Amino acid dipepetide frequency for Tenacibaculum sp. Bg11-29

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.427AlaAla: 3.427 ± 0.079	0.517AlaCys: 0.517 ± 0.025	2.883AlaAsp: 2.883 ± 0.064	3.161AlaGlu: 3.161 ± 0.063	2.95AlaPhe: 2.95 ± 0.051	3.666AlaGly: 3.666 ± 0.092	0.959AlaHis: 0.959 ± 0.032	5.438AlaIle: 5.438 ± 0.085	4.698AlaLys: 4.698 ± 0.073	5.29AlaLeu: 5.29 ± 0.082	1.225AlaMet: 1.225 ± 0.04	3.49AlaAsn: 3.49 ± 0.068	1.73AlaPro: 1.73 ± 0.047	1.876AlaGln: 1.876 ± 0.042	1.642AlaArg: 1.642 ± 0.044	3.994AlaSer: 3.994 ± 0.069	3.797AlaThr: 3.797 ± 0.088	3.572AlaVal: 3.572 ± 0.067	0.519AlaTrp: 0.519 ± 0.024	2.238AlaTyr: 2.238 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.425CysAla: 0.425 ± 0.024	0.102CysCys: 0.102 ± 0.01	0.444CysAsp: 0.444 ± 0.027	0.464CysGlu: 0.464 ± 0.025	0.424CysPhe: 0.424 ± 0.019	0.621CysGly: 0.621 ± 0.03	0.159CysHis: 0.159 ± 0.013	0.592CysIle: 0.592 ± 0.024	0.641CysLys: 0.641 ± 0.024	0.652CysLeu: 0.652 ± 0.022	0.136CysMet: 0.136 ± 0.011	0.513CysAsn: 0.513 ± 0.025	0.317CysPro: 0.317 ± 0.021	0.191CysGln: 0.191 ± 0.015	0.19CysArg: 0.19 ± 0.014	0.67CysSer: 0.67 ± 0.051	0.523CysThr: 0.523 ± 0.061	0.405CysVal: 0.405 ± 0.02	0.069CysTrp: 0.069 ± 0.007	0.296CysTyr: 0.296 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.198AspAla: 3.198 ± 0.061	0.423AspCys: 0.423 ± 0.029	2.666AspAsp: 2.666 ± 0.057	3.328AspGlu: 3.328 ± 0.062	3.42AspPhe: 3.42 ± 0.049	3.227AspGly: 3.227 ± 0.091	0.676AspHis: 0.676 ± 0.028	4.425AspIle: 4.425 ± 0.069	4.533AspLys: 4.533 ± 0.069	4.93AspLeu: 4.93 ± 0.072	0.866AspMet: 0.866 ± 0.024	3.397AspAsn: 3.397 ± 0.073	1.278AspPro: 1.278 ± 0.035	1.185AspGln: 1.185 ± 0.095	1.521AspArg: 1.521 ± 0.033	3.181AspSer: 3.181 ± 0.064	2.8AspThr: 2.8 ± 0.047	3.511AspVal: 3.511 ± 0.076	0.674AspTrp: 0.674 ± 0.019	2.499AspTyr: 2.499 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	3.745GluAla: 3.745 ± 0.083	0.362GluCys: 0.362 ± 0.018	3.089GluAsp: 3.089 ± 0.049	4.744GluGlu: 4.744 ± 0.072	3.035GluPhe: 3.035 ± 0.05	3.411GluGly: 3.411 ± 0.064	1.053GluHis: 1.053 ± 0.028	5.852GluIle: 5.852 ± 0.083	6.536GluLys: 6.536 ± 0.092	6.132GluLeu: 6.132 ± 0.075	1.379GluMet: 1.379 ± 0.031	4.972GluAsn: 4.972 ± 0.072	1.221GluPro: 1.221 ± 0.035	2.053GluGln: 2.053 ± 0.05	2.152GluArg: 2.152 ± 0.043	3.31GluSer: 3.31 ± 0.075	3.601GluThr: 3.601 ± 0.065	4.198GluVal: 4.198 ± 0.06	0.601GluTrp: 0.601 ± 0.023	2.525GluTyr: 2.525 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.457PheAla: 2.457 ± 0.051	0.448PheCys: 0.448 ± 0.021	2.971PheAsp: 2.971 ± 0.054	3.112PheGlu: 3.112 ± 0.051	2.966PhePhe: 2.966 ± 0.071	3.403PheGly: 3.403 ± 0.06	0.792PheHis: 0.792 ± 0.023	4.487PheIle: 4.487 ± 0.07	4.613PheLys: 4.613 ± 0.07	5.065PheLeu: 5.065 ± 0.083	1.035PheMet: 1.035 ± 0.031	3.852PheAsn: 3.852 ± 0.062	1.552PhePro: 1.552 ± 0.036	1.356PheGln: 1.356 ± 0.031	1.444PheArg: 1.444 ± 0.036	4.38PheSer: 4.38 ± 0.069	3.332PheThr: 3.332 ± 0.061	2.9PheVal: 2.9 ± 0.047	0.551PheTrp: 0.551 ± 0.022	2.298PheTyr: 2.298 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	3.775GlyAla: 3.775 ± 0.078	0.618GlyCys: 0.618 ± 0.052	3.098GlyAsp: 3.098 ± 0.064	3.348GlyGlu: 3.348 ± 0.072	3.534GlyPhe: 3.534 ± 0.06	4.262GlyGly: 4.262 ± 0.095	0.962GlyHis: 0.962 ± 0.03	5.229GlyIle: 5.229 ± 0.07	5.084GlyLys: 5.084 ± 0.075	5.35GlyLeu: 5.35 ± 0.075	1.368GlyMet: 1.368 ± 0.034	3.801GlyAsn: 3.801 ± 0.074	1.033GlyPro: 1.033 ± 0.036	1.504GlyGln: 1.504 ± 0.041	1.817GlyArg: 1.817 ± 0.041	3.717GlySer: 3.717 ± 0.079	3.908GlyThr: 3.908 ± 0.12	4.236GlyVal: 4.236 ± 0.062	0.674GlyTrp: 0.674 ± 0.025	2.699GlyTyr: 2.699 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.847HisAla: 0.847 ± 0.024	0.162HisCys: 0.162 ± 0.011	0.717HisAsp: 0.717 ± 0.027	0.932HisGlu: 0.932 ± 0.034	1.083HisPhe: 1.083 ± 0.028	0.864HisGly: 0.864 ± 0.024	0.429HisHis: 0.429 ± 0.019	1.362HisIle: 1.362 ± 0.036	1.406HisLys: 1.406 ± 0.041	1.622HisLeu: 1.622 ± 0.031	0.273HisMet: 0.273 ± 0.014	0.988HisAsn: 0.988 ± 0.03	0.766HisPro: 0.766 ± 0.031	0.705HisGln: 0.705 ± 0.024	0.552HisArg: 0.552 ± 0.023	1.06HisSer: 1.06 ± 0.029	0.956HisThr: 0.956 ± 0.027	0.814HisVal: 0.814 ± 0.025	0.212HisTrp: 0.212 ± 0.015	0.776HisTyr: 0.776 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.494IleAla: 5.494 ± 0.08	0.722IleCys: 0.722 ± 0.052	5.134IleAsp: 5.134 ± 0.064	5.856IleGlu: 5.856 ± 0.079	3.731IlePhe: 3.731 ± 0.073	5.14IleGly: 5.14 ± 0.075	1.417IleHis: 1.417 ± 0.042	7.375IleIle: 7.375 ± 0.108	7.482IleLys: 7.482 ± 0.099	7.438IleLeu: 7.438 ± 0.105	1.332IleMet: 1.332 ± 0.039	6.058IleAsn: 6.058 ± 0.077	3.177IlePro: 3.177 ± 0.06	2.576IleGln: 2.576 ± 0.045	2.446IleArg: 2.446 ± 0.052	6.408IleSer: 6.408 ± 0.089	5.88IleThr: 5.88 ± 0.128	4.882IleVal: 4.882 ± 0.074	0.684IleTrp: 0.684 ± 0.024	2.994IleTyr: 2.994 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.896LysAla: 4.896 ± 0.076	0.423LysCys: 0.423 ± 0.018	4.533LysAsp: 4.533 ± 0.063	7.915LysGlu: 7.915 ± 0.112	3.384LysPhe: 3.384 ± 0.058	5.157LysGly: 5.157 ± 0.078	1.633LysHis: 1.633 ± 0.035	7.854LysIle: 7.854 ± 0.095	9.547LysLys: 9.547 ± 0.147	7.549LysLeu: 7.549 ± 0.099	2.191LysMet: 2.191 ± 0.043	6.951LysAsn: 6.951 ± 0.104	2.479LysPro: 2.479 ± 0.067	2.987LysGln: 2.987 ± 0.054	3.108LysArg: 3.108 ± 0.052	5.366LysSer: 5.366 ± 0.074	5.54LysThr: 5.54 ± 0.08	5.11LysVal: 5.11 ± 0.066	0.897LysTrp: 0.897 ± 0.026	3.573LysTyr: 3.573 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.278LeuAla: 5.278 ± 0.082	0.598LeuCys: 0.598 ± 0.022	4.636LeuAsp: 4.636 ± 0.063	5.816LeuGlu: 5.816 ± 0.071	5.185LeuPhe: 5.185 ± 0.081	5.482LeuGly: 5.482 ± 0.083	1.519LeuHis: 1.519 ± 0.038	7.586LeuIle: 7.586 ± 0.11	8.84LeuLys: 8.84 ± 0.12	8.797LeuLeu: 8.797 ± 0.125	1.811LeuMet: 1.811 ± 0.046	6.238LeuAsn: 6.238 ± 0.09	3.273LeuPro: 3.273 ± 0.049	3.1LeuGln: 3.1 ± 0.053	2.728LeuArg: 2.728 ± 0.044	6.612LeuSer: 6.612 ± 0.082	5.407LeuThr: 5.407 ± 0.082	5.032LeuVal: 5.032 ± 0.072	0.749LeuTrp: 0.749 ± 0.027	3.135LeuTyr: 3.135 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.222MetAla: 1.222 ± 0.041	0.139MetCys: 0.139 ± 0.011	0.888MetAsp: 0.888 ± 0.027	1.015MetGlu: 1.015 ± 0.033	0.811MetPhe: 0.811 ± 0.025	1.111MetGly: 1.111 ± 0.03	0.337MetHis: 0.337 ± 0.015	1.535MetIle: 1.535 ± 0.04	2.165MetLys: 2.165 ± 0.041	1.781MetLeu: 1.781 ± 0.041	0.492MetMet: 0.492 ± 0.021	1.375MetAsn: 1.375 ± 0.034	0.702MetPro: 0.702 ± 0.026	0.687MetGln: 0.687 ± 0.022	0.759MetArg: 0.759 ± 0.026	1.326MetSer: 1.326 ± 0.033	1.025MetThr: 1.025 ± 0.027	1.098MetVal: 1.098 ± 0.034	0.14MetTrp: 0.14 ± 0.011	0.698MetTyr: 0.698 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.709AsnAla: 3.709 ± 0.07	0.648AsnCys: 0.648 ± 0.047	3.555AsnAsp: 3.555 ± 0.082	4.283AsnGlu: 4.283 ± 0.067	3.522AsnPhe: 3.522 ± 0.061	4.238AsnGly: 4.238 ± 0.103	1.101AsnHis: 1.101 ± 0.031	5.912AsnIle: 5.912 ± 0.081	6.264AsnLys: 6.264 ± 0.092	6.094AsnLeu: 6.094 ± 0.085	1.175AsnMet: 1.175 ± 0.036	5.059AsnAsn: 5.059 ± 0.09	2.515AsnPro: 2.515 ± 0.046	2.23AsnGln: 2.23 ± 0.05	2.076AsnArg: 2.076 ± 0.047	4.616AsnSer: 4.616 ± 0.072	4.521AsnThr: 4.521 ± 0.085	3.783AsnVal: 3.783 ± 0.072	0.831AsnTrp: 0.831 ± 0.025	3.319AsnTyr: 3.319 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	1.609ProAla: 1.609 ± 0.061	0.206ProCys: 0.206 ± 0.013	1.539ProAsp: 1.539 ± 0.036	2.166ProGlu: 2.166 ± 0.046	1.786ProPhe: 1.786 ± 0.034	1.497ProGly: 1.497 ± 0.039	0.527ProHis: 0.527 ± 0.021	2.758ProIle: 2.758 ± 0.044	2.758ProLys: 2.758 ± 0.068	2.624ProLeu: 2.624 ± 0.046	0.599ProMet: 0.599 ± 0.025	2.284ProAsn: 2.284 ± 0.056	0.685ProPro: 0.685 ± 0.024	0.922ProGln: 0.922 ± 0.029	0.726ProArg: 0.726 ± 0.028	2.132ProSer: 2.132 ± 0.057	2.067ProThr: 2.067 ± 0.049	1.981ProVal: 1.981 ± 0.047	0.284ProTrp: 0.284 ± 0.015	1.275ProTyr: 1.275 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.575GlnAla: 1.575 ± 0.057	0.167GlnCys: 0.167 ± 0.012	1.292GlnAsp: 1.292 ± 0.03	2.207GlnGlu: 2.207 ± 0.046	1.585GlnPhe: 1.585 ± 0.033	1.503GlnGly: 1.503 ± 0.034	0.555GlnHis: 0.555 ± 0.02	2.656GlnIle: 2.656 ± 0.054	3.049GlnLys: 3.049 ± 0.061	3.201GlnLeu: 3.201 ± 0.054	0.648GlnMet: 0.648 ± 0.023	2.097GlnAsn: 2.097 ± 0.041	0.95GlnPro: 0.95 ± 0.03	1.381GlnGln: 1.381 ± 0.037	1.049GlnArg: 1.049 ± 0.027	1.703GlnSer: 1.703 ± 0.038	1.761GlnThr: 1.761 ± 0.043	1.753GlnVal: 1.753 ± 0.042	0.297GlnTrp: 0.297 ± 0.015	1.265GlnTyr: 1.265 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.73ArgAla: 1.73 ± 0.042	0.187ArgCys: 0.187 ± 0.013	1.484ArgAsp: 1.484 ± 0.035	1.946ArgGlu: 1.946 ± 0.042	1.749ArgPhe: 1.749 ± 0.04	1.676ArgGly: 1.676 ± 0.04	0.469ArgHis: 0.469 ± 0.019	2.699ArgIle: 2.699 ± 0.054	3.02ArgLys: 3.02 ± 0.058	2.856ArgLeu: 2.856 ± 0.053	0.756ArgMet: 0.756 ± 0.03	2.019ArgAsn: 2.019 ± 0.037	0.826ArgPro: 0.826 ± 0.027	0.845ArgGln: 0.845 ± 0.025	1.111ArgArg: 1.111 ± 0.031	1.686ArgSer: 1.686 ± 0.041	1.644ArgThr: 1.644 ± 0.04	1.892ArgVal: 1.892 ± 0.043	0.321ArgTrp: 0.321 ± 0.016	1.375ArgTyr: 1.375 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	3.41SerAla: 3.41 ± 0.059	0.726SerCys: 0.726 ± 0.037	3.443SerAsp: 3.443 ± 0.066	4.035SerGlu: 4.035 ± 0.056	4.305SerPhe: 4.305 ± 0.069	4.328SerGly: 4.328 ± 0.085	0.996SerHis: 0.996 ± 0.028	5.891SerIle: 5.891 ± 0.076	5.904SerLys: 5.904 ± 0.095	6.401SerLeu: 6.401 ± 0.084	1.144SerMet: 1.144 ± 0.036	4.475SerAsn: 4.475 ± 0.083	1.972SerPro: 1.972 ± 0.042	1.938SerGln: 1.938 ± 0.047	1.849SerArg: 1.849 ± 0.039	4.628SerSer: 4.628 ± 0.095	3.771SerThr: 3.771 ± 0.064	4.069SerVal: 4.069 ± 0.066	0.714SerTrp: 0.714 ± 0.025	3.086SerTyr: 3.086 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	3.847ThrAla: 3.847 ± 0.096	0.431ThrCys: 0.431 ± 0.029	3.385ThrAsp: 3.385 ± 0.106	3.453ThrGlu: 3.453 ± 0.071	3.069ThrPhe: 3.069 ± 0.056	3.956ThrGly: 3.956 ± 0.104	1.024ThrHis: 1.024 ± 0.03	5.878ThrIle: 5.878 ± 0.133	4.87ThrLys: 4.87 ± 0.068	5.407ThrLeu: 5.407 ± 0.077	0.879ThrMet: 0.879 ± 0.027	4.037ThrAsn: 4.037 ± 0.07	2.561ThrPro: 2.561 ± 0.075	1.831ThrGln: 1.831 ± 0.041	1.604ThrArg: 1.604 ± 0.035	4.305ThrSer: 4.305 ± 0.068	4.313ThrThr: 4.313 ± 0.166	4.116ThrVal: 4.116 ± 0.179	0.623ThrTrp: 0.623 ± 0.057	2.535ThrTyr: 2.535 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	3.767ValAla: 3.767 ± 0.065	0.488ValCys: 0.488 ± 0.023	3.259ValAsp: 3.259 ± 0.056	3.356ValGlu: 3.356 ± 0.059	3.409ValPhe: 3.409 ± 0.061	3.433ValGly: 3.433 ± 0.067	0.929ValHis: 0.929 ± 0.027	4.904ValIle: 4.904 ± 0.066	4.82ValLys: 4.82 ± 0.067	5.81ValLeu: 5.81 ± 0.071	1.106ValMet: 1.106 ± 0.03	4.159ValAsn: 4.159 ± 0.065	1.86ValPro: 1.86 ± 0.042	1.526ValGln: 1.526 ± 0.039	1.751ValArg: 1.751 ± 0.042	4.558ValSer: 4.558 ± 0.073	4.049ValThr: 4.049 ± 0.173	3.96ValVal: 3.96 ± 0.083	0.572ValTrp: 0.572 ± 0.021	2.328ValTyr: 2.328 ± 0.066	0.0ValXaa: 0.0 ± 0.0
Trp	0.552TrpAla: 0.552 ± 0.023	0.093TrpCys: 0.093 ± 0.009	0.522TrpAsp: 0.522 ± 0.021	0.621TrpGlu: 0.621 ± 0.024	0.577TrpPhe: 0.577 ± 0.024	0.574TrpGly: 0.574 ± 0.019	0.21TrpHis: 0.21 ± 0.012	0.757TrpIle: 0.757 ± 0.026	0.916TrpLys: 0.916 ± 0.029	1.011TrpLeu: 1.011 ± 0.053	0.252TrpMet: 0.252 ± 0.015	0.755TrpAsn: 0.755 ± 0.022	0.165TrpPro: 0.165 ± 0.013	0.343TrpGln: 0.343 ± 0.016	0.365TrpArg: 0.365 ± 0.017	0.623TrpSer: 0.623 ± 0.028	0.506TrpThr: 0.506 ± 0.028	0.617TrpVal: 0.617 ± 0.022	0.145TrpTrp: 0.145 ± 0.01	0.401TrpTyr: 0.401 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.109TyrAla: 2.109 ± 0.041	0.374TyrCys: 0.374 ± 0.019	2.199TyrAsp: 2.199 ± 0.044	2.214TyrGlu: 2.214 ± 0.044	2.491TyrPhe: 2.491 ± 0.052	2.466TyrGly: 2.466 ± 0.041	0.775TyrHis: 0.775 ± 0.025	3.036TyrIle: 3.036 ± 0.056	3.944TyrLys: 3.944 ± 0.075	3.814TyrLeu: 3.814 ± 0.064	0.639TyrMet: 0.639 ± 0.022	2.935TyrAsn: 2.935 ± 0.058	1.365TyrPro: 1.365 ± 0.032	1.459TyrGln: 1.459 ± 0.035	1.401TyrArg: 1.401 ± 0.037	2.809TyrSer: 2.809 ± 0.049	2.722TyrThr: 2.722 ± 0.119	2.117TyrVal: 2.117 ± 0.044	0.446TyrTrp: 0.446 ± 0.019	1.942TyrTyr: 1.942 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3926 proteins (1305142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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