Amino acid dipepetide frequency for Halovenus aranensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.222AlaAla: 11.222 ± 0.148	0.752AlaCys: 0.752 ± 0.032	8.565AlaAsp: 8.565 ± 0.111	8.223AlaGlu: 8.223 ± 0.109	3.639AlaPhe: 3.639 ± 0.065	8.793AlaGly: 8.793 ± 0.106	1.712AlaHis: 1.712 ± 0.048	4.554AlaIle: 4.554 ± 0.069	1.85AlaLys: 1.85 ± 0.041	9.762AlaLeu: 9.762 ± 0.129	2.009AlaMet: 2.009 ± 0.043	2.303AlaAsn: 2.303 ± 0.049	3.418AlaPro: 3.418 ± 0.062	2.586AlaGln: 2.586 ± 0.052	5.622AlaArg: 5.622 ± 0.092	5.275AlaSer: 5.275 ± 0.091	7.079AlaThr: 7.079 ± 0.1	10.486AlaVal: 10.486 ± 0.137	1.024AlaTrp: 1.024 ± 0.029	2.483AlaTyr: 2.483 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.601CysAla: 0.601 ± 0.029	0.092CysCys: 0.092 ± 0.01	0.613CysAsp: 0.613 ± 0.026	0.63CysGlu: 0.63 ± 0.026	0.212CysPhe: 0.212 ± 0.017	0.854CysGly: 0.854 ± 0.037	0.184CysHis: 0.184 ± 0.012	0.319CysIle: 0.319 ± 0.018	0.125CysLys: 0.125 ± 0.013	0.678CysLeu: 0.678 ± 0.027	0.109CysMet: 0.109 ± 0.011	0.203CysAsn: 0.203 ± 0.014	0.585CysPro: 0.585 ± 0.027	0.225CysGln: 0.225 ± 0.016	0.522CysArg: 0.522 ± 0.026	0.47CysSer: 0.47 ± 0.024	0.425CysThr: 0.425 ± 0.023	0.501CysVal: 0.501 ± 0.021	0.113CysTrp: 0.113 ± 0.01	0.218CysTyr: 0.218 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.447AspAla: 8.447 ± 0.112	0.72AspCys: 0.72 ± 0.031	7.603AspAsp: 7.603 ± 0.116	8.157AspGlu: 8.157 ± 0.119	2.018AspPhe: 2.018 ± 0.053	7.986AspGly: 7.986 ± 0.129	1.838AspHis: 1.838 ± 0.044	4.36AspIle: 4.36 ± 0.072	1.223AspLys: 1.223 ± 0.04	6.524AspLeu: 6.524 ± 0.092	1.198AspMet: 1.198 ± 0.039	1.695AspAsn: 1.695 ± 0.052	4.034AspPro: 4.034 ± 0.069	2.152AspGln: 2.152 ± 0.051	5.831AspArg: 5.831 ± 0.086	4.588AspSer: 4.588 ± 0.078	4.799AspThr: 4.799 ± 0.075	6.499AspVal: 6.499 ± 0.089	1.042AspTrp: 1.042 ± 0.035	1.76AspTyr: 1.76 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.392GluAla: 8.392 ± 0.13	0.605GluCys: 0.605 ± 0.026	5.881GluAsp: 5.881 ± 0.099	7.358GluGlu: 7.358 ± 0.131	3.136GluPhe: 3.136 ± 0.062	5.233GluGly: 5.233 ± 0.081	2.079GluHis: 2.079 ± 0.05	4.084GluIle: 4.084 ± 0.089	1.967GluLys: 1.967 ± 0.053	7.725GluLeu: 7.725 ± 0.111	2.165GluMet: 2.165 ± 0.05	2.667GluAsn: 2.667 ± 0.061	3.854GluPro: 3.854 ± 0.062	3.749GluGln: 3.749 ± 0.073	7.198GluArg: 7.198 ± 0.103	5.481GluSer: 5.481 ± 0.078	7.803GluThr: 7.803 ± 0.106	5.77GluVal: 5.77 ± 0.092	1.137GluTrp: 1.137 ± 0.037	2.899GluTyr: 2.899 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.367PheAla: 3.367 ± 0.074	0.288PheCys: 0.288 ± 0.016	3.174PheAsp: 3.174 ± 0.053	3.629PheGlu: 3.629 ± 0.068	1.004PhePhe: 1.004 ± 0.041	3.267PheGly: 3.267 ± 0.07	0.577PheHis: 0.577 ± 0.021	1.21PheIle: 1.21 ± 0.042	0.513PheLys: 0.513 ± 0.024	2.947PheLeu: 2.947 ± 0.071	0.49PheMet: 0.49 ± 0.023	0.774PheAsn: 0.774 ± 0.026	1.246PhePro: 1.246 ± 0.039	0.912PheGln: 0.912 ± 0.029	1.751PheArg: 1.751 ± 0.044	1.767PheSer: 1.767 ± 0.045	1.914PheThr: 1.914 ± 0.052	3.082PheVal: 3.082 ± 0.058	0.382PheTrp: 0.382 ± 0.022	0.891PheTyr: 0.891 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.183GlyAla: 7.183 ± 0.105	0.765GlyCys: 0.765 ± 0.03	6.405GlyAsp: 6.405 ± 0.099	7.068GlyGlu: 7.068 ± 0.086	3.061GlyPhe: 3.061 ± 0.061	6.84GlyGly: 6.84 ± 0.114	1.681GlyHis: 1.681 ± 0.046	4.195GlyIle: 4.195 ± 0.067	1.871GlyLys: 1.871 ± 0.05	7.255GlyLeu: 7.255 ± 0.109	1.614GlyMet: 1.614 ± 0.042	2.0GlyAsn: 2.0 ± 0.047	3.154GlyPro: 3.154 ± 0.067	2.369GlyGln: 2.369 ± 0.054	4.355GlyArg: 4.355 ± 0.066	4.676GlySer: 4.676 ± 0.086	5.929GlyThr: 5.929 ± 0.084	7.193GlyVal: 7.193 ± 0.097	1.07GlyTrp: 1.07 ± 0.037	2.593GlyTyr: 2.593 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.912HisAla: 1.912 ± 0.043	0.211HisCys: 0.211 ± 0.013	1.861HisAsp: 1.861 ± 0.046	1.769HisGlu: 1.769 ± 0.053	0.521HisPhe: 0.521 ± 0.027	1.843HisGly: 1.843 ± 0.048	0.53HisHis: 0.53 ± 0.024	0.862HisIle: 0.862 ± 0.032	0.363HisLys: 0.363 ± 0.021	1.752HisLeu: 1.752 ± 0.039	0.303HisMet: 0.303 ± 0.017	0.576HisAsn: 0.576 ± 0.027	1.198HisPro: 1.198 ± 0.034	0.542HisGln: 0.542 ± 0.023	1.274HisArg: 1.274 ± 0.039	0.964HisSer: 0.964 ± 0.031	1.152HisThr: 1.152 ± 0.037	1.77HisVal: 1.77 ± 0.043	0.246HisTrp: 0.246 ± 0.016	0.562HisTyr: 0.562 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.706IleAla: 4.706 ± 0.069	0.278IleCys: 0.278 ± 0.016	4.212IleAsp: 4.212 ± 0.077	4.994IleGlu: 4.994 ± 0.08	1.125IlePhe: 1.125 ± 0.037	3.519IleGly: 3.519 ± 0.08	0.894IleHis: 0.894 ± 0.033	1.552IleIle: 1.552 ± 0.05	0.818IleLys: 0.818 ± 0.035	3.25IleLeu: 3.25 ± 0.072	0.513IleMet: 0.513 ± 0.026	1.073IleAsn: 1.073 ± 0.037	2.019IlePro: 2.019 ± 0.045	1.372IleGln: 1.372 ± 0.038	2.604IleArg: 2.604 ± 0.048	2.384IleSer: 2.384 ± 0.063	2.536IleThr: 2.536 ± 0.051	3.52IleVal: 3.52 ± 0.072	0.342IleTrp: 0.342 ± 0.019	0.962IleTyr: 0.962 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	1.784LysAla: 1.784 ± 0.05	0.136LysCys: 0.136 ± 0.011	1.059LysAsp: 1.059 ± 0.041	1.506LysGlu: 1.506 ± 0.048	0.529LysPhe: 0.529 ± 0.026	1.223LysGly: 1.223 ± 0.045	0.542LysHis: 0.542 ± 0.025	0.902LysIle: 0.902 ± 0.033	0.582LysLys: 0.582 ± 0.034	1.84LysLeu: 1.84 ± 0.05	0.417LysMet: 0.417 ± 0.02	0.578LysAsn: 0.578 ± 0.03	0.974LysPro: 0.974 ± 0.028	1.047LysGln: 1.047 ± 0.034	1.698LysArg: 1.698 ± 0.049	1.272LysSer: 1.272 ± 0.038	1.516LysThr: 1.516 ± 0.038	1.162LysVal: 1.162 ± 0.033	0.197LysTrp: 0.197 ± 0.014	0.581LysTyr: 0.581 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	10.436LeuAla: 10.436 ± 0.135	0.703LeuCys: 0.703 ± 0.026	8.241LeuAsp: 8.241 ± 0.103	6.85LeuGlu: 6.85 ± 0.11	3.241LeuPhe: 3.241 ± 0.07	7.657LeuGly: 7.657 ± 0.11	1.494LeuHis: 1.494 ± 0.041	2.818LeuIle: 2.818 ± 0.071	1.665LeuLys: 1.665 ± 0.041	8.462LeuLeu: 8.462 ± 0.137	1.296LeuMet: 1.296 ± 0.038	1.97LeuAsn: 1.97 ± 0.05	3.86LeuPro: 3.86 ± 0.07	2.458LeuGln: 2.458 ± 0.054	5.226LeuArg: 5.226 ± 0.082	5.922LeuSer: 5.922 ± 0.096	5.611LeuThr: 5.611 ± 0.085	8.561LeuVal: 8.561 ± 0.12	0.903LeuTrp: 0.903 ± 0.034	2.25LeuTyr: 2.25 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.756MetAla: 1.756 ± 0.042	0.117MetCys: 0.117 ± 0.01	1.263MetAsp: 1.263 ± 0.037	1.258MetGlu: 1.258 ± 0.038	0.529MetPhe: 0.529 ± 0.023	1.393MetGly: 1.393 ± 0.04	0.377MetHis: 0.377 ± 0.022	0.584MetIle: 0.584 ± 0.024	0.439MetLys: 0.439 ± 0.023	1.527MetLeu: 1.527 ± 0.041	0.315MetMet: 0.315 ± 0.018	0.602MetAsn: 0.602 ± 0.025	0.8MetPro: 0.8 ± 0.028	0.557MetGln: 0.557 ± 0.022	1.052MetArg: 1.052 ± 0.032	1.537MetSer: 1.537 ± 0.046	1.687MetThr: 1.687 ± 0.042	1.433MetVal: 1.433 ± 0.04	0.155MetTrp: 0.155 ± 0.013	0.406MetTyr: 0.406 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.52AsnAla: 2.52 ± 0.057	0.234AsnCys: 0.234 ± 0.017	1.76AsnAsp: 1.76 ± 0.048	2.001AsnGlu: 2.001 ± 0.056	0.688AsnPhe: 0.688 ± 0.029	2.001AsnGly: 2.001 ± 0.054	0.581AsnHis: 0.581 ± 0.024	1.246AsnIle: 1.246 ± 0.044	0.56AsnLys: 0.56 ± 0.03	2.044AsnLeu: 2.044 ± 0.053	0.443AsnMet: 0.443 ± 0.021	0.62AsnAsn: 0.62 ± 0.028	1.624AsnPro: 1.624 ± 0.045	0.746AsnGln: 0.746 ± 0.027	1.709AsnArg: 1.709 ± 0.042	1.154AsnSer: 1.154 ± 0.041	1.476AsnThr: 1.476 ± 0.043	2.256AsnVal: 2.256 ± 0.05	0.302AsnTrp: 0.302 ± 0.019	0.684AsnTyr: 0.684 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.507ProAla: 4.507 ± 0.078	0.264ProCys: 0.264 ± 0.017	4.508ProAsp: 4.508 ± 0.08	4.814ProGlu: 4.814 ± 0.077	1.525ProPhe: 1.525 ± 0.041	3.462ProGly: 3.462 ± 0.057	0.843ProHis: 0.843 ± 0.03	1.667ProIle: 1.667 ± 0.041	0.843ProLys: 0.843 ± 0.027	3.576ProLeu: 3.576 ± 0.065	0.819ProMet: 0.819 ± 0.029	1.018ProAsn: 1.018 ± 0.029	2.047ProPro: 2.047 ± 0.051	1.163ProGln: 1.163 ± 0.037	2.097ProArg: 2.097 ± 0.044	2.512ProSer: 2.512 ± 0.046	3.276ProThr: 3.276 ± 0.067	4.041ProVal: 4.041 ± 0.068	0.445ProTrp: 0.445 ± 0.022	1.096ProTyr: 1.096 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.013GlnAla: 3.013 ± 0.056	0.2GlnCys: 0.2 ± 0.016	1.547GlnAsp: 1.547 ± 0.045	2.279GlnGlu: 2.279 ± 0.054	1.336GlnPhe: 1.336 ± 0.036	1.86GlnGly: 1.86 ± 0.044	0.663GlnHis: 0.663 ± 0.027	1.326GlnIle: 1.326 ± 0.04	0.686GlnLys: 0.686 ± 0.029	2.983GlnLeu: 2.983 ± 0.058	0.668GlnMet: 0.668 ± 0.027	0.873GlnAsn: 0.873 ± 0.03	1.396GlnPro: 1.396 ± 0.034	1.52GlnGln: 1.52 ± 0.051	2.557GlnArg: 2.557 ± 0.057	2.064GlnSer: 2.064 ± 0.047	2.436GlnThr: 2.436 ± 0.057	2.26GlnVal: 2.26 ± 0.052	0.35GlnTrp: 0.35 ± 0.017	0.949GlnTyr: 0.949 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.816ArgAla: 5.816 ± 0.094	0.475ArgCys: 0.475 ± 0.023	4.771ArgAsp: 4.771 ± 0.075	6.537ArgGlu: 6.537 ± 0.092	2.097ArgPhe: 2.097 ± 0.046	4.139ArgGly: 4.139 ± 0.063	1.261ArgHis: 1.261 ± 0.037	2.871ArgIle: 2.871 ± 0.051	1.498ArgLys: 1.498 ± 0.041	5.999ArgLeu: 5.999 ± 0.091	1.214ArgMet: 1.214 ± 0.036	1.668ArgAsn: 1.668 ± 0.042	2.482ArgPro: 2.482 ± 0.052	2.392ArgGln: 2.392 ± 0.054	4.624ArgArg: 4.624 ± 0.085	3.191ArgSer: 3.191 ± 0.057	3.76ArgThr: 3.76 ± 0.061	4.931ArgVal: 4.931 ± 0.076	0.756ArgTrp: 0.756 ± 0.031	1.995ArgTyr: 1.995 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.332SerAla: 5.332 ± 0.074	0.368SerCys: 0.368 ± 0.019	4.411SerAsp: 4.411 ± 0.089	4.77SerGlu: 4.77 ± 0.076	2.05SerPhe: 2.05 ± 0.048	4.982SerGly: 4.982 ± 0.082	1.122SerHis: 1.122 ± 0.033	2.419SerIle: 2.419 ± 0.052	1.277SerLys: 1.277 ± 0.039	5.333SerLeu: 5.333 ± 0.082	1.176SerMet: 1.176 ± 0.039	1.458SerAsn: 1.458 ± 0.036	2.615SerPro: 2.615 ± 0.059	1.786SerGln: 1.786 ± 0.047	3.313SerArg: 3.313 ± 0.056	3.029SerSer: 3.029 ± 0.073	3.771SerThr: 3.771 ± 0.067	5.22SerVal: 5.22 ± 0.072	0.69SerTrp: 0.69 ± 0.03	1.592SerTyr: 1.592 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	7.633ThrAla: 7.633 ± 0.098	0.378ThrCys: 0.378 ± 0.02	5.905ThrAsp: 5.905 ± 0.1	5.758ThrGlu: 5.758 ± 0.083	2.173ThrPhe: 2.173 ± 0.05	5.843ThrGly: 5.843 ± 0.079	1.322ThrHis: 1.322 ± 0.039	2.962ThrIle: 2.962 ± 0.055	1.119ThrLys: 1.119 ± 0.035	6.32ThrLeu: 6.32 ± 0.092	1.091ThrMet: 1.091 ± 0.036	1.547ThrAsn: 1.547 ± 0.044	3.549ThrPro: 3.549 ± 0.064	1.924ThrGln: 1.924 ± 0.055	3.408ThrArg: 3.408 ± 0.057	3.06ThrSer: 3.06 ± 0.055	4.73ThrThr: 4.73 ± 0.081	7.86ThrVal: 7.86 ± 0.114	0.637ThrTrp: 0.637 ± 0.024	1.782ThrTyr: 1.782 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	9.428ValAla: 9.428 ± 0.123	0.721ValCys: 0.721 ± 0.025	7.362ValAsp: 7.362 ± 0.096	8.036ValGlu: 8.036 ± 0.107	3.007ValPhe: 3.007 ± 0.061	7.4ValGly: 7.4 ± 0.109	1.614ValHis: 1.614 ± 0.043	3.36ValIle: 3.36 ± 0.061	1.375ValLys: 1.375 ± 0.041	7.983ValLeu: 7.983 ± 0.108	1.309ValMet: 1.309 ± 0.036	1.947ValAsn: 1.947 ± 0.05	3.957ValPro: 3.957 ± 0.066	2.123ValGln: 2.123 ± 0.049	4.828ValArg: 4.828 ± 0.066	5.41ValSer: 5.41 ± 0.078	6.778ValThr: 6.778 ± 0.098	8.826ValVal: 8.826 ± 0.124	0.811ValTrp: 0.811 ± 0.029	2.186ValTyr: 2.186 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.887TrpAla: 0.887 ± 0.032	0.12TrpCys: 0.12 ± 0.01	0.743TrpAsp: 0.743 ± 0.03	0.972TrpGlu: 0.972 ± 0.035	0.409TrpPhe: 0.409 ± 0.022	0.781TrpGly: 0.781 ± 0.029	0.25TrpHis: 0.25 ± 0.016	0.401TrpIle: 0.401 ± 0.022	0.297TrpLys: 0.297 ± 0.019	1.222TrpLeu: 1.222 ± 0.038	0.239TrpMet: 0.239 ± 0.014	0.335TrpAsn: 0.335 ± 0.017	0.415TrpPro: 0.415 ± 0.022	0.438TrpGln: 0.438 ± 0.024	0.773TrpArg: 0.773 ± 0.029	0.575TrpSer: 0.575 ± 0.026	0.778TrpThr: 0.778 ± 0.029	0.855TrpVal: 0.855 ± 0.03	0.171TrpTrp: 0.171 ± 0.015	0.412TrpTyr: 0.412 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.416TyrAla: 2.416 ± 0.052	0.252TyrCys: 0.252 ± 0.016	2.592TyrAsp: 2.592 ± 0.055	2.577TyrGlu: 2.577 ± 0.058	0.884TyrPhe: 0.884 ± 0.034	2.199TyrGly: 2.199 ± 0.051	0.647TyrHis: 0.647 ± 0.028	0.977TyrIle: 0.977 ± 0.035	0.473TyrLys: 0.473 ± 0.025	2.444TyrLeu: 2.444 ± 0.054	0.399TyrMet: 0.399 ± 0.02	0.743TyrAsn: 0.743 ± 0.033	1.29TyrPro: 1.29 ± 0.04	0.906TyrGln: 0.906 ± 0.033	2.036TyrArg: 2.036 ± 0.045	1.383TyrSer: 1.383 ± 0.041	1.549TyrThr: 1.549 ± 0.039	2.235TyrVal: 2.235 ± 0.043	0.299TyrTrp: 0.299 ± 0.018	0.839TyrTyr: 0.839 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3354 proteins (979672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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