Amino acid dipepetide frequency for Thioalkalivibrio nitratireducens (strain DSM 14787 / UNIQEM 213 / ALEN2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.364AlaAla: 15.364 ± 0.189	1.218AlaCys: 1.218 ± 0.037	6.535AlaAsp: 6.535 ± 0.074	7.613AlaGlu: 7.613 ± 0.102	3.851AlaPhe: 3.851 ± 0.06	10.61AlaGly: 10.61 ± 0.134	2.505AlaHis: 2.505 ± 0.05	4.906AlaIle: 4.906 ± 0.068	1.933AlaLys: 1.933 ± 0.048	14.057AlaLeu: 14.057 ± 0.13	2.953AlaMet: 2.953 ± 0.051	2.166AlaAsn: 2.166 ± 0.042	5.439AlaPro: 5.439 ± 0.094	4.005AlaGln: 4.005 ± 0.062	10.514AlaArg: 10.514 ± 0.114	5.357AlaSer: 5.357 ± 0.076	5.182AlaThr: 5.182 ± 0.074	8.708AlaVal: 8.708 ± 0.1	1.899AlaTrp: 1.899 ± 0.045	2.297AlaTyr: 2.297 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.02CysAla: 1.02 ± 0.033	0.129CysCys: 0.129 ± 0.011	0.459CysAsp: 0.459 ± 0.022	0.506CysGlu: 0.506 ± 0.021	0.267CysPhe: 0.267 ± 0.019	0.951CysGly: 0.951 ± 0.033	0.344CysHis: 0.344 ± 0.022	0.324CysIle: 0.324 ± 0.017	0.152CysLys: 0.152 ± 0.012	0.908CysLeu: 0.908 ± 0.031	0.18CysMet: 0.18 ± 0.013	0.22CysAsn: 0.22 ± 0.014	0.712CysPro: 0.712 ± 0.067	0.304CysGln: 0.304 ± 0.018	0.93CysArg: 0.93 ± 0.071	0.521CysSer: 0.521 ± 0.02	0.453CysThr: 0.453 ± 0.023	0.674CysVal: 0.674 ± 0.025	0.123CysTrp: 0.123 ± 0.011	0.21CysTyr: 0.21 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.225AspAla: 7.225 ± 0.081	0.478AspCys: 0.478 ± 0.023	3.414AspAsp: 3.414 ± 0.069	3.625AspGlu: 3.625 ± 0.056	2.078AspPhe: 2.078 ± 0.046	5.127AspGly: 5.127 ± 0.084	1.435AspHis: 1.435 ± 0.035	2.326AspIle: 2.326 ± 0.047	0.924AspLys: 0.924 ± 0.033	6.463AspLeu: 6.463 ± 0.084	1.07AspMet: 1.07 ± 0.034	0.992AspAsn: 0.992 ± 0.028	4.419AspPro: 4.419 ± 0.069	1.741AspGln: 1.741 ± 0.048	5.394AspArg: 5.394 ± 0.071	2.354AspSer: 2.354 ± 0.056	2.759AspThr: 2.759 ± 0.058	3.776AspVal: 3.776 ± 0.055	1.149AspTrp: 1.149 ± 0.04	1.547AspTyr: 1.547 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.567GluAla: 7.567 ± 0.094	0.43GluCys: 0.43 ± 0.02	3.004GluAsp: 3.004 ± 0.055	3.235GluGlu: 3.235 ± 0.063	2.069GluPhe: 2.069 ± 0.046	4.451GluGly: 4.451 ± 0.068	1.891GluHis: 1.891 ± 0.049	3.279GluIle: 3.279 ± 0.051	1.406GluLys: 1.406 ± 0.037	6.767GluLeu: 6.767 ± 0.09	1.433GluMet: 1.433 ± 0.038	1.406GluAsn: 1.406 ± 0.038	3.664GluPro: 3.664 ± 0.064	2.931GluGln: 2.931 ± 0.057	7.063GluArg: 7.063 ± 0.101	2.881GluSer: 2.881 ± 0.055	3.375GluThr: 3.375 ± 0.045	4.553GluVal: 4.553 ± 0.071	0.894GluTrp: 0.894 ± 0.032	1.346GluTyr: 1.346 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.783PheAla: 3.783 ± 0.06	0.331PheCys: 0.331 ± 0.016	2.394PheAsp: 2.394 ± 0.041	2.339PheGlu: 2.339 ± 0.049	1.27PhePhe: 1.27 ± 0.042	3.14PheGly: 3.14 ± 0.059	0.867PheHis: 0.867 ± 0.032	1.312PheIle: 1.312 ± 0.035	0.579PheLys: 0.579 ± 0.022	3.646PheLeu: 3.646 ± 0.062	0.691PheMet: 0.691 ± 0.026	0.817PheAsn: 0.817 ± 0.029	1.711PhePro: 1.711 ± 0.037	1.045PheGln: 1.045 ± 0.037	2.674PheArg: 2.674 ± 0.041	1.786PheSer: 1.786 ± 0.042	1.755PheThr: 1.755 ± 0.034	2.715PheVal: 2.715 ± 0.05	0.54PheTrp: 0.54 ± 0.026	0.805PheTyr: 0.805 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.429GlyAla: 8.429 ± 0.101	0.989GlyCys: 0.989 ± 0.035	4.673GlyAsp: 4.673 ± 0.077	5.117GlyGlu: 5.117 ± 0.071	3.274GlyPhe: 3.274 ± 0.053	6.716GlyGly: 6.716 ± 0.105	2.361GlyHis: 2.361 ± 0.047	4.347GlyIle: 4.347 ± 0.074	2.029GlyLys: 2.029 ± 0.046	9.33GlyLeu: 9.33 ± 0.115	2.239GlyMet: 2.239 ± 0.05	2.02GlyAsn: 2.02 ± 0.062	3.891GlyPro: 3.891 ± 0.062	3.021GlyGln: 3.021 ± 0.061	7.372GlyArg: 7.372 ± 0.089	4.5GlySer: 4.5 ± 0.078	4.472GlyThr: 4.472 ± 0.064	6.199GlyVal: 6.199 ± 0.077	1.519GlyTrp: 1.519 ± 0.046	2.338GlyTyr: 2.338 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.907HisAla: 2.907 ± 0.061	0.356HisCys: 0.356 ± 0.017	1.421HisAsp: 1.421 ± 0.039	1.431HisGlu: 1.431 ± 0.039	0.933HisPhe: 0.933 ± 0.03	2.452HisGly: 2.452 ± 0.052	0.747HisHis: 0.747 ± 0.027	0.876HisIle: 0.876 ± 0.034	0.426HisLys: 0.426 ± 0.021	2.661HisLeu: 2.661 ± 0.047	0.468HisMet: 0.468 ± 0.019	0.498HisAsn: 0.498 ± 0.019	1.946HisPro: 1.946 ± 0.047	0.82HisGln: 0.82 ± 0.029	2.382HisArg: 2.382 ± 0.047	1.129HisSer: 1.129 ± 0.033	1.025HisThr: 1.025 ± 0.032	1.61HisVal: 1.61 ± 0.039	0.561HisTrp: 0.561 ± 0.024	0.745HisTyr: 0.745 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.541IleAla: 5.541 ± 0.071	0.365IleCys: 0.365 ± 0.018	3.149IleAsp: 3.149 ± 0.063	3.277IleGlu: 3.277 ± 0.055	1.163IlePhe: 1.163 ± 0.033	4.052IleGly: 4.052 ± 0.067	1.128IleHis: 1.128 ± 0.031	1.488IleIle: 1.488 ± 0.046	0.876IleLys: 0.876 ± 0.031	4.138IleLeu: 4.138 ± 0.072	0.69IleMet: 0.69 ± 0.028	1.026IleAsn: 1.026 ± 0.028	2.446IlePro: 2.446 ± 0.05	1.316IleGln: 1.316 ± 0.037	3.676IleArg: 3.676 ± 0.06	1.964IleSer: 1.964 ± 0.045	2.19IleThr: 2.19 ± 0.05	3.223IleVal: 3.223 ± 0.061	0.493IleTrp: 0.493 ± 0.021	0.922IleTyr: 0.922 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.403LysAla: 2.403 ± 0.054	0.141LysCys: 0.141 ± 0.012	1.037LysAsp: 1.037 ± 0.035	1.032LysGlu: 1.032 ± 0.035	0.506LysPhe: 0.506 ± 0.021	1.609LysGly: 1.609 ± 0.043	0.489LysHis: 0.489 ± 0.022	0.885LysIle: 0.885 ± 0.031	0.672LysLys: 0.672 ± 0.027	1.905LysLeu: 1.905 ± 0.046	0.435LysMet: 0.435 ± 0.022	0.52LysAsn: 0.52 ± 0.024	1.263LysPro: 1.263 ± 0.032	0.686LysGln: 0.686 ± 0.025	1.804LysArg: 1.804 ± 0.045	0.995LysSer: 0.995 ± 0.034	1.213LysThr: 1.213 ± 0.035	1.466LysVal: 1.466 ± 0.049	0.231LysTrp: 0.231 ± 0.013	0.478LysTyr: 0.478 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.399LeuAla: 14.399 ± 0.137	0.91LeuCys: 0.91 ± 0.03	6.922LeuAsp: 6.922 ± 0.087	7.561LeuGlu: 7.561 ± 0.099	3.806LeuPhe: 3.806 ± 0.072	9.085LeuGly: 9.085 ± 0.105	2.755LeuHis: 2.755 ± 0.056	4.506LeuIle: 4.506 ± 0.077	2.474LeuLys: 2.474 ± 0.051	12.315LeuLeu: 12.315 ± 0.154	2.156LeuMet: 2.156 ± 0.048	2.522LeuAsn: 2.522 ± 0.054	6.392LeuPro: 6.392 ± 0.074	3.798LeuGln: 3.798 ± 0.062	9.927LeuArg: 9.927 ± 0.118	5.332LeuSer: 5.332 ± 0.068	5.224LeuThr: 5.224 ± 0.079	8.059LeuVal: 8.059 ± 0.109	1.39LeuTrp: 1.39 ± 0.044	2.15LeuTyr: 2.15 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.536MetAla: 2.536 ± 0.054	0.129MetCys: 0.129 ± 0.011	1.188MetAsp: 1.188 ± 0.038	1.202MetGlu: 1.202 ± 0.034	0.654MetPhe: 0.654 ± 0.027	1.555MetGly: 1.555 ± 0.042	0.561MetHis: 0.561 ± 0.02	1.015MetIle: 1.015 ± 0.03	0.689MetLys: 0.689 ± 0.029	2.484MetLeu: 2.484 ± 0.045	0.485MetMet: 0.485 ± 0.022	0.776MetAsn: 0.776 ± 0.025	1.314MetPro: 1.314 ± 0.033	0.893MetGln: 0.893 ± 0.028	1.826MetArg: 1.826 ± 0.04	1.244MetSer: 1.244 ± 0.031	1.423MetThr: 1.423 ± 0.037	1.508MetVal: 1.508 ± 0.047	0.169MetTrp: 0.169 ± 0.015	0.361MetTyr: 0.361 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.496AsnAla: 2.496 ± 0.047	0.216AsnCys: 0.216 ± 0.015	1.17AsnAsp: 1.17 ± 0.035	1.194AsnGlu: 1.194 ± 0.036	0.709AsnPhe: 0.709 ± 0.029	1.782AsnGly: 1.782 ± 0.06	0.552AsnHis: 0.552 ± 0.023	0.93AsnIle: 0.93 ± 0.033	0.42AsnLys: 0.42 ± 0.024	2.543AsnLeu: 2.543 ± 0.05	0.458AsnMet: 0.458 ± 0.022	0.512AsnAsn: 0.512 ± 0.019	1.734AsnPro: 1.734 ± 0.042	0.708AsnGln: 0.708 ± 0.023	2.076AsnArg: 2.076 ± 0.041	0.861AsnSer: 0.861 ± 0.029	1.107AsnThr: 1.107 ± 0.035	1.618AsnVal: 1.618 ± 0.036	0.355AsnTrp: 0.355 ± 0.017	0.527AsnTyr: 0.527 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.831ProAla: 6.831 ± 0.101	0.536ProCys: 0.536 ± 0.066	4.311ProAsp: 4.311 ± 0.074	5.229ProGlu: 5.229 ± 0.074	1.775ProPhe: 1.775 ± 0.04	5.872ProGly: 5.872 ± 0.08	1.155ProHis: 1.155 ± 0.032	1.943ProIle: 1.943 ± 0.044	0.976ProLys: 0.976 ± 0.029	5.422ProLeu: 5.422 ± 0.074	1.223ProMet: 1.223 ± 0.038	1.14ProAsn: 1.14 ± 0.035	3.252ProPro: 3.252 ± 0.063	1.68ProGln: 1.68 ± 0.037	4.118ProArg: 4.118 ± 0.067	2.445ProSer: 2.445 ± 0.043	2.205ProThr: 2.205 ± 0.047	4.763ProVal: 4.763 ± 0.073	0.906ProTrp: 0.906 ± 0.028	1.17ProTyr: 1.17 ± 0.054	0.0ProXaa: 0.0 ± 0.0
Gln	4.573GlnAla: 4.573 ± 0.063	0.286GlnCys: 0.286 ± 0.017	1.661GlnAsp: 1.661 ± 0.04	1.936GlnGlu: 1.936 ± 0.041	0.963GlnPhe: 0.963 ± 0.03	2.81GlnGly: 2.81 ± 0.049	0.935GlnHis: 0.935 ± 0.034	1.509GlnIle: 1.509 ± 0.036	0.718GlnLys: 0.718 ± 0.025	3.434GlnLeu: 3.434 ± 0.058	0.757GlnMet: 0.757 ± 0.027	0.662GlnAsn: 0.662 ± 0.024	2.098GlnPro: 2.098 ± 0.038	1.569GlnGln: 1.569 ± 0.043	3.704GlnArg: 3.704 ± 0.063	1.495GlnSer: 1.495 ± 0.039	1.602GlnThr: 1.602 ± 0.037	2.748GlnVal: 2.748 ± 0.05	0.556GlnTrp: 0.556 ± 0.023	0.677GlnTyr: 0.677 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.2ArgAla: 9.2 ± 0.105	0.889ArgCys: 0.889 ± 0.07	5.092ArgAsp: 5.092 ± 0.08	6.312ArgGlu: 6.312 ± 0.088	3.472ArgPhe: 3.472 ± 0.054	6.148ArgGly: 6.148 ± 0.085	2.546ArgHis: 2.546 ± 0.05	4.673ArgIle: 4.673 ± 0.074	1.891ArgLys: 1.891 ± 0.046	10.648ArgLeu: 10.648 ± 0.127	2.288ArgMet: 2.288 ± 0.044	2.139ArgAsn: 2.139 ± 0.046	4.754ArgPro: 4.754 ± 0.069	3.279ArgGln: 3.279 ± 0.063	8.135ArgArg: 8.135 ± 0.116	4.269ArgSer: 4.269 ± 0.064	3.62ArgThr: 3.62 ± 0.063	6.75ArgVal: 6.75 ± 0.089	1.443ArgTrp: 1.443 ± 0.033	2.407ArgTyr: 2.407 ± 0.079	0.0ArgXaa: 0.0 ± 0.0
Ser	5.271SerAla: 5.271 ± 0.073	0.46SerCys: 0.46 ± 0.023	2.654SerAsp: 2.654 ± 0.052	2.795SerGlu: 2.795 ± 0.056	1.67SerPhe: 1.67 ± 0.041	5.181SerGly: 5.181 ± 0.078	1.096SerHis: 1.096 ± 0.033	1.913SerIle: 1.913 ± 0.045	0.848SerLys: 0.848 ± 0.028	5.122SerLeu: 5.122 ± 0.072	1.17SerMet: 1.17 ± 0.035	0.961SerAsn: 0.961 ± 0.029	2.668SerPro: 2.668 ± 0.051	1.387SerGln: 1.387 ± 0.034	4.094SerArg: 4.094 ± 0.063	2.359SerSer: 2.359 ± 0.051	2.18SerThr: 2.18 ± 0.05	3.626SerVal: 3.626 ± 0.089	0.656SerTrp: 0.656 ± 0.023	0.964SerTyr: 0.964 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.262ThrAla: 5.262 ± 0.081	0.453ThrCys: 0.453 ± 0.025	2.722ThrAsp: 2.722 ± 0.056	2.724ThrGlu: 2.724 ± 0.053	1.466ThrPhe: 1.466 ± 0.037	5.031ThrGly: 5.031 ± 0.073	1.115ThrHis: 1.115 ± 0.035	1.857ThrIle: 1.857 ± 0.049	0.709ThrLys: 0.709 ± 0.026	6.098ThrLeu: 6.098 ± 0.073	0.939ThrMet: 0.939 ± 0.031	0.891ThrAsn: 0.891 ± 0.033	3.106ThrPro: 3.106 ± 0.059	1.376ThrGln: 1.376 ± 0.035	4.213ThrArg: 4.213 ± 0.062	1.954ThrSer: 1.954 ± 0.046	2.248ThrThr: 2.248 ± 0.053	4.008ThrVal: 4.008 ± 0.073	0.635ThrTrp: 0.635 ± 0.024	0.956ThrTyr: 0.956 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.721ValAla: 8.721 ± 0.103	0.677ValCys: 0.677 ± 0.022	4.555ValAsp: 4.555 ± 0.069	4.578ValGlu: 4.578 ± 0.063	2.776ValPhe: 2.776 ± 0.06	5.431ValGly: 5.431 ± 0.078	1.898ValHis: 1.898 ± 0.04	3.556ValIle: 3.556 ± 0.06	1.349ValLys: 1.349 ± 0.037	8.705ValLeu: 8.705 ± 0.096	1.617ValMet: 1.617 ± 0.037	1.756ValAsn: 1.756 ± 0.044	4.039ValPro: 4.039 ± 0.064	2.546ValGln: 2.546 ± 0.047	6.066ValArg: 6.066 ± 0.08	3.812ValSer: 3.812 ± 0.088	3.995ValThr: 3.995 ± 0.063	5.9ValVal: 5.9 ± 0.097	0.971ValTrp: 0.971 ± 0.037	1.551ValTyr: 1.551 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.295TrpAla: 1.295 ± 0.036	0.158TrpCys: 0.158 ± 0.01	0.74TrpAsp: 0.74 ± 0.026	0.754TrpGlu: 0.754 ± 0.027	0.606TrpPhe: 0.606 ± 0.025	0.902TrpGly: 0.902 ± 0.031	0.431TrpHis: 0.431 ± 0.021	0.762TrpIle: 0.762 ± 0.027	0.316TrpLys: 0.316 ± 0.016	2.281TrpLeu: 2.281 ± 0.053	0.375TrpMet: 0.375 ± 0.017	0.433TrpAsn: 0.433 ± 0.02	0.81TrpPro: 0.81 ± 0.029	0.742TrpGln: 0.742 ± 0.03	1.375TrpArg: 1.375 ± 0.041	0.742TrpSer: 0.742 ± 0.025	0.677TrpThr: 0.677 ± 0.023	1.142TrpVal: 1.142 ± 0.035	0.314TrpTrp: 0.314 ± 0.017	0.357TrpTyr: 0.357 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.288TyrAla: 2.288 ± 0.046	0.236TyrCys: 0.236 ± 0.014	1.195TyrAsp: 1.195 ± 0.042	1.185TyrGlu: 1.185 ± 0.038	0.892TyrPhe: 0.892 ± 0.03	1.93TyrGly: 1.93 ± 0.046	0.584TyrHis: 0.584 ± 0.023	0.717TyrIle: 0.717 ± 0.026	0.383TyrLys: 0.383 ± 0.02	2.752TyrLeu: 2.752 ± 0.054	0.384TyrMet: 0.384 ± 0.019	0.511TyrAsn: 0.511 ± 0.023	1.292TyrPro: 1.292 ± 0.06	0.846TyrGln: 0.846 ± 0.029	2.611TyrArg: 2.611 ± 0.078	1.078TyrSer: 1.078 ± 0.031	1.06TyrThr: 1.06 ± 0.029	1.455TyrVal: 1.455 ± 0.038	0.409TyrTrp: 0.409 ± 0.018	0.623TyrTyr: 0.623 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3764 proteins (1108119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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