Amino acid dipepetide frequency for Thioflavicoccus mobilis 8321

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.33AlaAla: 16.33 ± 0.198
1.254AlaCys: 1.254 ± 0.038
6.906AlaAsp: 6.906 ± 0.083
8.584AlaGlu: 8.584 ± 0.117
3.78AlaPhe: 3.78 ± 0.053
9.953AlaGly: 9.953 ± 0.115
2.37AlaHis: 2.37 ± 0.048
5.804AlaIle: 5.804 ± 0.073
2.991AlaLys: 2.991 ± 0.058
13.972AlaLeu: 13.972 ± 0.152
2.77AlaMet: 2.77 ± 0.049
2.611AlaAsn: 2.611 ± 0.061
5.552AlaPro: 5.552 ± 0.088
4.024AlaGln: 4.024 ± 0.065
9.72AlaArg: 9.72 ± 0.127
5.47AlaSer: 5.47 ± 0.077
5.819AlaThr: 5.819 ± 0.074
8.486AlaVal: 8.486 ± 0.107
1.691AlaTrp: 1.691 ± 0.042
2.402AlaTyr: 2.402 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.068CysAla: 1.068 ± 0.033
0.154CysCys: 0.154 ± 0.012
0.613CysAsp: 0.613 ± 0.025
0.591CysGlu: 0.591 ± 0.027
0.327CysPhe: 0.327 ± 0.017
1.054CysGly: 1.054 ± 0.029
0.371CysHis: 0.371 ± 0.024
0.411CysIle: 0.411 ± 0.019
0.202CysLys: 0.202 ± 0.013
1.041CysLeu: 1.041 ± 0.032
0.163CysMet: 0.163 ± 0.012
0.257CysAsn: 0.257 ± 0.016
0.665CysPro: 0.665 ± 0.03
0.313CysGln: 0.313 ± 0.018
0.946CysArg: 0.946 ± 0.032
0.498CysSer: 0.498 ± 0.025
0.502CysThr: 0.502 ± 0.023
0.657CysVal: 0.657 ± 0.027
0.131CysTrp: 0.131 ± 0.011
0.255CysTyr: 0.255 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.539AspAla: 6.539 ± 0.086
0.648AspCys: 0.648 ± 0.024
3.397AspAsp: 3.397 ± 0.069
4.247AspGlu: 4.247 ± 0.063
2.113AspPhe: 2.113 ± 0.05
5.429AspGly: 5.429 ± 0.096
1.258AspHis: 1.258 ± 0.033
2.481AspIle: 2.481 ± 0.052
1.414AspLys: 1.414 ± 0.043
7.15AspLeu: 7.15 ± 0.091
1.093AspMet: 1.093 ± 0.032
1.283AspAsn: 1.283 ± 0.037
3.885AspPro: 3.885 ± 0.064
2.027AspGln: 2.027 ± 0.047
4.53AspArg: 4.53 ± 0.072
2.34AspSer: 2.34 ± 0.049
2.492AspThr: 2.492 ± 0.06
3.546AspVal: 3.546 ± 0.062
1.228AspTrp: 1.228 ± 0.034
1.81AspTyr: 1.81 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
7.946GluAla: 7.946 ± 0.125
0.446GluCys: 0.446 ± 0.022
3.121GluAsp: 3.121 ± 0.055
3.671GluGlu: 3.671 ± 0.067
1.478GluPhe: 1.478 ± 0.038
4.31GluGly: 4.31 ± 0.057
1.525GluHis: 1.525 ± 0.046
3.387GluIle: 3.387 ± 0.058
1.64GluLys: 1.64 ± 0.042
6.93GluLeu: 6.93 ± 0.088
1.35GluMet: 1.35 ± 0.037
1.24GluAsn: 1.24 ± 0.034
3.398GluPro: 3.398 ± 0.065
2.829GluGln: 2.829 ± 0.051
7.137GluArg: 7.137 ± 0.114
2.733GluSer: 2.733 ± 0.057
3.485GluThr: 3.485 ± 0.058
4.697GluVal: 4.697 ± 0.08
0.696GluTrp: 0.696 ± 0.026
1.14GluTyr: 1.14 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.993PheAla: 3.993 ± 0.061
0.392PheCys: 0.392 ± 0.02
2.37PheAsp: 2.37 ± 0.05
2.116PheGlu: 2.116 ± 0.043
1.367PhePhe: 1.367 ± 0.042
2.981PheGly: 2.981 ± 0.052
0.733PheHis: 0.733 ± 0.023
1.443PheIle: 1.443 ± 0.037
0.765PheLys: 0.765 ± 0.031
3.372PheLeu: 3.372 ± 0.066
0.592PheMet: 0.592 ± 0.024
0.869PheAsn: 0.869 ± 0.029
1.52PhePro: 1.52 ± 0.037
1.012PheGln: 1.012 ± 0.031
2.21PheArg: 2.21 ± 0.047
1.922PheSer: 1.922 ± 0.041
1.71PheThr: 1.71 ± 0.038
2.574PheVal: 2.574 ± 0.048
0.484PheTrp: 0.484 ± 0.025
0.929PheTyr: 0.929 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
8.426GlyAla: 8.426 ± 0.112
1.061GlyCys: 1.061 ± 0.034
4.803GlyAsp: 4.803 ± 0.071
5.444GlyGlu: 5.444 ± 0.084
3.006GlyPhe: 3.006 ± 0.058
6.86GlyGly: 6.86 ± 0.099
2.031GlyHis: 2.031 ± 0.047
4.232GlyIle: 4.232 ± 0.074
2.258GlyLys: 2.258 ± 0.054
9.772GlyLeu: 9.772 ± 0.114
1.864GlyMet: 1.864 ± 0.045
1.862GlyAsn: 1.862 ± 0.049
3.615GlyPro: 3.615 ± 0.061
2.905GlyGln: 2.905 ± 0.045
7.018GlyArg: 7.018 ± 0.088
4.066GlySer: 4.066 ± 0.071
4.15GlyThr: 4.15 ± 0.071
6.048GlyVal: 6.048 ± 0.072
1.4GlyTrp: 1.4 ± 0.036
2.46GlyTyr: 2.46 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.263HisAla: 2.263 ± 0.046
0.319HisCys: 0.319 ± 0.017
1.23HisAsp: 1.23 ± 0.035
1.234HisGlu: 1.234 ± 0.036
0.829HisPhe: 0.829 ± 0.026
2.044HisGly: 2.044 ± 0.043
0.681HisHis: 0.681 ± 0.025
0.853HisIle: 0.853 ± 0.029
0.462HisLys: 0.462 ± 0.019
2.671HisLeu: 2.671 ± 0.048
0.401HisMet: 0.401 ± 0.02
0.491HisAsn: 0.491 ± 0.024
1.578HisPro: 1.578 ± 0.037
0.843HisGln: 0.843 ± 0.031
2.067HisArg: 2.067 ± 0.049
0.986HisSer: 0.986 ± 0.03
0.913HisThr: 0.913 ± 0.032
1.405HisVal: 1.405 ± 0.035
0.448HisTrp: 0.448 ± 0.017
0.666HisTyr: 0.666 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.581IleAla: 6.581 ± 0.097
0.458IleCys: 0.458 ± 0.019
3.586IleAsp: 3.586 ± 0.058
3.745IleGlu: 3.745 ± 0.064
1.33IlePhe: 1.33 ± 0.039
4.474IleGly: 4.474 ± 0.063
1.098IleHis: 1.098 ± 0.032
1.693IleIle: 1.693 ± 0.044
1.232IleLys: 1.232 ± 0.038
4.533IleLeu: 4.533 ± 0.068
0.708IleMet: 0.708 ± 0.029
1.206IleAsn: 1.206 ± 0.035
2.414IlePro: 2.414 ± 0.043
1.459IleGln: 1.459 ± 0.037
3.36IleArg: 3.36 ± 0.052
2.1IleSer: 2.1 ± 0.046
2.183IleThr: 2.183 ± 0.046
3.355IleVal: 3.355 ± 0.057
0.539IleTrp: 0.539 ± 0.023
1.086IleTyr: 1.086 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
2.979LysAla: 2.979 ± 0.065
0.176LysCys: 0.176 ± 0.014
1.417LysAsp: 1.417 ± 0.039
1.5LysGlu: 1.5 ± 0.042
0.529LysPhe: 0.529 ± 0.022
2.087LysGly: 2.087 ± 0.047
0.491LysHis: 0.491 ± 0.021
1.17LysIle: 1.17 ± 0.033
0.902LysLys: 0.902 ± 0.041
2.389LysLeu: 2.389 ± 0.052
0.492LysMet: 0.492 ± 0.02
0.586LysAsn: 0.586 ± 0.025
1.405LysPro: 1.405 ± 0.041
0.901LysGln: 0.901 ± 0.027
2.147LysArg: 2.147 ± 0.048
1.242LysSer: 1.242 ± 0.029
1.517LysThr: 1.517 ± 0.041
1.909LysVal: 1.909 ± 0.048
0.262LysTrp: 0.262 ± 0.016
0.568LysTyr: 0.568 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.082LeuAla: 16.082 ± 0.167
1.077LeuCys: 1.077 ± 0.031
6.965LeuAsp: 6.965 ± 0.09
6.675LeuGlu: 6.675 ± 0.084
3.918LeuPhe: 3.918 ± 0.059
9.285LeuGly: 9.285 ± 0.109
2.369LeuHis: 2.369 ± 0.048
5.544LeuIle: 5.544 ± 0.085
2.779LeuLys: 2.779 ± 0.051
12.035LeuLeu: 12.035 ± 0.141
2.247LeuMet: 2.247 ± 0.055
2.304LeuAsn: 2.304 ± 0.051
6.126LeuPro: 6.126 ± 0.085
3.188LeuGln: 3.188 ± 0.059
8.914LeuArg: 8.914 ± 0.098
5.764LeuSer: 5.764 ± 0.085
5.755LeuThr: 5.755 ± 0.083
8.719LeuVal: 8.719 ± 0.107
1.442LeuTrp: 1.442 ± 0.047
2.395LeuTyr: 2.395 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.501MetAla: 2.501 ± 0.051
0.131MetCys: 0.131 ± 0.01
1.069MetAsp: 1.069 ± 0.033
1.023MetGlu: 1.023 ± 0.029
0.486MetPhe: 0.486 ± 0.021
1.477MetGly: 1.477 ± 0.038
0.392MetHis: 0.392 ± 0.02
0.987MetIle: 0.987 ± 0.031
0.758MetLys: 0.758 ± 0.028
2.13MetLeu: 2.13 ± 0.049
0.453MetMet: 0.453 ± 0.023
0.603MetAsn: 0.603 ± 0.024
1.249MetPro: 1.249 ± 0.034
0.752MetGln: 0.752 ± 0.028
1.615MetArg: 1.615 ± 0.034
1.341MetSer: 1.341 ± 0.035
1.375MetThr: 1.375 ± 0.037
1.36MetVal: 1.36 ± 0.036
0.135MetTrp: 0.135 ± 0.01
0.309MetTyr: 0.309 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.493AsnAla: 2.493 ± 0.052
0.259AsnCys: 0.259 ± 0.016
1.291AsnAsp: 1.291 ± 0.036
1.233AsnGlu: 1.233 ± 0.031
0.722AsnPhe: 0.722 ± 0.029
1.937AsnGly: 1.937 ± 0.045
0.493AsnHis: 0.493 ± 0.02
1.053AsnIle: 1.053 ± 0.037
0.572AsnLys: 0.572 ± 0.025
2.662AsnLeu: 2.662 ± 0.057
0.474AsnMet: 0.474 ± 0.021
0.541AsnAsn: 0.541 ± 0.024
1.657AsnPro: 1.657 ± 0.039
0.757AsnGln: 0.757 ± 0.027
1.876AsnArg: 1.876 ± 0.043
0.944AsnSer: 0.944 ± 0.031
0.988AsnThr: 0.988 ± 0.037
1.457AsnVal: 1.457 ± 0.038
0.377AsnTrp: 0.377 ± 0.022
0.584AsnTyr: 0.584 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.396ProAla: 6.396 ± 0.101
