Amino acid dipepetide frequency for Lachancea fermentati (Zygosaccharomyces fermentati)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.097AlaAla: 5.097 ± 0.079	0.814AlaCys: 0.814 ± 0.016	2.983AlaAsp: 2.983 ± 0.037	3.733AlaGlu: 3.733 ± 0.044	2.527AlaPhe: 2.527 ± 0.03	3.467AlaGly: 3.467 ± 0.048	1.363AlaHis: 1.363 ± 0.025	3.746AlaIle: 3.746 ± 0.049	4.135AlaLys: 4.135 ± 0.05	6.25AlaLeu: 6.25 ± 0.063	1.442AlaMet: 1.442 ± 0.022	2.921AlaAsn: 2.921 ± 0.033	2.794AlaPro: 2.794 ± 0.045	2.571AlaGln: 2.571 ± 0.039	3.111AlaArg: 3.111 ± 0.042	5.493AlaSer: 5.493 ± 0.055	3.731AlaThr: 3.731 ± 0.041	3.827AlaVal: 3.827 ± 0.045	0.587AlaTrp: 0.587 ± 0.015	1.836AlaTyr: 1.836 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.772CysAla: 0.772 ± 0.017	0.32CysCys: 0.32 ± 0.013	0.76CysAsp: 0.76 ± 0.017	0.686CysGlu: 0.686 ± 0.018	0.701CysPhe: 0.701 ± 0.019	0.975CysGly: 0.975 ± 0.023	0.355CysHis: 0.355 ± 0.013	0.926CysIle: 0.926 ± 0.021	0.721CysLys: 0.721 ± 0.018	1.356CysLeu: 1.356 ± 0.026	0.29CysMet: 0.29 ± 0.011	0.604CysAsn: 0.604 ± 0.016	0.549CysPro: 0.549 ± 0.018	0.466CysGln: 0.466 ± 0.014	0.61CysArg: 0.61 ± 0.016	1.116CysSer: 1.116 ± 0.024	0.651CysThr: 0.651 ± 0.016	0.908CysVal: 0.908 ± 0.017	0.179CysTrp: 0.179 ± 0.009	0.504CysTyr: 0.504 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.568AspAla: 3.568 ± 0.043	0.684AspCys: 0.684 ± 0.017	4.462AspAsp: 4.462 ± 0.058	5.093AspGlu: 5.093 ± 0.061	2.757AspPhe: 2.757 ± 0.034	3.073AspGly: 3.073 ± 0.04	1.148AspHis: 1.148 ± 0.021	3.75AspIle: 3.75 ± 0.045	3.33AspLys: 3.33 ± 0.037	5.707AspLeu: 5.707 ± 0.049	1.166AspMet: 1.166 ± 0.022	2.673AspAsn: 2.673 ± 0.038	2.498AspPro: 2.498 ± 0.033	1.912AspGln: 1.912 ± 0.027	2.277AspArg: 2.277 ± 0.03	4.697AspSer: 4.697 ± 0.059	2.877AspThr: 2.877 ± 0.033	3.88AspVal: 3.88 ± 0.042	0.652AspTrp: 0.652 ± 0.015	2.126AspTyr: 2.126 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	3.862GluAla: 3.862 ± 0.045	0.716GluCys: 0.716 ± 0.016	4.49GluAsp: 4.49 ± 0.056	6.15GluGlu: 6.15 ± 0.076	2.851GluPhe: 2.851 ± 0.039	2.975GluGly: 2.975 ± 0.035	1.442GluHis: 1.442 ± 0.025	4.293GluIle: 4.293 ± 0.043	5.085GluLys: 5.085 ± 0.05	6.771GluLeu: 6.771 ± 0.067	1.435GluMet: 1.435 ± 0.024	3.825GluAsn: 3.825 ± 0.044	2.171GluPro: 2.171 ± 0.029	2.795GluGln: 2.795 ± 0.03	3.295GluArg: 3.295 ± 0.044	5.059GluSer: 5.059 ± 0.048	3.532GluThr: 3.532 ± 0.048	3.73GluVal: 3.73 ± 0.039	0.696GluTrp: 0.696 ± 0.017	2.203GluTyr: 2.203 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	2.616PheAla: 2.616 ± 0.035	0.607PheCys: 0.607 ± 0.015	2.791PheAsp: 2.791 ± 0.042	2.93PheGlu: 2.93 ± 0.034	2.114PhePhe: 2.114 ± 0.035	2.745PheGly: 2.745 ± 0.049	1.054PheHis: 1.054 ± 0.02	2.68PheIle: 2.68 ± 0.036	2.857PheLys: 2.857 ± 0.037	4.201PheLeu: 4.201 ± 0.047	0.937PheMet: 0.937 ± 0.02	2.229PheAsn: 2.229 ± 0.033	1.808PhePro: 1.808 ± 0.025	1.873PheGln: 1.873 ± 0.029	1.784PheArg: 1.784 ± 0.027	3.702PheSer: 3.702 ± 0.046	2.489PheThr: 2.489 ± 0.033	2.792PheVal: 2.792 ± 0.034	0.533PheTrp: 0.533 ± 0.015	1.574PheTyr: 1.574 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	3.442GlyAla: 3.442 ± 0.048	0.823GlyCys: 0.823 ± 0.018	2.899GlyAsp: 2.899 ± 0.035	3.151GlyGlu: 3.151 ± 0.041	2.581GlyPhe: 2.581 ± 0.037	3.572GlyGly: 3.572 ± 0.058	1.235GlyHis: 1.235 ± 0.021	3.467GlyIle: 3.467 ± 0.04	3.624GlyLys: 3.624 ± 0.038	4.868GlyLeu: 4.868 ± 0.049	1.071GlyMet: 1.071 ± 0.024	2.731GlyAsn: 2.731 ± 0.039	1.841GlyPro: 1.841 ± 0.035	1.833GlyGln: 1.833 ± 0.032	2.473GlyArg: 2.473 ± 0.033	4.981GlySer: 4.981 ± 0.052	3.05GlyThr: 3.05 ± 0.047	3.539GlyVal: 3.539 ± 0.04	0.67GlyTrp: 0.67 ± 0.016	1.898GlyTyr: 1.898 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.3HisAla: 1.3 ± 0.023	0.343HisCys: 0.343 ± 0.013	1.288HisAsp: 1.288 ± 0.026	1.398HisGlu: 1.398 ± 0.025	1.006HisPhe: 1.006 ± 0.02	1.301HisGly: 1.301 ± 0.027	0.663HisHis: 0.663 ± 0.019	1.303HisIle: 1.303 ± 0.024	1.293HisLys: 1.293 ± 0.023	2.227HisLeu: 2.227 ± 0.031	0.458HisMet: 0.458 ± 0.014	1.027HisAsn: 1.027 ± 0.022	1.103HisPro: 1.103 ± 0.023	0.876HisGln: 0.876 ± 0.021	1.107HisArg: 1.107 ± 0.024	1.847HisSer: 1.847 ± 0.031	1.12HisThr: 1.12 ± 0.021	1.358HisVal: 1.358 ± 0.025	0.268HisTrp: 0.268 ± 0.012	0.812HisTyr: 0.812 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.834IleAla: 3.834 ± 0.037	0.897IleCys: 0.897 ± 0.02	3.762IleAsp: 3.762 ± 0.036	3.933IleGlu: 3.933 ± 0.047	2.656IlePhe: 2.656 ± 0.039	3.126IleGly: 3.126 ± 0.044	1.317IleHis: 1.317 ± 0.021	3.576IleIle: 3.576 ± 0.037	3.844IleLys: 3.844 ± 0.041	5.838IleLeu: 5.838 ± 0.065	1.26IleMet: 1.26 ± 0.021	2.979IleAsn: 2.979 ± 0.037	3.133IlePro: 3.133 ± 0.037	2.199IleGln: 2.199 ± 0.028	2.73IleArg: 2.73 ± 0.034	5.374IleSer: 5.374 ± 0.05	3.428IleThr: 3.428 ± 0.04	3.826IleVal: 3.826 ± 0.042	0.658IleTrp: 0.658 ± 0.017	1.901IleTyr: 1.901 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.74LysAla: 3.74 ± 0.048	0.843LysCys: 0.843 ± 0.02	3.723LysAsp: 3.723 ± 0.042	4.726LysGlu: 4.726 ± 0.055	2.994LysPhe: 2.994 ± 0.034	2.87LysGly: 2.87 ± 0.036	1.458LysHis: 1.458 ± 0.026	4.131LysIle: 4.131 ± 0.049	5.657LysLys: 5.657 ± 0.068	6.864LysLeu: 6.864 ± 0.064	1.436LysMet: 1.436 ± 0.025	3.518LysAsn: 3.518 ± 0.043	2.858LysPro: 2.858 ± 0.036	2.678LysGln: 2.678 ± 0.033	3.976LysArg: 3.976 ± 0.049	5.31LysSer: 5.31 ± 0.052	3.595LysThr: 3.595 ± 0.039	3.899LysVal: 3.899 ± 0.041	0.766LysTrp: 0.766 ± 0.017	2.375LysTyr: 2.375 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	6.079LeuAla: 6.079 ± 0.06	1.428LeuCys: 1.428 ± 0.025	5.548LeuAsp: 5.548 ± 0.05	6.529LeuGlu: 6.529 ± 0.064	4.168LeuPhe: 4.168 ± 0.049	4.9LeuGly: 4.9 ± 0.047	2.147LeuHis: 2.147 ± 0.032	5.449LeuIle: 5.449 ± 0.066	7.1LeuLys: 7.1 ± 0.069	9.599LeuLeu: 9.599 ± 0.083	2.009LeuMet: 2.009 ± 0.031	5.04LeuAsn: 5.04 ± 0.044	4.735LeuPro: 4.735 ± 0.04	4.381LeuGln: 4.381 ± 0.044	5.068LeuArg: 5.068 ± 0.05	8.431LeuSer: 8.431 ± 0.057	5.261LeuThr: 5.261 ± 0.044	5.554LeuVal: 5.554 ± 0.052	0.976LeuTrp: 0.976 ± 0.02	3.04LeuTyr: 3.04 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.482MetAla: 1.482 ± 0.025	0.333MetCys: 0.333 ± 0.01	1.252MetAsp: 1.252 ± 0.023	1.268MetGlu: 1.268 ± 0.021	0.843MetPhe: 0.843 ± 0.02	1.241MetGly: 1.241 ± 0.021	0.392MetHis: 0.392 ± 0.013	1.251MetIle: 1.251 ± 0.026	1.412MetLys: 1.412 ± 0.024	1.929MetLeu: 1.929 ± 0.031	0.499MetMet: 0.499 ± 0.016	1.12MetAsn: 1.12 ± 0.023	0.878MetPro: 0.878 ± 0.022	0.732MetGln: 0.732 ± 0.018	0.979MetArg: 0.979 ± 0.021	2.073MetSer: 2.073 ± 0.03	1.112MetThr: 1.112 ± 0.022	1.232MetVal: 1.232 ± 0.021	0.203MetTrp: 0.203 ± 0.008	0.593MetTyr: 0.593 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.071AsnAla: 3.071 ± 0.035	0.668AsnCys: 0.668 ± 0.016	3.167AsnAsp: 3.167 ± 0.04	3.45AsnGlu: 3.45 ± 0.041	2.301AsnPhe: 2.301 ± 0.033	2.993AsnGly: 2.993 ± 0.04	1.035AsnHis: 1.035 ± 0.022	3.045AsnIle: 3.045 ± 0.032	3.119AsnLys: 3.119 ± 0.04	4.679AsnLeu: 4.679 ± 0.047	1.05AsnMet: 1.05 ± 0.02	2.591AsnAsn: 2.591 ± 0.045	2.292AsnPro: 2.292 ± 0.033	1.746AsnGln: 1.746 ± 0.029	2.083AsnArg: 2.083 ± 0.029	4.712AsnSer: 4.712 ± 0.051	2.689AsnThr: 2.689 ± 0.034	3.16AsnVal: 3.16 ± 0.04	0.582AsnTrp: 0.582 ± 0.015	1.793AsnTyr: 1.793 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	2.843ProAla: 2.843 ± 0.048	0.405ProCys: 0.405 ± 0.013	2.327ProAsp: 2.327 ± 0.032	3.097ProGlu: 3.097 ± 0.039	1.878ProPhe: 1.878 ± 0.028	2.186ProGly: 2.186 ± 0.034	1.029ProHis: 1.029 ± 0.023	2.575ProIle: 2.575 ± 0.032	2.675ProLys: 2.675 ± 0.034	4.235ProLeu: 4.235 ± 0.04	0.83ProMet: 0.83 ± 0.019	2.122ProAsn: 2.122 ± 0.03	2.548ProPro: 2.548 ± 0.057	2.103ProGln: 2.103 ± 0.038	2.011ProArg: 2.011 ± 0.034	4.225ProSer: 4.225 ± 0.051	2.748ProThr: 2.748 ± 0.039	2.845ProVal: 2.845 ± 0.038	0.48ProTrp: 0.48 ± 0.022	1.359ProTyr: 1.359 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	2.324GlnAla: 2.324 ± 0.035	0.455GlnCys: 0.455 ± 0.014	2.15GlnAsp: 2.15 ± 0.032	2.877GlnGlu: 2.877 ± 0.036	1.745GlnPhe: 1.745 ± 0.029	1.868GlnGly: 1.868 ± 0.033	0.919GlnHis: 0.919 ± 0.022	2.398GlnIle: 2.398 ± 0.039	2.639GlnLys: 2.639 ± 0.037	4.221GlnLeu: 4.221 ± 0.041	0.886GlnMet: 0.886 ± 0.021	2.022GlnAsn: 2.022 ± 0.034	1.753GlnPro: 1.753 ± 0.03	2.679GlnGln: 2.679 ± 0.09	2.209GlnArg: 2.209 ± 0.033	3.083GlnSer: 3.083 ± 0.041	2.013GlnThr: 2.013 ± 0.029	2.276GlnVal: 2.276 ± 0.035	0.443GlnTrp: 0.443 ± 0.014	1.335GlnTyr: 1.335 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.023ArgAla: 3.023 ± 0.041	0.667ArgCys: 0.667 ± 0.018	2.715ArgAsp: 2.715 ± 0.032	3.197ArgGlu: 3.197 ± 0.036	2.08ArgPhe: 2.08 ± 0.028	2.46ArgGly: 2.46 ± 0.036	1.102ArgHis: 1.102 ± 0.023	2.999ArgIle: 2.999 ± 0.033	3.769ArgLys: 3.769 ± 0.045	4.529ArgLeu: 4.529 ± 0.042	1.006ArgMet: 1.006 ± 0.019	2.484ArgAsn: 2.484 ± 0.029	1.942ArgPro: 1.942 ± 0.033	1.967ArgGln: 1.967 ± 0.028	3.291ArgArg: 3.291 ± 0.041	3.96ArgSer: 3.96 ± 0.051	2.493ArgThr: 2.493 ± 0.033	2.698ArgVal: 2.698 ± 0.034	0.555ArgTrp: 0.555 ± 0.015	1.632ArgTyr: 1.632 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	5.185SerAla: 5.185 ± 0.053	1.074SerCys: 1.074 ± 0.022	4.695SerAsp: 4.695 ± 0.05	5.186SerGlu: 5.186 ± 0.049	3.779SerPhe: 3.779 ± 0.043	4.806SerGly: 4.806 ± 0.059	1.929SerHis: 1.929 ± 0.027	5.176SerIle: 5.176 ± 0.054	5.974SerLys: 5.974 ± 0.053	8.322SerLeu: 8.322 ± 0.065	1.805SerMet: 1.805 ± 0.03	4.536SerAsn: 4.536 ± 0.047	3.916SerPro: 3.916 ± 0.061	3.559SerGln: 3.559 ± 0.041	4.152SerArg: 4.152 ± 0.046	10.009SerSer: 10.009 ± 0.177	5.697SerThr: 5.697 ± 0.096	4.995SerVal: 4.995 ± 0.046	0.852SerTrp: 0.852 ± 0.02	2.527SerTyr: 2.527 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.594ThrAla: 3.594 ± 0.045	0.738ThrCys: 0.738 ± 0.02	2.871ThrAsp: 2.871 ± 0.037	3.22ThrGlu: 3.22 ± 0.038	2.426ThrPhe: 2.426 ± 0.03	3.262ThrGly: 3.262 ± 0.061	1.175ThrHis: 1.175 ± 0.019	3.391ThrIle: 3.391 ± 0.04	3.553ThrLys: 3.553 ± 0.036	5.444ThrLeu: 5.444 ± 0.046	1.089ThrMet: 1.089 ± 0.023	2.688ThrAsn: 2.688 ± 0.034	3.019ThrPro: 3.019 ± 0.055	1.978ThrGln: 1.978 ± 0.027	2.524ThrArg: 2.524 ± 0.032	5.311ThrSer: 5.311 ± 0.083	3.769ThrThr: 3.769 ± 0.124	3.579ThrVal: 3.579 ± 0.045	0.608ThrTrp: 0.608 ± 0.016	1.664ThrTyr: 1.664 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	4.051ValAla: 4.051 ± 0.05	0.843ValCys: 0.843 ± 0.021	3.721ValAsp: 3.721 ± 0.041	4.025ValGlu: 4.025 ± 0.045	2.775ValPhe: 2.775 ± 0.033	3.363ValGly: 3.363 ± 0.036	1.285ValHis: 1.285 ± 0.027	3.605ValIle: 3.605 ± 0.042	3.868ValLys: 3.868 ± 0.042	5.991ValLeu: 5.991 ± 0.051	1.209ValMet: 1.209 ± 0.022	2.874ValAsn: 2.874 ± 0.036	2.992ValPro: 2.992 ± 0.035	2.173ValGln: 2.173 ± 0.025	2.727ValArg: 2.727 ± 0.038	5.291ValSer: 5.291 ± 0.049	3.383ValThr: 3.383 ± 0.043	4.147ValVal: 4.147 ± 0.045	0.65ValTrp: 0.65 ± 0.017	1.9ValTyr: 1.9 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.587TrpAla: 0.587 ± 0.015	0.272TrpCys: 0.272 ± 0.011	0.685TrpAsp: 0.685 ± 0.018	0.64TrpGlu: 0.64 ± 0.015	0.555TrpPhe: 0.555 ± 0.015	0.592TrpGly: 0.592 ± 0.017	0.239TrpHis: 0.239 ± 0.01	0.635TrpIle: 0.635 ± 0.016	0.807TrpLys: 0.807 ± 0.019	1.035TrpLeu: 1.035 ± 0.019	0.241TrpMet: 0.241 ± 0.01	0.637TrpAsn: 0.637 ± 0.016	0.346TrpPro: 0.346 ± 0.011	0.417TrpGln: 0.417 ± 0.013	0.617TrpArg: 0.617 ± 0.017	0.912TrpSer: 0.912 ± 0.023	0.571TrpThr: 0.571 ± 0.024	0.591TrpVal: 0.591 ± 0.016	0.178TrpTrp: 0.178 ± 0.01	0.388TrpTyr: 0.388 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.959TyrAla: 1.959 ± 0.029	0.518TyrCys: 0.518 ± 0.015	2.039TyrAsp: 2.039 ± 0.031	2.086TyrGlu: 2.086 ± 0.029	1.581TyrPhe: 1.581 ± 0.026	1.974TyrGly: 1.974 ± 0.043	0.812TyrHis: 0.812 ± 0.019	1.874TyrIle: 1.874 ± 0.027	1.957TyrLys: 1.957 ± 0.028	3.376TyrLeu: 3.376 ± 0.04	0.703TyrMet: 0.703 ± 0.016	1.605TyrAsn: 1.605 ± 0.025	1.345TyrPro: 1.345 ± 0.023	1.362TyrGln: 1.362 ± 0.026	1.546TyrArg: 1.546 ± 0.026	2.589TyrSer: 2.589 ± 0.039	1.69TyrThr: 1.69 ± 0.031	2.039TyrVal: 2.039 ± 0.027	0.407TyrTrp: 0.407 ± 0.014	1.325TyrTyr: 1.325 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5229 proteins (2551543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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