Human papillomavirus 40

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 8

Average proteome isoelectric point is 6.2

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 8 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A159DWL1|A0A159DWL1_HPV40 E4 OS=Human papillomavirus 40 OX=10615 PE=3 SV=1
MM1 pKa = 7.35HH2 pKa = 7.7GEE4 pKa = 4.19RR5 pKa = 11.84PTLGDD10 pKa = 3.22IVLNLQPEE18 pKa = 4.63PVCLNCNEE26 pKa = 4.34QLDD29 pKa = 4.31SSDD32 pKa = 4.69SEE34 pKa = 4.85DD35 pKa = 4.82DD36 pKa = 4.08HH37 pKa = 7.51EE38 pKa = 4.76QDD40 pKa = 4.81QLDD43 pKa = 3.93SLHH46 pKa = 6.54SRR48 pKa = 11.84EE49 pKa = 4.52RR50 pKa = 11.84EE51 pKa = 3.92QPTQQDD57 pKa = 3.75LQVNLQSFKK66 pKa = 11.13VVTRR70 pKa = 11.84CVFCQCLVRR79 pKa = 11.84LAVHH83 pKa = 6.69CSITDD88 pKa = 3.13ITQFQQLLMGTLHH101 pKa = 6.84IVCPNCAATEE111 pKa = 4.05

Molecular weight: 12.56 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|I0JV18|I0JV18_HPV40 Protein E6 OS=Human papillomavirus 40 OX=10615 GN=E6 PE=3 SV=1
MM1 pKa = 7.58SARR4 pKa = 11.84CGSQARR10 pKa = 11.84TLYY13 pKa = 9.87EE14 pKa = 4.86LCDD17 pKa = 3.41QCNITLPTLQIDD29 pKa = 4.1CVFCKK34 pKa = 9.91TVLKK38 pKa = 9.18TAEE41 pKa = 3.88VLAFAFRR48 pKa = 11.84EE49 pKa = 4.42LYY51 pKa = 10.12VVWRR55 pKa = 11.84DD56 pKa = 4.01DD57 pKa = 4.0FPHH60 pKa = 6.74AACPRR65 pKa = 11.84CLDD68 pKa = 3.32LHH70 pKa = 6.61GKK72 pKa = 8.52VNQYY76 pKa = 11.24RR77 pKa = 11.84NFRR80 pKa = 11.84YY81 pKa = 9.24AAYY84 pKa = 9.71APTVEE89 pKa = 4.68EE90 pKa = 4.26EE91 pKa = 4.07TGLTILQVRR100 pKa = 11.84IRR102 pKa = 11.84CCKK105 pKa = 8.35CHH107 pKa = 6.74KK108 pKa = 9.78PLSPVEE114 pKa = 4.13KK115 pKa = 9.5TNHH118 pKa = 5.32IVKK121 pKa = 8.87KK122 pKa = 7.95TQFFKK127 pKa = 11.3LKK129 pKa = 10.49DD130 pKa = 3.3SWTGYY135 pKa = 10.19CLHH138 pKa = 6.78CWKK141 pKa = 10.73KK142 pKa = 10.9CMEE145 pKa = 4.32KK146 pKa = 10.46GQRR149 pKa = 11.84SEE151 pKa = 4.28TLCC154 pKa = 4.26

Molecular weight: 17.89 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

8

0

8

2401

43

647

300.1

33.51

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.414 ± 0.486

2.707 ± 0.587

5.998 ± 0.463

5.206 ± 0.628

3.623 ± 0.538

6.206 ± 0.428

2.874 ± 0.339

4.29 ± 0.507

4.748 ± 0.689

8.955 ± 0.888

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.958 ± 0.268

3.207 ± 0.522

6.289 ± 0.974

4.623 ± 0.591

5.289 ± 0.298

7.164 ± 0.612

8.247 ± 0.924

7.205 ± 0.436

1.499 ± 0.314

3.499 ± 0.366
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski