Amino acid dipepetide frequency for Aspergillus violaceofuscus (strain CBS 115571)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.275AlaAla: 10.275 ± 0.068
1.186AlaCys: 1.186 ± 0.017
4.465AlaAsp: 4.465 ± 0.031
5.234AlaGlu: 5.234 ± 0.037
3.209AlaPhe: 3.209 ± 0.028
6.247AlaGly: 6.247 ± 0.036
2.053AlaHis: 2.053 ± 0.02
4.299AlaIle: 4.299 ± 0.031
3.484AlaLys: 3.484 ± 0.029
8.346AlaLeu: 8.346 ± 0.042
1.998AlaMet: 1.998 ± 0.019
2.808AlaAsn: 2.808 ± 0.025
4.88AlaPro: 4.88 ± 0.043
3.633AlaGln: 3.633 ± 0.032
5.395AlaArg: 5.395 ± 0.038
7.435AlaSer: 7.435 ± 0.048
5.74AlaThr: 5.74 ± 0.042
5.822AlaVal: 5.822 ± 0.042
1.291AlaTrp: 1.291 ± 0.016
2.312AlaTyr: 2.312 ± 0.022
0.0AlaXaa: 0.0 ± 0.0
Cys
1.071CysAla: 1.071 ± 0.013
0.286CysCys: 0.286 ± 0.009
0.713CysAsp: 0.713 ± 0.012
0.616CysGlu: 0.616 ± 0.012
0.565CysPhe: 0.565 ± 0.01
0.974CysGly: 0.974 ± 0.016
0.357CysHis: 0.357 ± 0.009
0.731CysIle: 0.731 ± 0.013
0.445CysLys: 0.445 ± 0.009
1.446CysLeu: 1.446 ± 0.018
0.298CysMet: 0.298 ± 0.007
0.422CysAsn: 0.422 ± 0.009
0.723CysPro: 0.723 ± 0.015
0.491CysGln: 0.491 ± 0.01
0.86CysArg: 0.86 ± 0.013
1.002CysSer: 1.002 ± 0.016
0.776CysThr: 0.776 ± 0.014
0.881CysVal: 0.881 ± 0.014
0.219CysTrp: 0.219 ± 0.006
0.386CysTyr: 0.386 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
4.824AspAla: 4.824 ± 0.033
0.655AspCys: 0.655 ± 0.011
3.892AspAsp: 3.892 ± 0.042
4.185AspGlu: 4.185 ± 0.038
2.077AspPhe: 2.077 ± 0.023
3.89AspGly: 3.89 ± 0.028
1.342AspHis: 1.342 ± 0.017
2.743AspIle: 2.743 ± 0.026
1.923AspLys: 1.923 ± 0.019
5.26AspLeu: 5.26 ± 0.036
1.123AspMet: 1.123 ± 0.013
1.699AspAsn: 1.699 ± 0.019
3.446AspPro: 3.446 ± 0.027
1.921AspGln: 1.921 ± 0.018
3.232AspArg: 3.232 ± 0.033
3.921AspSer: 3.921 ± 0.033
2.897AspThr: 2.897 ± 0.023
3.449AspVal: 3.449 ± 0.028
0.917AspTrp: 0.917 ± 0.013
1.64AspTyr: 1.64 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
5.333GluAla: 5.333 ± 0.038
0.64GluCys: 0.64 ± 0.011
3.933GluAsp: 3.933 ± 0.037
5.306GluGlu: 5.306 ± 0.057
1.882GluPhe: 1.882 ± 0.018
3.772GluGly: 3.772 ± 0.029
1.407GluHis: 1.407 ± 0.018
2.927GluIle: 2.927 ± 0.025
3.1GluLys: 3.1 ± 0.033
5.111GluLeu: 5.111 ± 0.031
1.418GluMet: 1.418 ± 0.015
2.007GluAsn: 2.007 ± 0.021
2.75GluPro: 2.75 ± 0.035
2.51GluGln: 2.51 ± 0.025
3.873GluArg: 3.873 ± 0.031
4.124GluSer: 4.124 ± 0.033
3.508GluThr: 3.508 ± 0.027
3.634GluVal: 3.634 ± 0.029
0.874GluTrp: 0.874 ± 0.012
1.645GluTyr: 1.645 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
3.163PheAla: 3.163 ± 0.025
0.608PheCys: 0.608 ± 0.011
2.217PheAsp: 2.217 ± 0.018
2.026PheGlu: 2.026 ± 0.019
1.667PhePhe: 1.667 ± 0.022
2.755PheGly: 2.755 ± 0.027
0.992PheHis: 0.992 ± 0.014
1.725PheIle: 1.725 ± 0.018
1.232PheLys: 1.232 ± 0.016
3.659PheLeu: 3.659 ± 0.027
0.742PheMet: 0.742 ± 0.011
1.281PheAsn: 1.281 ± 0.016
2.011PhePro: 2.011 ± 0.02
1.436PheGln: 1.436 ± 0.017
2.05PheArg: 2.05 ± 0.02
2.91PheSer: 2.91 ± 0.025
2.169PheThr: 2.169 ± 0.02
2.45PheVal: 2.45 ± 0.024
0.675PheTrp: 0.675 ± 0.013
1.144PheTyr: 1.144 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
5.57GlyAla: 5.57 ± 0.041
0.964GlyCys: 0.964 ± 0.015
3.532GlyAsp: 3.532 ± 0.027
3.62GlyGlu: 3.62 ± 0.026
2.816GlyPhe: 2.816 ± 0.024
5.842GlyGly: 5.842 ± 0.048
1.694GlyHis: 1.694 ± 0.018
3.317GlyIle: 3.317 ± 0.026
2.957GlyLys: 2.957 ± 0.025
6.418GlyLeu: 6.418 ± 0.035
1.548GlyMet: 1.548 ± 0.017
2.296GlyAsn: 2.296 ± 0.026
3.391GlyPro: 3.391 ± 0.028
2.581GlyGln: 2.581 ± 0.022
4.261GlyArg: 4.261 ± 0.034
5.623GlySer: 5.623 ± 0.04
3.951GlyThr: 3.951 ± 0.028
4.655GlyVal: 4.655 ± 0.034
1.232GlyTrp: 1.232 ± 0.018
2.201GlyTyr: 2.201 ± 0.025
0.0GlyXaa: 0.0 ± 0.0
His
2.103HisAla: 2.103 ± 0.021
0.371HisCys: 0.371 ± 0.009
1.358HisAsp: 1.358 ± 0.017
1.391HisGlu: 1.391 ± 0.017
0.956HisPhe: 0.956 ± 0.013
1.807HisGly: 1.807 ± 0.019
1.073HisHis: 1.073 ± 0.018
1.195HisIle: 1.195 ± 0.015
0.796HisLys: 0.796 ± 0.012
2.537HisLeu: 2.537 ± 0.022
0.484HisMet: 0.484 ± 0.009
0.831HisAsn: 0.831 ± 0.013
1.901HisPro: 1.901 ± 0.019
1.105HisGln: 1.105 ± 0.017
1.746HisArg: 1.746 ± 0.021
1.879HisSer: 1.879 ± 0.02
1.38HisThr: 1.38 ± 0.016
1.479HisVal: 1.479 ± 0.014
0.388HisTrp: 0.388 ± 0.008
0.752HisTyr: 0.752 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
4.149IleAla: 4.149 ± 0.033
0.771IleCys: 0.771 ± 0.011
2.687IleAsp: 2.687 ± 0.022
2.586IleGlu: 2.586 ± 0.025
1.949IlePhe: 1.949 ± 0.021
3.031IleGly: 3.031 ± 0.025
1.26IleHis: 1.26 ± 0.013
2.38IleIle: 2.38 ± 0.023
1.794IleLys: 1.794 ± 0.022
4.654IleLeu: 4.654 ± 0.036
0.909IleMet: 0.909 ± 0.013
1.631IleAsn: 1.631 ± 0.017
3.106IlePro: 3.106 ± 0.024
1.874IleGln: 1.874 ± 0.02
2.797IleArg: 2.797 ± 0.024
3.623IleSer: 3.623 ± 0.022
2.788IleThr: 2.788 ± 0.025
3.101IleVal: 3.101 ± 0.026
0.712IleTrp: 0.712 ± 0.012
1.454IleTyr: 1.454 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
3.657LysAla: 3.657 ± 0.03
0.461LysCys: 0.461 ± 0.011
2.258LysAsp: 2.258 ± 0.027
2.8LysGlu: 2.8 ± 0.032
1.198LysPhe: 1.198 ± 0.018
2.547LysGly: 2.547 ± 0.02
1.008LysHis: 1.008 ± 0.014
1.892LysIle: 1.892 ± 0.022
2.597LysLys: 2.597 ± 0.034
3.581LysLeu: 3.581 ± 0.027
0.833LysMet: 0.833 ± 0.012
1.415LysAsn: 1.415 ± 0.018
2.399LysPro: 2.399 ± 0.028
1.658LysGln: 1.658 ± 0.02
2.968LysArg: 2.968 ± 0.026
2.962LysSer: 2.962 ± 0.024
2.429LysThr: 2.429 ± 0.022
2.509LysVal: 2.509 ± 0.027
0.561LysTrp: 0.561 ± 0.01
1.181LysTyr: 1.181 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
8.503LeuAla: 8.503 ± 0.051
1.342LeuCys: 1.342 ± 0.017
5.244LeuAsp: 5.244 ± 0.034
5.545LeuGlu: 5.545 ± 0.043
3.475LeuPhe: 3.475 ± 0.029
6.252LeuGly: 6.252 ± 0.038
2.474LeuHis: 2.474 ± 0.022
4.001LeuIle: 4.001 ± 0.034
3.694LeuLys: 3.694 ± 0.029
9.152LeuLeu: 9.152 ± 0.061
1.826LeuMet: 1.826 ± 0.019
3.096LeuAsn: 3.096 ± 0.023
5.759LeuPro: 5.759 ± 0.036
4.08LeuGln: 4.08 ± 0.03
6.224LeuArg: 6.224 ± 0.036
7.493LeuSer: 7.493 ± 0.039
5.253LeuThr: 5.253 ± 0.033
5.845LeuVal: 5.845 ± 0.037
1.292LeuTrp: 1.292 ± 0.017
2.559LeuTyr: 2.559 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
2.121MetAla: 2.121 ± 0.022
0.248MetCys: 0.248 ± 0.006
1.162MetAsp: 1.162 ± 0.015
1.2MetGlu: 1.2 ± 0.014
0.721MetPhe: 0.721 ± 0.013
1.415MetGly: 1.415 ± 0.015
0.494MetHis: 0.494 ± 0.01
0.994MetIle: 0.994 ± 0.014
0.874MetLys: 0.874 ± 0.012
1.871MetLeu: 1.871 ± 0.02
0.56MetMet: 0.56 ± 0.012
0.734MetAsn: 0.734 ± 0.011
1.189MetPro: 1.189 ± 0.016
0.881MetGln: 0.881 ± 0.012
1.268MetArg: 1.268 ± 0.016
1.757MetSer: 1.757 ± 0.015
1.298MetThr: 1.298 ± 0.017
1.356MetVal: 1.356 ± 0.016
0.256MetTrp: 0.256 ± 0.006
0.503MetTyr: 0.503 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
2.971AsnAla: 2.971 ± 0.023
0.432AsnCys: 0.432 ± 0.009
1.711AsnAsp: 1.711 ± 0.019
1.808AsnGlu: 1.808 ± 0.018
1.222AsnPhe: 1.222 ± 0.015
2.571AsnGly: 2.571 ± 0.028
0.866AsnHis: 0.866 ± 0.013
1.78AsnIle: 1.78 ± 0.019
1.253AsnLys: 1.253 ± 0.017
3.161AsnLeu: 3.161 ± 0.024
0.734AsnMet: 0.734 ± 0.013
1.376AsnAsn: 1.376 ± 0.019
2.412AsnPro: 2.412 ± 0.019
1.253AsnGln: 1.253 ± 0.016
1.901AsnArg: 1.901 ± 0.018
2.469AsnSer: 2.469 ± 0.024
2.029AsnThr: 2.029 ± 0.023
2.158AsnVal: 2.158 ± 0.018
0.535AsnTrp: 0.535 ± 0.011
1.021AsnTyr: 1.021 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
5.72ProAla: 5.72 ± 0.042
0.611ProCys: 0.611 ± 0.013
3.238ProAsp: 3.238 ± 0.028
3.808ProGlu: 3.808 ± 0.035
2.087ProPhe: 2.087 ± 0.019
3.984ProGly: 3.984 ± 0.028
1.466ProHis: 1.466 ± 0.019
2.452ProIle: 2.452 ± 0.022
2.261ProLys: 2.261 ± 0.021
4.944ProLeu: 4.944 ± 0.034
1.039ProMet: 1.039 ± 0.017
2.001ProAsn: 2.001 ± 0.021
5.086ProPro: 5.086 ± 0.066
2.525ProGln: 2.525 ± 0.029
3.618ProArg: 3.618 ± 0.028
6.036ProSer: 6.036 ± 0.049
4.232ProThr: 4.232 ± 0.031
3.774ProVal: 3.774 ± 0.029
0.809ProTrp: 0.809 ± 0.011
1.562ProTyr: 1.562 ± 0.019
0.0ProXaa: 0.0 ± 0.0
Gln
3.667GlnAla: 3.667 ± 0.028
0.499GlnCys: 0.499 ± 0.009
2.013GlnAsp: 2.013 ± 0.018
2.396GlnGlu: 2.396 ± 0.026
1.317GlnPhe: 1.317 ± 0.015
2.464GlnGly: 2.464 ± 0.024
1.164GlnHis: 1.164 ± 0.015
1.915GlnIle: 1.915 ± 0.02
1.742GlnLys: 1.742 ± 0.02
3.671GlnLeu: 3.671 ± 0.027
0.881GlnMet: 0.881 ± 0.012
1.403GlnAsn: 1.403 ± 0.017
2.749GlnPro: 2.749 ± 0.036
2.752GlnGln: 2.752 ± 0.057
2.789GlnArg: 2.789 ± 0.025
3.138GlnSer: 3.138 ± 0.029
2.467GlnThr: 2.467 ± 0.022
2.281GlnVal: 2.281 ± 0.021
0.607GlnTrp: 0.607 ± 0.01
1.187GlnTyr: 1.187 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
5.098ArgAla: 5.098 ± 0.034
0.824ArgCys: 0.824 ± 0.012
3.377ArgAsp: 3.377 ± 0.034
3.889ArgGlu: 3.889 ± 0.035
2.287ArgPhe: 2.287 ± 0.02
3.871ArgGly: 3.871 ± 0.033
1.685ArgHis: 1.685 ± 0.019
2.885ArgIle: 2.885 ± 0.023
3.161ArgLys: 3.161 ± 0.025
5.974ArgLeu: 5.974 ± 0.04
1.318ArgMet: 1.318 ± 0.017
2.118ArgAsn: 2.118 ± 0.02
3.628ArgPro: 3.628 ± 0.033
2.707ArgGln: 2.707 ± 0.026
5.301ArgArg: 5.301 ± 0.042
4.882ArgSer: 4.882 ± 0.042
3.479ArgThr: 3.479 ± 0.03
3.712ArgVal: 3.712 ± 0.027
1.047ArgTrp: 1.047 ± 0.012
1.778ArgTyr: 1.778 ± 0.019
0.0ArgXaa: 0.0 ± 0.0
Ser
6.925SerAla: 6.925 ± 0.043
0.96SerCys: 0.96 ± 0.016
4.07SerAsp: 4.07 ± 0.036
3.945SerGlu: 3.945 ± 0.036
2.99SerPhe: 2.99 ± 0.023
5.435SerGly: 5.435 ± 0.042
2.053SerHis: 2.053 ± 0.022
3.798SerIle: 3.798 ± 0.031
3.105SerLys: 3.105 ± 0.029
7.49SerLeu: 7.49 ± 0.045
1.637SerMet: 1.637 ± 0.019
2.706SerAsn: 2.706 ± 0.027
5.537SerPro: 5.537 ± 0.046
3.241SerGln: 3.241 ± 0.027
4.943SerArg: 4.943 ± 0.044
9.023SerSer: 9.023 ± 0.07
5.683SerThr: 5.683 ± 0.042
4.637SerVal: 4.637 ± 0.029
1.154SerTrp: 1.154 ± 0.015
2.091SerTyr: 2.091 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
5.762ThrAla: 5.762 ± 0.036
0.809ThrCys: 0.809 ± 0.013
2.913ThrAsp: 2.913 ± 0.027
3.114ThrGlu: 3.114 ± 0.024
2.22ThrPhe: 2.22 ± 0.021
4.328ThrGly: 4.328 ± 0.031
1.417ThrHis: 1.417 ± 0.016
3.069ThrIle: 3.069 ± 0.026
2.283ThrLys: 2.283 ± 0.023
5.563ThrLeu: 5.563 ± 0.036
1.185ThrMet: 1.185 ± 0.015
2.012ThrAsn: 2.012 ± 0.02
4.372ThrPro: 4.372 ± 0.037
2.205ThrGln: 2.205 ± 0.023
3.287ThrArg: 3.287 ± 0.026
5.279ThrSer: 5.279 ± 0.033
5.069ThrThr: 5.069 ± 0.058
4.061ThrVal: 4.061 ± 0.037
0.894ThrTrp: 0.894 ± 0.013
1.698ThrTyr: 1.698 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
5.649ValAla: 5.649 ± 0.036
0.93ValCys: 0.93 ± 0.013
3.747ValAsp: 3.747 ± 0.03
3.874ValGlu: 3.874 ± 0.028
2.523ValPhe: 2.523 ± 0.025
4.228ValGly: 4.228 ± 0.032
1.524ValHis: 1.524 ± 0.018
2.964ValIle: 2.964 ± 0.023
2.503ValLys: 2.503 ± 0.023
5.923ValLeu: 5.923 ± 0.038
1.362ValMet: 1.362 ± 0.016
2.122ValAsn: 2.122 ± 0.021
3.671ValPro: 3.671 ± 0.027
2.52ValGln: 2.52 ± 0.024
3.711ValArg: 3.711 ± 0.032
4.712ValSer: 4.712 ± 0.035
3.668ValThr: 3.668 ± 0.031
4.677ValVal: 4.677 ± 0.034
0.931ValTrp: 0.931 ± 0.014
1.873ValTyr: 1.873 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
1.236TrpAla: 1.236 ± 0.016
0.209TrpCys: 0.209 ± 0.006
0.9TrpAsp: 0.9 ± 0.013
0.882TrpGlu: 0.882 ± 0.014
0.56TrpPhe: 0.56 ± 0.01
0.958TrpGly: 0.958 ± 0.014
0.374TrpHis: 0.374 ± 0.009
0.756TrpIle: 0.756 ± 0.013
0.747TrpLys: 0.747 ± 0.011
1.446TrpLeu: 1.446 ± 0.019
0.385TrpMet: 0.385 ± 0.008
0.627TrpAsn: 0.627 ± 0.01
0.648TrpPro: 0.648 ± 0.011
0.593TrpGln: 0.593 ± 0.011
1.016TrpArg: 1.016 ± 0.014
1.114TrpSer: 1.114 ± 0.015
0.997TrpThr: 0.997 ± 0.015
0.967TrpVal: 0.967 ± 0.014
0.302TrpTrp: 0.302 ± 0.007
0.452TrpTyr: 0.452 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.314TyrAla: 2.314 ± 0.022
0.455TyrCys: 0.455 ± 0.009
1.607TyrAsp: 1.607 ± 0.02
1.53TyrGlu: 1.53 ± 0.017
1.189TyrPhe: 1.189 ± 0.016
2.096TyrGly: 2.096 ± 0.025
0.827TyrHis: 0.827 ± 0.012
1.435TyrIle: 1.435 ± 0.017
0.965TyrLys: 0.965 ± 0.014
2.899TyrLeu: 2.899 ± 0.024
0.623TyrMet: 0.623 ± 0.01
1.077TyrAsn: 1.077 ± 0.014
1.595TyrPro: 1.595 ± 0.017
1.138TyrGln: 1.138 ± 0.016
1.78TyrArg: 1.78 ± 0.019
2.046TyrSer: 2.046 ± 0.022
1.727TyrThr: 1.727 ± 0.02
1.666TyrVal: 1.666 ± 0.02
0.471TyrTrp: 0.471 ± 0.01
0.995TyrTyr: 0.995 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.016XaaXaa: 0.016 ± 0.012
Statistics based on 12074 proteins (5671855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski