Amino acid dipepetide frequency for Nocardioides seonyuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.152AlaAla: 18.152 ± 0.183	1.044AlaCys: 1.044 ± 0.026	8.032AlaAsp: 8.032 ± 0.09	7.989AlaGlu: 7.989 ± 0.103	3.537AlaPhe: 3.537 ± 0.063	11.904AlaGly: 11.904 ± 0.104	2.639AlaHis: 2.639 ± 0.054	4.282AlaIle: 4.282 ± 0.069	2.473AlaLys: 2.473 ± 0.058	13.527AlaLeu: 13.527 ± 0.131	2.88AlaMet: 2.88 ± 0.046	1.896AlaAsn: 1.896 ± 0.041	5.971AlaPro: 5.971 ± 0.096	3.53AlaGln: 3.53 ± 0.06	9.569AlaArg: 9.569 ± 0.112	6.663AlaSer: 6.663 ± 0.078	7.363AlaThr: 7.363 ± 0.08	11.186AlaVal: 11.186 ± 0.114	1.964AlaTrp: 1.964 ± 0.044	2.22AlaTyr: 2.22 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.863CysAla: 0.863 ± 0.028	0.097CysCys: 0.097 ± 0.01	0.462CysAsp: 0.462 ± 0.021	0.445CysGlu: 0.445 ± 0.019	0.212CysPhe: 0.212 ± 0.014	0.859CysGly: 0.859 ± 0.028	0.176CysHis: 0.176 ± 0.012	0.198CysIle: 0.198 ± 0.013	0.123CysLys: 0.123 ± 0.011	0.664CysLeu: 0.664 ± 0.023	0.112CysMet: 0.112 ± 0.01	0.137CysAsn: 0.137 ± 0.013	0.446CysPro: 0.446 ± 0.022	0.176CysGln: 0.176 ± 0.011	0.571CysArg: 0.571 ± 0.024	0.479CysSer: 0.479 ± 0.02	0.482CysThr: 0.482 ± 0.025	0.648CysVal: 0.648 ± 0.026	0.111CysTrp: 0.111 ± 0.015	0.128CysTyr: 0.128 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.727AspAla: 7.727 ± 0.088	0.38AspCys: 0.38 ± 0.019	4.665AspAsp: 4.665 ± 0.084	4.541AspGlu: 4.541 ± 0.066	1.721AspPhe: 1.721 ± 0.04	6.042AspGly: 6.042 ± 0.094	1.684AspHis: 1.684 ± 0.041	2.015AspIle: 2.015 ± 0.043	1.155AspLys: 1.155 ± 0.041	7.416AspLeu: 7.416 ± 0.089	0.956AspMet: 0.956 ± 0.025	1.088AspAsn: 1.088 ± 0.029	4.506AspPro: 4.506 ± 0.064	1.891AspGln: 1.891 ± 0.045	4.873AspArg: 4.873 ± 0.071	2.852AspSer: 2.852 ± 0.049	3.046AspThr: 3.046 ± 0.053	6.248AspVal: 6.248 ± 0.078	1.014AspTrp: 1.014 ± 0.033	1.246AspTyr: 1.246 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.586GluAla: 7.586 ± 0.082	0.395GluCys: 0.395 ± 0.019	3.264GluAsp: 3.264 ± 0.059	3.757GluGlu: 3.757 ± 0.069	1.563GluPhe: 1.563 ± 0.039	4.7GluGly: 4.7 ± 0.073	1.709GluHis: 1.709 ± 0.037	2.445GluIle: 2.445 ± 0.045	1.381GluLys: 1.381 ± 0.042	6.452GluLeu: 6.452 ± 0.079	1.147GluMet: 1.147 ± 0.035	0.892GluAsn: 0.892 ± 0.03	3.361GluPro: 3.361 ± 0.067	2.404GluGln: 2.404 ± 0.045	5.237GluArg: 5.237 ± 0.067	3.107GluSer: 3.107 ± 0.049	3.161GluThr: 3.161 ± 0.057	5.927GluVal: 5.927 ± 0.078	0.984GluTrp: 0.984 ± 0.027	0.86GluTyr: 0.86 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.531PheAla: 3.531 ± 0.058	0.269PheCys: 0.269 ± 0.017	2.079PheAsp: 2.079 ± 0.04	1.724PheGlu: 1.724 ± 0.041	0.917PhePhe: 0.917 ± 0.03	2.964PheGly: 2.964 ± 0.054	0.648PheHis: 0.648 ± 0.022	0.842PheIle: 0.842 ± 0.029	0.514PheLys: 0.514 ± 0.022	2.67PheLeu: 2.67 ± 0.057	0.471PheMet: 0.471 ± 0.018	0.582PheAsn: 0.582 ± 0.025	1.283PhePro: 1.283 ± 0.036	0.6PheGln: 0.6 ± 0.023	1.733PheArg: 1.733 ± 0.04	1.553PheSer: 1.553 ± 0.034	1.811PheThr: 1.811 ± 0.04	2.657PheVal: 2.657 ± 0.043	0.427PheTrp: 0.427 ± 0.02	0.571PheTyr: 0.571 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.126GlyAla: 10.126 ± 0.093	0.83GlyCys: 0.83 ± 0.028	5.597GlyAsp: 5.597 ± 0.075	5.412GlyGlu: 5.412 ± 0.078	2.948GlyPhe: 2.948 ± 0.06	7.901GlyGly: 7.901 ± 0.113	2.209GlyHis: 2.209 ± 0.044	3.623GlyIle: 3.623 ± 0.054	2.186GlyLys: 2.186 ± 0.052	9.344GlyLeu: 9.344 ± 0.098	2.086GlyMet: 2.086 ± 0.042	1.662GlyAsn: 1.662 ± 0.05	4.461GlyPro: 4.461 ± 0.06	2.684GlyGln: 2.684 ± 0.047	7.09GlyArg: 7.09 ± 0.08	5.662GlySer: 5.662 ± 0.081	5.584GlyThr: 5.584 ± 0.083	7.982GlyVal: 7.982 ± 0.083	1.706GlyTrp: 1.706 ± 0.039	1.973GlyTyr: 1.973 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.639HisAla: 2.639 ± 0.05	0.183HisCys: 0.183 ± 0.013	1.758HisAsp: 1.758 ± 0.039	1.391HisGlu: 1.391 ± 0.037	0.573HisPhe: 0.573 ± 0.023	2.252HisGly: 2.252 ± 0.051	0.739HisHis: 0.739 ± 0.024	0.544HisIle: 0.544 ± 0.02	0.347HisLys: 0.347 ± 0.019	2.47HisLeu: 2.47 ± 0.047	0.326HisMet: 0.326 ± 0.016	0.377HisAsn: 0.377 ± 0.016	1.697HisPro: 1.697 ± 0.038	0.658HisGln: 0.658 ± 0.023	1.874HisArg: 1.874 ± 0.042	0.951HisSer: 0.951 ± 0.029	1.127HisThr: 1.127 ± 0.034	2.287HisVal: 2.287 ± 0.041	0.343HisTrp: 0.343 ± 0.021	0.454HisTyr: 0.454 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.795IleAla: 4.795 ± 0.071	0.259IleCys: 0.259 ± 0.015	2.633IleAsp: 2.633 ± 0.046	2.461IleGlu: 2.461 ± 0.056	0.793IlePhe: 0.793 ± 0.028	3.577IleGly: 3.577 ± 0.059	0.715IleHis: 0.715 ± 0.025	1.041IleIle: 1.041 ± 0.032	0.781IleLys: 0.781 ± 0.026	2.657IleLeu: 2.657 ± 0.054	0.495IleMet: 0.495 ± 0.022	0.786IleAsn: 0.786 ± 0.026	1.759IlePro: 1.759 ± 0.04	0.795IleGln: 0.795 ± 0.023	2.117IleArg: 2.117 ± 0.042	1.945IleSer: 1.945 ± 0.045	2.321IleThr: 2.321 ± 0.039	3.05IleVal: 3.05 ± 0.056	0.403IleTrp: 0.403 ± 0.019	0.544IleTyr: 0.544 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.608LysAla: 2.608 ± 0.048	0.106LysCys: 0.106 ± 0.01	1.153LysAsp: 1.153 ± 0.035	1.085LysGlu: 1.085 ± 0.036	0.462LysPhe: 0.462 ± 0.022	1.655LysGly: 1.655 ± 0.044	0.424LysHis: 0.424 ± 0.018	0.782LysIle: 0.782 ± 0.026	0.794LysLys: 0.794 ± 0.041	1.704LysLeu: 1.704 ± 0.041	0.396LysMet: 0.396 ± 0.019	0.427LysAsn: 0.427 ± 0.022	1.125LysPro: 1.125 ± 0.031	0.677LysGln: 0.677 ± 0.03	1.436LysArg: 1.436 ± 0.044	1.147LysSer: 1.147 ± 0.033	1.123LysThr: 1.123 ± 0.037	2.074LysVal: 2.074 ± 0.051	0.253LysTrp: 0.253 ± 0.014	0.423LysTyr: 0.423 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.786LeuAla: 14.786 ± 0.144	0.693LeuCys: 0.693 ± 0.022	7.447LeuAsp: 7.447 ± 0.088	5.805LeuGlu: 5.805 ± 0.074	2.473LeuPhe: 2.473 ± 0.056	9.753LeuGly: 9.753 ± 0.102	2.12LeuHis: 2.12 ± 0.049	2.88LeuIle: 2.88 ± 0.052	1.831LeuLys: 1.831 ± 0.048	10.631LeuLeu: 10.631 ± 0.137	1.77LeuMet: 1.77 ± 0.05	1.56LeuAsn: 1.56 ± 0.038	5.735LeuPro: 5.735 ± 0.076	2.322LeuGln: 2.322 ± 0.046	7.789LeuArg: 7.789 ± 0.089	5.482LeuSer: 5.482 ± 0.075	6.452LeuThr: 6.452 ± 0.076	10.681LeuVal: 10.681 ± 0.113	1.21LeuTrp: 1.21 ± 0.035	1.431LeuTyr: 1.431 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.384MetAla: 2.384 ± 0.041	0.149MetCys: 0.149 ± 0.01	0.958MetAsp: 0.958 ± 0.025	0.882MetGlu: 0.882 ± 0.025	0.513MetPhe: 0.513 ± 0.023	1.505MetGly: 1.505 ± 0.033	0.389MetHis: 0.389 ± 0.02	0.664MetIle: 0.664 ± 0.025	0.449MetLys: 0.449 ± 0.018	1.971MetLeu: 1.971 ± 0.044	0.397MetMet: 0.397 ± 0.02	0.392MetAsn: 0.392 ± 0.018	1.171MetPro: 1.171 ± 0.031	0.51MetGln: 0.51 ± 0.022	1.604MetArg: 1.604 ± 0.034	1.587MetSer: 1.587 ± 0.034	1.713MetThr: 1.713 ± 0.036	1.677MetVal: 1.677 ± 0.036	0.239MetTrp: 0.239 ± 0.012	0.26MetTyr: 0.26 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.136AsnAla: 2.136 ± 0.042	0.138AsnCys: 0.138 ± 0.011	1.066AsnAsp: 1.066 ± 0.034	0.858AsnGlu: 0.858 ± 0.033	0.477AsnPhe: 0.477 ± 0.022	1.629AsnGly: 1.629 ± 0.045	0.397AsnHis: 0.397 ± 0.016	0.689AsnIle: 0.689 ± 0.024	0.391AsnLys: 0.391 ± 0.02	1.793AsnLeu: 1.793 ± 0.039	0.285AsnMet: 0.285 ± 0.016	0.389AsnAsn: 0.389 ± 0.021	1.355AsnPro: 1.355 ± 0.033	0.521AsnGln: 0.521 ± 0.021	1.193AsnArg: 1.193 ± 0.034	0.783AsnSer: 0.783 ± 0.026	0.957AsnThr: 0.957 ± 0.03	1.465AsnVal: 1.465 ± 0.038	0.245AsnTrp: 0.245 ± 0.015	0.371AsnTyr: 0.371 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.973ProAla: 6.973 ± 0.091	0.267ProCys: 0.267 ± 0.016	4.392ProAsp: 4.392 ± 0.069	4.088ProGlu: 4.088 ± 0.066	1.472ProPhe: 1.472 ± 0.033	5.792ProGly: 5.792 ± 0.078	1.29ProHis: 1.29 ± 0.036	1.565ProIle: 1.565 ± 0.039	0.948ProLys: 0.948 ± 0.028	4.745ProLeu: 4.745 ± 0.07	1.104ProMet: 1.104 ± 0.034	0.81ProAsn: 0.81 ± 0.025	2.924ProPro: 2.924 ± 0.059	1.474ProGln: 1.474 ± 0.034	3.784ProArg: 3.784 ± 0.062	3.338ProSer: 3.338 ± 0.063	3.616ProThr: 3.616 ± 0.084	5.119ProVal: 5.119 ± 0.071	0.96ProTrp: 0.96 ± 0.031	1.071ProTyr: 1.071 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.543GlnAla: 3.543 ± 0.054	0.157GlnCys: 0.157 ± 0.012	1.366GlnAsp: 1.366 ± 0.038	1.45GlnGlu: 1.45 ± 0.04	0.721GlnPhe: 0.721 ± 0.025	2.285GlnGly: 2.285 ± 0.044	0.691GlnHis: 0.691 ± 0.027	0.992GlnIle: 0.992 ± 0.032	0.531GlnLys: 0.531 ± 0.026	2.971GlnLeu: 2.971 ± 0.053	0.55GlnMet: 0.55 ± 0.021	0.417GlnAsn: 0.417 ± 0.018	1.676GlnPro: 1.676 ± 0.04	1.13GlnGln: 1.13 ± 0.037	2.5GlnArg: 2.5 ± 0.052	1.292GlnSer: 1.292 ± 0.034	1.435GlnThr: 1.435 ± 0.038	3.001GlnVal: 3.001 ± 0.049	0.476GlnTrp: 0.476 ± 0.023	0.456GlnTyr: 0.456 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.932ArgAla: 8.932 ± 0.106	0.5ArgCys: 0.5 ± 0.021	4.58ArgAsp: 4.58 ± 0.061	4.731ArgGlu: 4.731 ± 0.073	2.25ArgPhe: 2.25 ± 0.044	5.776ArgGly: 5.776 ± 0.074	2.031ArgHis: 2.031 ± 0.045	3.016ArgIle: 3.016 ± 0.049	1.512ArgLys: 1.512 ± 0.034	8.332ArgLeu: 8.332 ± 0.107	1.775ArgMet: 1.775 ± 0.036	1.347ArgAsn: 1.347 ± 0.037	4.264ArgPro: 4.264 ± 0.066	2.195ArgGln: 2.195 ± 0.046	7.477ArgArg: 7.477 ± 0.1	4.345ArgSer: 4.345 ± 0.065	4.484ArgThr: 4.484 ± 0.063	6.495ArgVal: 6.495 ± 0.076	1.425ArgTrp: 1.425 ± 0.034	1.419ArgTyr: 1.419 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.505SerAla: 6.505 ± 0.081	0.39SerCys: 0.39 ± 0.019	3.155SerAsp: 3.155 ± 0.053	2.929SerGlu: 2.929 ± 0.055	1.703SerPhe: 1.703 ± 0.041	5.881SerGly: 5.881 ± 0.075	1.16SerHis: 1.16 ± 0.031	1.904SerIle: 1.904 ± 0.04	0.979SerLys: 0.979 ± 0.033	5.461SerLeu: 5.461 ± 0.078	1.327SerMet: 1.327 ± 0.034	0.916SerAsn: 0.916 ± 0.031	3.226SerPro: 3.226 ± 0.064	1.429SerGln: 1.429 ± 0.039	4.16SerArg: 4.16 ± 0.056	3.547SerSer: 3.547 ± 0.073	3.712SerThr: 3.712 ± 0.068	4.89SerVal: 4.89 ± 0.076	1.022SerTrp: 1.022 ± 0.033	1.353SerTyr: 1.353 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.264ThrAla: 7.264 ± 0.088	0.5ThrCys: 0.5 ± 0.024	3.589ThrAsp: 3.589 ± 0.06	3.098ThrGlu: 3.098 ± 0.06	1.835ThrPhe: 1.835 ± 0.048	5.901ThrGly: 5.901 ± 0.073	1.298ThrHis: 1.298 ± 0.033	2.251ThrIle: 2.251 ± 0.045	1.119ThrLys: 1.119 ± 0.031	5.917ThrLeu: 5.917 ± 0.073	1.12ThrMet: 1.12 ± 0.032	1.09ThrAsn: 1.09 ± 0.032	4.006ThrPro: 4.006 ± 0.079	1.472ThrGln: 1.472 ± 0.035	4.109ThrArg: 4.109 ± 0.064	3.852ThrSer: 3.852 ± 0.065	4.361ThrThr: 4.361 ± 0.078	5.512ThrVal: 5.512 ± 0.084	1.073ThrTrp: 1.073 ± 0.033	1.327ThrTyr: 1.327 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	12.399ValAla: 12.399 ± 0.117	0.732ValCys: 0.732 ± 0.026	6.309ValAsp: 6.309 ± 0.082	5.95ValGlu: 5.95 ± 0.074	2.482ValPhe: 2.482 ± 0.047	7.807ValGly: 7.807 ± 0.082	1.991ValHis: 1.991 ± 0.043	3.194ValIle: 3.194 ± 0.054	1.696ValLys: 1.696 ± 0.041	10.278ValLeu: 10.278 ± 0.104	1.699ValMet: 1.699 ± 0.037	1.68ValAsn: 1.68 ± 0.037	5.074ValPro: 5.074 ± 0.059	2.157ValGln: 2.157 ± 0.037	7.014ValArg: 7.014 ± 0.082	5.039ValSer: 5.039 ± 0.074	5.975ValThr: 5.975 ± 0.075	10.886ValVal: 10.886 ± 0.117	1.175ValTrp: 1.175 ± 0.032	1.337ValTyr: 1.337 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.646TrpAla: 1.646 ± 0.038	0.165TrpCys: 0.165 ± 0.012	0.87TrpAsp: 0.87 ± 0.029	0.72TrpGlu: 0.72 ± 0.024	0.559TrpPhe: 0.559 ± 0.021	1.166TrpGly: 1.166 ± 0.03	0.382TrpHis: 0.382 ± 0.017	0.547TrpIle: 0.547 ± 0.021	0.312TrpLys: 0.312 ± 0.017	1.978TrpLeu: 1.978 ± 0.044	0.286TrpMet: 0.286 ± 0.016	0.345TrpAsn: 0.345 ± 0.017	0.778TrpPro: 0.778 ± 0.028	0.547TrpGln: 0.547 ± 0.022	1.342TrpArg: 1.342 ± 0.041	1.08TrpSer: 1.08 ± 0.034	1.009TrpThr: 1.009 ± 0.031	1.311TrpVal: 1.311 ± 0.038	0.427TrpTrp: 0.427 ± 0.018	0.266TrpTyr: 0.266 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.224TyrAla: 2.224 ± 0.046	0.136TyrCys: 0.136 ± 0.01	1.693TyrAsp: 1.693 ± 0.037	1.012TyrGlu: 1.012 ± 0.03	0.636TyrPhe: 0.636 ± 0.024	1.719TyrGly: 1.719 ± 0.04	0.298TyrHis: 0.298 ± 0.016	0.453TyrIle: 0.453 ± 0.02	0.332TyrLys: 0.332 ± 0.017	1.871TyrLeu: 1.871 ± 0.043	0.229TyrMet: 0.229 ± 0.015	0.346TyrAsn: 0.346 ± 0.019	0.915TyrPro: 0.915 ± 0.026	0.47TyrGln: 0.47 ± 0.019	1.414TyrArg: 1.414 ± 0.04	0.942TyrSer: 0.942 ± 0.028	0.962TyrThr: 0.962 ± 0.035	1.778TyrVal: 1.778 ± 0.038	0.281TyrTrp: 0.281 ± 0.017	0.384TyrTyr: 0.384 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3712 proteins (1194092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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