Amino acid dipepetide frequency for Thiospirochaeta perfilievii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.112AlaAla: 3.112 ± 0.081	0.441AlaCys: 0.441 ± 0.022	2.515AlaAsp: 2.515 ± 0.057	2.774AlaGlu: 2.774 ± 0.063	2.167AlaPhe: 2.167 ± 0.053	3.684AlaGly: 3.684 ± 0.1	0.793AlaHis: 0.793 ± 0.029	4.438AlaIle: 4.438 ± 0.066	3.581AlaLys: 3.581 ± 0.067	5.238AlaLeu: 5.238 ± 0.086	1.16AlaMet: 1.16 ± 0.034	2.236AlaAsn: 2.236 ± 0.058	1.334AlaPro: 1.334 ± 0.038	1.26AlaGln: 1.26 ± 0.037	1.602AlaArg: 1.602 ± 0.047	3.158AlaSer: 3.158 ± 0.065	2.636AlaThr: 2.636 ± 0.06	3.302AlaVal: 3.302 ± 0.061	0.378AlaTrp: 0.378 ± 0.018	1.707AlaTyr: 1.707 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.42CysAla: 0.42 ± 0.019	0.145CysCys: 0.145 ± 0.011	0.535CysAsp: 0.535 ± 0.022	0.441CysGlu: 0.441 ± 0.023	0.423CysPhe: 0.423 ± 0.022	0.787CysGly: 0.787 ± 0.029	0.168CysHis: 0.168 ± 0.012	0.638CysIle: 0.638 ± 0.023	0.636CysLys: 0.636 ± 0.025	0.681CysLeu: 0.681 ± 0.024	0.177CysMet: 0.177 ± 0.014	0.482CysAsn: 0.482 ± 0.025	0.369CysPro: 0.369 ± 0.022	0.194CysGln: 0.194 ± 0.013	0.335CysArg: 0.335 ± 0.019	0.7CysSer: 0.7 ± 0.027	0.394CysThr: 0.394 ± 0.019	0.428CysVal: 0.428 ± 0.019	0.063CysTrp: 0.063 ± 0.008	0.393CysTyr: 0.393 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.5AspAla: 2.5 ± 0.05	0.448AspCys: 0.448 ± 0.022	3.409AspAsp: 3.409 ± 0.098	4.131AspGlu: 4.131 ± 0.095	3.432AspPhe: 3.432 ± 0.054	3.67AspGly: 3.67 ± 0.074	0.764AspHis: 0.764 ± 0.028	6.4AspIle: 6.4 ± 0.086	5.04AspLys: 5.04 ± 0.078	6.211AspLeu: 6.211 ± 0.087	1.254AspMet: 1.254 ± 0.035	3.731AspAsn: 3.731 ± 0.066	1.883AspPro: 1.883 ± 0.037	1.334AspGln: 1.334 ± 0.047	2.402AspArg: 2.402 ± 0.048	4.595AspSer: 4.595 ± 0.072	2.639AspThr: 2.639 ± 0.061	3.498AspVal: 3.498 ± 0.066	0.628AspTrp: 0.628 ± 0.026	2.862AspTyr: 2.862 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	3.527GluAla: 3.527 ± 0.068	0.472GluCys: 0.472 ± 0.022	4.268GluAsp: 4.268 ± 0.095	5.082GluGlu: 5.082 ± 0.117	3.132GluPhe: 3.132 ± 0.063	3.533GluGly: 3.533 ± 0.066	0.944GluHis: 0.944 ± 0.03	6.522GluIle: 6.522 ± 0.097	5.464GluLys: 5.464 ± 0.092	7.125GluLeu: 7.125 ± 0.106	1.558GluMet: 1.558 ± 0.039	4.223GluAsn: 4.223 ± 0.068	1.499GluPro: 1.499 ± 0.04	1.56GluGln: 1.56 ± 0.048	2.338GluArg: 2.338 ± 0.055	4.892GluSer: 4.892 ± 0.07	3.206GluThr: 3.206 ± 0.055	4.294GluVal: 4.294 ± 0.068	0.524GluTrp: 0.524 ± 0.026	2.861GluTyr: 2.861 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.063PheAla: 2.063 ± 0.048	0.437PheCys: 0.437 ± 0.02	2.993PheAsp: 2.993 ± 0.062	2.669PheGlu: 2.669 ± 0.05	2.592PhePhe: 2.592 ± 0.065	2.834PheGly: 2.834 ± 0.057	0.671PheHis: 0.671 ± 0.028	5.009PheIle: 5.009 ± 0.079	4.049PheLys: 4.049 ± 0.074	4.715PheLeu: 4.715 ± 0.085	0.999PheMet: 0.999 ± 0.034	3.572PheAsn: 3.572 ± 0.063	1.612PhePro: 1.612 ± 0.04	1.096PheGln: 1.096 ± 0.034	1.491PheArg: 1.491 ± 0.038	4.406PheSer: 4.406 ± 0.075	2.965PheThr: 2.965 ± 0.052	2.622PheVal: 2.622 ± 0.049	0.434PheTrp: 0.434 ± 0.022	2.181PheTyr: 2.181 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	3.429GlyAla: 3.429 ± 0.085	0.685GlyCys: 0.685 ± 0.027	3.854GlyAsp: 3.854 ± 0.067	4.213GlyGlu: 4.213 ± 0.063	3.501GlyPhe: 3.501 ± 0.063	4.052GlyGly: 4.052 ± 0.089	0.996GlyHis: 0.996 ± 0.03	6.062GlyIle: 6.062 ± 0.087	4.397GlyLys: 4.397 ± 0.072	6.285GlyLeu: 6.285 ± 0.085	1.482GlyMet: 1.482 ± 0.041	3.219GlyAsn: 3.219 ± 0.085	1.241GlyPro: 1.241 ± 0.034	1.468GlyGln: 1.468 ± 0.037	2.393GlyArg: 2.393 ± 0.052	4.395GlySer: 4.395 ± 0.097	3.314GlyThr: 3.314 ± 0.128	4.69GlyVal: 4.69 ± 0.083	0.613GlyTrp: 0.613 ± 0.024	2.823GlyTyr: 2.823 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.613HisAla: 0.613 ± 0.027	0.158HisCys: 0.158 ± 0.012	0.751HisAsp: 0.751 ± 0.026	0.825HisGlu: 0.825 ± 0.03	0.819HisPhe: 0.819 ± 0.032	1.035HisGly: 1.035 ± 0.031	0.306HisHis: 0.306 ± 0.018	1.34HisIle: 1.34 ± 0.036	1.053HisLys: 1.053 ± 0.028	1.506HisLeu: 1.506 ± 0.043	0.256HisMet: 0.256 ± 0.015	0.918HisAsn: 0.918 ± 0.03	0.691HisPro: 0.691 ± 0.027	0.363HisGln: 0.363 ± 0.018	0.618HisArg: 0.618 ± 0.026	1.051HisSer: 1.051 ± 0.031	0.762HisThr: 0.762 ± 0.028	0.722HisVal: 0.722 ± 0.027	0.14HisTrp: 0.14 ± 0.012	0.66HisTyr: 0.66 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.396IleAla: 4.396 ± 0.075	0.761IleCys: 0.761 ± 0.026	6.4IleAsp: 6.4 ± 0.087	6.484IleGlu: 6.484 ± 0.08	4.506IlePhe: 4.506 ± 0.066	5.41IleGly: 5.41 ± 0.073	1.338IleHis: 1.338 ± 0.036	8.733IleIle: 8.733 ± 0.126	7.855IleLys: 7.855 ± 0.099	9.378IleLeu: 9.378 ± 0.124	1.736IleMet: 1.736 ± 0.043	6.132IleAsn: 6.132 ± 0.09	3.753IlePro: 3.753 ± 0.066	2.162IleGln: 2.162 ± 0.044	2.921IleArg: 2.921 ± 0.055	7.961IleSer: 7.961 ± 0.094	5.565IleThr: 5.565 ± 0.104	5.333IleVal: 5.333 ± 0.072	0.603IleTrp: 0.603 ± 0.026	3.609IleTyr: 3.609 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	3.633LysAla: 3.633 ± 0.065	0.585LysCys: 0.585 ± 0.027	5.374LysAsp: 5.374 ± 0.072	6.973LysGlu: 6.973 ± 0.107	2.775LysPhe: 2.775 ± 0.052	4.466LysGly: 4.466 ± 0.069	1.135LysHis: 1.135 ± 0.037	7.215LysIle: 7.215 ± 0.085	7.269LysLys: 7.269 ± 0.113	7.026LysLeu: 7.026 ± 0.091	1.913LysMet: 1.913 ± 0.044	5.333LysAsn: 5.333 ± 0.079	2.315LysPro: 2.315 ± 0.047	2.023LysGln: 2.023 ± 0.049	3.293LysArg: 3.293 ± 0.061	5.855LysSer: 5.855 ± 0.071	4.068LysThr: 4.068 ± 0.064	4.523LysVal: 4.523 ± 0.067	0.659LysTrp: 0.659 ± 0.025	3.366LysTyr: 3.366 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	4.758LeuAla: 4.758 ± 0.074	0.78LeuCys: 0.78 ± 0.028	6.437LeuAsp: 6.437 ± 0.097	7.161LeuGlu: 7.161 ± 0.097	5.317LeuPhe: 5.317 ± 0.081	6.338LeuGly: 6.338 ± 0.084	1.374LeuHis: 1.374 ± 0.038	8.71LeuIle: 8.71 ± 0.106	8.487LeuLys: 8.487 ± 0.108	10.324LeuLeu: 10.324 ± 0.154	2.021LeuMet: 2.021 ± 0.045	6.402LeuAsn: 6.402 ± 0.075	3.345LeuPro: 3.345 ± 0.064	2.23LeuGln: 2.23 ± 0.05	3.238LeuArg: 3.238 ± 0.063	8.045LeuSer: 8.045 ± 0.1	5.574LeuThr: 5.574 ± 0.097	5.398LeuVal: 5.398 ± 0.077	0.777LeuTrp: 0.777 ± 0.029	3.889LeuTyr: 3.889 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	1.343MetAla: 1.343 ± 0.039	0.171MetCys: 0.171 ± 0.013	1.544MetAsp: 1.544 ± 0.037	1.599MetGlu: 1.599 ± 0.048	0.984MetPhe: 0.984 ± 0.027	1.552MetGly: 1.552 ± 0.044	0.272MetHis: 0.272 ± 0.014	1.693MetIle: 1.693 ± 0.044	1.823MetLys: 1.823 ± 0.04	1.883MetLeu: 1.883 ± 0.044	0.493MetMet: 0.493 ± 0.024	1.291MetAsn: 1.291 ± 0.033	0.71MetPro: 0.71 ± 0.024	0.483MetGln: 0.483 ± 0.021	0.671MetArg: 0.671 ± 0.024	1.472MetSer: 1.472 ± 0.038	1.02MetThr: 1.02 ± 0.035	1.429MetVal: 1.429 ± 0.035	0.157MetTrp: 0.157 ± 0.01	0.611MetTyr: 0.611 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.14AsnAla: 2.14 ± 0.05	0.548AsnCys: 0.548 ± 0.025	2.889AsnAsp: 2.889 ± 0.06	3.28AsnGlu: 3.28 ± 0.055	3.019AsnPhe: 3.019 ± 0.064	3.666AsnGly: 3.666 ± 0.081	0.899AsnHis: 0.899 ± 0.028	6.675AsnIle: 6.675 ± 0.092	5.114AsnLys: 5.114 ± 0.065	5.996AsnLeu: 5.996 ± 0.094	1.313AsnMet: 1.313 ± 0.036	4.272AsnAsn: 4.272 ± 0.087	2.336AsnPro: 2.336 ± 0.045	1.703AsnGln: 1.703 ± 0.038	3.094AsnArg: 3.094 ± 0.055	5.508AsnSer: 5.508 ± 0.084	2.71AsnThr: 2.71 ± 0.064	2.785AsnVal: 2.785 ± 0.059	0.687AsnTrp: 0.687 ± 0.033	2.807AsnTyr: 2.807 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	1.382ProAla: 1.382 ± 0.036	0.268ProCys: 0.268 ± 0.017	1.791ProAsp: 1.791 ± 0.044	2.448ProGlu: 2.448 ± 0.057	1.662ProPhe: 1.662 ± 0.044	2.18ProGly: 2.18 ± 0.047	0.55ProHis: 0.55 ± 0.025	2.873ProIle: 2.873 ± 0.051	2.296ProLys: 2.296 ± 0.05	3.121ProLeu: 3.121 ± 0.056	0.608ProMet: 0.608 ± 0.025	1.781ProAsn: 1.781 ± 0.041	0.803ProPro: 0.803 ± 0.032	0.864ProGln: 0.864 ± 0.03	0.948ProArg: 0.948 ± 0.031	2.083ProSer: 2.083 ± 0.045	1.711ProThr: 1.711 ± 0.045	2.184ProVal: 2.184 ± 0.049	0.365ProTrp: 0.365 ± 0.021	1.389ProTyr: 1.389 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.239GlnAla: 1.239 ± 0.044	0.176GlnCys: 0.176 ± 0.014	1.387GlnAsp: 1.387 ± 0.045	1.695GlnGlu: 1.695 ± 0.043	1.134GlnPhe: 1.134 ± 0.035	1.591GlnGly: 1.591 ± 0.041	0.329GlnHis: 0.329 ± 0.019	2.307GlnIle: 2.307 ± 0.052	1.98GlnLys: 1.98 ± 0.043	2.406GlnLeu: 2.406 ± 0.045	0.62GlnMet: 0.62 ± 0.023	1.491GlnAsn: 1.491 ± 0.041	0.575GlnPro: 0.575 ± 0.025	0.662GlnGln: 0.662 ± 0.04	0.99GlnArg: 0.99 ± 0.033	1.586GlnSer: 1.586 ± 0.039	1.134GlnThr: 1.134 ± 0.036	1.535GlnVal: 1.535 ± 0.04	0.275GlnTrp: 0.275 ± 0.015	0.974GlnTyr: 0.974 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.854ArgAla: 1.854 ± 0.045	0.3ArgCys: 0.3 ± 0.014	2.595ArgAsp: 2.595 ± 0.05	3.002ArgGlu: 3.002 ± 0.06	1.741ArgPhe: 1.741 ± 0.049	2.292ArgGly: 2.292 ± 0.052	0.547ArgHis: 0.547 ± 0.025	2.981ArgIle: 2.981 ± 0.055	2.483ArgLys: 2.483 ± 0.051	3.393ArgLeu: 3.393 ± 0.062	0.769ArgMet: 0.769 ± 0.031	1.903ArgAsn: 1.903 ± 0.044	1.011ArgPro: 1.011 ± 0.034	0.769ArgGln: 0.769 ± 0.027	1.395ArgArg: 1.395 ± 0.033	2.498ArgSer: 2.498 ± 0.052	1.62ArgThr: 1.62 ± 0.04	3.121ArgVal: 3.121 ± 0.057	0.343ArgTrp: 0.343 ± 0.018	1.457ArgTyr: 1.457 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.274SerAla: 3.274 ± 0.064	0.767SerCys: 0.767 ± 0.029	4.21SerAsp: 4.21 ± 0.068	4.327SerGlu: 4.327 ± 0.074	4.142SerPhe: 4.142 ± 0.068	5.401SerGly: 5.401 ± 0.11	1.092SerHis: 1.092 ± 0.029	7.792SerIle: 7.792 ± 0.101	5.64SerLys: 5.64 ± 0.074	8.288SerLeu: 8.288 ± 0.105	1.575SerMet: 1.575 ± 0.041	4.398SerAsn: 4.398 ± 0.065	2.095SerPro: 2.095 ± 0.042	1.941SerGln: 1.941 ± 0.037	2.884SerArg: 2.884 ± 0.049	6.003SerSer: 6.003 ± 0.092	3.817SerThr: 3.817 ± 0.074	4.727SerVal: 4.727 ± 0.081	0.802SerTrp: 0.802 ± 0.035	3.173SerTyr: 3.173 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	2.713ThrAla: 2.713 ± 0.074	0.369ThrCys: 0.369 ± 0.018	2.939ThrAsp: 2.939 ± 0.075	2.988ThrGlu: 2.988 ± 0.061	2.642ThrPhe: 2.642 ± 0.059	3.869ThrGly: 3.869 ± 0.116	0.812ThrHis: 0.812 ± 0.031	5.123ThrIle: 5.123 ± 0.108	3.714ThrLys: 3.714 ± 0.055	5.83ThrLeu: 5.83 ± 0.096	1.009ThrMet: 1.009 ± 0.026	2.872ThrAsn: 2.872 ± 0.077	2.215ThrPro: 2.215 ± 0.047	1.358ThrGln: 1.358 ± 0.032	1.559ThrArg: 1.559 ± 0.042	3.615ThrSer: 3.615 ± 0.071	3.234ThrThr: 3.234 ± 0.113	3.378ThrVal: 3.378 ± 0.08	0.497ThrTrp: 0.497 ± 0.023	1.881ThrTyr: 1.881 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	3.098ValAla: 3.098 ± 0.067	0.48ValCys: 0.48 ± 0.021	4.029ValAsp: 4.029 ± 0.083	4.216ValGlu: 4.216 ± 0.067	2.76ValPhe: 2.76 ± 0.053	3.731ValGly: 3.731 ± 0.061	0.801ValHis: 0.801 ± 0.031	5.79ValIle: 5.79 ± 0.073	4.847ValLys: 4.847 ± 0.063	6.116ValLeu: 6.116 ± 0.082	1.301ValMet: 1.301 ± 0.038	3.504ValAsn: 3.504 ± 0.061	1.767ValPro: 1.767 ± 0.037	1.269ValGln: 1.269 ± 0.033	1.928ValArg: 1.928 ± 0.039	4.445ValSer: 4.445 ± 0.078	3.509ValThr: 3.509 ± 0.079	4.249ValVal: 4.249 ± 0.073	0.474ValTrp: 0.474 ± 0.023	2.206ValTyr: 2.206 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.484TrpAla: 0.484 ± 0.023	0.072TrpCys: 0.072 ± 0.009	0.688TrpAsp: 0.688 ± 0.027	0.608TrpGlu: 0.608 ± 0.027	0.43TrpPhe: 0.43 ± 0.019	0.639TrpGly: 0.639 ± 0.026	0.125TrpHis: 0.125 ± 0.01	0.732TrpIle: 0.732 ± 0.029	0.613TrpLys: 0.613 ± 0.025	0.833TrpLeu: 0.833 ± 0.03	0.232TrpMet: 0.232 ± 0.017	0.601TrpAsn: 0.601 ± 0.028	0.221TrpPro: 0.221 ± 0.016	0.246TrpGln: 0.246 ± 0.015	0.321TrpArg: 0.321 ± 0.017	0.652TrpSer: 0.652 ± 0.025	0.41TrpThr: 0.41 ± 0.022	0.539TrpVal: 0.539 ± 0.021	0.108TrpTrp: 0.108 ± 0.01	0.363TrpTyr: 0.363 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.539TyrAla: 1.539 ± 0.043	0.344TyrCys: 0.344 ± 0.017	2.22TyrAsp: 2.22 ± 0.057	2.105TyrGlu: 2.105 ± 0.043	2.232TyrPhe: 2.232 ± 0.046	2.379TyrGly: 2.379 ± 0.041	0.673TyrHis: 0.673 ± 0.024	4.003TyrIle: 4.003 ± 0.071	3.46TyrLys: 3.46 ± 0.063	4.249TyrLeu: 4.249 ± 0.074	0.727TyrMet: 0.727 ± 0.026	3.082TyrAsn: 3.082 ± 0.069	1.532TyrPro: 1.532 ± 0.039	1.102TyrGln: 1.102 ± 0.035	1.651TyrArg: 1.651 ± 0.041	3.427TyrSer: 3.427 ± 0.064	2.331TyrThr: 2.331 ± 0.051	1.764TyrVal: 1.764 ± 0.043	0.394TyrTrp: 0.394 ± 0.022	1.944TyrTyr: 1.944 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3264 proteins (1103600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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