Amino acid dipepetide frequency for Coptotermes formosanus (Formosan subterranean termite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.959AlaAla: 5.959 ± 0.05	1.34AlaCys: 1.34 ± 0.022	3.282AlaAsp: 3.282 ± 0.024	4.272AlaGlu: 4.272 ± 0.039	2.295AlaPhe: 2.295 ± 0.022	4.113AlaGly: 4.113 ± 0.027	1.528AlaHis: 1.528 ± 0.017	2.944AlaIle: 2.944 ± 0.023	3.178AlaLys: 3.178 ± 0.025	5.979AlaLeu: 5.979 ± 0.043	1.486AlaMet: 1.486 ± 0.017	2.299AlaAsn: 2.299 ± 0.02	2.869AlaPro: 2.869 ± 0.027	2.473AlaGln: 2.473 ± 0.024	3.259AlaArg: 3.259 ± 0.025	5.328AlaSer: 5.328 ± 0.041	3.943AlaThr: 3.943 ± 0.027	5.467AlaVal: 5.467 ± 0.033	0.662AlaTrp: 0.662 ± 0.011	1.64AlaTyr: 1.64 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.23CysAla: 1.23 ± 0.015	0.644CysCys: 0.644 ± 0.012	1.297CysAsp: 1.297 ± 0.017	1.314CysGlu: 1.314 ± 0.021	0.812CysPhe: 0.812 ± 0.012	1.615CysGly: 1.615 ± 0.026	0.729CysHis: 0.729 ± 0.013	1.117CysIle: 1.117 ± 0.019	1.185CysLys: 1.185 ± 0.015	2.104CysLeu: 2.104 ± 0.025	0.481CysMet: 0.481 ± 0.009	1.055CysAsn: 1.055 ± 0.018	1.155CysPro: 1.155 ± 0.027	0.943CysGln: 0.943 ± 0.016	1.326CysArg: 1.326 ± 0.038	1.993CysSer: 1.993 ± 0.028	1.252CysThr: 1.252 ± 0.018	1.62CysVal: 1.62 ± 0.023	0.277CysTrp: 0.277 ± 0.006	0.657CysTyr: 0.657 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.076AspAla: 3.076 ± 0.024	1.153AspCys: 1.153 ± 0.019	3.226AspAsp: 3.226 ± 0.028	3.756AspGlu: 3.756 ± 0.031	2.053AspPhe: 2.053 ± 0.019	3.361AspGly: 3.361 ± 0.031	1.19AspHis: 1.19 ± 0.013	3.21AspIle: 3.21 ± 0.025	2.85AspLys: 2.85 ± 0.027	4.742AspLeu: 4.742 ± 0.03	1.342AspMet: 1.342 ± 0.018	2.134AspAsn: 2.134 ± 0.022	2.436AspPro: 2.436 ± 0.03	1.664AspGln: 1.664 ± 0.019	2.671AspArg: 2.671 ± 0.028	4.438AspSer: 4.438 ± 0.03	3.02AspThr: 3.02 ± 0.026	3.962AspVal: 3.962 ± 0.03	0.642AspTrp: 0.642 ± 0.011	1.569AspTyr: 1.569 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.215GluAla: 4.215 ± 0.039	1.401GluCys: 1.401 ± 0.039	4.112GluAsp: 4.112 ± 0.035	6.221GluGlu: 6.221 ± 0.075	2.131GluPhe: 2.131 ± 0.02	3.683GluGly: 3.683 ± 0.033	1.677GluHis: 1.677 ± 0.019	3.12GluIle: 3.12 ± 0.026	4.335GluLys: 4.335 ± 0.047	5.932GluLeu: 5.932 ± 0.045	1.667GluMet: 1.667 ± 0.019	3.046GluAsn: 3.046 ± 0.028	2.46GluPro: 2.46 ± 0.026	2.842GluGln: 2.842 ± 0.029	3.743GluArg: 3.743 ± 0.041	4.342GluSer: 4.342 ± 0.036	3.637GluThr: 3.637 ± 0.035	4.459GluVal: 4.459 ± 0.041	0.705GluTrp: 0.705 ± 0.012	1.744GluTyr: 1.744 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.039PheAla: 2.039 ± 0.02	0.91PheCys: 0.91 ± 0.013	1.785PheAsp: 1.785 ± 0.021	2.003PheGlu: 2.003 ± 0.017	1.426PhePhe: 1.426 ± 0.02	2.302PheGly: 2.302 ± 0.027	1.122PheHis: 1.122 ± 0.014	1.874PheIle: 1.874 ± 0.023	1.806PheLys: 1.806 ± 0.019	3.703PheLeu: 3.703 ± 0.03	0.843PheMet: 0.843 ± 0.013	1.455PheAsn: 1.455 ± 0.017	1.824PhePro: 1.824 ± 0.017	1.589PheGln: 1.589 ± 0.019	2.027PheArg: 2.027 ± 0.021	3.134PheSer: 3.134 ± 0.025	2.158PheThr: 2.158 ± 0.021	2.573PheVal: 2.573 ± 0.025	0.47PheTrp: 0.47 ± 0.008	1.21PheTyr: 1.21 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	3.558GlyAla: 3.558 ± 0.032	1.266GlyCys: 1.266 ± 0.019	3.214GlyAsp: 3.214 ± 0.025	3.516GlyGlu: 3.516 ± 0.036	2.247GlyPhe: 2.247 ± 0.023	4.813GlyGly: 4.813 ± 0.056	1.735GlyHis: 1.735 ± 0.021	3.101GlyIle: 3.101 ± 0.024	3.522GlyLys: 3.522 ± 0.03	5.006GlyLeu: 5.006 ± 0.035	1.386GlyMet: 1.386 ± 0.016	2.809GlyAsn: 2.809 ± 0.025	2.585GlyPro: 2.585 ± 0.04	2.301GlyGln: 2.301 ± 0.025	3.387GlyArg: 3.387 ± 0.028	5.546GlySer: 5.546 ± 0.042	3.698GlyThr: 3.698 ± 0.031	3.961GlyVal: 3.961 ± 0.033	0.672GlyTrp: 0.672 ± 0.012	1.903GlyTyr: 1.903 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.496HisAla: 1.496 ± 0.016	0.734HisCys: 0.734 ± 0.013	1.238HisAsp: 1.238 ± 0.015	1.505HisGlu: 1.505 ± 0.019	1.129HisPhe: 1.129 ± 0.013	1.615HisGly: 1.615 ± 0.019	1.362HisHis: 1.362 ± 0.028	1.573HisIle: 1.573 ± 0.015	1.519HisLys: 1.519 ± 0.019	2.83HisLeu: 2.83 ± 0.026	0.71HisMet: 0.71 ± 0.012	1.261HisAsn: 1.261 ± 0.015	1.52HisPro: 1.52 ± 0.017	1.354HisGln: 1.354 ± 0.018	1.67HisArg: 1.67 ± 0.018	2.465HisSer: 2.465 ± 0.022	1.694HisThr: 1.694 ± 0.02	1.904HisVal: 1.904 ± 0.017	0.344HisTrp: 0.344 ± 0.007	0.927HisTyr: 0.927 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.01IleAla: 3.01 ± 0.023	1.188IleCys: 1.188 ± 0.016	2.254IleAsp: 2.254 ± 0.023	2.681IleGlu: 2.681 ± 0.026	1.848IlePhe: 1.848 ± 0.021	2.493IleGly: 2.493 ± 0.023	1.418IleHis: 1.418 ± 0.018	2.555IleIle: 2.555 ± 0.029	2.657IleLys: 2.657 ± 0.024	4.731IleLeu: 4.731 ± 0.032	1.129IleMet: 1.129 ± 0.015	2.125IleAsn: 2.125 ± 0.021	2.71IlePro: 2.71 ± 0.023	2.218IleGln: 2.218 ± 0.021	2.645IleArg: 2.645 ± 0.022	3.981IleSer: 3.981 ± 0.029	2.996IleThr: 2.996 ± 0.028	3.18IleVal: 3.18 ± 0.025	0.534IleTrp: 0.534 ± 0.012	1.389IleTyr: 1.389 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.339LysAla: 3.339 ± 0.027	1.304LysCys: 1.304 ± 0.021	3.021LysAsp: 3.021 ± 0.03	4.441LysGlu: 4.441 ± 0.053	2.002LysPhe: 2.002 ± 0.021	2.915LysGly: 2.915 ± 0.028	1.619LysHis: 1.619 ± 0.017	2.745LysIle: 2.745 ± 0.023	4.421LysLys: 4.421 ± 0.049	5.475LysLeu: 5.475 ± 0.037	1.402LysMet: 1.402 ± 0.016	2.467LysAsn: 2.467 ± 0.022	2.737LysPro: 2.737 ± 0.041	2.662LysGln: 2.662 ± 0.025	3.411LysArg: 3.411 ± 0.026	4.121LysSer: 4.121 ± 0.033	3.187LysThr: 3.187 ± 0.028	3.687LysVal: 3.687 ± 0.029	0.669LysTrp: 0.669 ± 0.012	1.84LysTyr: 1.84 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	6.077LeuAla: 6.077 ± 0.036	2.152LeuCys: 2.152 ± 0.024	4.742LeuAsp: 4.742 ± 0.034	6.131LeuGlu: 6.131 ± 0.049	3.245LeuPhe: 3.245 ± 0.034	4.914LeuGly: 4.914 ± 0.036	2.944LeuHis: 2.944 ± 0.024	3.901LeuIle: 3.901 ± 0.029	5.664LeuLys: 5.664 ± 0.04	9.571LeuLeu: 9.571 ± 0.076	2.091LeuMet: 2.091 ± 0.02	3.837LeuAsn: 3.837 ± 0.03	5.041LeuPro: 5.041 ± 0.037	5.268LeuGln: 5.268 ± 0.035	5.334LeuArg: 5.334 ± 0.037	7.415LeuSer: 7.415 ± 0.046	5.148LeuThr: 5.148 ± 0.034	5.814LeuVal: 5.814 ± 0.038	1.049LeuTrp: 1.049 ± 0.016	2.719LeuTyr: 2.719 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.783MetAla: 1.783 ± 0.019	0.539MetCys: 0.539 ± 0.01	1.246MetAsp: 1.246 ± 0.015	1.631MetGlu: 1.631 ± 0.018	0.887MetPhe: 0.887 ± 0.011	1.26MetGly: 1.26 ± 0.019	0.534MetHis: 0.534 ± 0.009	0.903MetIle: 0.903 ± 0.013	1.54MetLys: 1.54 ± 0.019	2.174MetLeu: 2.174 ± 0.021	0.604MetMet: 0.604 ± 0.011	0.991MetAsn: 0.991 ± 0.015	1.081MetPro: 1.081 ± 0.013	1.02MetGln: 1.02 ± 0.013	1.135MetArg: 1.135 ± 0.014	1.817MetSer: 1.817 ± 0.02	1.254MetThr: 1.254 ± 0.016	1.468MetVal: 1.468 ± 0.017	0.299MetTrp: 0.299 ± 0.007	0.689MetTyr: 0.689 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.472AsnAla: 2.472 ± 0.019	0.997AsnCys: 0.997 ± 0.017	1.912AsnAsp: 1.912 ± 0.019	2.486AsnGlu: 2.486 ± 0.024	1.676AsnPhe: 1.676 ± 0.02	2.668AsnGly: 2.668 ± 0.023	1.118AsnHis: 1.118 ± 0.013	2.685AsnIle: 2.685 ± 0.024	2.64AsnLys: 2.64 ± 0.026	3.864AsnLeu: 3.864 ± 0.029	1.107AsnMet: 1.107 ± 0.014	2.319AsnAsn: 2.319 ± 0.029	2.08AsnPro: 2.08 ± 0.024	1.608AsnGln: 1.608 ± 0.017	2.162AsnArg: 2.162 ± 0.018	3.806AsnSer: 3.806 ± 0.03	2.619AsnThr: 2.619 ± 0.025	3.062AsnVal: 3.062 ± 0.025	0.493AsnTrp: 0.493 ± 0.009	1.336AsnTyr: 1.336 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	3.476ProAla: 3.476 ± 0.032	0.921ProCys: 0.921 ± 0.026	2.732ProAsp: 2.732 ± 0.023	3.355ProGlu: 3.355 ± 0.046	1.715ProPhe: 1.715 ± 0.018	3.241ProGly: 3.241 ± 0.057	1.538ProHis: 1.538 ± 0.017	1.985ProIle: 1.985 ± 0.022	2.372ProLys: 2.372 ± 0.024	4.332ProLeu: 4.332 ± 0.033	0.883ProMet: 0.883 ± 0.015	1.945ProAsn: 1.945 ± 0.02	4.363ProPro: 4.363 ± 0.066	2.341ProGln: 2.341 ± 0.026	2.513ProArg: 2.513 ± 0.025	4.767ProSer: 4.767 ± 0.046	3.003ProThr: 3.003 ± 0.033	4.053ProVal: 4.053 ± 0.031	0.517ProTrp: 0.517 ± 0.01	1.556ProTyr: 1.556 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.711GlnAla: 2.711 ± 0.027	0.983GlnCys: 0.983 ± 0.017	2.145GlnAsp: 2.145 ± 0.02	3.163GlnGlu: 3.163 ± 0.035	1.475GlnPhe: 1.475 ± 0.017	2.261GlnGly: 2.261 ± 0.023	1.592GlnHis: 1.592 ± 0.019	1.926GlnIle: 1.926 ± 0.017	2.6GlnLys: 2.6 ± 0.027	4.356GlnLeu: 4.356 ± 0.032	1.068GlnMet: 1.068 ± 0.012	2.05GlnAsn: 2.05 ± 0.022	2.229GlnPro: 2.229 ± 0.025	3.431GlnGln: 3.431 ± 0.052	2.569GlnArg: 2.569 ± 0.026	3.08GlnSer: 3.08 ± 0.025	2.374GlnThr: 2.374 ± 0.024	2.76GlnVal: 2.76 ± 0.023	0.501GlnTrp: 0.501 ± 0.009	1.315GlnTyr: 1.315 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.056ArgAla: 3.056 ± 0.026	1.206ArgCys: 1.206 ± 0.021	2.948ArgAsp: 2.948 ± 0.033	3.534ArgGlu: 3.534 ± 0.037	1.944ArgPhe: 1.944 ± 0.019	3.1ArgGly: 3.1 ± 0.03	1.786ArgHis: 1.786 ± 0.018	2.654ArgIle: 2.654 ± 0.022	3.754ArgLys: 3.754 ± 0.031	5.066ArgLeu: 5.066 ± 0.036	1.225ArgMet: 1.225 ± 0.015	2.638ArgAsn: 2.638 ± 0.022	2.655ArgPro: 2.655 ± 0.04	2.532ArgGln: 2.532 ± 0.024	4.14ArgArg: 4.14 ± 0.039	4.264ArgSer: 4.264 ± 0.038	2.966ArgThr: 2.966 ± 0.024	3.274ArgVal: 3.274 ± 0.025	0.659ArgTrp: 0.659 ± 0.012	1.697ArgTyr: 1.697 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	5.448SerAla: 5.448 ± 0.041	1.883SerCys: 1.883 ± 0.025	4.628SerAsp: 4.628 ± 0.034	5.061SerGlu: 5.061 ± 0.036	2.781SerPhe: 2.781 ± 0.025	5.654SerGly: 5.654 ± 0.04	2.38SerHis: 2.38 ± 0.025	3.406SerIle: 3.406 ± 0.024	4.231SerLys: 4.231 ± 0.03	7.376SerLeu: 7.376 ± 0.041	1.602SerMet: 1.602 ± 0.016	3.532SerAsn: 3.532 ± 0.029	4.863SerPro: 4.863 ± 0.05	3.402SerGln: 3.402 ± 0.03	4.304SerArg: 4.304 ± 0.036	9.414SerSer: 9.414 ± 0.088	4.995SerThr: 4.995 ± 0.045	6.169SerVal: 6.169 ± 0.04	0.894SerTrp: 0.894 ± 0.014	2.281SerTyr: 2.281 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	4.336ThrAla: 4.336 ± 0.026	1.356ThrCys: 1.356 ± 0.021	3.015ThrAsp: 3.015 ± 0.022	3.787ThrGlu: 3.787 ± 0.036	2.144ThrPhe: 2.144 ± 0.019	3.838ThrGly: 3.838 ± 0.032	1.516ThrHis: 1.516 ± 0.019	2.494ThrIle: 2.494 ± 0.022	2.973ThrLys: 2.973 ± 0.025	5.35ThrLeu: 5.35 ± 0.031	1.143ThrMet: 1.143 ± 0.013	2.362ThrAsn: 2.362 ± 0.023	3.371ThrPro: 3.371 ± 0.03	2.279ThrGln: 2.279 ± 0.022	2.699ThrArg: 2.699 ± 0.022	5.461ThrSer: 5.461 ± 0.04	3.721ThrThr: 3.721 ± 0.052	4.734ThrVal: 4.734 ± 0.032	0.684ThrTrp: 0.684 ± 0.012	1.638ThrTyr: 1.638 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.784ValAla: 4.784 ± 0.028	1.798ValCys: 1.798 ± 0.023	3.544ValAsp: 3.544 ± 0.031	4.229ValGlu: 4.229 ± 0.036	2.637ValPhe: 2.637 ± 0.025	3.884ValGly: 3.884 ± 0.029	1.837ValHis: 1.837 ± 0.018	3.41ValIle: 3.41 ± 0.026	3.849ValLys: 3.849 ± 0.028	6.572ValLeu: 6.572 ± 0.043	1.689ValMet: 1.689 ± 0.017	2.833ValAsn: 2.833 ± 0.025	3.837ValPro: 3.837 ± 0.03	2.91ValGln: 2.91 ± 0.022	3.615ValArg: 3.615 ± 0.028	5.729ValSer: 5.729 ± 0.039	4.899ValThr: 4.899 ± 0.036	4.981ValVal: 4.981 ± 0.036	0.822ValTrp: 0.822 ± 0.014	1.99ValTyr: 1.99 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.607TrpAla: 0.607 ± 0.009	0.268TrpCys: 0.268 ± 0.008	0.644TrpAsp: 0.644 ± 0.012	0.687TrpGlu: 0.687 ± 0.012	0.477TrpPhe: 0.477 ± 0.011	0.63TrpGly: 0.63 ± 0.012	0.313TrpHis: 0.313 ± 0.007	0.563TrpIle: 0.563 ± 0.011	0.787TrpLys: 0.787 ± 0.014	1.194TrpLeu: 1.194 ± 0.017	0.285TrpMet: 0.285 ± 0.007	0.606TrpAsn: 0.606 ± 0.011	0.446TrpPro: 0.446 ± 0.009	0.505TrpGln: 0.505 ± 0.01	0.714TrpArg: 0.714 ± 0.012	0.83TrpSer: 0.83 ± 0.014	0.657TrpThr: 0.657 ± 0.013	0.691TrpVal: 0.691 ± 0.011	0.191TrpTrp: 0.191 ± 0.006	0.371TrpTyr: 0.371 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.641TyrAla: 1.641 ± 0.018	0.767TyrCys: 0.767 ± 0.012	1.511TyrAsp: 1.511 ± 0.016	1.7TyrGlu: 1.7 ± 0.019	1.328TyrPhe: 1.328 ± 0.018	1.866TyrGly: 1.866 ± 0.023	0.911TyrHis: 0.911 ± 0.012	1.576TyrIle: 1.576 ± 0.019	1.584TyrLys: 1.584 ± 0.017	2.701TyrLeu: 2.701 ± 0.022	0.713TyrMet: 0.713 ± 0.01	1.347TyrAsn: 1.347 ± 0.015	1.345TyrPro: 1.345 ± 0.017	1.245TyrGln: 1.245 ± 0.017	1.772TyrArg: 1.772 ± 0.017	2.374TyrSer: 2.374 ± 0.024	1.678TyrThr: 1.678 ± 0.017	2.032TyrVal: 2.032 ± 0.021	0.381TyrTrp: 0.381 ± 0.01	1.069TyrTyr: 1.069 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12806 proteins (6406585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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