Amino acid dipepetide frequency for Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.489AlaAla: 6.489 ± 0.046	1.004AlaCys: 1.004 ± 0.016	3.167AlaAsp: 3.167 ± 0.019	4.201AlaGlu: 4.201 ± 0.028	2.125AlaPhe: 2.125 ± 0.015	3.96AlaGly: 3.96 ± 0.022	1.401AlaHis: 1.401 ± 0.012	3.489AlaIle: 3.489 ± 0.017	3.814AlaLys: 3.814 ± 0.024	5.663AlaLeu: 5.663 ± 0.03	1.569AlaMet: 1.569 ± 0.012	3.081AlaAsn: 3.081 ± 0.02	3.521AlaPro: 3.521 ± 0.028	2.723AlaGln: 2.723 ± 0.02	2.952AlaArg: 2.952 ± 0.018	5.732AlaSer: 5.732 ± 0.026	4.262AlaThr: 4.262 ± 0.022	4.251AlaVal: 4.251 ± 0.022	0.519AlaTrp: 0.519 ± 0.006	1.566AlaTyr: 1.566 ± 0.013	0.001AlaXaa: 0.001 ± 0.0
Cys	1.021CysAla: 1.021 ± 0.012	0.453CysCys: 0.453 ± 0.008	1.166CysAsp: 1.166 ± 0.016	1.139CysGlu: 1.139 ± 0.015	0.685CysPhe: 0.685 ± 0.008	1.258CysGly: 1.258 ± 0.018	0.442CysHis: 0.442 ± 0.006	0.932CysIle: 0.932 ± 0.015	0.967CysLys: 0.967 ± 0.01	1.53CysLeu: 1.53 ± 0.014	0.368CysMet: 0.368 ± 0.005	0.881CysAsn: 0.881 ± 0.012	0.96CysPro: 0.96 ± 0.019	0.707CysGln: 0.707 ± 0.012	1.019CysArg: 1.019 ± 0.019	1.576CysSer: 1.576 ± 0.019	0.988CysThr: 0.988 ± 0.016	1.12CysVal: 1.12 ± 0.016	0.19CysTrp: 0.19 ± 0.004	0.545CysTyr: 0.545 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.168AspAla: 3.168 ± 0.021	0.983AspCys: 0.983 ± 0.015	4.33AspAsp: 4.33 ± 0.035	4.522AspGlu: 4.522 ± 0.032	2.131AspPhe: 2.131 ± 0.013	3.43AspGly: 3.43 ± 0.021	1.305AspHis: 1.305 ± 0.012	3.076AspIle: 3.076 ± 0.017	3.027AspLys: 3.027 ± 0.023	4.755AspLeu: 4.755 ± 0.023	1.239AspMet: 1.239 ± 0.01	2.518AspAsn: 2.518 ± 0.017	2.689AspPro: 2.689 ± 0.025	2.028AspGln: 2.028 ± 0.015	2.957AspArg: 2.957 ± 0.025	4.649AspSer: 4.649 ± 0.029	2.645AspThr: 2.645 ± 0.016	3.375AspVal: 3.375 ± 0.021	0.569AspTrp: 0.569 ± 0.007	1.789AspTyr: 1.789 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	4.159GluAla: 4.159 ± 0.031	1.162GluCys: 1.162 ± 0.022	4.148GluAsp: 4.148 ± 0.025	6.083GluGlu: 6.083 ± 0.049	2.157GluPhe: 2.157 ± 0.014	3.031GluGly: 3.031 ± 0.019	1.597GluHis: 1.597 ± 0.014	3.615GluIle: 3.615 ± 0.023	4.69GluLys: 4.69 ± 0.037	5.72GluLeu: 5.72 ± 0.035	1.652GluMet: 1.652 ± 0.013	3.353GluAsn: 3.353 ± 0.02	2.853GluPro: 2.853 ± 0.022	3.09GluGln: 3.09 ± 0.027	3.859GluArg: 3.859 ± 0.025	4.777GluSer: 4.777 ± 0.026	3.576GluThr: 3.576 ± 0.025	3.748GluVal: 3.748 ± 0.021	0.593GluTrp: 0.593 ± 0.009	1.854GluTyr: 1.854 ± 0.013	0.001GluXaa: 0.001 ± 0.0
Phe	2.118PheAla: 2.118 ± 0.014	0.714PheCys: 0.714 ± 0.008	2.127PheAsp: 2.127 ± 0.014	2.167PheGlu: 2.167 ± 0.014	1.422PhePhe: 1.422 ± 0.017	2.304PheGly: 2.304 ± 0.02	0.935PheHis: 0.935 ± 0.009	1.957PheIle: 1.957 ± 0.016	1.968PheLys: 1.968 ± 0.014	3.218PheLeu: 3.218 ± 0.022	0.838PheMet: 0.838 ± 0.008	1.805PheAsn: 1.805 ± 0.012	1.575PhePro: 1.575 ± 0.012	1.456PheGln: 1.456 ± 0.009	1.962PheArg: 1.962 ± 0.016	2.787PheSer: 2.787 ± 0.017	2.006PheThr: 2.006 ± 0.016	2.33PheVal: 2.33 ± 0.015	0.413PheTrp: 0.413 ± 0.006	1.217PheTyr: 1.217 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	3.797GlyAla: 3.797 ± 0.025	0.943GlyCys: 0.943 ± 0.011	3.091GlyAsp: 3.091 ± 0.021	3.3GlyGlu: 3.3 ± 0.021	2.213GlyPhe: 2.213 ± 0.018	5.887GlyGly: 5.887 ± 0.054	1.509GlyHis: 1.509 ± 0.015	2.894GlyIle: 2.894 ± 0.018	3.277GlyLys: 3.277 ± 0.019	4.434GlyLeu: 4.434 ± 0.028	1.377GlyMet: 1.377 ± 0.012	2.886GlyAsn: 2.886 ± 0.02	2.766GlyPro: 2.766 ± 0.029	2.264GlyGln: 2.264 ± 0.02	2.909GlyArg: 2.909 ± 0.02	5.973GlySer: 5.973 ± 0.035	3.504GlyThr: 3.504 ± 0.022	3.347GlyVal: 3.347 ± 0.019	0.61GlyTrp: 0.61 ± 0.008	1.892GlyTyr: 1.892 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.303HisAla: 1.303 ± 0.009	0.531HisCys: 0.531 ± 0.008	1.174HisAsp: 1.174 ± 0.01	1.388HisGlu: 1.388 ± 0.013	0.967HisPhe: 0.967 ± 0.009	1.411HisGly: 1.411 ± 0.012	1.729HisHis: 1.729 ± 0.025	1.32HisIle: 1.32 ± 0.011	1.299HisLys: 1.299 ± 0.012	2.425HisLeu: 2.425 ± 0.019	0.669HisMet: 0.669 ± 0.008	1.179HisAsn: 1.179 ± 0.011	1.585HisPro: 1.585 ± 0.013	1.678HisGln: 1.678 ± 0.017	1.485HisArg: 1.485 ± 0.01	2.208HisSer: 2.208 ± 0.017	1.381HisThr: 1.381 ± 0.016	1.438HisVal: 1.438 ± 0.011	0.257HisTrp: 0.257 ± 0.004	0.867HisTyr: 0.867 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.512IleAla: 3.512 ± 0.018	1.158IleCys: 1.158 ± 0.014	3.147IleAsp: 3.147 ± 0.022	3.45IleGlu: 3.45 ± 0.023	1.971IlePhe: 1.971 ± 0.015	2.879IleGly: 2.879 ± 0.02	1.299IleHis: 1.299 ± 0.011	2.898IleIle: 2.898 ± 0.018	3.118IleLys: 3.118 ± 0.016	4.509IleLeu: 4.509 ± 0.023	1.127IleMet: 1.127 ± 0.011	2.626IleAsn: 2.626 ± 0.015	2.985IlePro: 2.985 ± 0.017	2.335IleGln: 2.335 ± 0.017	2.82IleArg: 2.82 ± 0.017	4.332IleSer: 4.332 ± 0.018	3.139IleThr: 3.139 ± 0.02	3.469IleVal: 3.469 ± 0.018	0.488IleTrp: 0.488 ± 0.007	1.587IleTyr: 1.587 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	3.566LysAla: 3.566 ± 0.019	1.156LysCys: 1.156 ± 0.015	3.257LysAsp: 3.257 ± 0.02	4.222LysGlu: 4.222 ± 0.029	2.065LysPhe: 2.065 ± 0.015	2.552LysGly: 2.552 ± 0.017	1.602LysHis: 1.602 ± 0.015	3.315LysIle: 3.315 ± 0.018	4.786LysLys: 4.786 ± 0.036	5.493LysLeu: 5.493 ± 0.031	1.46LysMet: 1.46 ± 0.012	2.81LysAsn: 2.81 ± 0.017	3.276LysPro: 3.276 ± 0.029	2.842LysGln: 2.842 ± 0.019	3.645LysArg: 3.645 ± 0.026	4.662LysSer: 4.662 ± 0.027	3.402LysThr: 3.402 ± 0.02	3.382LysVal: 3.382 ± 0.02	0.581LysTrp: 0.581 ± 0.007	1.877LysTyr: 1.877 ± 0.013	0.001LysXaa: 0.001 ± 0.0
Leu	5.662LeuAla: 5.662 ± 0.025	1.524LeuCys: 1.524 ± 0.012	4.8LeuAsp: 4.8 ± 0.033	5.977LeuGlu: 5.977 ± 0.042	2.962LeuPhe: 2.962 ± 0.02	4.371LeuGly: 4.371 ± 0.023	2.299LeuHis: 2.299 ± 0.018	4.327LeuIle: 4.327 ± 0.024	5.682LeuLys: 5.682 ± 0.034	8.105LeuLeu: 8.105 ± 0.044	1.966LeuMet: 1.966 ± 0.014	4.386LeuAsn: 4.386 ± 0.022	4.529LeuPro: 4.529 ± 0.022	4.551LeuGln: 4.551 ± 0.031	4.904LeuArg: 4.904 ± 0.024	6.774LeuSer: 6.774 ± 0.032	4.772LeuThr: 4.772 ± 0.021	5.009LeuVal: 5.009 ± 0.026	0.79LeuTrp: 0.79 ± 0.009	2.377LeuTyr: 2.377 ± 0.017	0.001LeuXaa: 0.001 ± 0.0
Met	1.712MetAla: 1.712 ± 0.013	0.392MetCys: 0.392 ± 0.006	1.38MetAsp: 1.38 ± 0.009	1.621MetGlu: 1.621 ± 0.013	0.88MetPhe: 0.88 ± 0.009	1.216MetGly: 1.216 ± 0.012	0.574MetHis: 0.574 ± 0.006	1.188MetIle: 1.188 ± 0.011	1.474MetLys: 1.474 ± 0.011	2.039MetLeu: 2.039 ± 0.014	0.72MetMet: 0.72 ± 0.01	1.166MetAsn: 1.166 ± 0.009	1.128MetPro: 1.128 ± 0.009	1.071MetGln: 1.071 ± 0.012	1.189MetArg: 1.189 ± 0.01	1.879MetSer: 1.879 ± 0.013	1.253MetThr: 1.253 ± 0.01	1.365MetVal: 1.365 ± 0.011	0.21MetTrp: 0.21 ± 0.004	0.678MetTyr: 0.678 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.043AsnAla: 3.043 ± 0.024	0.862AsnCys: 0.862 ± 0.011	2.672AsnAsp: 2.672 ± 0.017	3.006AsnGlu: 3.006 ± 0.018	1.763AsnPhe: 1.763 ± 0.013	3.649AsnGly: 3.649 ± 0.025	1.323AsnHis: 1.323 ± 0.016	2.744AsnIle: 2.744 ± 0.016	2.558AsnLys: 2.558 ± 0.015	4.39AsnLeu: 4.39 ± 0.024	1.134AsnMet: 1.134 ± 0.011	3.595AsnAsn: 3.595 ± 0.037	2.478AsnPro: 2.478 ± 0.021	2.217AsnGln: 2.217 ± 0.018	2.68AsnArg: 2.68 ± 0.014	4.547AsnSer: 4.547 ± 0.028	2.567AsnThr: 2.567 ± 0.015	3.091AsnVal: 3.091 ± 0.018	0.448AsnTrp: 0.448 ± 0.006	1.54AsnTyr: 1.54 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	3.849ProAla: 3.849 ± 0.027	0.683ProCys: 0.683 ± 0.025	2.648ProAsp: 2.648 ± 0.016	3.563ProGlu: 3.563 ± 0.025	1.663ProPhe: 1.663 ± 0.015	3.127ProGly: 3.127 ± 0.036	1.281ProHis: 1.281 ± 0.012	2.748ProIle: 2.748 ± 0.018	3.13ProLys: 3.13 ± 0.023	4.164ProLeu: 4.164 ± 0.024	1.178ProMet: 1.178 ± 0.01	2.544ProAsn: 2.544 ± 0.021	5.146ProPro: 5.146 ± 0.047	2.693ProGln: 2.693 ± 0.028	2.372ProArg: 2.372 ± 0.016	5.262ProSer: 5.262 ± 0.035	3.679ProThr: 3.679 ± 0.026	3.592ProVal: 3.592 ± 0.025	0.43ProTrp: 0.43 ± 0.006	1.515ProTyr: 1.515 ± 0.016	0.001ProXaa: 0.001 ± 0.0
Gln	2.729GlnAla: 2.729 ± 0.02	0.847GlnCys: 0.847 ± 0.014	1.972GlnAsp: 1.972 ± 0.013	2.917GlnGlu: 2.917 ± 0.026	1.518GlnPhe: 1.518 ± 0.011	1.955GlnGly: 1.955 ± 0.02	1.673GlnHis: 1.673 ± 0.016	2.478GlnIle: 2.478 ± 0.017	2.689GlnLys: 2.689 ± 0.02	4.298GlnLeu: 4.298 ± 0.029	1.203GlnMet: 1.203 ± 0.013	2.295GlnAsn: 2.295 ± 0.018	2.837GlnPro: 2.837 ± 0.029	6.051GlnGln: 6.051 ± 0.098	2.623GlnArg: 2.623 ± 0.017	3.65GlnSer: 3.65 ± 0.023	2.5GlnThr: 2.5 ± 0.017	2.299GlnVal: 2.299 ± 0.013	0.427GlnTrp: 0.427 ± 0.006	1.385GlnTyr: 1.385 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	2.948ArgAla: 2.948 ± 0.016	1.009ArgCys: 1.009 ± 0.014	2.929ArgAsp: 2.929 ± 0.021	3.463ArgGlu: 3.463 ± 0.025	2.013ArgPhe: 2.013 ± 0.016	2.728ArgGly: 2.728 ± 0.021	1.475ArgHis: 1.475 ± 0.012	2.79ArgIle: 2.79 ± 0.014	3.974ArgLys: 3.974 ± 0.025	4.619ArgLeu: 4.619 ± 0.028	1.249ArgMet: 1.249 ± 0.009	2.723ArgAsn: 2.723 ± 0.018	2.68ArgPro: 2.68 ± 0.025	2.421ArgGln: 2.421 ± 0.016	3.884ArgArg: 3.884 ± 0.027	4.489ArgSer: 4.489 ± 0.029	2.796ArgThr: 2.796 ± 0.016	2.753ArgVal: 2.753 ± 0.016	0.565ArgTrp: 0.565 ± 0.007	1.697ArgTyr: 1.697 ± 0.014	0.001ArgXaa: 0.001 ± 0.0
Ser	5.695SerAla: 5.695 ± 0.026	1.369SerCys: 1.369 ± 0.018	4.58SerAsp: 4.58 ± 0.026	4.779SerGlu: 4.779 ± 0.025	2.88SerPhe: 2.88 ± 0.015	5.836SerGly: 5.836 ± 0.031	2.023SerHis: 2.023 ± 0.014	4.301SerIle: 4.301 ± 0.02	4.661SerLys: 4.661 ± 0.022	6.842SerLeu: 6.842 ± 0.032	1.831SerMet: 1.831 ± 0.013	4.777SerAsn: 4.777 ± 0.029	5.158SerPro: 5.158 ± 0.046	3.556SerGln: 3.556 ± 0.022	4.234SerArg: 4.234 ± 0.03	11.712SerSer: 11.712 ± 0.085	5.995SerThr: 5.995 ± 0.039	4.878SerVal: 4.878 ± 0.019	0.75SerTrp: 0.75 ± 0.01	2.257SerTyr: 2.257 ± 0.015	0.001SerXaa: 0.001 ± 0.0
Thr	4.287ThrAla: 4.287 ± 0.026	1.03ThrCys: 1.03 ± 0.015	2.835ThrAsp: 2.835 ± 0.021	3.496ThrGlu: 3.496 ± 0.026	1.993ThrPhe: 1.993 ± 0.014	3.617ThrGly: 3.617 ± 0.025	1.225ThrHis: 1.225 ± 0.011	3.418ThrIle: 3.418 ± 0.02	3.076ThrLys: 3.076 ± 0.018	4.881ThrLeu: 4.881 ± 0.026	1.266ThrMet: 1.266 ± 0.011	2.831ThrAsn: 2.831 ± 0.017	3.996ThrPro: 3.996 ± 0.03	2.183ThrGln: 2.183 ± 0.024	2.491ThrArg: 2.491 ± 0.019	5.56ThrSer: 5.56 ± 0.03	5.247ThrThr: 5.247 ± 0.081	4.052ThrVal: 4.052 ± 0.032	0.501ThrTrp: 0.501 ± 0.008	1.517ThrTyr: 1.517 ± 0.013	0.001ThrXaa: 0.001 ± 0.0
Val	4.247ValAla: 4.247 ± 0.024	1.226ValCys: 1.226 ± 0.014	3.424ValAsp: 3.424 ± 0.019	4.02ValGlu: 4.02 ± 0.027	2.225ValPhe: 2.225 ± 0.014	3.237ValGly: 3.237 ± 0.019	1.476ValHis: 1.476 ± 0.011	3.292ValIle: 3.292 ± 0.02	3.537ValLys: 3.537 ± 0.02	5.241ValLeu: 5.241 ± 0.025	1.344ValMet: 1.344 ± 0.011	2.758ValAsn: 2.758 ± 0.016	3.386ValPro: 3.386 ± 0.02	2.736ValGln: 2.736 ± 0.016	2.905ValArg: 2.905 ± 0.017	4.599ValSer: 4.599 ± 0.02	3.747ValThr: 3.747 ± 0.036	4.158ValVal: 4.158 ± 0.023	0.587ValTrp: 0.587 ± 0.007	1.751ValTyr: 1.751 ± 0.012	0.0ValXaa: 0.0 ± 0.0
Trp	0.519TrpAla: 0.519 ± 0.008	0.171TrpCys: 0.171 ± 0.004	0.536TrpAsp: 0.536 ± 0.007	0.55TrpGlu: 0.55 ± 0.007	0.402TrpPhe: 0.402 ± 0.007	0.485TrpGly: 0.485 ± 0.007	0.233TrpHis: 0.233 ± 0.004	0.607TrpIle: 0.607 ± 0.007	0.641TrpLys: 0.641 ± 0.008	0.917TrpLeu: 0.917 ± 0.01	0.286TrpMet: 0.286 ± 0.005	0.575TrpAsn: 0.575 ± 0.008	0.364TrpPro: 0.364 ± 0.006	0.381TrpGln: 0.381 ± 0.006	0.567TrpArg: 0.567 ± 0.008	0.701TrpSer: 0.701 ± 0.009	0.521TrpThr: 0.521 ± 0.008	0.508TrpVal: 0.508 ± 0.007	0.153TrpTrp: 0.153 ± 0.004	0.308TrpTyr: 0.308 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.662TyrAla: 1.662 ± 0.013	0.728TyrCys: 0.728 ± 0.012	1.804TyrAsp: 1.804 ± 0.013	1.853TyrGlu: 1.853 ± 0.015	1.282TyrPhe: 1.282 ± 0.014	1.94TyrGly: 1.94 ± 0.016	0.893TyrHis: 0.893 ± 0.011	1.463TyrIle: 1.463 ± 0.013	1.581TyrLys: 1.581 ± 0.013	2.524TyrLeu: 2.524 ± 0.017	0.658TyrMet: 0.658 ± 0.007	1.518TyrAsn: 1.518 ± 0.012	1.355TyrPro: 1.355 ± 0.017	1.363TyrGln: 1.363 ± 0.01	1.75TyrArg: 1.75 ± 0.014	2.246TyrSer: 2.246 ± 0.015	1.522TyrThr: 1.522 ± 0.013	1.73TyrVal: 1.73 ± 0.014	0.346TyrTrp: 0.346 ± 0.006	1.183TyrTyr: 1.183 ± 0.011	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 21531 proteins (14460630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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