0.453ProCys: 0.453 ± 0.023
3.658ProAsp: 3.658 ± 0.057
4.058ProGlu: 4.058 ± 0.064
1.86ProPhe: 1.86 ± 0.043
4.894ProGly: 4.894 ± 0.076
1.076ProHis: 1.076 ± 0.035
2.415ProIle: 2.415 ± 0.046
1.31ProLys: 1.31 ± 0.039
5.66ProLeu: 5.66 ± 0.077
1.037ProMet: 1.037 ± 0.03
1.248ProAsn: 1.248 ± 0.036
3.255ProPro: 3.255 ± 0.076
1.849ProGln: 1.849 ± 0.042
3.632ProArg: 3.632 ± 0.058
2.942ProSer: 2.942 ± 0.051
2.669ProThr: 2.669 ± 0.05
4.14ProVal: 4.14 ± 0.067
0.84ProTrp: 0.84 ± 0.029
1.278ProTyr: 1.278 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.669GlnAla: 4.669 ± 0.075
0.303GlnCys: 0.303 ± 0.017
1.673GlnAsp: 1.673 ± 0.037
1.766GlnGlu: 1.766 ± 0.043
1.014GlnPhe: 1.014 ± 0.035
2.799GlnGly: 2.799 ± 0.054
0.719GlnHis: 0.719 ± 0.026
1.87GlnIle: 1.87 ± 0.041
0.713GlnLys: 0.713 ± 0.027
3.538GlnLeu: 3.538 ± 0.059
0.752GlnMet: 0.752 ± 0.024
0.647GlnAsn: 0.647 ± 0.023
1.838GlnPro: 1.838 ± 0.042
1.422GlnGln: 1.422 ± 0.043
3.335GlnArg: 3.335 ± 0.064
1.515GlnSer: 1.515 ± 0.037
1.652GlnThr: 1.652 ± 0.048
2.934GlnVal: 2.934 ± 0.051
0.465GlnTrp: 0.465 ± 0.023
0.676GlnTyr: 0.676 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.595ArgAla: 8.595 ± 0.118
0.873ArgCys: 0.873 ± 0.034
4.63ArgAsp: 4.63 ± 0.06
5.127ArgGlu: 5.127 ± 0.082
3.358ArgPhe: 3.358 ± 0.061
5.499ArgGly: 5.499 ± 0.082
2.267ArgHis: 2.267 ± 0.042
4.342ArgIle: 4.342 ± 0.053
1.792ArgLys: 1.792 ± 0.046
10.976ArgLeu: 10.976 ± 0.127
1.688ArgMet: 1.688 ± 0.033
1.75ArgAsn: 1.75 ± 0.041
4.438ArgPro: 4.438 ± 0.07
3.248ArgGln: 3.248 ± 0.062
8.023ArgArg: 8.023 ± 0.106
3.615ArgSer: 3.615 ± 0.062
3.665ArgThr: 3.665 ± 0.062
5.772ArgVal: 5.772 ± 0.069
1.386ArgTrp: 1.386 ± 0.043
2.34ArgTyr: 2.34 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.371SerAla: 5.371 ± 0.067
0.493SerCys: 0.493 ± 0.025
2.814SerAsp: 2.814 ± 0.056
2.666SerGlu: 2.666 ± 0.052
1.757SerPhe: 1.757 ± 0.037
4.91SerGly: 4.91 ± 0.08
1.045SerHis: 1.045 ± 0.034
2.209SerIle: 2.209 ± 0.042
1.142SerLys: 1.142 ± 0.033
5.467SerLeu: 5.467 ± 0.084
0.986SerMet: 0.986 ± 0.028
1.153SerAsn: 1.153 ± 0.031
2.964SerPro: 2.964 ± 0.055
1.561SerGln: 1.561 ± 0.041
3.62SerArg: 3.62 ± 0.063
2.506SerSer: 2.506 ± 0.06
2.288SerThr: 2.288 ± 0.051
3.257SerVal: 3.257 ± 0.048
0.686SerTrp: 0.686 ± 0.027
1.146SerTyr: 1.146 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.66ThrAla: 5.66 ± 0.072
0.499ThrCys: 0.499 ± 0.023
2.755ThrAsp: 2.755 ± 0.051
2.826ThrGlu: 2.826 ± 0.053
1.637ThrPhe: 1.637 ± 0.045
4.58ThrGly: 4.58 ± 0.074
1.076ThrHis: 1.076 ± 0.031
2.332ThrIle: 2.332 ± 0.05
1.146ThrLys: 1.146 ± 0.031
6.215ThrLeu: 6.215 ± 0.089
0.932ThrMet: 0.932 ± 0.028
1.11ThrAsn: 1.11 ± 0.035
3.216ThrPro: 3.216 ± 0.056
1.45ThrGln: 1.45 ± 0.035
3.659ThrArg: 3.659 ± 0.059
2.411ThrSer: 2.411 ± 0.046
2.624ThrThr: 2.624 ± 0.054
3.593ThrVal: 3.593 ± 0.058
0.636ThrTrp: 0.636 ± 0.028
1.121ThrTyr: 1.121 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
9.051ValAla: 9.051 ± 0.103
0.736ValCys: 0.736 ± 0.026
4.41ValAsp: 4.41 ± 0.07
4.581ValGlu: 4.581 ± 0.069
2.486ValPhe: 2.486 ± 0.052
5.68ValGly: 5.68 ± 0.087
1.489ValHis: 1.489 ± 0.038
3.427ValIle: 3.427 ± 0.064
1.724ValLys: 1.724 ± 0.043
7.898ValLeu: 7.898 ± 0.095
1.441ValMet: 1.441 ± 0.033
1.736ValAsn: 1.736 ± 0.043
3.797ValPro: 3.797 ± 0.063
2.172ValGln: 2.172 ± 0.042
5.586ValArg: 5.586 ± 0.074
3.674ValSer: 3.674 ± 0.058
4.033ValThr: 4.033 ± 0.077
5.789ValVal: 5.789 ± 0.091
0.873ValTrp: 0.873 ± 0.03
1.634ValTyr: 1.634 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.221TrpAla: 1.221 ± 0.036
0.179TrpCys: 0.179 ± 0.011
0.766TrpAsp: 0.766 ± 0.031
0.716TrpGlu: 0.716 ± 0.025
0.434TrpPhe: 0.434 ± 0.021
1.008TrpGly: 1.008 ± 0.033
0.393TrpHis: 0.393 ± 0.021
0.624TrpIle: 0.624 ± 0.025
0.324TrpLys: 0.324 ± 0.018
2.156TrpLeu: 2.156 ± 0.056
0.312TrpMet: 0.312 ± 0.019
0.323TrpAsn: 0.323 ± 0.019
0.82TrpPro: 0.82 ± 0.028
0.661TrpGln: 0.661 ± 0.026
1.44TrpArg: 1.44 ± 0.037
0.809TrpSer: 0.809 ± 0.028
0.642TrpThr: 0.642 ± 0.024
0.969TrpVal: 0.969 ± 0.034
0.226TrpTrp: 0.226 ± 0.016
0.325TrpTyr: 0.325 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.324TyrAla: 2.324 ± 0.041
0.309TyrCys: 0.309 ± 0.018
1.438TyrAsp: 1.438 ± 0.043
1.356TyrGlu: 1.356 ± 0.033
0.925TyrPhe: 0.925 ± 0.034
2.019TyrGly: 2.019 ± 0.049
0.509TyrHis: 0.509 ± 0.02
0.863TyrIle: 0.863 ± 0.028
0.543TyrLys: 0.543 ± 0.021
3.015TyrLeu: 3.015 ± 0.066
0.39TyrMet: 0.39 ± 0.019
0.548TyrAsn: 0.548 ± 0.022
1.28TyrPro: 1.28 ± 0.035
0.925TyrGln: 0.925 ± 0.032
2.55TyrArg: 2.55 ± 0.047
1.163TyrSer: 1.163 ± 0.03
1.016TyrThr: 1.016 ± 0.033
1.55TyrVal: 1.55 ± 0.048
0.401TyrTrp: 0.401 ± 0.022
0.737TyrTyr: 0.737 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3528 proteins (1133450 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski