.603PheAla: 2.603 ± 0.024
0.93PheCys: 0.93 ± 0.015
2.356PheAsp: 2.356 ± 0.023
2.384PheGlu: 2.384 ± 0.025
1.918PhePhe: 1.918 ± 0.024
2.418PheGly: 2.418 ± 0.025
1.089PheHis: 1.089 ± 0.015
2.438PheIle: 2.438 ± 0.025
1.988PheLys: 1.988 ± 0.022
4.108PheLeu: 4.108 ± 0.034
0.885PheMet: 0.885 ± 0.016
1.968PheAsn: 1.968 ± 0.018
2.083PhePro: 2.083 ± 0.022
1.58PheGln: 1.58 ± 0.018
2.279PheArg: 2.279 ± 0.02
3.803PheSer: 3.803 ± 0.032
2.409PheThr: 2.409 ± 0.026
2.589PheVal: 2.589 ± 0.026
0.458PheTrp: 0.458 ± 0.011
1.43PheTyr: 1.43 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
3.247GlyAla: 3.247 ± 0.03
1.098GlyCys: 1.098 ± 0.017
3.078GlyAsp: 3.078 ± 0.04
3.354GlyGlu: 3.354 ± 0.06
2.341GlyPhe: 2.341 ± 0.027
4.534GlyGly: 4.534 ± 0.057
1.349GlyHis: 1.349 ± 0.019
3.07GlyIle: 3.07 ± 0.026
2.905GlyLys: 2.905 ± 0.025
4.781GlyLeu: 4.781 ± 0.037
1.203GlyMet: 1.203 ± 0.015
2.646GlyAsn: 2.646 ± 0.023
2.496GlyPro: 2.496 ± 0.094
1.957GlyGln: 1.957 ± 0.023
3.122GlyArg: 3.122 ± 0.03
5.069GlySer: 5.069 ± 0.042
2.94GlyThr: 2.94 ± 0.028
3.516GlyVal: 3.516 ± 0.024
0.58GlyTrp: 0.58 ± 0.012
1.7GlyTyr: 1.7 ± 0.024
0.001GlyXaa: 0.001 ± 0.0
His
1.25HisAla: 1.25 ± 0.014
0.563HisCys: 0.563 ± 0.012
0.955HisAsp: 0.955 ± 0.015
1.228HisGlu: 1.228 ± 0.017
1.187HisPhe: 1.187 ± 0.015
1.203HisGly: 1.203 ± 0.018
0.893HisHis: 0.893 ± 0.02
1.296HisIle: 1.296 ± 0.016
1.054HisLys: 1.054 ± 0.015
2.676HisLeu: 2.676 ± 0.025
0.489HisMet: 0.489 ± 0.011
0.985HisAsn: 0.985 ± 0.016
1.459HisPro: 1.459 ± 0.019
1.147HisGln: 1.147 ± 0.018
1.597HisArg: 1.597 ± 0.02
2.224HisSer: 2.224 ± 0.025
1.157HisThr: 1.157 ± 0.018
1.232HisVal: 1.232 ± 0.017
0.289HisTrp: 0.289 ± 0.008
0.787HisTyr: 0.787 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
3.714IleAla: 3.714 ± 0.031
1.341IleCys: 1.341 ± 0.019
3.149IleAsp: 3.149 ± 0.023
3.521IleGlu: 3.521 ± 0.032
2.56IlePhe: 2.56 ± 0.027
2.976IleGly: 2.976 ± 0.025
1.34IleHis: 1.34 ± 0.016
3.133IleIle: 3.133 ± 0.033
2.807IleLys: 2.807 ± 0.026
5.325IleLeu: 5.325 ± 0.041
1.114IleMet: 1.114 ± 0.017
2.585IleAsn: 2.585 ± 0.023
3.302IlePro: 3.302 ± 0.026
2.19IleGln: 2.19 ± 0.024
3.26IleArg: 3.26 ± 0.027
5.352IleSer: 5.352 ± 0.032
3.161IleThr: 3.161 ± 0.027
3.269IleVal: 3.269 ± 0.029
0.592IleTrp: 0.592 ± 0.011
1.755IleTyr: 1.755 ± 0.022
0.001IleXaa: 0.001 ± 0.001
Lys
3.545LysAla: 3.545 ± 0.033
1.076LysCys: 1.076 ± 0.02
2.553LysAsp: 2.553 ± 0.025
3.758LysGlu: 3.758 ± 0.036
1.993LysPhe: 1.993 ± 0.021
2.301LysGly: 2.301 ± 0.037
1.262LysHis: 1.262 ± 0.017
3.019LysIle: 3.019 ± 0.027
3.619LysLys: 3.619 ± 0.035
4.959LysLeu: 4.959 ± 0.041
1.375LysMet: 1.375 ± 0.016
2.474LysAsn: 2.474 ± 0.023
2.842LysPro: 2.842 ± 0.034
2.052LysGln: 2.052 ± 0.021
3.681LysArg: 3.681 ± 0.03
4.828LysSer: 4.828 ± 0.038
2.996LysThr: 2.996 ± 0.028
3.04LysVal: 3.04 ± 0.028
0.57LysTrp: 0.57 ± 0.01
1.555LysTyr: 1.555 ± 0.02
0.001LysXaa: 0.001 ± 0.0
Leu
6.406LeuAla: 6.406 ± 0.039
1.943LeuCys: 1.943 ± 0.022
4.765LeuAsp: 4.765 ± 0.037
5.97LeuGlu: 5.97 ± 0.055
3.922LeuPhe: 3.922 ± 0.033
4.5LeuGly: 4.5 ± 0.032
2.402LeuHis: 2.402 ± 0.026
5.479LeuIle: 5.479 ± 0.041
5.506LeuLys: 5.506 ± 0.04
9.747LeuLeu: 9.747 ± 0.073
2.045LeuMet: 2.045 ± 0.021
4.593LeuAsn: 4.593 ± 0.031
5.693LeuPro: 5.693 ± 0.042
4.134LeuGln: 4.134 ± 0.04
5.867LeuArg: 5.867 ± 0.042
8.574LeuSer: 8.574 ± 0.06
5.335LeuThr: 5.335 ± 0.035
5.288LeuVal: 5.288 ± 0.037
0.938LeuTrp: 0.938 ± 0.016
2.46LeuTyr: 2.46 ± 0.024
0.001LeuXaa: 0.001 ± 0.0
Met
1.622MetAla: 1.622 ± 0.018
0.383MetCys: 0.383 ± 0.009
1.238MetAsp: 1.238 ± 0.016
1.659MetGlu: 1.659 ± 0.017
0.729MetPhe: 0.729 ± 0.012
1.182MetGly: 1.182 ± 0.017
0.504MetHis: 0.504 ± 0.009
1.074MetIle: 1.074 ± 0.015
1.291MetLys: 1.291 ± 0.016
1.962MetLeu: 1.962 ± 0.02
0.522MetMet: 0.522 ± 0.01
1.107MetAsn: 1.107 ± 0.016
1.206MetPro: 1.206 ± 0.018
0.882MetGln: 0.882 ± 0.013
1.258MetArg: 1.258 ± 0.016
1.873MetSer: 1.873 ± 0.02
1.282MetThr: 1.282 ± 0.016
1.259MetVal: 1.259 ± 0.014
0.203MetTrp: 0.203 ± 0.007
0.498MetTyr: 0.498 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.147AsnAla: 3.147 ± 0.025
0.994AsnCys: 0.994 ± 0.018
2.392AsnAsp: 2.392 ± 0.022
3.065AsnGlu: 3.065 ± 0.028
2.143AsnPhe: 2.143 ± 0.022
3.097AsnGly: 3.097 ± 0.03
1.055AsnHis: 1.055 ± 0.016
2.606AsnIle: 2.606 ± 0.025
2.155AsnLys: 2.155 ± 0.022
4.61AsnLeu: 4.61 ± 0.03
0.946AsnMet: 0.946 ± 0.015
2.203AsnAsn: 2.203 ± 0.026
2.689AsnPro: 2.689 ± 0.031
1.982AsnGln: 1.982 ± 0.025
2.694AsnArg: 2.694 ± 0.022
4.647AsnSer: 4.647 ± 0.035
2.477AsnThr: 2.477 ± 0.024
2.71AsnVal: 2.71 ± 0.026
0.535AsnTrp: 0.535 ± 0.01
1.425AsnTyr: 1.425 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
3.007ProAla: 3.007 ± 0.025
0.872ProCys: 0.872 ± 0.021
2.672ProAsp: 2.672 ± 0.028
3.264ProGlu: 3.264 ± 0.027
2.104ProPhe: 2.104 ± 0.021
2.859ProGly: 2.859 ± 0.077
1.307ProHis: 1.307 ± 0.021
3.14ProIle: 3.14 ± 0.03
2.833ProLys: 2.833 ± 0.033
4.943ProLeu: 4.943 ± 0.037
1.11ProMet: 1.11 ± 0.015
2.683ProAsn: 2.683 ± 0.026
5.383ProPro: 5.383 ± 0.079
2.396ProGln: 2.396 ± 0.031
2.819ProArg: 2.819 ± 0.03
6.019ProSer: 6.019 ± 0.053
3.69ProThr: 3.69 ± 0.039
3.23ProVal: 3.23 ± 0.033
0.5ProTrp: 0.5 ± 0.009
1.378ProTyr: 1.378 ± 0.016
0.001ProXaa: 0.001 ± 0.0
Gln
2.45GlnAla: 2.45 ± 0.024
0.763GlnCys: 0.763 ± 0.014
1.522GlnAsp: 1.522 ± 0.018
2.256GlnGlu: 2.256 ± 0.025
1.504GlnPhe: 1.504 ± 0.02
1.701GlnGly: 1.701 ± 0.034
1.083GlnHis: 1.083 ± 0.019
2.32GlnIle: 2.32 ± 0.025
2.114GlnLys: 2.114 ± 0.02
4.066GlnLeu: 4.066 ± 0.034
1.057GlnMet: 1.057 ± 0.016
1.992GlnAsn: 1.992 ± 0.022
2.382GlnPro: 2.382 ± 0.031
2.865GlnGln: 2.865 ± 0.065
2.55GlnArg: 2.55 ± 0.022
3.654GlnSer: 3.654 ± 0.032
2.315GlnThr: 2.315 ± 0.023
2.252GlnVal: 2.252 ± 0.023
0.496GlnTrp: 0.496 ± 0.011
1.031GlnTyr: 1.031 ± 0.015
0.001GlnXaa: 0.001 ± 0.001
Arg
3.228ArgAla: 3.228 ± 0.025
1.26ArgCys: 1.26 ± 0.022
2.582ArgAsp: 2.582 ± 0.025
3.254ArgGlu: 3.254 ± 0.028
2.432ArgPhe: 2.432 ± 0.026
3.03ArgGly: 3.03 ± 0.046
1.593ArgHis: 1.593 ± 0.021
3.349ArgIle: 3.349 ± 0.03
3.497ArgLys: 3.497 ± 0.028
6.191ArgLeu: 6.191 ± 0.045
1.283ArgMet: 1.283 ± 0.018
2.73ArgAsn: 2.73 ± 0.027
2.856ArgPro: 2.856 ± 0.029
2.533ArgGln: 2.533 ± 0.024
4.966ArgArg: 4.966 ± 0.046
4.971ArgSer: 4.971 ± 0.039
2.84ArgThr: 2.84 ± 0.023
3.197ArgVal: 3.197 ± 0.027
0.629ArgTrp: 0.629 ± 0.011
1.686ArgTyr: 1.686 ± 0.019
0.001ArgXaa: 0.001 ± 0.0
Ser
6.017SerAla: 6.017 ± 0.045
1.658SerCys: 1.658 ± 0.023
4.716SerAsp: 4.716 ± 0.04
5.329SerGlu: 5.329 ± 0.046
3.467SerPhe: 3.467 ± 0.028
5.613SerGly: 5.613 ± 0.035
2.109SerHis: 2.109 ± 0.023
4.948SerIle: 4.948 ± 0.033
4.746SerLys: 4.746 ± 0.034
8.422SerLeu: 8.422 ± 0.054
1.91SerMet: 1.91 ± 0.018
4.694SerAsn: 4.694 ± 0.034
5.581SerPro: 5.581 ± 0.052
3.742SerGln: 3.742 ± 0.036
5.171SerArg: 5.171 ± 0.042
11.607SerSer: 11.607 ± 0.102
6.358SerThr: 6.358 ± 0.057
5.365SerVal: 5.365 ± 0.038
0.869SerTrp: 0.869 ± 0.015
2.166SerTyr: 2.166 ± 0.025
0.002SerXaa: 0.002 ± 0.001
Thr
3.984ThrAla: 3.984 ± 0.031
1.116ThrCys: 1.116 ± 0.017
2.814ThrAsp: 2.814 ± 0.027
3.369ThrGlu: 3.369 ± 0.033
2.285ThrPhe: 2.285 ± 0.023
3.34ThrGly: 3.34 ± 0.03
1.24ThrHis: 1.24 ± 0.018
3.046ThrIle: 3.046 ± 0.024
2.766ThrLys: 2.766 ± 0.024
5.082ThrLeu: 5.082 ± 0.034
1.146ThrMet: 1.146 ± 0.015
2.736ThrAsn: 2.736 ± 0.026
3.758ThrPro: 3.758 ± 0.037
2.06ThrGln: 2.06 ± 0.025
2.745ThrArg: 2.745 ± 0.024
6.005ThrSer: 6.005 ± 0.053
4.038ThrThr: 4.038 ± 0.047
3.528ThrVal: 3.528 ± 0.029
0.578ThrTrp: 0.578 ± 0.011
1.532ThrTyr: 1.532 ± 0.02
0.001ThrXaa: 0.001 ± 0.0
Val
4.079ValAla: 4.079 ± 0.032
1.329ValCys: 1.329 ± 0.02
3.487ValAsp: 3.487 ± 0.027
3.949ValGlu: 3.949 ± 0.032
2.572ValPhe: 2.572 ± 0.023
3.317ValGly: 3.317 ± 0.028
1.332ValHis: 1.332 ± 0.015
3.352ValIle: 3.352 ± 0.03
3.201ValLys: 3.201 ± 0.03
5.23ValLeu: 5.23 ± 0.038
1.227ValMet: 1.227 ± 0.016
2.929ValAsn: 2.929 ± 0.024
3.104ValPro: 3.104 ± 0.028
2.136ValGln: 2.136 ± 0.025
3.072ValArg: 3.072 ± 0.025
5.108ValSer: 5.108 ± 0.038
3.392ValThr: 3.392 ± 0.032
3.961ValVal: 3.961 ± 0.036
0.609ValTrp: 0.609 ± 0.013
1.77ValTyr: 1.77 ± 0.021
0.001ValXaa: 0.001 ± 0.0
Trp
0.537TrpAla: 0.537 ± 0.01
0.233TrpCys: 0.233 ± 0.006
0.516TrpAsp: 0.516 ± 0.01
0.559TrpGlu: 0.559 ± 0.011
0.477TrpPhe: 0.477 ± 0.011
0.455TrpGly: 0.455 ± 0.01
0.26TrpHis: 0.26 ± 0.007
0.646TrpIle: 0.646 ± 0.011
0.655TrpLys: 0.655 ± 0.012
1.105TrpLeu: 1.105 ± 0.017
0.285TrpMet: 0.285 ± 0.009
0.572TrpAsn: 0.572 ± 0.011
0.523TrpPro: 0.523 ± 0.011
0.396TrpGln: 0.396 ± 0.009
0.749TrpArg: 0.749 ± 0.012
0.891TrpSer: 0.891 ± 0.015
0.598TrpThr: 0.598 ± 0.012
0.522TrpVal: 0.522 ± 0.01
0.144TrpTrp: 0.144 ± 0.005
0.306TrpTyr: 0.306 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.768TyrAla: 1.768 ± 0.019
0.659TyrCys: 0.659 ± 0.013
1.479TyrAsp: 1.479 ± 0.018
1.67TyrGlu: 1.67 ± 0.02
1.459TyrPhe: 1.459 ± 0.018
1.616TyrGly: 1.616 ± 0.02
0.743TyrHis: 0.743 ± 0.012
1.546TyrIle: 1.546 ± 0.02
1.292TyrLys: 1.292 ± 0.017
3.025TyrLeu: 3.025 ± 0.027
0.61TyrMet: 0.61 ± 0.012
1.228TyrAsn: 1.228 ± 0.017
1.422TyrPro: 1.422 ± 0.018
1.132TyrGln: 1.132 ± 0.016
1.771TyrArg: 1.771 ± 0.021
2.32TyrSer: 2.32 ± 0.023
1.474TyrThr: 1.474 ± 0.019
1.629TyrVal: 1.629 ± 0.02
0.348TyrTrp: 0.348 ± 0.009
0.999TyrTyr: 0.999 ± 0.017
0.001TyrXaa: 0.001 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.001XaaHis: 0.001 ± 0.0
0.002XaaIle: 0.002 ± 0.001
0.001XaaLys: 0.001 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.001XaaMet: 0.001 ± 0.0
0.001XaaAsn: 0.001 ± 0.0
0.002XaaPro: 0.002 ± 0.001
0.001XaaGln: 0.001 ± 0.0
0.002XaaArg: 0.002 ± 0.001
0.001XaaSer: 0.001 ± 0.0
0.002XaaThr: 0.002 ± 0.001
0.001XaaVal: 0.001 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.098XaaXaa: 0.098 ± 0.03
Statistics based on 13592 proteins (5151847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski