Amino acid dipepetide frequency for Thalassolituus oleivorans MIL-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.68AlaAla: 9.68 ± 0.136
0.969AlaCys: 0.969 ± 0.032
5.872AlaAsp: 5.872 ± 0.099
6.395AlaGlu: 6.395 ± 0.083
3.366AlaPhe: 3.366 ± 0.057
6.877AlaGly: 6.877 ± 0.109
1.833AlaHis: 1.833 ± 0.049
5.98AlaIle: 5.98 ± 0.083
4.17AlaLys: 4.17 ± 0.075
10.524AlaLeu: 10.524 ± 0.132
2.843AlaMet: 2.843 ± 0.051
3.675AlaAsn: 3.675 ± 0.073
3.443AlaPro: 3.443 ± 0.077
3.876AlaGln: 3.876 ± 0.066
4.467AlaArg: 4.467 ± 0.061
5.834AlaSer: 5.834 ± 0.089
5.154AlaThr: 5.154 ± 0.124
6.447AlaVal: 6.447 ± 0.085
1.196AlaTrp: 1.196 ± 0.038
2.439AlaTyr: 2.439 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.802CysAla: 0.802 ± 0.029
0.126CysCys: 0.126 ± 0.01
0.586CysAsp: 0.586 ± 0.027
0.537CysGlu: 0.537 ± 0.019
0.341CysPhe: 0.341 ± 0.018
0.819CysGly: 0.819 ± 0.029
0.31CysHis: 0.31 ± 0.02
0.569CysIle: 0.569 ± 0.028
0.387CysLys: 0.387 ± 0.021
0.964CysLeu: 0.964 ± 0.031
0.233CysMet: 0.233 ± 0.015
0.314CysAsn: 0.314 ± 0.017
0.489CysPro: 0.489 ± 0.023
0.417CysGln: 0.417 ± 0.018
0.543CysArg: 0.543 ± 0.024
0.603CysSer: 0.603 ± 0.024
0.466CysThr: 0.466 ± 0.023
0.642CysVal: 0.642 ± 0.025
0.114CysTrp: 0.114 ± 0.01
0.31CysTyr: 0.31 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.541AspAla: 5.541 ± 0.098
0.553AspCys: 0.553 ± 0.025
3.865AspAsp: 3.865 ± 0.086
4.063AspGlu: 4.063 ± 0.06
2.448AspPhe: 2.448 ± 0.051
4.593AspGly: 4.593 ± 0.133
1.24AspHis: 1.24 ± 0.034
4.14AspIle: 4.14 ± 0.066
2.516AspLys: 2.516 ± 0.06
5.831AspLeu: 5.831 ± 0.083
1.548AspMet: 1.548 ± 0.043
2.37AspAsn: 2.37 ± 0.064
2.288AspPro: 2.288 ± 0.05
2.243AspGln: 2.243 ± 0.049
2.795AspArg: 2.795 ± 0.055
3.617AspSer: 3.617 ± 0.069
3.178AspThr: 3.178 ± 0.072
4.453AspVal: 4.453 ± 0.083
0.961AspTrp: 0.961 ± 0.028
1.987AspTyr: 1.987 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.715GluAla: 5.715 ± 0.092
0.539GluCys: 0.539 ± 0.022
3.037GluAsp: 3.037 ± 0.055
3.637GluGlu: 3.637 ± 0.07
2.419GluPhe: 2.419 ± 0.048
3.714GluGly: 3.714 ± 0.062
1.675GluHis: 1.675 ± 0.042
3.595GluIle: 3.595 ± 0.063
3.116GluLys: 3.116 ± 0.067
6.846GluLeu: 6.846 ± 0.08
1.623GluMet: 1.623 ± 0.041
2.388GluAsn: 2.388 ± 0.047
2.075GluPro: 2.075 ± 0.048
3.618GluGln: 3.618 ± 0.072
4.029GluArg: 4.029 ± 0.068
3.455GluSer: 3.455 ± 0.059
3.031GluThr: 3.031 ± 0.061
4.187GluVal: 4.187 ± 0.067
0.879GluTrp: 0.879 ± 0.027
1.852GluTyr: 1.852 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.469PheAla: 3.469 ± 0.057
0.445PheCys: 0.445 ± 0.02
2.661PheAsp: 2.661 ± 0.063
2.215PheGlu: 2.215 ± 0.05
1.601PhePhe: 1.601 ± 0.044
2.901PheGly: 2.901 ± 0.061
0.739PheHis: 0.739 ± 0.027
2.38PheIle: 2.38 ± 0.051
1.611PheLys: 1.611 ± 0.041
3.273PheLeu: 3.273 ± 0.064
1.013PheMet: 1.013 ± 0.031
1.821PheAsn: 1.821 ± 0.04
1.469PhePro: 1.469 ± 0.043
1.202PheGln: 1.202 ± 0.036
1.77PheArg: 1.77 ± 0.046
2.956PheSer: 2.956 ± 0.057
2.228PheThr: 2.228 ± 0.05
2.511PheVal: 2.511 ± 0.058
0.554PheTrp: 0.554 ± 0.023
1.208PheTyr: 1.208 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.778GlyAla: 5.778 ± 0.095
0.845GlyCys: 0.845 ± 0.029
4.259GlyAsp: 4.259 ± 0.076
4.348GlyGlu: 4.348 ± 0.06
3.101GlyPhe: 3.101 ± 0.057
4.963GlyGly: 4.963 ± 0.088
1.628GlyHis: 1.628 ± 0.037
4.644GlyIle: 4.644 ± 0.068
3.428GlyLys: 3.428 ± 0.066
7.256GlyLeu: 7.256 ± 0.096
2.048GlyMet: 2.048 ± 0.049
2.62GlyAsn: 2.62 ± 0.065
1.831GlyPro: 1.831 ± 0.045
2.712GlyGln: 2.712 ± 0.05
3.683GlyArg: 3.683 ± 0.061
4.392GlySer: 4.392 ± 0.09
3.757GlyThr: 3.757 ± 0.074
5.278GlyVal: 5.278 ± 0.078
1.053GlyTrp: 1.053 ± 0.034
2.49GlyTyr: 2.49 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.769HisAla: 1.769 ± 0.046
0.326HisCys: 0.326 ± 0.017
1.205HisAsp: 1.205 ± 0.031
1.218HisGlu: 1.218 ± 0.035
1.003HisPhe: 1.003 ± 0.027
1.613HisGly: 1.613 ± 0.043
0.67HisHis: 0.67 ± 0.027
1.406HisIle: 1.406 ± 0.037
0.876HisLys: 0.876 ± 0.025
2.28HisLeu: 2.28 ± 0.048
0.568HisMet: 0.568 ± 0.025
0.799HisAsn: 0.799 ± 0.026
1.202HisPro: 1.202 ± 0.036
1.011HisGln: 1.011 ± 0.031
1.174HisArg: 1.174 ± 0.033
1.353HisSer: 1.353 ± 0.033
1.099HisThr: 1.099 ± 0.034
1.248HisVal: 1.248 ± 0.038
0.424HisTrp: 0.424 ± 0.021
0.772HisTyr: 0.772 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.364IleAla: 6.364 ± 0.084
0.57IleCys: 0.57 ± 0.026
4.143IleAsp: 4.143 ± 0.058
4.268IleGlu: 4.268 ± 0.064
1.976IlePhe: 1.976 ± 0.051
4.416IleGly: 4.416 ± 0.066
1.291IleHis: 1.291 ± 0.036
3.168IleIle: 3.168 ± 0.057
2.611IleLys: 2.611 ± 0.05
5.09IleLeu: 5.09 ± 0.076
1.262IleMet: 1.262 ± 0.035
2.744IleAsn: 2.744 ± 0.06
2.772IlePro: 2.772 ± 0.051
2.232IleGln: 2.232 ± 0.047
3.388IleArg: 3.388 ± 0.054
4.137IleSer: 4.137 ± 0.062
3.536IleThr: 3.536 ± 0.063
3.853IleVal: 3.853 ± 0.067
0.652IleTrp: 0.652 ± 0.026
1.536IleTyr: 1.536 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.569LysAla: 4.569 ± 0.081
0.294LysCys: 0.294 ± 0.017
2.595LysAsp: 2.595 ± 0.059
2.697LysGlu: 2.697 ± 0.064
1.23LysPhe: 1.23 ± 0.036
2.87LysGly: 2.87 ± 0.058
0.959LysHis: 0.959 ± 0.027
2.388LysIle: 2.388 ± 0.047
2.255LysLys: 2.255 ± 0.058
4.134LysLeu: 4.134 ± 0.065
1.099LysMet: 1.099 ± 0.031
1.867LysAsn: 1.867 ± 0.043
2.116LysPro: 2.116 ± 0.047
2.085LysGln: 2.085 ± 0.039
2.65LysArg: 2.65 ± 0.055
2.731LysSer: 2.731 ± 0.045
2.589LysThr: 2.589 ± 0.052
3.05LysVal: 3.05 ± 0.06
0.435LysTrp: 0.435 ± 0.019
1.121LysTyr: 1.121 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
10.66LeuAla: 10.66 ± 0.118
0.959LeuCys: 0.959 ± 0.032
6.068LeuAsp: 6.068 ± 0.09
5.92LeuGlu: 5.92 ± 0.097
3.744LeuPhe: 3.744 ± 0.077
6.894LeuGly: 6.894 ± 0.091
2.139LeuHis: 2.139 ± 0.047
5.912LeuIle: 5.912 ± 0.076
4.673LeuLys: 4.673 ± 0.076
11.073LeuLeu: 11.073 ± 0.165
2.698LeuMet: 2.698 ± 0.049
4.561LeuAsn: 4.561 ± 0.068
5.044LeuPro: 5.044 ± 0.069
4.234LeuGln: 4.234 ± 0.067
5.467LeuArg: 5.467 ± 0.074
7.359LeuSer: 7.359 ± 0.092
6.291LeuThr: 6.291 ± 0.1
6.884LeuVal: 6.884 ± 0.096
1.194LeuTrp: 1.194 ± 0.037
2.603LeuTyr: 2.603 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.745MetAla: 2.745 ± 0.047
0.192MetCys: 0.192 ± 0.012
1.381MetAsp: 1.381 ± 0.035
1.284MetGlu: 1.284 ± 0.036
0.782MetPhe: 0.782 ± 0.027
1.797MetGly: 1.797 ± 0.04
0.518MetHis: 0.518 ± 0.021
1.458MetIle: 1.458 ± 0.041
1.313MetLys: 1.313 ± 0.031
2.654MetLeu: 2.654 ± 0.056
0.79MetMet: 0.79 ± 0.03
1.15MetAsn: 1.15 ± 0.032
1.335MetPro: 1.335 ± 0.035
1.146MetGln: 1.146 ± 0.03
1.39MetArg: 1.39 ± 0.035
1.928MetSer: 1.928 ± 0.041
1.736MetThr: 1.736 ± 0.038
1.711MetVal: 1.711 ± 0.041
0.209MetTrp: 0.209 ± 0.015
0.474MetTyr: 0.474 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.882AsnAla: 3.882 ± 0.087
0.384AsnCys: 0.384 ± 0.02
2.576AsnAsp: 2.576 ± 0.054
2.305AsnGlu: 2.305 ± 0.048
1.4AsnPhe: 1.4 ± 0.04
3.098AsnGly: 3.098 ± 0.067
0.84AsnHis: 0.84 ± 0.031
2.491AsnIle: 2.491 ± 0.056
1.746AsnLys: 1.746 ± 0.042
3.727AsnLeu: 3.727 ± 0.055
0.954AsnMet: 0.954 ± 0.026
1.793AsnAsn: 1.793 ± 0.052
2.136AsnPro: 2.136 ± 0.049
1.67AsnGln: 1.67 ± 0.038
2.081AsnArg: 2.081 ± 0.044
2.685AsnSer: 2.685 ± 0.086
2.31AsnThr: 2.31 ± 0.065
2.474AsnVal: 2.474 ± 0.05
0.557AsnTrp: 0.557 ± 0.025
1.256AsnTyr: 1.256 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
3.801ProAla: 3.801 ± 0.064
0.308ProCys: 0.308 ± 0.016
2.776ProAsp: 2.776 ± 0.059
3.39ProGlu: 3.39 ± 0.059
1.615ProPhe: 1.615 ± 0.036
2.626ProGly: 2.626 ± 0.049
0.882ProHis: 0.882 ± 0.032
2.36ProIle: 2.36 ± 0.046
1.84ProLys: 1.84 ± 0.039
4.28ProLeu: 4.28 ± 0.066
1.124ProMet: 1.124 ± 0.03
1.733ProAsn: 1.733 ± 0.045
1.289ProPro: 1.289 ± 0.041
1.611ProGln: 1.611 ± 0.036
1.661ProArg: 1.661 ± 0.043
2.528ProSer: 2.528 ± 0.054
2.225ProThr: 2.225 ± 0.046
3.329ProVal: 3.329 ± 0.061
0.564ProTrp: 0.564 ± 0.024
1.164ProTyr: 1.164 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.41GlnAla: 4.41 ± 0.068
0.378GlnCys: 0.378 ± 0.02
1.88GlnAsp: 1.88 ± 0.043
2.251GlnGlu: 2.251 ± 0.052
1.64GlnPhe: 1.64 ± 0.04
2.782GlnGly: 2.782 ± 0.049
1.089GlnHis: 1.089 ± 0.033
2.354GlnIle: 2.354 ± 0.041
1.706GlnLys: 1.706 ± 0.04
4.982GlnLeu: 4.982 ± 0.078
1.041GlnMet: 1.041 ± 0.035
1.449GlnAsn: 1.449 ± 0.037
1.712GlnPro: 1.712 ± 0.043
2.897GlnGln: 2.897 ± 0.07
2.992GlnArg: 2.992 ± 0.059
2.47GlnSer: 2.47 ± 0.05
2.199GlnThr: 2.199 ± 0.048
3.0GlnVal: 3.0 ± 0.059
0.785GlnTrp: 0.785 ± 0.023
1.195GlnTyr: 1.195 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
4.275ArgAla: 4.275 ± 0.074
0.459ArgCys: 0.459 ± 0.021
3.037ArgAsp: 3.037 ± 0.06
3.387ArgGlu: 3.387 ± 0.062
2.364ArgPhe: 2.364 ± 0.045
3.023ArgGly: 3.023 ± 0.06
1.39ArgHis: 1.39 ± 0.036
3.584ArgIle: 3.584 ± 0.059
2.367ArgLys: 2.367 ± 0.053
6.005ArgLeu: 6.005 ± 0.08
1.503ArgMet: 1.503 ± 0.038
2.1ArgAsn: 2.1 ± 0.043
1.936ArgPro: 1.936 ± 0.05
2.546ArgGln: 2.546 ± 0.049
3.133ArgArg: 3.133 ± 0.066
3.09ArgSer: 3.09 ± 0.047
2.512ArgThr: 2.512 ± 0.05
3.61ArgVal: 3.61 ± 0.062
0.89ArgTrp: 0.89 ± 0.028
2.039ArgTyr: 2.039 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.195SerAla: 6.195 ± 0.086
0.558SerCys: 0.558 ± 0.025
4.041SerAsp: 4.041 ± 0.089
3.906SerGlu: 3.906 ± 0.059
2.43SerPhe: 2.43 ± 0.053
5.273SerGly: 5.273 ± 0.096
1.416SerHis: 1.416 ± 0.039
3.779SerIle: 3.779 ± 0.058
2.607SerLys: 2.607 ± 0.056
6.726SerLeu: 6.726 ± 0.087
1.63SerMet: 1.63 ± 0.038
2.556SerAsn: 2.556 ± 0.064
2.474SerPro: 2.474 ± 0.051
2.644SerGln: 2.644 ± 0.047
3.208SerArg: 3.208 ± 0.058
4.391SerSer: 4.391 ± 0.095
3.45SerThr: 3.45 ± 0.07
4.545SerVal: 4.545 ± 0.077
0.875SerTrp: 0.875 ± 0.028
2.011SerTyr: 2.011 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.222ThrAla: 5.222 ± 0.135
0.478ThrCys: 0.478 ± 0.021
3.53ThrAsp: 3.53 ± 0.079
3.176ThrGlu: 3.176 ± 0.062
1.981ThrPhe: 1.981 ± 0.072
4.419ThrGly: 4.419 ± 0.095
1.13ThrHis: 1.13 ± 0.034
3.143ThrIle: 3.143 ± 0.058
1.912ThrLys: 1.912 ± 0.049
6.506ThrLeu: 6.506 ± 0.086
1.128ThrMet: 1.128 ± 0.031
2.076ThrAsn: 2.076 ± 0.047
2.948ThrPro: 2.948 ± 0.062
2.186ThrGln: 2.186 ± 0.049
2.59ThrArg: 2.59 ± 0.049
3.573ThrSer: 3.573 ± 0.074
3.16ThrThr: 3.16 ± 0.066
3.794ThrVal: 3.794 ± 0.088
0.622ThrTrp: 0.622 ± 0.025
1.574ThrTyr: 1.574 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
6.803ValAla: 6.803 ± 0.103
0.709ValCys: 0.709 ± 0.024
4.323ValAsp: 4.323 ± 0.067
4.217ValGlu: 4.217 ± 0.066
2.704ValPhe: 2.704 ± 0.057
4.592ValGly: 4.592 ± 0.075
1.25ValHis: 1.25 ± 0.035
4.374ValIle: 4.374 ± 0.066
2.937ValLys: 2.937 ± 0.056
6.917ValLeu: 6.917 ± 0.082
1.917ValMet: 1.917 ± 0.049
2.809ValAsn: 2.809 ± 0.064
2.654ValPro: 2.654 ± 0.056
2.333ValGln: 2.333 ± 0.052
3.573ValArg: 3.573 ± 0.065
4.778ValSer: 4.778 ± 0.08
4.23ValThr: 4.23 ± 0.086
5.379ValVal: 5.379 ± 0.083
0.809ValTrp: 0.809 ± 0.03
1.793ValTyr: 1.793 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.988TrpAla: 0.988 ± 0.033
0.145TrpCys: 0.145 ± 0.011
0.682TrpAsp: 0.682 ± 0.03
0.554TrpGlu: 0.554 ± 0.024
0.577TrpPhe: 0.577 ± 0.025
0.78TrpGly: 0.78 ± 0.028
0.39TrpHis: 0.39 ± 0.019
0.727TrpIle: 0.727 ± 0.029
0.45TrpLys: 0.45 ± 0.021
2.08TrpLeu: 2.08 ± 0.059
0.39TrpMet: 0.39 ± 0.018
0.493TrpAsn: 0.493 ± 0.021
0.562TrpPro: 0.562 ± 0.019
0.964TrpGln: 0.964 ± 0.035
0.792TrpArg: 0.792 ± 0.025
0.804TrpSer: 0.804 ± 0.029
0.591TrpThr: 0.591 ± 0.027
0.918TrpVal: 0.918 ± 0.026
0.193TrpTrp: 0.193 ± 0.014
0.377TrpTyr: 0.377 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.373TyrAla: 2.373 ± 0.048
0.336TyrCys: 0.336 ± 0.016
1.717TyrAsp: 1.717 ± 0.041
1.663TyrGlu: 1.663 ± 0.04
1.308TyrPhe: 1.308 ± 0.036
2.062TyrGly: 2.062 ± 0.044
0.628TyrHis: 0.628 ± 0.026
1.556TyrIle: 1.556 ± 0.035
1.209TyrLys: 1.209 ± 0.032
3.23TyrLeu: 3.23 ± 0.058
0.581TyrMet: 0.581 ± 0.025
1.047TyrAsn: 1.047 ± 0.031
1.33TyrPro: 1.33 ± 0.036
1.587TyrGln: 1.587 ± 0.038
1.864TyrArg: 1.864 ± 0.046
2.031TyrSer: 2.031 ± 0.05
1.403TyrThr: 1.403 ± 0.04
1.787TyrVal: 1.787 ± 0.045
0.491TyrTrp: 0.491 ± 0.023
0.907TyrTyr: 0.907 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3634 proteins (1170392 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski