Amino acid dipepetide frequency for Periconia macrospinosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.51AlaAla: 8.51 ± 0.045	1.199AlaCys: 1.199 ± 0.012	3.923AlaAsp: 3.923 ± 0.025	4.739AlaGlu: 4.739 ± 0.031	3.224AlaPhe: 3.224 ± 0.021	5.483AlaGly: 5.483 ± 0.034	1.845AlaHis: 1.845 ± 0.017	4.391AlaIle: 4.391 ± 0.024	4.081AlaLys: 4.081 ± 0.027	7.721AlaLeu: 7.721 ± 0.039	1.919AlaMet: 1.919 ± 0.017	3.044AlaAsn: 3.044 ± 0.021	4.591AlaPro: 4.591 ± 0.036	3.297AlaGln: 3.297 ± 0.023	4.64AlaArg: 4.64 ± 0.021	7.095AlaSer: 7.095 ± 0.037	5.226AlaThr: 5.226 ± 0.027	5.156AlaVal: 5.156 ± 0.029	1.255AlaTrp: 1.255 ± 0.013	2.267AlaTyr: 2.267 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.052CysAla: 1.052 ± 0.012	0.31CysCys: 0.31 ± 0.011	0.685CysAsp: 0.685 ± 0.011	0.644CysGlu: 0.644 ± 0.01	0.604CysPhe: 0.604 ± 0.009	1.032CysGly: 1.032 ± 0.013	0.364CysHis: 0.364 ± 0.007	0.835CysIle: 0.835 ± 0.012	0.61CysLys: 0.61 ± 0.01	1.306CysLeu: 1.306 ± 0.015	0.321CysMet: 0.321 ± 0.007	0.504CysAsn: 0.504 ± 0.009	0.703CysPro: 0.703 ± 0.012	0.476CysGln: 0.476 ± 0.008	0.822CysArg: 0.822 ± 0.011	1.002CysSer: 1.002 ± 0.012	0.832CysThr: 0.832 ± 0.012	0.903CysVal: 0.903 ± 0.011	0.234CysTrp: 0.234 ± 0.006	0.405CysTyr: 0.405 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.567AspAla: 4.567 ± 0.027	0.65AspCys: 0.65 ± 0.009	3.86AspAsp: 3.86 ± 0.032	4.108AspGlu: 4.108 ± 0.038	2.187AspPhe: 2.187 ± 0.017	3.819AspGly: 3.819 ± 0.021	1.212AspHis: 1.212 ± 0.013	3.038AspIle: 3.038 ± 0.023	2.363AspLys: 2.363 ± 0.021	4.726AspLeu: 4.726 ± 0.031	1.26AspMet: 1.26 ± 0.012	1.822AspAsn: 1.822 ± 0.017	3.171AspPro: 3.171 ± 0.022	1.763AspGln: 1.763 ± 0.016	2.856AspArg: 2.856 ± 0.026	3.789AspSer: 3.789 ± 0.026	2.919AspThr: 2.919 ± 0.021	3.6AspVal: 3.6 ± 0.023	0.94AspTrp: 0.94 ± 0.012	1.569AspTyr: 1.569 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	5.021GluAla: 5.021 ± 0.034	0.689GluCys: 0.689 ± 0.01	3.972GluAsp: 3.972 ± 0.032	5.342GluGlu: 5.342 ± 0.045	1.941GluPhe: 1.941 ± 0.018	3.786GluGly: 3.786 ± 0.027	1.427GluHis: 1.427 ± 0.014	3.014GluIle: 3.014 ± 0.023	3.889GluLys: 3.889 ± 0.027	5.026GluLeu: 5.026 ± 0.03	1.443GluMet: 1.443 ± 0.014	2.409GluAsn: 2.409 ± 0.018	2.575GluPro: 2.575 ± 0.021	2.425GluGln: 2.425 ± 0.022	3.872GluArg: 3.872 ± 0.027	3.975GluSer: 3.975 ± 0.029	3.3GluThr: 3.3 ± 0.022	3.464GluVal: 3.464 ± 0.023	0.97GluTrp: 0.97 ± 0.012	1.715GluTyr: 1.715 ± 0.016	0.001GluXaa: 0.001 ± 0.0
Phe	3.191PheAla: 3.191 ± 0.022	0.616PheCys: 0.616 ± 0.009	2.233PheAsp: 2.233 ± 0.017	2.194PheGlu: 2.194 ± 0.017	1.807PhePhe: 1.807 ± 0.021	2.862PheGly: 2.862 ± 0.022	0.958PheHis: 0.958 ± 0.011	1.907PheIle: 1.907 ± 0.017	1.617PheLys: 1.617 ± 0.017	3.624PheLeu: 3.624 ± 0.027	0.797PheMet: 0.797 ± 0.011	1.532PheAsn: 1.532 ± 0.014	2.077PhePro: 2.077 ± 0.016	1.445PheGln: 1.445 ± 0.014	2.014PheArg: 2.014 ± 0.018	3.101PheSer: 3.101 ± 0.022	2.334PheThr: 2.334 ± 0.017	2.509PheVal: 2.509 ± 0.018	0.726PheTrp: 0.726 ± 0.011	1.165PheTyr: 1.165 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.109GlyAla: 5.109 ± 0.033	0.954GlyCys: 0.954 ± 0.013	3.395GlyAsp: 3.395 ± 0.025	3.643GlyGlu: 3.643 ± 0.027	2.818GlyPhe: 2.818 ± 0.024	5.784GlyGly: 5.784 ± 0.044	1.636GlyHis: 1.636 ± 0.016	3.612GlyIle: 3.612 ± 0.026	3.645GlyLys: 3.645 ± 0.026	5.813GlyLeu: 5.813 ± 0.03	1.601GlyMet: 1.601 ± 0.015	2.591GlyAsn: 2.591 ± 0.023	3.046GlyPro: 3.046 ± 0.021	2.373GlyGln: 2.373 ± 0.019	3.932GlyArg: 3.932 ± 0.026	5.254GlySer: 5.254 ± 0.03	3.936GlyThr: 3.936 ± 0.026	4.382GlyVal: 4.382 ± 0.027	1.246GlyTrp: 1.246 ± 0.012	2.103GlyTyr: 2.103 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	1.954HisAla: 1.954 ± 0.015	0.391HisCys: 0.391 ± 0.008	1.336HisAsp: 1.336 ± 0.013	1.355HisGlu: 1.355 ± 0.015	1.004HisPhe: 1.004 ± 0.012	1.662HisGly: 1.662 ± 0.013	0.976HisHis: 0.976 ± 0.016	1.324HisIle: 1.324 ± 0.012	0.973HisLys: 0.973 ± 0.012	2.341HisLeu: 2.341 ± 0.02	0.521HisMet: 0.521 ± 0.007	0.925HisAsn: 0.925 ± 0.012	1.719HisPro: 1.719 ± 0.017	1.049HisGln: 1.049 ± 0.013	1.577HisArg: 1.577 ± 0.016	1.947HisSer: 1.947 ± 0.017	1.476HisThr: 1.476 ± 0.016	1.502HisVal: 1.502 ± 0.016	0.369HisTrp: 0.369 ± 0.007	0.738HisTyr: 0.738 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.366IleAla: 4.366 ± 0.027	0.819IleCys: 0.819 ± 0.01	2.841IleAsp: 2.841 ± 0.018	2.931IleGlu: 2.931 ± 0.021	2.131IlePhe: 2.131 ± 0.02	3.242IleGly: 3.242 ± 0.024	1.334IleHis: 1.334 ± 0.014	2.65IleIle: 2.65 ± 0.024	2.311IleLys: 2.311 ± 0.019	4.733IleLeu: 4.733 ± 0.029	1.073IleMet: 1.073 ± 0.012	1.921IleAsn: 1.921 ± 0.015	3.203IlePro: 3.203 ± 0.026	1.949IleGln: 1.949 ± 0.017	2.811IleArg: 2.811 ± 0.02	3.982IleSer: 3.982 ± 0.026	3.065IleThr: 3.065 ± 0.02	3.329IleVal: 3.329 ± 0.022	0.786IleTrp: 0.786 ± 0.01	1.501IleTyr: 1.501 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.168LysAla: 4.168 ± 0.031	0.6LysCys: 0.6 ± 0.01	2.913LysAsp: 2.913 ± 0.023	3.531LysGlu: 3.531 ± 0.028	1.519LysPhe: 1.519 ± 0.015	3.126LysGly: 3.126 ± 0.029	1.228LysHis: 1.228 ± 0.013	2.421LysIle: 2.421 ± 0.019	3.532LysLys: 3.532 ± 0.035	4.195LysLeu: 4.195 ± 0.027	1.044LysMet: 1.044 ± 0.012	1.965LysAsn: 1.965 ± 0.017	2.8LysPro: 2.8 ± 0.026	1.933LysGln: 1.933 ± 0.017	3.468LysArg: 3.468 ± 0.027	3.549LysSer: 3.549 ± 0.026	3.007LysThr: 3.007 ± 0.023	2.839LysVal: 2.839 ± 0.021	0.756LysTrp: 0.756 ± 0.01	1.461LysTyr: 1.461 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.561LeuAla: 7.561 ± 0.033	1.336LeuCys: 1.336 ± 0.013	4.996LeuAsp: 4.996 ± 0.025	5.42LeuGlu: 5.42 ± 0.029	3.514LeuPhe: 3.514 ± 0.027	5.756LeuGly: 5.756 ± 0.033	2.404LeuHis: 2.404 ± 0.019	4.051LeuIle: 4.051 ± 0.028	4.275LeuLys: 4.275 ± 0.027	8.513LeuLeu: 8.513 ± 0.044	1.739LeuMet: 1.739 ± 0.014	3.261LeuAsn: 3.261 ± 0.019	5.65LeuPro: 5.65 ± 0.037	3.84LeuGln: 3.84 ± 0.026	5.672LeuArg: 5.672 ± 0.029	7.304LeuSer: 7.304 ± 0.035	4.897LeuThr: 4.897 ± 0.027	5.423LeuVal: 5.423 ± 0.03	1.283LeuTrp: 1.283 ± 0.014	2.463LeuTyr: 2.463 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.084MetAla: 2.084 ± 0.017	0.284MetCys: 0.284 ± 0.006	1.217MetAsp: 1.217 ± 0.014	1.296MetGlu: 1.296 ± 0.014	0.785MetPhe: 0.785 ± 0.012	1.423MetGly: 1.423 ± 0.013	0.536MetHis: 0.536 ± 0.008	1.01MetIle: 1.01 ± 0.011	1.057MetLys: 1.057 ± 0.011	1.893MetLeu: 1.893 ± 0.015	0.58MetMet: 0.58 ± 0.01	0.852MetAsn: 0.852 ± 0.011	1.257MetPro: 1.257 ± 0.013	0.874MetGln: 0.874 ± 0.012	1.306MetArg: 1.306 ± 0.014	1.837MetSer: 1.837 ± 0.016	1.235MetThr: 1.235 ± 0.013	1.341MetVal: 1.341 ± 0.017	0.296MetTrp: 0.296 ± 0.006	0.597MetTyr: 0.597 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.321AsnAla: 3.321 ± 0.025	0.492AsnCys: 0.492 ± 0.008	2.022AsnAsp: 2.022 ± 0.015	2.114AsnGlu: 2.114 ± 0.02	1.492AsnPhe: 1.492 ± 0.014	3.023AsnGly: 3.023 ± 0.025	0.942AsnHis: 0.942 ± 0.011	2.21AsnIle: 2.21 ± 0.019	1.676AsnLys: 1.676 ± 0.015	3.371AsnLeu: 3.371 ± 0.022	0.885AsnMet: 0.885 ± 0.011	1.709AsnAsn: 1.709 ± 0.023	2.58AsnPro: 2.58 ± 0.019	1.393AsnGln: 1.393 ± 0.016	1.995AsnArg: 1.995 ± 0.016	2.883AsnSer: 2.883 ± 0.022	2.441AsnThr: 2.441 ± 0.02	2.406AsnVal: 2.406 ± 0.019	0.611AsnTrp: 0.611 ± 0.01	1.11AsnTyr: 1.11 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	4.842ProAla: 4.842 ± 0.033	0.583ProCys: 0.583 ± 0.009	2.964ProAsp: 2.964 ± 0.021	3.56ProGlu: 3.56 ± 0.024	2.173ProPhe: 2.173 ± 0.018	3.622ProGly: 3.622 ± 0.026	1.469ProHis: 1.469 ± 0.014	2.71ProIle: 2.71 ± 0.021	2.765ProLys: 2.765 ± 0.025	4.808ProLeu: 4.808 ± 0.03	1.038ProMet: 1.038 ± 0.013	2.37ProAsn: 2.37 ± 0.021	5.31ProPro: 5.31 ± 0.064	2.47ProGln: 2.47 ± 0.027	3.258ProArg: 3.258 ± 0.023	6.074ProSer: 6.074 ± 0.043	4.246ProThr: 4.246 ± 0.028	3.299ProVal: 3.299 ± 0.022	0.787ProTrp: 0.787 ± 0.011	1.577ProTyr: 1.577 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.194GlnAla: 3.194 ± 0.024	0.499GlnCys: 0.499 ± 0.009	2.012GlnAsp: 2.012 ± 0.017	2.283GlnGlu: 2.283 ± 0.021	1.322GlnPhe: 1.322 ± 0.012	2.338GlnGly: 2.338 ± 0.018	1.155GlnHis: 1.155 ± 0.014	1.922GlnIle: 1.922 ± 0.016	2.073GlnLys: 2.073 ± 0.02	3.413GlnLeu: 3.413 ± 0.022	0.856GlnMet: 0.856 ± 0.012	1.707GlnAsn: 1.707 ± 0.016	2.438GlnPro: 2.438 ± 0.024	2.445GlnGln: 2.445 ± 0.04	2.571GlnArg: 2.571 ± 0.02	3.076GlnSer: 3.076 ± 0.023	2.366GlnThr: 2.366 ± 0.017	2.058GlnVal: 2.058 ± 0.016	0.613GlnTrp: 0.613 ± 0.009	1.202GlnTyr: 1.202 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.555ArgAla: 4.555 ± 0.027	0.788ArgCys: 0.788 ± 0.011	3.13ArgAsp: 3.13 ± 0.025	3.668ArgGlu: 3.668 ± 0.026	2.244ArgPhe: 2.244 ± 0.018	3.616ArgGly: 3.616 ± 0.023	1.548ArgHis: 1.548 ± 0.015	3.056ArgIle: 3.056 ± 0.02	3.545ArgLys: 3.545 ± 0.026	5.349ArgLeu: 5.349 ± 0.029	1.347ArgMet: 1.347 ± 0.013	2.419ArgAsn: 2.419 ± 0.017	3.273ArgPro: 3.273 ± 0.023	2.43ArgGln: 2.43 ± 0.02	4.782ArgArg: 4.782 ± 0.039	4.57ArgSer: 4.57 ± 0.032	3.3ArgThr: 3.3 ± 0.02	3.269ArgVal: 3.269 ± 0.022	0.983ArgTrp: 0.983 ± 0.013	1.703ArgTyr: 1.703 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.367SerAla: 6.367 ± 0.032	0.974SerCys: 0.974 ± 0.011	3.882SerAsp: 3.882 ± 0.026	3.98SerGlu: 3.98 ± 0.024	3.162SerPhe: 3.162 ± 0.021	5.152SerGly: 5.152 ± 0.029	2.013SerHis: 2.013 ± 0.016	4.202SerIle: 4.202 ± 0.029	3.83SerLys: 3.83 ± 0.027	7.23SerLeu: 7.23 ± 0.039	1.722SerMet: 1.722 ± 0.016	3.171SerAsn: 3.171 ± 0.023	5.409SerPro: 5.409 ± 0.04	3.151SerGln: 3.151 ± 0.022	4.728SerArg: 4.728 ± 0.031	8.767SerSer: 8.767 ± 0.062	5.763SerThr: 5.763 ± 0.031	4.54SerVal: 4.54 ± 0.027	1.181SerTrp: 1.181 ± 0.012	2.159SerTyr: 2.159 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.19ThrAla: 5.19 ± 0.029	0.851ThrCys: 0.851 ± 0.012	2.747ThrAsp: 2.747 ± 0.016	3.028ThrGlu: 3.028 ± 0.019	2.435ThrPhe: 2.435 ± 0.018	3.933ThrGly: 3.933 ± 0.027	1.48ThrHis: 1.48 ± 0.013	3.304ThrIle: 3.304 ± 0.024	2.76ThrLys: 2.76 ± 0.02	5.569ThrLeu: 5.569 ± 0.028	1.231ThrMet: 1.231 ± 0.015	2.333ThrAsn: 2.333 ± 0.017	4.417ThrPro: 4.417 ± 0.033	2.181ThrGln: 2.181 ± 0.019	3.171ThrArg: 3.171 ± 0.018	5.477ThrSer: 5.477 ± 0.032	4.631ThrThr: 4.631 ± 0.036	3.709ThrVal: 3.709 ± 0.024	0.938ThrTrp: 0.938 ± 0.011	1.77ThrTyr: 1.77 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.125ValAla: 5.125 ± 0.029	0.922ValCys: 0.922 ± 0.012	3.522ValAsp: 3.522 ± 0.021	3.92ValGlu: 3.92 ± 0.026	2.509ValPhe: 2.509 ± 0.017	4.097ValGly: 4.097 ± 0.027	1.44ValHis: 1.44 ± 0.015	2.932ValIle: 2.932 ± 0.025	2.963ValLys: 2.963 ± 0.022	5.575ValLeu: 5.575 ± 0.029	1.317ValMet: 1.317 ± 0.014	2.227ValAsn: 2.227 ± 0.018	3.486ValPro: 3.486 ± 0.025	2.364ValGln: 2.364 ± 0.017	3.421ValArg: 3.421 ± 0.023	4.462ValSer: 4.462 ± 0.029	3.403ValThr: 3.403 ± 0.022	4.328ValVal: 4.328 ± 0.029	0.935ValTrp: 0.935 ± 0.012	1.756ValTyr: 1.756 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	1.168TrpAla: 1.168 ± 0.012	0.234TrpCys: 0.234 ± 0.005	0.938TrpAsp: 0.938 ± 0.012	0.918TrpGlu: 0.918 ± 0.01	0.59TrpPhe: 0.59 ± 0.008	1.022TrpGly: 1.022 ± 0.013	0.382TrpHis: 0.382 ± 0.008	0.877TrpIle: 0.877 ± 0.01	0.891TrpLys: 0.891 ± 0.011	1.428TrpLeu: 1.428 ± 0.015	0.398TrpMet: 0.398 ± 0.007	0.716TrpAsn: 0.716 ± 0.011	0.655TrpPro: 0.655 ± 0.01	0.579TrpGln: 0.579 ± 0.009	1.018TrpArg: 1.018 ± 0.013	1.136TrpSer: 1.136 ± 0.012	0.988TrpThr: 0.988 ± 0.014	0.979TrpVal: 0.979 ± 0.012	0.302TrpTrp: 0.302 ± 0.006	0.479TrpTyr: 0.479 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.262TyrAla: 2.262 ± 0.018	0.451TyrCys: 0.451 ± 0.008	1.632TyrAsp: 1.632 ± 0.014	1.581TyrGlu: 1.581 ± 0.014	1.248TyrPhe: 1.248 ± 0.014	2.09TyrGly: 2.09 ± 0.017	0.792TyrHis: 0.792 ± 0.011	1.513TyrIle: 1.513 ± 0.014	1.198TyrLys: 1.198 ± 0.013	2.723TyrLeu: 2.723 ± 0.019	0.67TyrMet: 0.67 ± 0.01	1.197TyrAsn: 1.197 ± 0.016	1.565TyrPro: 1.565 ± 0.017	1.106TyrGln: 1.106 ± 0.012	1.663TyrArg: 1.663 ± 0.015	2.101TyrSer: 2.101 ± 0.016	1.79TyrThr: 1.79 ± 0.015	1.671TyrVal: 1.671 ± 0.015	0.487TyrTrp: 0.487 ± 0.008	0.984TyrTyr: 0.984 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.004

Statistics based on 18722 proteins (7677607 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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