Amino acid dipepetide frequency for Tautonia plasticadhaerens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.437AlaAla: 13.437 ± 0.108
1.101AlaCys: 1.101 ± 0.021
7.455AlaAsp: 7.455 ± 0.064
8.459AlaGlu: 8.459 ± 0.081
3.962AlaPhe: 3.962 ± 0.042
10.763AlaGly: 10.763 ± 0.084
1.776AlaHis: 1.776 ± 0.034
5.154AlaIle: 5.154 ± 0.048
2.071AlaLys: 2.071 ± 0.037
12.173AlaLeu: 12.173 ± 0.096
2.66AlaMet: 2.66 ± 0.038
1.953AlaAsn: 1.953 ± 0.036
6.558AlaPro: 6.558 ± 0.074
2.4AlaGln: 2.4 ± 0.031
10.158AlaArg: 10.158 ± 0.083
7.189AlaSer: 7.189 ± 0.057
5.303AlaThr: 5.303 ± 0.056
8.577AlaVal: 8.577 ± 0.074
1.761AlaTrp: 1.761 ± 0.034
2.173AlaTyr: 2.173 ± 0.03
0.0AlaXaa: 0.0 ± 0.0
Cys
0.683CysAla: 0.683 ± 0.018
0.163CysCys: 0.163 ± 0.011
0.553CysAsp: 0.553 ± 0.015
0.477CysGlu: 0.477 ± 0.015
0.272CysPhe: 0.272 ± 0.012
0.907CysGly: 0.907 ± 0.022
0.352CysHis: 0.352 ± 0.015
0.253CysIle: 0.253 ± 0.01
0.18CysLys: 0.18 ± 0.007
0.954CysLeu: 0.954 ± 0.02
0.141CysMet: 0.141 ± 0.008
0.19CysAsn: 0.19 ± 0.007
0.673CysPro: 0.673 ± 0.019
0.236CysGln: 0.236 ± 0.009
0.907CysArg: 0.907 ± 0.02
0.514CysSer: 0.514 ± 0.014
0.376CysThr: 0.376 ± 0.013
0.587CysVal: 0.587 ± 0.015
0.192CysTrp: 0.192 ± 0.009
0.234CysTyr: 0.234 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.42AspAla: 7.42 ± 0.071
0.467AspCys: 0.467 ± 0.016
4.511AspAsp: 4.511 ± 0.053
4.461AspGlu: 4.461 ± 0.053
1.977AspPhe: 1.977 ± 0.034
6.824AspGly: 6.824 ± 0.083
1.491AspHis: 1.491 ± 0.023
1.468AspIle: 1.468 ± 0.025
0.729AspLys: 0.729 ± 0.02
7.234AspLeu: 7.234 ± 0.067
0.701AspMet: 0.701 ± 0.018
0.888AspAsn: 0.888 ± 0.022
6.144AspPro: 6.144 ± 0.071
1.666AspGln: 1.666 ± 0.031
7.925AspArg: 7.925 ± 0.073
2.702AspSer: 2.702 ± 0.034
1.995AspThr: 1.995 ± 0.035
3.959AspVal: 3.959 ± 0.045
1.072AspTrp: 1.072 ± 0.024
1.351AspTyr: 1.351 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
9.123GluAla: 9.123 ± 0.085
0.382GluCys: 0.382 ± 0.015
3.312GluAsp: 3.312 ± 0.039
3.884GluGlu: 3.884 ± 0.05
1.926GluPhe: 1.926 ± 0.03
5.949GluGly: 5.949 ± 0.047
1.419GluHis: 1.419 ± 0.028
2.447GluIle: 2.447 ± 0.037
1.27GluLys: 1.27 ± 0.029
6.253GluLeu: 6.253 ± 0.053
1.052GluMet: 1.052 ± 0.023
1.017GluAsn: 1.017 ± 0.022
4.457GluPro: 4.457 ± 0.051
2.28GluGln: 2.28 ± 0.031
5.251GluArg: 5.251 ± 0.054
3.25GluSer: 3.25 ± 0.032
2.69GluThr: 2.69 ± 0.035
5.243GluVal: 5.243 ± 0.053
0.766GluTrp: 0.766 ± 0.02
1.155GluTyr: 1.155 ± 0.019
0.0GluXaa: 0.0 ± 0.0
Phe
3.518PheAla: 3.518 ± 0.038
0.301PheCys: 0.301 ± 0.011
2.691PheAsp: 2.691 ± 0.035
2.338PheGlu: 2.338 ± 0.034
1.085PhePhe: 1.085 ± 0.022
3.393PheGly: 3.393 ± 0.044
0.689PheHis: 0.689 ± 0.016
0.942PheIle: 0.942 ± 0.02
0.546PheLys: 0.546 ± 0.016
3.377PheLeu: 3.377 ± 0.039
0.428PheMet: 0.428 ± 0.014
0.772PheAsn: 0.772 ± 0.019
1.757PhePro: 1.757 ± 0.027
0.786PheGln: 0.786 ± 0.017
2.81PheArg: 2.81 ± 0.037
1.896PheSer: 1.896 ± 0.03
1.462PheThr: 1.462 ± 0.024
2.461PheVal: 2.461 ± 0.033
0.468PheTrp: 0.468 ± 0.016
0.746PheTyr: 0.746 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
8.752GlyAla: 8.752 ± 0.078
0.9GlyCys: 0.9 ± 0.021
5.97GlyAsp: 5.97 ± 0.062
5.783GlyGlu: 5.783 ± 0.047
3.243GlyPhe: 3.243 ± 0.043
9.84GlyGly: 9.84 ± 0.108
2.062GlyHis: 2.062 ± 0.031
3.693GlyIle: 3.693 ± 0.04
2.251GlyLys: 2.251 ± 0.035
10.214GlyLeu: 10.214 ± 0.077
2.171GlyMet: 2.171 ± 0.04
1.961GlyAsn: 1.961 ± 0.081
7.113GlyPro: 7.113 ± 0.074
2.721GlyGln: 2.721 ± 0.043
9.809GlyArg: 9.809 ± 0.077
5.695GlySer: 5.695 ± 0.058
4.91GlyThr: 4.91 ± 0.058
6.763GlyVal: 6.763 ± 0.069
1.686GlyTrp: 1.686 ± 0.029
2.112GlyTyr: 2.112 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.026HisAla: 2.026 ± 0.031
0.246HisCys: 0.246 ± 0.01
1.225HisAsp: 1.225 ± 0.022
1.119HisGlu: 1.119 ± 0.022
0.7HisPhe: 0.7 ± 0.018
1.876HisGly: 1.876 ± 0.031
0.618HisHis: 0.618 ± 0.017
0.533HisIle: 0.533 ± 0.016
0.32HisLys: 0.32 ± 0.011
2.302HisLeu: 2.302 ± 0.033
0.267HisMet: 0.267 ± 0.01
0.404HisAsn: 0.404 ± 0.014
1.724HisPro: 1.724 ± 0.029
0.512HisGln: 0.512 ± 0.015
2.093HisArg: 2.093 ± 0.031
0.892HisSer: 0.892 ± 0.02
0.704HisThr: 0.704 ± 0.017
1.362HisVal: 1.362 ± 0.025
0.39HisTrp: 0.39 ± 0.011
0.514HisTyr: 0.514 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
4.968IleAla: 4.968 ± 0.046
0.368IleCys: 0.368 ± 0.012
3.29IleAsp: 3.29 ± 0.038
2.924IleGlu: 2.924 ± 0.035
1.063IlePhe: 1.063 ± 0.02
4.09IleGly: 4.09 ± 0.055
0.716IleHis: 0.716 ± 0.018
1.183IleIle: 1.183 ± 0.025
0.806IleLys: 0.806 ± 0.019
3.69IleLeu: 3.69 ± 0.042
0.439IleMet: 0.439 ± 0.012
0.894IleAsn: 0.894 ± 0.019
2.55IlePro: 2.55 ± 0.032
0.9IleGln: 0.9 ± 0.02
3.809IleArg: 3.809 ± 0.039
1.903IleSer: 1.903 ± 0.031
1.781IleThr: 1.781 ± 0.027
2.914IleVal: 2.914 ± 0.037
0.496IleTrp: 0.496 ± 0.015
0.84IleTyr: 0.84 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
2.604LysAla: 2.604 ± 0.04
0.138LysCys: 0.138 ± 0.007
1.099LysAsp: 1.099 ± 0.024
1.096LysGlu: 1.096 ± 0.025
0.56LysPhe: 0.56 ± 0.016
1.744LysGly: 1.744 ± 0.033
0.404LysHis: 0.404 ± 0.015
0.838LysIle: 0.838 ± 0.022
0.695LysLys: 0.695 ± 0.022
1.97LysLeu: 1.97 ± 0.03
0.337LysMet: 0.337 ± 0.011
0.426LysAsn: 0.426 ± 0.014
1.353LysPro: 1.353 ± 0.027
0.624LysGln: 0.624 ± 0.016
1.527LysArg: 1.527 ± 0.026
1.017LysSer: 1.017 ± 0.022
1.033LysThr: 1.033 ± 0.022
1.688LysVal: 1.688 ± 0.035
0.236LysTrp: 0.236 ± 0.01
0.484LysTyr: 0.484 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
13.791LeuAla: 13.791 ± 0.109
0.926LeuCys: 0.926 ± 0.02
7.571LeuAsp: 7.571 ± 0.067
5.871LeuGlu: 5.871 ± 0.059
2.943LeuPhe: 2.943 ± 0.042
10.274LeuGly: 10.274 ± 0.077
1.798LeuHis: 1.798 ± 0.032
4.304LeuIle: 4.304 ± 0.045
2.304LeuLys: 2.304 ± 0.031
10.534LeuLeu: 10.534 ± 0.093
1.756LeuMet: 1.756 ± 0.029
1.947LeuAsn: 1.947 ± 0.032
6.247LeuPro: 6.247 ± 0.052
2.139LeuGln: 2.139 ± 0.031
8.663LeuArg: 8.663 ± 0.071
5.483LeuSer: 5.483 ± 0.042
4.705LeuThr: 4.705 ± 0.045
8.055LeuVal: 8.055 ± 0.065
1.325LeuTrp: 1.325 ± 0.028
1.996LeuTyr: 1.996 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.437MetAla: 2.437 ± 0.035
0.109MetCys: 0.109 ± 0.006
0.959MetAsp: 0.959 ± 0.021
0.897MetGlu: 0.897 ± 0.019
0.443MetPhe: 0.443 ± 0.014
1.541MetGly: 1.541 ± 0.03
0.327MetHis: 0.327 ± 0.01
0.955MetIle: 0.955 ± 0.02
0.515MetLys: 0.515 ± 0.015
1.857MetLeu: 1.857 ± 0.031
0.402MetMet: 0.402 ± 0.015
0.501MetAsn: 0.501 ± 0.013
1.391MetPro: 1.391 ± 0.025
0.461MetGln: 0.461 ± 0.014
1.366MetArg: 1.366 ± 0.024
1.136MetSer: 1.136 ± 0.022
1.294MetThr: 1.294 ± 0.024
1.223MetVal: 1.223 ± 0.025
0.142MetTrp: 0.142 ± 0.008
0.25MetTyr: 0.25 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.116AsnAla: 2.116 ± 0.036
0.198AsnCys: 0.198 ± 0.009
1.126AsnAsp: 1.126 ± 0.026
0.957AsnGlu: 0.957 ± 0.022
0.715AsnPhe: 0.715 ± 0.018
1.707AsnGly: 1.707 ± 0.033
0.432AsnHis: 0.432 ± 0.013
0.683AsnIle: 0.683 ± 0.017
0.329AsnLys: 0.329 ± 0.012
2.222AsnLeu: 2.222 ± 0.042
0.301AsnMet: 0.301 ± 0.011
0.534AsnAsn: 0.534 ± 0.019
1.675AsnPro: 1.675 ± 0.026
0.573AsnGln: 0.573 ± 0.016
1.741AsnArg: 1.741 ± 0.028
0.949AsnSer: 0.949 ± 0.025
0.923AsnThr: 0.923 ± 0.031
1.417AsnVal: 1.417 ± 0.03
0.32AsnTrp: 0.32 ± 0.011
0.539AsnTyr: 0.539 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
7.786ProAla: 7.786 ± 0.074
0.416ProCys: 0.416 ± 0.014
5.731ProAsp: 5.731 ± 0.057
5.792ProGlu: 5.792 ± 0.055
2.059ProPhe: 2.059 ± 0.03
8.606ProGly: 8.606 ± 0.09
1.124ProHis: 1.124 ± 0.023
3.069ProIle: 3.069 ± 0.031
1.295ProLys: 1.295 ± 0.023
5.108ProLeu: 5.108 ± 0.044
1.475ProMet: 1.475 ± 0.024
1.348ProAsn: 1.348 ± 0.027
5.534ProPro: 5.534 ± 0.079
1.35ProGln: 1.35 ± 0.032
4.994ProArg: 4.994 ± 0.051
4.396ProSer: 4.396 ± 0.049
3.555ProThr: 3.555 ± 0.045
4.66ProVal: 4.66 ± 0.045
0.937ProTrp: 0.937 ± 0.019
1.222ProTyr: 1.222 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
3.403GlnAla: 3.403 ± 0.048
0.232GlnCys: 0.232 ± 0.009
1.295GlnAsp: 1.295 ± 0.027
1.398GlnGlu: 1.398 ± 0.025
0.935GlnPhe: 0.935 ± 0.021
2.321GlnGly: 2.321 ± 0.038
0.501GlnHis: 0.501 ± 0.014
1.096GlnIle: 1.096 ± 0.021
0.55GlnLys: 0.55 ± 0.018
2.482GlnLeu: 2.482 ± 0.037
0.509GlnMet: 0.509 ± 0.012
0.482GlnAsn: 0.482 ± 0.017
1.487GlnPro: 1.487 ± 0.027
0.907GlnGln: 0.907 ± 0.028
1.843GlnArg: 1.843 ± 0.027
1.321GlnSer: 1.321 ± 0.024
1.083GlnThr: 1.083 ± 0.021
2.252GlnVal: 2.252 ± 0.036
0.341GlnTrp: 0.341 ± 0.012
0.562GlnTyr: 0.562 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
9.314ArgAla: 9.314 ± 0.072
0.823ArgCys: 0.823 ± 0.021
5.238ArgAsp: 5.238 ± 0.05
5.159ArgGlu: 5.159 ± 0.049
3.387ArgPhe: 3.387 ± 0.032
7.06ArgGly: 7.06 ± 0.058
1.961ArgHis: 1.961 ± 0.033
3.888ArgIle: 3.888 ± 0.045
1.835ArgLys: 1.835 ± 0.029
10.173ArgLeu: 10.173 ± 0.086
1.855ArgMet: 1.855 ± 0.028
1.604ArgAsn: 1.604 ± 0.026
6.873ArgPro: 6.873 ± 0.071
2.396ArgGln: 2.396 ± 0.033
9.564ArgArg: 9.564 ± 0.082
5.502ArgSer: 5.502 ± 0.053
3.861ArgThr: 3.861 ± 0.041
6.373ArgVal: 6.373 ± 0.061
1.704ArgTrp: 1.704 ± 0.03
1.979ArgTyr: 1.979 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.033SerAla: 6.033 ± 0.056
0.568SerCys: 0.568 ± 0.015
2.957SerAsp: 2.957 ± 0.035
2.734SerGlu: 2.734 ± 0.033
1.835SerPhe: 1.835 ± 0.027
6.346SerGly: 6.346 ± 0.068
1.05SerHis: 1.05 ± 0.022
2.454SerIle: 2.454 ± 0.029
1.195SerLys: 1.195 ± 0.021
5.19SerLeu: 5.19 ± 0.041
1.108SerMet: 1.108 ± 0.02
1.255SerAsn: 1.255 ± 0.023
4.567SerPro: 4.567 ± 0.059
1.355SerGln: 1.355 ± 0.023
4.882SerArg: 4.882 ± 0.05
3.145SerSer: 3.145 ± 0.041
2.912SerThr: 2.912 ± 0.035
3.571SerVal: 3.571 ± 0.04
1.035SerTrp: 1.035 ± 0.021
1.422SerTyr: 1.422 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
4.882ThrAla: 4.882 ± 0.061
0.432ThrCys: 0.432 ± 0.013
2.616ThrAsp: 2.616 ± 0.034
2.211ThrGlu: 2.211 ± 0.029
1.816ThrPhe: 1.816 ± 0.031
4.655ThrGly: 4.655 ± 0.044
0.841ThrHis: 0.841 ± 0.019
2.505ThrIle: 2.505 ± 0.039
0.869ThrLys: 0.869 ± 0.023
5.226ThrLeu: 5.226 ± 0.053
0.817ThrMet: 0.817 ± 0.016
0.99ThrAsn: 0.99 ± 0.022
3.595ThrPro: 3.595 ± 0.052
0.947ThrGln: 0.947 ± 0.019
3.49ThrArg: 3.49 ± 0.038
2.457ThrSer: 2.457 ± 0.033
2.492ThrThr: 2.492 ± 0.041
3.609ThrVal: 3.609 ± 0.043
0.739ThrTrp: 0.739 ± 0.019
1.11ThrTyr: 1.11 ± 0.023
0.0ThrXaa: 0.0 ± 0.0
Val
9.047ValAla: 9.047 ± 0.065
0.64ValCys: 0.64 ± 0.018
4.923ValAsp: 4.923 ± 0.048
5.419ValGlu: 5.419 ± 0.054
2.218ValPhe: 2.218 ± 0.03
6.674ValGly: 6.674 ± 0.049
1.317ValHis: 1.317 ± 0.021
2.976ValIle: 2.976 ± 0.04
1.366ValLys: 1.366 ± 0.028
7.636ValLeu: 7.636 ± 0.063
1.154ValMet: 1.154 ± 0.026
1.46ValAsn: 1.46 ± 0.028
4.703ValPro: 4.703 ± 0.053
1.631ValGln: 1.631 ± 0.029
6.099ValArg: 6.099 ± 0.052
4.156ValSer: 4.156 ± 0.043
3.524ValThr: 3.524 ± 0.047
6.97ValVal: 6.97 ± 0.063
0.818ValTrp: 0.818 ± 0.022
1.429ValTyr: 1.429 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
1.601TrpAla: 1.601 ± 0.03
0.174TrpCys: 0.174 ± 0.008
1.033TrpAsp: 1.033 ± 0.027
0.82TrpGlu: 0.82 ± 0.02
0.514TrpPhe: 0.514 ± 0.014
1.149TrpGly: 1.149 ± 0.02
0.362TrpHis: 0.362 ± 0.014
0.622TrpIle: 0.622 ± 0.014
0.337TrpLys: 0.337 ± 0.011
1.727TrpLeu: 1.727 ± 0.035
0.322TrpMet: 0.322 ± 0.012
0.332TrpAsn: 0.332 ± 0.012
0.863TrpPro: 0.863 ± 0.02
0.439TrpGln: 0.439 ± 0.014
1.332TrpArg: 1.332 ± 0.023
0.981TrpSer: 0.981 ± 0.021
0.791TrpThr: 0.791 ± 0.019
1.034TrpVal: 1.034 ± 0.019
0.286TrpTrp: 0.286 ± 0.011
0.339TrpTyr: 0.339 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.143TyrAla: 2.143 ± 0.028
0.259TyrCys: 0.259 ± 0.008
1.431TyrAsp: 1.431 ± 0.027
1.328TyrGlu: 1.328 ± 0.027
0.813TyrPhe: 0.813 ± 0.02
1.93TyrGly: 1.93 ± 0.035
0.587TyrHis: 0.587 ± 0.016
0.563TyrIle: 0.563 ± 0.017
0.412TyrLys: 0.412 ± 0.013
2.308TyrLeu: 2.308 ± 0.033
0.31TyrMet: 0.31 ± 0.011
0.5TyrAsn: 0.5 ± 0.016
1.19TyrPro: 1.19 ± 0.025
0.68TyrGln: 0.68 ± 0.017
2.283TyrArg: 2.283 ± 0.033
1.031TyrSer: 1.031 ± 0.019
0.908TyrThr: 0.908 ± 0.021
1.44TyrVal: 1.44 ± 0.024
0.344TyrTrp: 0.344 ± 0.012
0.626TyrTyr: 0.626 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7326 proteins (2572131 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski