Amino acid dipepetide frequency for Salinadaptatus halalkaliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.717AlaAla: 11.717 ± 0.133	0.73AlaCys: 0.73 ± 0.025	9.895AlaAsp: 9.895 ± 0.111	7.723AlaGlu: 7.723 ± 0.095	3.839AlaPhe: 3.839 ± 0.06	8.917AlaGly: 8.917 ± 0.094	1.759AlaHis: 1.759 ± 0.042	5.94AlaIle: 5.94 ± 0.085	1.696AlaLys: 1.696 ± 0.043	9.727AlaLeu: 9.727 ± 0.112	1.997AlaMet: 1.997 ± 0.041	2.424AlaAsn: 2.424 ± 0.05	3.486AlaPro: 3.486 ± 0.057	2.292AlaGln: 2.292 ± 0.043	5.551AlaArg: 5.551 ± 0.082	5.436AlaSer: 5.436 ± 0.062	7.636AlaThr: 7.636 ± 0.095	9.937AlaVal: 9.937 ± 0.103	1.032AlaTrp: 1.032 ± 0.028	2.657AlaTyr: 2.657 ± 0.047	0.001AlaXaa: 0.001 ± 0.001
Cys	0.576CysAla: 0.576 ± 0.025	0.109CysCys: 0.109 ± 0.01	0.617CysAsp: 0.617 ± 0.023	0.618CysGlu: 0.618 ± 0.024	0.197CysPhe: 0.197 ± 0.014	0.846CysGly: 0.846 ± 0.03	0.219CysHis: 0.219 ± 0.016	0.245CysIle: 0.245 ± 0.015	0.136CysLys: 0.136 ± 0.011	0.688CysLeu: 0.688 ± 0.027	0.111CysMet: 0.111 ± 0.009	0.177CysAsn: 0.177 ± 0.014	0.528CysPro: 0.528 ± 0.025	0.199CysGln: 0.199 ± 0.013	0.557CysArg: 0.557 ± 0.024	0.492CysSer: 0.492 ± 0.022	0.453CysThr: 0.453 ± 0.02	0.488CysVal: 0.488 ± 0.018	0.098CysTrp: 0.098 ± 0.009	0.238CysTyr: 0.238 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.493AspAla: 9.493 ± 0.096	0.688AspCys: 0.688 ± 0.029	9.548AspAsp: 9.548 ± 0.132	8.737AspGlu: 8.737 ± 0.102	1.801AspPhe: 1.801 ± 0.039	8.261AspGly: 8.261 ± 0.096	2.083AspHis: 2.083 ± 0.05	3.809AspIle: 3.809 ± 0.063	0.952AspLys: 0.952 ± 0.036	7.165AspLeu: 7.165 ± 0.087	1.1AspMet: 1.1 ± 0.033	1.413AspAsn: 1.413 ± 0.04	4.74AspPro: 4.74 ± 0.067	2.075AspGln: 2.075 ± 0.042	6.953AspArg: 6.953 ± 0.088	3.959AspSer: 3.959 ± 0.066	4.288AspThr: 4.288 ± 0.069	7.458AspVal: 7.458 ± 0.097	0.983AspTrp: 0.983 ± 0.032	1.826AspTyr: 1.826 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.611GluAla: 8.611 ± 0.094	0.559GluCys: 0.559 ± 0.026	6.389GluAsp: 6.389 ± 0.083	6.393GluGlu: 6.393 ± 0.098	3.004GluPhe: 3.004 ± 0.05	5.222GluGly: 5.222 ± 0.072	2.091GluHis: 2.091 ± 0.044	4.604GluIle: 4.604 ± 0.064	1.679GluLys: 1.679 ± 0.045	7.995GluLeu: 7.995 ± 0.079	1.873GluMet: 1.873 ± 0.037	2.33GluAsn: 2.33 ± 0.049	4.546GluPro: 4.546 ± 0.073	3.148GluGln: 3.148 ± 0.06	7.383GluArg: 7.383 ± 0.085	5.583GluSer: 5.583 ± 0.076	7.872GluThr: 7.872 ± 0.095	5.106GluVal: 5.106 ± 0.069	1.135GluTrp: 1.135 ± 0.03	2.912GluTyr: 2.912 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.456PheAla: 3.456 ± 0.068	0.31PheCys: 0.31 ± 0.016	3.364PheAsp: 3.364 ± 0.05	3.249PheGlu: 3.249 ± 0.047	1.004PhePhe: 1.004 ± 0.031	3.13PheGly: 3.13 ± 0.055	0.621PheHis: 0.621 ± 0.022	1.039PheIle: 1.039 ± 0.033	0.419PheLys: 0.419 ± 0.018	2.742PheLeu: 2.742 ± 0.058	0.494PheMet: 0.494 ± 0.022	0.661PheAsn: 0.661 ± 0.026	1.212PhePro: 1.212 ± 0.033	0.78PheGln: 0.78 ± 0.023	1.574PheArg: 1.574 ± 0.036	1.599PheSer: 1.599 ± 0.041	1.771PheThr: 1.771 ± 0.038	3.33PheVal: 3.33 ± 0.059	0.382PheTrp: 0.382 ± 0.018	0.864PheTyr: 0.864 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	7.474GlyAla: 7.474 ± 0.1	0.774GlyCys: 0.774 ± 0.028	6.594GlyAsp: 6.594 ± 0.089	6.738GlyGlu: 6.738 ± 0.084	2.992GlyPhe: 2.992 ± 0.06	6.556GlyGly: 6.556 ± 0.09	1.684GlyHis: 1.684 ± 0.039	4.59GlyIle: 4.59 ± 0.071	1.689GlyLys: 1.689 ± 0.042	7.302GlyLeu: 7.302 ± 0.104	1.575GlyMet: 1.575 ± 0.04	1.897GlyAsn: 1.897 ± 0.045	3.265GlyPro: 3.265 ± 0.054	2.068GlyGln: 2.068 ± 0.037	4.557GlyArg: 4.557 ± 0.06	4.998GlySer: 4.998 ± 0.067	5.859GlyThr: 5.859 ± 0.074	6.989GlyVal: 6.989 ± 0.089	1.128GlyTrp: 1.128 ± 0.032	2.731GlyTyr: 2.731 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.993HisAla: 1.993 ± 0.041	0.211HisCys: 0.211 ± 0.014	1.94HisAsp: 1.94 ± 0.041	1.788HisGlu: 1.788 ± 0.044	0.516HisPhe: 0.516 ± 0.023	2.027HisGly: 2.027 ± 0.044	0.574HisHis: 0.574 ± 0.021	0.705HisIle: 0.705 ± 0.023	0.311HisLys: 0.311 ± 0.017	1.661HisLeu: 1.661 ± 0.039	0.284HisMet: 0.284 ± 0.015	0.458HisAsn: 0.458 ± 0.019	1.235HisPro: 1.235 ± 0.032	0.545HisGln: 0.545 ± 0.019	1.389HisArg: 1.389 ± 0.033	0.943HisSer: 0.943 ± 0.028	1.134HisThr: 1.134 ± 0.03	1.882HisVal: 1.882 ± 0.046	0.228HisTrp: 0.228 ± 0.013	0.572HisTyr: 0.572 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.448IleAla: 5.448 ± 0.075	0.334IleCys: 0.334 ± 0.017	5.155IleAsp: 5.155 ± 0.059	4.764IleGlu: 4.764 ± 0.073	1.144IlePhe: 1.144 ± 0.034	4.361IleGly: 4.361 ± 0.065	0.874IleHis: 0.874 ± 0.03	1.482IleIle: 1.482 ± 0.041	0.724IleLys: 0.724 ± 0.027	3.372IleLeu: 3.372 ± 0.061	0.56IleMet: 0.56 ± 0.02	1.013IleAsn: 1.013 ± 0.03	2.135IlePro: 2.135 ± 0.05	1.247IleGln: 1.247 ± 0.04	2.542IleArg: 2.542 ± 0.042	2.368IleSer: 2.368 ± 0.044	2.829IleThr: 2.829 ± 0.051	4.696IleVal: 4.696 ± 0.066	0.403IleTrp: 0.403 ± 0.018	1.077IleTyr: 1.077 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.618LysAla: 1.618 ± 0.044	0.113LysCys: 0.113 ± 0.01	0.991LysAsp: 0.991 ± 0.033	1.122LysGlu: 1.122 ± 0.039	0.467LysPhe: 0.467 ± 0.021	1.194LysGly: 1.194 ± 0.031	0.476LysHis: 0.476 ± 0.024	0.806LysIle: 0.806 ± 0.03	0.471LysLys: 0.471 ± 0.024	1.605LysLeu: 1.605 ± 0.041	0.345LysMet: 0.345 ± 0.017	0.519LysAsn: 0.519 ± 0.023	0.919LysPro: 0.919 ± 0.029	0.721LysGln: 0.721 ± 0.027	1.607LysArg: 1.607 ± 0.034	1.088LysSer: 1.088 ± 0.032	1.261LysThr: 1.261 ± 0.036	0.949LysVal: 0.949 ± 0.03	0.208LysTrp: 0.208 ± 0.013	0.525LysTyr: 0.525 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	10.707LeuAla: 10.707 ± 0.114	0.65LeuCys: 0.65 ± 0.023	5.581LeuAsp: 5.581 ± 0.067	12.311LeuGlu: 12.311 ± 0.122	3.085LeuPhe: 3.085 ± 0.06	7.198LeuGly: 7.198 ± 0.101	1.444LeuHis: 1.444 ± 0.037	3.154LeuIle: 3.154 ± 0.065	1.398LeuLys: 1.398 ± 0.038	8.44LeuLeu: 8.44 ± 0.111	1.127LeuMet: 1.127 ± 0.031	1.628LeuAsn: 1.628 ± 0.038	4.004LeuPro: 4.004 ± 0.064	2.195LeuGln: 2.195 ± 0.043	4.686LeuArg: 4.686 ± 0.069	5.354LeuSer: 5.354 ± 0.074	5.212LeuThr: 5.212 ± 0.06	8.307LeuVal: 8.307 ± 0.112	0.86LeuTrp: 0.86 ± 0.028	2.182LeuTyr: 2.182 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.885MetAla: 1.885 ± 0.046	0.112MetCys: 0.112 ± 0.01	1.202MetAsp: 1.202 ± 0.033	1.008MetGlu: 1.008 ± 0.026	0.484MetPhe: 0.484 ± 0.019	1.441MetGly: 1.441 ± 0.036	0.339MetHis: 0.339 ± 0.015	0.756MetIle: 0.756 ± 0.024	0.387MetLys: 0.387 ± 0.018	1.503MetLeu: 1.503 ± 0.033	0.311MetMet: 0.311 ± 0.016	0.577MetAsn: 0.577 ± 0.022	0.792MetPro: 0.792 ± 0.023	0.499MetGln: 0.499 ± 0.021	0.934MetArg: 0.934 ± 0.027	1.414MetSer: 1.414 ± 0.032	1.532MetThr: 1.532 ± 0.033	1.268MetVal: 1.268 ± 0.037	0.15MetTrp: 0.15 ± 0.011	0.415MetTyr: 0.415 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.497AsnAla: 2.497 ± 0.05	0.212AsnCys: 0.212 ± 0.014	1.79AsnAsp: 1.79 ± 0.039	1.88AsnGlu: 1.88 ± 0.041	0.614AsnPhe: 0.614 ± 0.02	1.953AsnGly: 1.953 ± 0.043	0.548AsnHis: 0.548 ± 0.021	0.892AsnIle: 0.892 ± 0.03	0.434AsnLys: 0.434 ± 0.019	1.857AsnLeu: 1.857 ± 0.04	0.386AsnMet: 0.386 ± 0.016	0.523AsnAsn: 0.523 ± 0.023	1.482AsnPro: 1.482 ± 0.037	0.639AsnGln: 0.639 ± 0.027	1.714AsnArg: 1.714 ± 0.039	0.954AsnSer: 0.954 ± 0.031	1.265AsnThr: 1.265 ± 0.037	2.272AsnVal: 2.272 ± 0.045	0.341AsnTrp: 0.341 ± 0.018	0.668AsnTyr: 0.668 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.773ProAla: 4.773 ± 0.074	0.252ProCys: 0.252 ± 0.014	5.011ProAsp: 5.011 ± 0.075	4.25ProGlu: 4.25 ± 0.065	1.509ProPhe: 1.509 ± 0.038	3.463ProGly: 3.463 ± 0.051	0.902ProHis: 0.902 ± 0.024	2.372ProIle: 2.372 ± 0.041	0.794ProLys: 0.794 ± 0.026	3.636ProLeu: 3.636 ± 0.065	0.842ProMet: 0.842 ± 0.027	1.188ProAsn: 1.188 ± 0.032	2.219ProPro: 2.219 ± 0.046	1.073ProGln: 1.073 ± 0.03	2.172ProArg: 2.172 ± 0.039	2.692ProSer: 2.692 ± 0.052	3.523ProThr: 3.523 ± 0.052	3.955ProVal: 3.955 ± 0.062	0.494ProTrp: 0.494 ± 0.022	1.085ProTyr: 1.085 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.588GlnAla: 2.588 ± 0.048	0.193GlnCys: 0.193 ± 0.011	1.537GlnAsp: 1.537 ± 0.047	1.856GlnGlu: 1.856 ± 0.043	1.102GlnPhe: 1.102 ± 0.031	1.608GlnGly: 1.608 ± 0.034	0.567GlnHis: 0.567 ± 0.021	1.291GlnIle: 1.291 ± 0.037	0.54GlnLys: 0.54 ± 0.026	2.785GlnLeu: 2.785 ± 0.049	0.538GlnMet: 0.538 ± 0.02	0.719GlnAsn: 0.719 ± 0.023	1.332GlnPro: 1.332 ± 0.031	1.219GlnGln: 1.219 ± 0.043	2.12GlnArg: 2.12 ± 0.045	1.706GlnSer: 1.706 ± 0.043	1.895GlnThr: 1.895 ± 0.037	1.8GlnVal: 1.8 ± 0.038	0.354GlnTrp: 0.354 ± 0.019	0.981GlnTyr: 0.981 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.717ArgAla: 5.717 ± 0.08	0.482ArgCys: 0.482 ± 0.021	4.835ArgAsp: 4.835 ± 0.066	6.273ArgGlu: 6.273 ± 0.087	2.17ArgPhe: 2.17 ± 0.045	4.066ArgGly: 4.066 ± 0.058	1.256ArgHis: 1.256 ± 0.034	3.142ArgIle: 3.142 ± 0.048	1.33ArgLys: 1.33 ± 0.034	6.025ArgLeu: 6.025 ± 0.076	1.231ArgMet: 1.231 ± 0.029	1.621ArgAsn: 1.621 ± 0.039	2.551ArgPro: 2.551 ± 0.043	1.903ArgGln: 1.903 ± 0.039	4.819ArgArg: 4.819 ± 0.076	3.903ArgSer: 3.903 ± 0.066	4.289ArgThr: 4.289 ± 0.058	4.653ArgVal: 4.653 ± 0.066	0.737ArgTrp: 0.737 ± 0.026	1.921ArgTyr: 1.921 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.143SerAla: 5.143 ± 0.07	0.357SerCys: 0.357 ± 0.017	4.59SerAsp: 4.59 ± 0.066	4.254SerGlu: 4.254 ± 0.071	1.92SerPhe: 1.92 ± 0.04	4.842SerGly: 4.842 ± 0.067	1.07SerHis: 1.07 ± 0.03	2.974SerIle: 2.974 ± 0.051	1.147SerLys: 1.147 ± 0.033	5.041SerLeu: 5.041 ± 0.067	1.201SerMet: 1.201 ± 0.033	1.445SerAsn: 1.445 ± 0.038	2.657SerPro: 2.657 ± 0.052	1.554SerGln: 1.554 ± 0.041	3.332SerArg: 3.332 ± 0.051	3.609SerSer: 3.609 ± 0.072	3.871SerThr: 3.871 ± 0.065	4.925SerVal: 4.925 ± 0.074	0.643SerTrp: 0.643 ± 0.022	1.459SerTyr: 1.459 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.355ThrAla: 7.355 ± 0.085	0.426ThrCys: 0.426 ± 0.019	6.682ThrAsp: 6.682 ± 0.086	4.957ThrGlu: 4.957 ± 0.07	2.065ThrPhe: 2.065 ± 0.043	5.782ThrGly: 5.782 ± 0.073	1.253ThrHis: 1.253 ± 0.034	3.911ThrIle: 3.911 ± 0.063	1.048ThrLys: 1.048 ± 0.034	6.068ThrLeu: 6.068 ± 0.067	1.127ThrMet: 1.127 ± 0.033	1.627ThrAsn: 1.627 ± 0.04	3.218ThrPro: 3.218 ± 0.053	1.513ThrGln: 1.513 ± 0.038	3.356ThrArg: 3.356 ± 0.051	3.103ThrSer: 3.103 ± 0.055	4.788ThrThr: 4.788 ± 0.071	7.292ThrVal: 7.292 ± 0.107	0.614ThrTrp: 0.614 ± 0.022	1.767ThrTyr: 1.767 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.677ValAla: 9.677 ± 0.11	0.7ValCys: 0.7 ± 0.022	7.95ValAsp: 7.95 ± 0.092	7.136ValGlu: 7.136 ± 0.082	2.839ValPhe: 2.839 ± 0.056	7.501ValGly: 7.501 ± 0.11	1.665ValHis: 1.665 ± 0.039	3.432ValIle: 3.432 ± 0.062	1.148ValLys: 1.148 ± 0.033	8.109ValLeu: 8.109 ± 0.111	1.31ValMet: 1.31 ± 0.036	1.714ValAsn: 1.714 ± 0.035	4.225ValPro: 4.225 ± 0.058	1.934ValGln: 1.934 ± 0.037	5.016ValArg: 5.016 ± 0.074	5.062ValSer: 5.062 ± 0.066	6.217ValThr: 6.217 ± 0.087	8.705ValVal: 8.705 ± 0.119	0.763ValTrp: 0.763 ± 0.026	2.104ValTyr: 2.104 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.877TrpAla: 0.877 ± 0.027	0.107TrpCys: 0.107 ± 0.01	0.813TrpAsp: 0.813 ± 0.029	0.844TrpGlu: 0.844 ± 0.029	0.429TrpPhe: 0.429 ± 0.019	0.776TrpGly: 0.776 ± 0.027	0.292TrpHis: 0.292 ± 0.015	0.615TrpIle: 0.615 ± 0.022	0.256TrpLys: 0.256 ± 0.019	1.314TrpLeu: 1.314 ± 0.04	0.224TrpMet: 0.224 ± 0.014	0.37TrpAsn: 0.37 ± 0.018	0.441TrpPro: 0.441 ± 0.023	0.401TrpGln: 0.401 ± 0.017	0.73TrpArg: 0.73 ± 0.026	0.581TrpSer: 0.581 ± 0.025	0.747TrpThr: 0.747 ± 0.024	0.756TrpVal: 0.756 ± 0.027	0.195TrpTrp: 0.195 ± 0.013	0.349TrpTyr: 0.349 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.785TyrAla: 2.785 ± 0.048	0.272TyrCys: 0.272 ± 0.014	2.851TyrAsp: 2.851 ± 0.061	2.536TyrGlu: 2.536 ± 0.047	0.819TyrPhe: 0.819 ± 0.024	2.314TyrGly: 2.314 ± 0.046	0.682TyrHis: 0.682 ± 0.023	0.768TyrIle: 0.768 ± 0.029	0.446TyrLys: 0.446 ± 0.019	2.486TyrLeu: 2.486 ± 0.053	0.371TyrMet: 0.371 ± 0.017	0.618TyrAsn: 0.618 ± 0.021	1.218TyrPro: 1.218 ± 0.031	0.722TyrGln: 0.722 ± 0.023	1.935TyrArg: 1.935 ± 0.046	1.189TyrSer: 1.189 ± 0.031	1.511TyrThr: 1.511 ± 0.03	2.436TyrVal: 2.436 ± 0.046	0.37TyrTrp: 0.37 ± 0.02	0.905TyrTyr: 0.905 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4165 proteins (1243612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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