Amino acid dipepetide frequency for Treponema succinifaciens (strain ATCC 33096 / DSM 2489 / 6091)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.959AlaAla: 5.959 ± 0.092	0.976AlaCys: 0.976 ± 0.041	4.028AlaAsp: 4.028 ± 0.078	5.676AlaGlu: 5.676 ± 0.1	3.434AlaPhe: 3.434 ± 0.071	4.973AlaGly: 4.973 ± 0.087	0.933AlaHis: 0.933 ± 0.036	4.476AlaIle: 4.476 ± 0.07	5.659AlaLys: 5.659 ± 0.086	6.222AlaLeu: 6.222 ± 0.101	1.714AlaMet: 1.714 ± 0.047	2.701AlaAsn: 2.701 ± 0.068	1.798AlaPro: 1.798 ± 0.05	2.383AlaGln: 2.383 ± 0.058	2.681AlaArg: 2.681 ± 0.063	4.733AlaSer: 4.733 ± 0.08	2.935AlaThr: 2.935 ± 0.069	5.49AlaVal: 5.49 ± 0.101	0.632AlaTrp: 0.632 ± 0.028	2.102AlaTyr: 2.102 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.28CysAla: 1.28 ± 0.041	0.272CysCys: 0.272 ± 0.019	0.733CysAsp: 0.733 ± 0.03	0.858CysGlu: 0.858 ± 0.034	0.756CysPhe: 0.756 ± 0.034	1.409CysGly: 1.409 ± 0.045	0.287CysHis: 0.287 ± 0.019	1.058CysIle: 1.058 ± 0.043	1.035CysLys: 1.035 ± 0.035	1.152CysLeu: 1.152 ± 0.039	0.328CysMet: 0.328 ± 0.02	0.648CysAsn: 0.648 ± 0.031	0.601CysPro: 0.601 ± 0.028	0.357CysGln: 0.357 ± 0.022	0.694CysArg: 0.694 ± 0.027	1.026CysSer: 1.026 ± 0.038	0.71CysThr: 0.71 ± 0.028	1.009CysVal: 1.009 ± 0.039	0.131CysTrp: 0.131 ± 0.013	0.552CysTyr: 0.552 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.411AspAla: 3.411 ± 0.064	0.798AspCys: 0.798 ± 0.036	3.069AspAsp: 3.069 ± 0.078	4.543AspGlu: 4.543 ± 0.089	4.045AspPhe: 4.045 ± 0.081	3.922AspGly: 3.922 ± 0.072	0.541AspHis: 0.541 ± 0.026	4.098AspIle: 4.098 ± 0.067	3.93AspLys: 3.93 ± 0.08	4.211AspLeu: 4.211 ± 0.084	1.18AspMet: 1.18 ± 0.04	2.373AspAsn: 2.373 ± 0.06	1.434AspPro: 1.434 ± 0.041	0.903AspGln: 0.903 ± 0.036	1.886AspArg: 1.886 ± 0.049	4.687AspSer: 4.687 ± 0.085	2.376AspThr: 2.376 ± 0.061	3.199AspVal: 3.199 ± 0.073	0.658AspTrp: 0.658 ± 0.026	2.411AspTyr: 2.411 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.287GluAla: 4.287 ± 0.086	0.894GluCys: 0.894 ± 0.034	3.519GluAsp: 3.519 ± 0.078	5.822GluGlu: 5.822 ± 0.126	3.45GluPhe: 3.45 ± 0.059	3.454GluGly: 3.454 ± 0.069	1.043GluHis: 1.043 ± 0.041	6.427GluIle: 6.427 ± 0.098	8.919GluLys: 8.919 ± 0.128	6.362GluLeu: 6.362 ± 0.091	1.689GluMet: 1.689 ± 0.049	6.242GluAsn: 6.242 ± 0.118	1.848GluPro: 1.848 ± 0.063	2.632GluGln: 2.632 ± 0.063	2.979GluArg: 2.979 ± 0.072	4.3GluSer: 4.3 ± 0.077	3.818GluThr: 3.818 ± 0.085	3.525GluVal: 3.525 ± 0.081	0.733GluTrp: 0.733 ± 0.033	2.828GluTyr: 2.828 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.92PheAla: 3.92 ± 0.091	1.04PheCys: 1.04 ± 0.03	3.194PheAsp: 3.194 ± 0.067	3.458PheGlu: 3.458 ± 0.082	3.245PhePhe: 3.245 ± 0.095	3.301PheGly: 3.301 ± 0.062	0.759PheHis: 0.759 ± 0.031	4.057PheIle: 4.057 ± 0.086	3.323PheLys: 3.323 ± 0.066	4.764PheLeu: 4.764 ± 0.087	1.185PheMet: 1.185 ± 0.041	2.414PheAsn: 2.414 ± 0.068	1.943PhePro: 1.943 ± 0.051	1.21PheGln: 1.21 ± 0.04	1.775PheArg: 1.775 ± 0.047	5.265PheSer: 5.265 ± 0.107	2.769PheThr: 2.769 ± 0.057	3.425PheVal: 3.425 ± 0.068	0.436PheTrp: 0.436 ± 0.025	2.231PheTyr: 2.231 ± 0.06	0.0PheXaa: 0.0 ± 0.0
Gly	4.046GlyAla: 4.046 ± 0.095	0.95GlyCys: 0.95 ± 0.037	2.746GlyAsp: 2.746 ± 0.057	3.959GlyGlu: 3.959 ± 0.076	3.534GlyPhe: 3.534 ± 0.072	4.135GlyGly: 4.135 ± 0.091	0.943GlyHis: 0.943 ± 0.035	5.97GlyIle: 5.97 ± 0.087	6.084GlyLys: 6.084 ± 0.104	4.946GlyLeu: 4.946 ± 0.083	1.586GlyMet: 1.586 ± 0.05	3.404GlyAsn: 3.404 ± 0.066	1.149GlyPro: 1.149 ± 0.039	1.574GlyGln: 1.574 ± 0.047	2.372GlyArg: 2.372 ± 0.065	4.012GlySer: 4.012 ± 0.088	3.94GlyThr: 3.94 ± 0.08	3.499GlyVal: 3.499 ± 0.077	0.72GlyTrp: 0.72 ± 0.033	2.421GlyTyr: 2.421 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	0.882HisAla: 0.882 ± 0.034	0.252HisCys: 0.252 ± 0.017	0.779HisAsp: 0.779 ± 0.034	0.927HisGlu: 0.927 ± 0.034	0.775HisPhe: 0.775 ± 0.03	1.093HisGly: 1.093 ± 0.038	0.292HisHis: 0.292 ± 0.026	1.222HisIle: 1.222 ± 0.043	0.964HisLys: 0.964 ± 0.03	1.294HisLeu: 1.294 ± 0.042	0.217HisMet: 0.217 ± 0.015	0.716HisAsn: 0.716 ± 0.036	0.714HisPro: 0.714 ± 0.031	0.407HisGln: 0.407 ± 0.024	0.597HisArg: 0.597 ± 0.026	0.982HisSer: 0.982 ± 0.03	0.745HisThr: 0.745 ± 0.032	0.739HisVal: 0.739 ± 0.026	0.158HisTrp: 0.158 ± 0.015	0.644HisTyr: 0.644 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.445IleAla: 5.445 ± 0.076	1.247IleCys: 1.247 ± 0.043	4.321IleAsp: 4.321 ± 0.085	5.603IleGlu: 5.603 ± 0.089	4.259IlePhe: 4.259 ± 0.099	4.163IleGly: 4.163 ± 0.08	1.135IleHis: 1.135 ± 0.04	5.26IleIle: 5.26 ± 0.097	5.929IleLys: 5.929 ± 0.086	7.121IleLeu: 7.121 ± 0.119	1.437IleMet: 1.437 ± 0.042	3.553IleAsn: 3.553 ± 0.076	3.516IlePro: 3.516 ± 0.069	2.517IleGln: 2.517 ± 0.054	2.872IleArg: 2.872 ± 0.068	6.457IleSer: 6.457 ± 0.096	3.894IleThr: 3.894 ± 0.083	4.677IleVal: 4.677 ± 0.082	0.551IleTrp: 0.551 ± 0.025	2.643IleTyr: 2.643 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.114LysAla: 5.114 ± 0.098	0.944LysCys: 0.944 ± 0.04	4.654LysAsp: 4.654 ± 0.088	6.691LysGlu: 6.691 ± 0.115	3.639LysPhe: 3.639 ± 0.063	4.08LysGly: 4.08 ± 0.077	1.018LysHis: 1.018 ± 0.036	7.986LysIle: 7.986 ± 0.115	8.794LysLys: 8.794 ± 0.107	6.182LysLeu: 6.182 ± 0.089	2.204LysMet: 2.204 ± 0.051	6.797LysAsn: 6.797 ± 0.113	2.212LysPro: 2.212 ± 0.046	2.408LysGln: 2.408 ± 0.054	2.987LysArg: 2.987 ± 0.064	5.614LysSer: 5.614 ± 0.089	4.893LysThr: 4.893 ± 0.081	4.257LysVal: 4.257 ± 0.071	0.794LysTrp: 0.794 ± 0.029	3.095LysTyr: 3.095 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.257LeuAla: 6.257 ± 0.092	1.584LeuCys: 1.584 ± 0.043	4.801LeuAsp: 4.801 ± 0.077	6.513LeuGlu: 6.513 ± 0.088	4.639LeuPhe: 4.639 ± 0.102	5.108LeuGly: 5.108 ± 0.088	1.331LeuHis: 1.331 ± 0.039	5.755LeuIle: 5.755 ± 0.087	7.514LeuLys: 7.514 ± 0.094	7.799LeuLeu: 7.799 ± 0.133	1.931LeuMet: 1.931 ± 0.057	4.544LeuAsn: 4.544 ± 0.07	3.504LeuPro: 3.504 ± 0.072	2.48LeuGln: 2.48 ± 0.059	3.396LeuArg: 3.396 ± 0.062	6.962LeuSer: 6.962 ± 0.088	3.928LeuThr: 3.928 ± 0.071	5.153LeuVal: 5.153 ± 0.086	0.791LeuTrp: 0.791 ± 0.033	3.215LeuTyr: 3.215 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.778MetAla: 1.778 ± 0.046	0.271MetCys: 0.271 ± 0.018	1.155MetAsp: 1.155 ± 0.043	1.79MetGlu: 1.79 ± 0.046	0.916MetPhe: 0.916 ± 0.036	1.405MetGly: 1.405 ± 0.048	0.376MetHis: 0.376 ± 0.023	1.522MetIle: 1.522 ± 0.048	2.197MetLys: 2.197 ± 0.059	1.894MetLeu: 1.894 ± 0.053	0.546MetMet: 0.546 ± 0.025	1.456MetAsn: 1.456 ± 0.048	0.809MetPro: 0.809 ± 0.033	0.846MetGln: 0.846 ± 0.029	0.858MetArg: 0.858 ± 0.033	1.569MetSer: 1.569 ± 0.042	1.238MetThr: 1.238 ± 0.039	1.128MetVal: 1.128 ± 0.037	0.159MetTrp: 0.159 ± 0.014	0.66MetTyr: 0.66 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.836AsnAla: 3.836 ± 0.079	0.765AsnCys: 0.765 ± 0.034	2.527AsnAsp: 2.527 ± 0.068	3.94AsnGlu: 3.94 ± 0.073	2.987AsnPhe: 2.987 ± 0.082	4.04AsnGly: 4.04 ± 0.072	0.765AsnHis: 0.765 ± 0.034	4.181AsnIle: 4.181 ± 0.069	3.727AsnLys: 3.727 ± 0.07	5.072AsnLeu: 5.072 ± 0.081	1.193AsnMet: 1.193 ± 0.038	2.429AsnAsn: 2.429 ± 0.058	2.642AsnPro: 2.642 ± 0.054	1.587AsnGln: 1.587 ± 0.048	1.942AsnArg: 1.942 ± 0.054	4.417AsnSer: 4.417 ± 0.082	2.312AsnThr: 2.312 ± 0.049	3.059AsnVal: 3.059 ± 0.053	0.581AsnTrp: 0.581 ± 0.024	1.961AsnTyr: 1.961 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.558ProAla: 2.558 ± 0.06	0.468ProCys: 0.468 ± 0.027	2.182ProAsp: 2.182 ± 0.046	3.358ProGlu: 3.358 ± 0.078	1.861ProPhe: 1.861 ± 0.05	1.936ProGly: 1.936 ± 0.054	0.534ProHis: 0.534 ± 0.029	1.82ProIle: 1.82 ± 0.055	2.219ProLys: 2.219 ± 0.057	3.039ProLeu: 3.039 ± 0.064	0.581ProMet: 0.581 ± 0.025	1.361ProAsn: 1.361 ± 0.038	0.881ProPro: 0.881 ± 0.034	1.149ProGln: 1.149 ± 0.035	1.064ProArg: 1.064 ± 0.036	2.327ProSer: 2.327 ± 0.052	1.308ProThr: 1.308 ± 0.041	2.931ProVal: 2.931 ± 0.062	0.303ProTrp: 0.303 ± 0.018	1.338ProTyr: 1.338 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.021GlnAla: 2.021 ± 0.047	0.309GlnCys: 0.309 ± 0.023	1.429GlnAsp: 1.429 ± 0.042	2.267GlnGlu: 2.267 ± 0.058	1.291GlnPhe: 1.291 ± 0.041	1.569GlnGly: 1.569 ± 0.048	0.419GlnHis: 0.419 ± 0.019	2.695GlnIle: 2.695 ± 0.053	3.222GlnLys: 3.222 ± 0.064	2.456GlnLeu: 2.456 ± 0.063	0.8GlnMet: 0.8 ± 0.033	2.23GlnAsn: 2.23 ± 0.056	0.771GlnPro: 0.771 ± 0.033	1.064GlnGln: 1.064 ± 0.037	1.157GlnArg: 1.157 ± 0.041	1.808GlnSer: 1.808 ± 0.053	1.603GlnThr: 1.603 ± 0.048	1.564GlnVal: 1.564 ± 0.042	0.278GlnTrp: 0.278 ± 0.02	0.956GlnTyr: 0.956 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.356ArgAla: 2.356 ± 0.059	0.512ArgCys: 0.512 ± 0.026	1.689ArgAsp: 1.689 ± 0.046	2.574ArgGlu: 2.574 ± 0.067	1.921ArgPhe: 1.921 ± 0.053	2.028ArgGly: 2.028 ± 0.06	0.626ArgHis: 0.626 ± 0.028	3.506ArgIle: 3.506 ± 0.056	3.478ArgLys: 3.478 ± 0.056	3.464ArgLeu: 3.464 ± 0.071	1.052ArgMet: 1.052 ± 0.036	2.303ArgAsn: 2.303 ± 0.059	1.156ArgPro: 1.156 ± 0.04	1.319ArgGln: 1.319 ± 0.037	1.738ArgArg: 1.738 ± 0.056	2.141ArgSer: 2.141 ± 0.064	2.024ArgThr: 2.024 ± 0.052	1.951ArgVal: 1.951 ± 0.051	0.383ArgTrp: 0.383 ± 0.02	1.427ArgTyr: 1.427 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.423SerAla: 5.423 ± 0.085	1.175SerCys: 1.175 ± 0.042	4.137SerAsp: 4.137 ± 0.083	5.637SerGlu: 5.637 ± 0.077	4.137SerPhe: 4.137 ± 0.079	5.572SerGly: 5.572 ± 0.091	1.064SerHis: 1.064 ± 0.032	5.186SerIle: 5.186 ± 0.084	5.295SerLys: 5.295 ± 0.079	6.909SerLeu: 6.909 ± 0.105	1.595SerMet: 1.595 ± 0.044	3.046SerAsn: 3.046 ± 0.077	2.305SerPro: 2.305 ± 0.059	2.185SerGln: 2.185 ± 0.057	2.732SerArg: 2.732 ± 0.056	5.895SerSer: 5.895 ± 0.108	3.245SerThr: 3.245 ± 0.067	5.448SerVal: 5.448 ± 0.096	0.735SerTrp: 0.735 ± 0.025	2.691SerTyr: 2.691 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.791ThrAla: 3.791 ± 0.08	0.576ThrCys: 0.576 ± 0.026	2.978ThrAsp: 2.978 ± 0.061	4.015ThrGlu: 4.015 ± 0.082	2.438ThrPhe: 2.438 ± 0.05	3.873ThrGly: 3.873 ± 0.074	0.712ThrHis: 0.712 ± 0.03	3.48ThrIle: 3.48 ± 0.083	3.551ThrLys: 3.551 ± 0.062	4.478ThrLeu: 4.478 ± 0.072	1.037ThrMet: 1.037 ± 0.038	2.089ThrAsn: 2.089 ± 0.053	1.927ThrPro: 1.927 ± 0.053	1.516ThrGln: 1.516 ± 0.044	1.652ThrArg: 1.652 ± 0.051	3.324ThrSer: 3.324 ± 0.075	2.447ThrThr: 2.447 ± 0.067	3.747ThrVal: 3.747 ± 0.071	0.43ThrTrp: 0.43 ± 0.024	1.521ThrTyr: 1.521 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.246ValAla: 4.246 ± 0.08	1.109ValCys: 1.109 ± 0.038	3.072ValAsp: 3.072 ± 0.064	4.097ValGlu: 4.097 ± 0.077	3.764ValPhe: 3.764 ± 0.074	2.998ValGly: 2.998 ± 0.066	0.9ValHis: 0.9 ± 0.035	4.316ValIle: 4.316 ± 0.081	4.566ValLys: 4.566 ± 0.08	5.858ValLeu: 5.858 ± 0.086	1.332ValMet: 1.332 ± 0.04	2.924ValAsn: 2.924 ± 0.064	2.581ValPro: 2.581 ± 0.052	2.051ValGln: 2.051 ± 0.051	2.382ValArg: 2.382 ± 0.058	5.173ValSer: 5.173 ± 0.085	2.912ValThr: 2.912 ± 0.073	3.912ValVal: 3.912 ± 0.093	0.565ValTrp: 0.565 ± 0.026	2.352ValTyr: 2.352 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.616TrpAla: 0.616 ± 0.028	0.195TrpCys: 0.195 ± 0.017	0.454TrpAsp: 0.454 ± 0.021	0.617TrpGlu: 0.617 ± 0.029	0.474TrpPhe: 0.474 ± 0.024	0.579TrpGly: 0.579 ± 0.028	0.205TrpHis: 0.205 ± 0.017	0.757TrpIle: 0.757 ± 0.031	0.887TrpLys: 0.887 ± 0.033	0.852TrpLeu: 0.852 ± 0.032	0.206TrpMet: 0.206 ± 0.015	0.783TrpAsn: 0.783 ± 0.033	0.211TrpPro: 0.211 ± 0.017	0.348TrpGln: 0.348 ± 0.023	0.393TrpArg: 0.393 ± 0.018	0.568TrpSer: 0.568 ± 0.024	0.526TrpThr: 0.526 ± 0.027	0.394TrpVal: 0.394 ± 0.022	0.112TrpTrp: 0.112 ± 0.01	0.368TrpTyr: 0.368 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.278TyrAla: 2.278 ± 0.057	0.559TyrCys: 0.559 ± 0.025	2.209TyrAsp: 2.209 ± 0.063	2.426TyrGlu: 2.426 ± 0.055	2.151TyrPhe: 2.151 ± 0.057	2.352TyrGly: 2.352 ± 0.061	0.515TyrHis: 0.515 ± 0.026	2.828TyrIle: 2.828 ± 0.06	3.071TyrLys: 3.071 ± 0.061	3.129TyrLeu: 3.129 ± 0.066	0.761TyrMet: 0.761 ± 0.029	1.951TyrAsn: 1.951 ± 0.057	1.215TyrPro: 1.215 ± 0.039	0.974TyrGln: 0.974 ± 0.033	1.491TyrArg: 1.491 ± 0.041	3.149TyrSer: 3.149 ± 0.07	1.961TyrThr: 1.961 ± 0.049	2.001TyrVal: 2.001 ± 0.052	0.394TyrTrp: 0.394 ± 0.024	1.505TyrTyr: 1.505 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2561 proteins (829679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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