Amino acid dipepetide frequency for Negativicoccus succinicivorans DORA_17_25

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.227AlaAla: 11.227 ± 0.221
0.787AlaCys: 0.787 ± 0.053
5.586AlaAsp: 5.586 ± 0.11
6.542AlaGlu: 6.542 ± 0.155
3.165AlaPhe: 3.165 ± 0.104
7.37AlaGly: 7.37 ± 0.152
1.807AlaHis: 1.807 ± 0.068
5.899AlaIle: 5.899 ± 0.143
5.208AlaLys: 5.208 ± 0.13
10.178AlaLeu: 10.178 ± 0.179
2.603AlaMet: 2.603 ± 0.08
3.042AlaAsn: 3.042 ± 0.093
3.294AlaPro: 3.294 ± 0.108
4.689AlaGln: 4.689 ± 0.132
5.143AlaArg: 5.143 ± 0.109
3.861AlaSer: 3.861 ± 0.105
5.22AlaThr: 5.22 ± 0.111
7.377AlaVal: 7.377 ± 0.162
0.92AlaTrp: 0.92 ± 0.053
2.92AlaTyr: 2.92 ± 0.073
0.007AlaXaa: 0.007 ± 0.004
Cys
0.812CysAla: 0.812 ± 0.044
0.137CysCys: 0.137 ± 0.023
0.542CysAsp: 0.542 ± 0.033
0.565CysGlu: 0.565 ± 0.039
0.36CysPhe: 0.36 ± 0.029
1.017CysGly: 1.017 ± 0.054
0.223CysHis: 0.223 ± 0.023
0.612CysIle: 0.612 ± 0.04
0.382CysLys: 0.382 ± 0.03
0.774CysLeu: 0.774 ± 0.04
0.205CysMet: 0.205 ± 0.02
0.295CysAsn: 0.295 ± 0.03
0.443CysPro: 0.443 ± 0.033
0.29CysGln: 0.29 ± 0.03
0.567CysArg: 0.567 ± 0.036
0.463CysSer: 0.463 ± 0.033
0.515CysThr: 0.515 ± 0.038
0.668CysVal: 0.668 ± 0.044
0.072CysTrp: 0.072 ± 0.014
0.362CysTyr: 0.362 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
5.035AspAla: 5.035 ± 0.101
0.454AspCys: 0.454 ± 0.033
2.833AspAsp: 2.833 ± 0.103
4.079AspGlu: 4.079 ± 0.118
2.308AspPhe: 2.308 ± 0.081
4.122AspGly: 4.122 ± 0.103
1.057AspHis: 1.057 ± 0.06
3.928AspIle: 3.928 ± 0.103
2.776AspLys: 2.776 ± 0.119
5.217AspLeu: 5.217 ± 0.11
1.332AspMet: 1.332 ± 0.056
1.888AspAsn: 1.888 ± 0.069
2.194AspPro: 2.194 ± 0.071
1.449AspGln: 1.449 ± 0.056
3.046AspArg: 3.046 ± 0.084
2.286AspSer: 2.286 ± 0.083
3.035AspThr: 3.035 ± 0.08
4.196AspVal: 4.196 ± 0.108
0.652AspTrp: 0.652 ± 0.039
2.203AspTyr: 2.203 ± 0.08
0.002AspXaa: 0.002 ± 0.003
Glu
5.865GluAla: 5.865 ± 0.126
0.445GluCys: 0.445 ± 0.033
3.408GluAsp: 3.408 ± 0.101
5.339GluGlu: 5.339 ± 0.145
2.212GluPhe: 2.212 ± 0.076
3.773GluGly: 3.773 ± 0.101
1.411GluHis: 1.411 ± 0.06
4.86GluIle: 4.86 ± 0.118
4.479GluLys: 4.479 ± 0.102
6.497GluLeu: 6.497 ± 0.137
2.124GluMet: 2.124 ± 0.082
3.064GluAsn: 3.064 ± 0.108
2.088GluPro: 2.088 ± 0.075
2.763GluGln: 2.763 ± 0.077
4.513GluArg: 4.513 ± 0.099
2.846GluSer: 2.846 ± 0.086
3.802GluThr: 3.802 ± 0.099
4.695GluVal: 4.695 ± 0.122
0.794GluTrp: 0.794 ± 0.038
2.324GluTyr: 2.324 ± 0.087
0.009GluXaa: 0.009 ± 0.004
Phe
3.489PheAla: 3.489 ± 0.108
0.452PheCys: 0.452 ± 0.035
1.957PheAsp: 1.957 ± 0.066
1.82PheGlu: 1.82 ± 0.071
1.649PhePhe: 1.649 ± 0.076
3.1PheGly: 3.1 ± 0.108
0.738PheHis: 0.738 ± 0.043
2.653PheIle: 2.653 ± 0.089
1.492PheLys: 1.492 ± 0.065
3.609PheLeu: 3.609 ± 0.11
0.985PheMet: 0.985 ± 0.054
1.323PheAsn: 1.323 ± 0.055
1.384PhePro: 1.384 ± 0.053
1.035PheGln: 1.035 ± 0.04
1.852PheArg: 1.852 ± 0.069
2.209PheSer: 2.209 ± 0.078
2.446PheThr: 2.446 ± 0.076
2.614PheVal: 2.614 ± 0.08
0.495PheTrp: 0.495 ± 0.038
1.305PheTyr: 1.305 ± 0.055
0.002PheXaa: 0.002 ± 0.003
Gly
6.605GlyAla: 6.605 ± 0.17
0.81GlyCys: 0.81 ± 0.05
3.755GlyAsp: 3.755 ± 0.103
4.459GlyGlu: 4.459 ± 0.101
2.734GlyPhe: 2.734 ± 0.076
4.968GlyGly: 4.968 ± 0.137
1.573GlyHis: 1.573 ± 0.059
5.474GlyIle: 5.474 ± 0.127
4.504GlyLys: 4.504 ± 0.114
6.515GlyLeu: 6.515 ± 0.134
2.151GlyMet: 2.151 ± 0.081
2.601GlyAsn: 2.601 ± 0.101
1.825GlyPro: 1.825 ± 0.077
2.191GlyGln: 2.191 ± 0.082
3.816GlyArg: 3.816 ± 0.104
3.705GlySer: 3.705 ± 0.093
4.662GlyThr: 4.662 ± 0.109
5.757GlyVal: 5.757 ± 0.118
0.72GlyTrp: 0.72 ± 0.046
2.819GlyTyr: 2.819 ± 0.08
0.02GlyXaa: 0.02 ± 0.008
His
1.915HisAla: 1.915 ± 0.069
0.243HisCys: 0.243 ± 0.025
1.129HisAsp: 1.129 ± 0.058
1.188HisGlu: 1.188 ± 0.056
0.913HisPhe: 0.913 ± 0.051
1.528HisGly: 1.528 ± 0.064
0.538HisHis: 0.538 ± 0.045
1.327HisIle: 1.327 ± 0.06
0.904HisLys: 0.904 ± 0.053
1.975HisLeu: 1.975 ± 0.074
0.497HisMet: 0.497 ± 0.032
0.695HisAsn: 0.695 ± 0.034
1.109HisPro: 1.109 ± 0.055
0.643HisGln: 0.643 ± 0.038
1.195HisArg: 1.195 ± 0.051
0.97HisSer: 0.97 ± 0.054
1.107HisThr: 1.107 ± 0.052
1.521HisVal: 1.521 ± 0.058
0.279HisTrp: 0.279 ± 0.023
0.837HisTyr: 0.837 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.626IleAla: 6.626 ± 0.141
0.808IleCys: 0.808 ± 0.048
3.858IleAsp: 3.858 ± 0.095
3.908IleGlu: 3.908 ± 0.122
2.385IlePhe: 2.385 ± 0.079
5.463IleGly: 5.463 ± 0.146
1.341IleHis: 1.341 ± 0.054
4.612IleIle: 4.612 ± 0.131
3.161IleLys: 3.161 ± 0.107
6.241IleLeu: 6.241 ± 0.142
1.602IleMet: 1.602 ± 0.06
2.664IleAsn: 2.664 ± 0.103
2.853IlePro: 2.853 ± 0.075
1.917IleGln: 1.917 ± 0.067
3.352IleArg: 3.352 ± 0.097
3.84IleSer: 3.84 ± 0.11
3.874IleThr: 3.874 ± 0.103
5.01IleVal: 5.01 ± 0.103
0.596IleTrp: 0.596 ± 0.038
2.239IleTyr: 2.239 ± 0.084
0.004IleXaa: 0.004 ± 0.003
Lys
4.63LysAla: 4.63 ± 0.115
0.351LysCys: 0.351 ± 0.027
3.114LysAsp: 3.114 ± 0.106
4.527LysGlu: 4.527 ± 0.116
1.408LysPhe: 1.408 ± 0.054
3.136LysGly: 3.136 ± 0.082
0.956LysHis: 0.956 ± 0.047
3.87LysIle: 3.87 ± 0.12
4.063LysLys: 4.063 ± 0.119
4.538LysLeu: 4.538 ± 0.108
1.723LysMet: 1.723 ± 0.064
2.824LysAsn: 2.824 ± 0.104
1.649LysPro: 1.649 ± 0.065
2.108LysGln: 2.108 ± 0.073
2.886LysArg: 2.886 ± 0.079
2.641LysSer: 2.641 ± 0.087
3.222LysThr: 3.222 ± 0.102
3.876LysVal: 3.876 ± 0.118
0.54LysTrp: 0.54 ± 0.039
2.065LysTyr: 2.065 ± 0.076
0.007LysXaa: 0.007 ± 0.004
Leu
11.193LeuAla: 11.193 ± 0.197
1.143LeuCys: 1.143 ± 0.054
4.86LeuAsp: 4.86 ± 0.097
5.544LeuGlu: 5.544 ± 0.118
3.651LeuPhe: 3.651 ± 0.123
7.024LeuGly: 7.024 ± 0.171
2.009LeuHis: 2.009 ± 0.075
5.629LeuIle: 5.629 ± 0.136
4.389LeuLys: 4.389 ± 0.112
10.023LeuLeu: 10.023 ± 0.211
2.151LeuMet: 2.151 ± 0.081
3.361LeuAsn: 3.361 ± 0.082
4.704LeuPro: 4.704 ± 0.122
4.074LeuGln: 4.074 ± 0.103
5.674LeuArg: 5.674 ± 0.124
5.13LeuSer: 5.13 ± 0.112
6.376LeuThr: 6.376 ± 0.119
6.646LeuVal: 6.646 ± 0.129
0.922LeuTrp: 0.922 ± 0.054
3.084LeuTyr: 3.084 ± 0.087
0.02LeuXaa: 0.02 ± 0.007
Met
2.657MetAla: 2.657 ± 0.085
0.173MetCys: 0.173 ± 0.019
1.273MetAsp: 1.273 ± 0.054
1.543MetGlu: 1.543 ± 0.056
0.772MetPhe: 0.772 ± 0.044
1.755MetGly: 1.755 ± 0.078
0.58MetHis: 0.58 ± 0.036
1.649MetIle: 1.649 ± 0.069
1.692MetLys: 1.692 ± 0.055
2.497MetLeu: 2.497 ± 0.081
0.763MetMet: 0.763 ± 0.045
1.109MetAsn: 1.109 ± 0.049
1.143MetPro: 1.143 ± 0.048
1.336MetGln: 1.336 ± 0.06
1.501MetArg: 1.501 ± 0.065
1.37MetSer: 1.37 ± 0.054
1.741MetThr: 1.741 ± 0.071
1.735MetVal: 1.735 ± 0.069
0.205MetTrp: 0.205 ± 0.023
0.821MetTyr: 0.821 ± 0.048
0.004MetXaa: 0.004 ± 0.003
Asn
3.179AsnAla: 3.179 ± 0.092
0.326AsnCys: 0.326 ± 0.03
2.047AsnAsp: 2.047 ± 0.069
2.657AsnGlu: 2.657 ± 0.088
1.388AsnPhe: 1.388 ± 0.061
2.704AsnGly: 2.704 ± 0.105
0.668AsnHis: 0.668 ± 0.037
3.021AsnIle: 3.021 ± 0.096
2.349AsnLys: 2.349 ± 0.099
3.372AsnLeu: 3.372 ± 0.098
1.019AsnMet: 1.019 ± 0.045
1.766AsnAsn: 1.766 ± 0.112
1.737AsnPro: 1.737 ± 0.063
1.255AsnGln: 1.255 ± 0.067
2.007AsnArg: 2.007 ± 0.074
1.692AsnSer: 1.692 ± 0.089
2.099AsnThr: 2.099 ± 0.09
2.673AsnVal: 2.673 ± 0.08
0.396AsnTrp: 0.396 ± 0.031
1.496AsnTyr: 1.496 ± 0.072
0.002AsnXaa: 0.002 ± 0.002
Pro
3.771ProAla: 3.771 ± 0.097
0.319ProCys: 0.319 ± 0.029
2.295ProAsp: 2.295 ± 0.084
3.213ProGlu: 3.213 ± 0.095
1.627ProPhe: 1.627 ± 0.057
2.677ProGly: 2.677 ± 0.087
0.97ProHis: 0.97 ± 0.049
2.284ProIle: 2.284 ± 0.068
1.813ProLys: 1.813 ± 0.061
4.095ProLeu: 4.095 ± 0.102
0.893ProMet: 0.893 ± 0.048
1.408ProAsn: 1.408 ± 0.059
1.233ProPro: 1.233 ± 0.056
1.991ProGln: 1.991 ± 0.069
1.813ProArg: 1.813 ± 0.074
1.827ProSer: 1.827 ± 0.069
2.209ProThr: 2.209 ± 0.064
3.066ProVal: 3.066 ± 0.094
0.389ProTrp: 0.389 ± 0.033
1.426ProTyr: 1.426 ± 0.054
0.007ProXaa: 0.007 ± 0.004
Gln
4.115GlnAla: 4.115 ± 0.118
0.252GlnCys: 0.252 ± 0.024
1.683GlnAsp: 1.683 ± 0.057
2.99GlnGlu: 2.99 ± 0.084
1.096GlnPhe: 1.096 ± 0.049
2.36GlnGly: 2.36 ± 0.07
0.74GlnHis: 0.74 ± 0.039
2.425GlnIle: 2.425 ± 0.064
2.432GlnLys: 2.432 ± 0.084
3.375GlnLeu: 3.375 ± 0.092
1.179GlnMet: 1.179 ± 0.055
1.627GlnAsn: 1.627 ± 0.057
1.471GlnPro: 1.471 ± 0.069
2.005GlnGln: 2.005 ± 0.124
2.275GlnArg: 2.275 ± 0.072
1.8GlnSer: 1.8 ± 0.073
2.326GlnThr: 2.326 ± 0.076
2.473GlnVal: 2.473 ± 0.077
0.49GlnTrp: 0.49 ± 0.039
1.296GlnTyr: 1.296 ± 0.056
0.009GlnXaa: 0.009 ± 0.005
Arg
4.848ArgAla: 4.848 ± 0.107
0.43ArgCys: 0.43 ± 0.031
3.06ArgAsp: 3.06 ± 0.095
4.493ArgGlu: 4.493 ± 0.109
2.194ArgPhe: 2.194 ± 0.071
3.514ArgGly: 3.514 ± 0.097
1.249ArgHis: 1.249 ± 0.056
3.384ArgIle: 3.384 ± 0.096
3.046ArgLys: 3.046 ± 0.077
5.598ArgLeu: 5.598 ± 0.131
1.471ArgMet: 1.471 ± 0.06
1.854ArgAsn: 1.854 ± 0.061
2.191ArgPro: 2.191 ± 0.086
2.416ArgGln: 2.416 ± 0.077
3.678ArgArg: 3.678 ± 0.111
2.567ArgSer: 2.567 ± 0.084
2.761ArgThr: 2.761 ± 0.072
3.762ArgVal: 3.762 ± 0.096
0.731ArgTrp: 0.731 ± 0.042
2.223ArgTyr: 2.223 ± 0.07
0.009ArgXaa: 0.009 ± 0.005
Ser
4.153SerAla: 4.153 ± 0.094
0.387SerCys: 0.387 ± 0.028
2.662SerAsp: 2.662 ± 0.094
3.116SerGlu: 3.116 ± 0.085
2.104SerPhe: 2.104 ± 0.067
4.135SerGly: 4.135 ± 0.103
1.033SerHis: 1.033 ± 0.046
3.249SerIle: 3.249 ± 0.095
2.464SerLys: 2.464 ± 0.088
5.035SerLeu: 5.035 ± 0.1
1.233SerMet: 1.233 ± 0.053
1.735SerAsn: 1.735 ± 0.096
1.921SerPro: 1.921 ± 0.063
1.773SerGln: 1.773 ± 0.064
2.527SerArg: 2.527 ± 0.072
2.524SerSer: 2.524 ± 0.103
2.421SerThr: 2.421 ± 0.072
3.739SerVal: 3.739 ± 0.1
0.574SerTrp: 0.574 ± 0.036
1.791SerTyr: 1.791 ± 0.06
0.004SerXaa: 0.004 ± 0.003
Thr
5.69ThrAla: 5.69 ± 0.111
0.468ThrCys: 0.468 ± 0.036
3.366ThrAsp: 3.366 ± 0.096
3.849ThrGlu: 3.849 ± 0.099
1.876ThrPhe: 1.876 ± 0.072
4.493ThrGly: 4.493 ± 0.109
1.183ThrHis: 1.183 ± 0.043
3.933ThrIle: 3.933 ± 0.096
3.069ThrLys: 3.069 ± 0.1
6.047ThrLeu: 6.047 ± 0.118
1.485ThrMet: 1.485 ± 0.049
2.052ThrAsn: 2.052 ± 0.089
3.035ThrPro: 3.035 ± 0.084
2.09ThrGln: 2.09 ± 0.068
2.662ThrArg: 2.662 ± 0.083
2.653ThrSer: 2.653 ± 0.089
3.282ThrThr: 3.282 ± 0.103
5.004ThrVal: 5.004 ± 0.113
0.594ThrTrp: 0.594 ± 0.037
2.005ThrTyr: 2.005 ± 0.093
0.004ThrXaa: 0.004 ± 0.003
Val
7.393ValAla: 7.393 ± 0.156
0.794ValCys: 0.794 ± 0.044
3.933ValAsp: 3.933 ± 0.097
4.511ValGlu: 4.511 ± 0.1
2.725ValPhe: 2.725 ± 0.086
5.163ValGly: 5.163 ± 0.107
1.366ValHis: 1.366 ± 0.057
4.767ValIle: 4.767 ± 0.096
3.649ValLys: 3.649 ± 0.096
7.159ValLeu: 7.159 ± 0.129
1.912ValMet: 1.912 ± 0.064
2.619ValAsn: 2.619 ± 0.084
3.204ValPro: 3.204 ± 0.089
2.322ValGln: 2.322 ± 0.076
3.946ValArg: 3.946 ± 0.107
3.899ValSer: 3.899 ± 0.089
5.285ValThr: 5.285 ± 0.116
5.663ValVal: 5.663 ± 0.126
0.675ValTrp: 0.675 ± 0.049
2.428ValTyr: 2.428 ± 0.078
0.004ValXaa: 0.004 ± 0.004
Trp
0.686TrpAla: 0.686 ± 0.044
0.115TrpCys: 0.115 ± 0.015
0.61TrpAsp: 0.61 ± 0.041
0.742TrpGlu: 0.742 ± 0.04
0.38TrpPhe: 0.38 ± 0.03
0.619TrpGly: 0.619 ± 0.043
0.277TrpHis: 0.277 ± 0.026
0.477TrpIle: 0.477 ± 0.032
0.517TrpLys: 0.517 ± 0.037
1.287TrpLeu: 1.287 ± 0.059
0.229TrpMet: 0.229 ± 0.02
0.463TrpAsn: 0.463 ± 0.032
0.416TrpPro: 0.416 ± 0.031
0.857TrpGln: 0.857 ± 0.051
0.763TrpArg: 0.763 ± 0.049
0.542TrpSer: 0.542 ± 0.035
0.502TrpThr: 0.502 ± 0.036
0.628TrpVal: 0.628 ± 0.037
0.259TrpTrp: 0.259 ± 0.029
0.337TrpTyr: 0.337 ± 0.026
0.004TrpXaa: 0.004 ± 0.003
Tyr
2.949TyrAla: 2.949 ± 0.082
0.405TyrCys: 0.405 ± 0.027
2.113TyrAsp: 2.113 ± 0.104
2.227TyrGlu: 2.227 ± 0.087
1.665TyrPhe: 1.665 ± 0.07
2.731TyrGly: 2.731 ± 0.085
0.792TyrHis: 0.792 ± 0.044
2.295TyrIle: 2.295 ± 0.073
1.744TyrLys: 1.744 ± 0.08
3.566TyrLeu: 3.566 ± 0.09
0.76TyrMet: 0.76 ± 0.045
1.462TyrAsn: 1.462 ± 0.072
1.424TyrPro: 1.424 ± 0.066
1.208TyrGln: 1.208 ± 0.054
2.248TyrArg: 2.248 ± 0.072
1.739TyrSer: 1.739 ± 0.074
1.942TyrThr: 1.942 ± 0.081
2.306TyrVal: 2.306 ± 0.066
0.405TyrTrp: 0.405 ± 0.027
1.519TyrTyr: 1.519 ± 0.066
0.004TyrXaa: 0.004 ± 0.003
Xaa
0.007XaaAla: 0.007 ± 0.004
0.004XaaCys: 0.004 ± 0.003
0.009XaaAsp: 0.009 ± 0.005
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.011XaaGly: 0.011 ± 0.005
0.004XaaHis: 0.004 ± 0.003
0.007XaaIle: 0.007 ± 0.004
0.0XaaLys: 0.0 ± 0.0
0.009XaaLeu: 0.009 ± 0.004
0.0XaaMet: 0.0 ± 0.0
0.004XaaAsn: 0.004 ± 0.003
0.009XaaPro: 0.009 ± 0.005
0.004XaaGln: 0.004 ± 0.003
0.016XaaArg: 0.016 ± 0.006
0.013XaaSer: 0.013 ± 0.006
0.013XaaThr: 0.013 ± 0.006
0.007XaaVal: 0.007 ± 0.004
0.002XaaTrp: 0.002 ± 0.002
0.004XaaTyr: 0.004 ± 0.003
0.992XaaXaa: 0.992 ± 0.148
Statistics based on 1679 proteins (444484 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski