Amino acid dipepetide frequency for Tilapia lake virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.645AlaAla: 6.645 ± 1.812
0.997AlaCys: 0.997 ± 0.589
3.654AlaAsp: 3.654 ± 0.865
3.654AlaGlu: 3.654 ± 0.691
2.326AlaPhe: 2.326 ± 0.493
3.987AlaGly: 3.987 ± 1.105
0.332AlaHis: 0.332 ± 0.285
5.316AlaIle: 5.316 ± 1.212
3.322AlaLys: 3.322 ± 1.495
7.309AlaLeu: 7.309 ± 1.787
2.99AlaMet: 2.99 ± 0.569
1.329AlaAsn: 1.329 ± 0.872
2.658AlaPro: 2.658 ± 0.752
2.326AlaGln: 2.326 ± 0.627
3.987AlaArg: 3.987 ± 1.262
8.306AlaSer: 8.306 ± 1.641
4.983AlaThr: 4.983 ± 1.301
5.316AlaVal: 5.316 ± 0.878
0.332AlaTrp: 0.332 ± 0.278
2.326AlaTyr: 2.326 ± 0.759
0.0AlaXaa: 0.0 ± 0.0
Cys
2.326CysAla: 2.326 ± 0.863
1.329CysCys: 1.329 ± 0.479
1.993CysAsp: 1.993 ± 0.589
0.664CysGlu: 0.664 ± 0.378
0.997CysPhe: 0.997 ± 0.427
1.993CysGly: 1.993 ± 0.82
1.329CysHis: 1.329 ± 0.579
0.664CysIle: 0.664 ± 0.375
2.99CysLys: 2.99 ± 0.786
2.99CysLeu: 2.99 ± 0.741
0.664CysMet: 0.664 ± 0.346
0.664CysAsn: 0.664 ± 0.629
1.329CysPro: 1.329 ± 0.381
0.0CysGln: 0.0 ± 0.0
1.329CysArg: 1.329 ± 0.648
3.322CysSer: 3.322 ± 0.992
2.326CysThr: 2.326 ± 1.113
1.661CysVal: 1.661 ± 0.6
0.997CysTrp: 0.997 ± 0.385
0.332CysTyr: 0.332 ± 0.3
0.0CysXaa: 0.0 ± 0.0
Asp
3.322AspAla: 3.322 ± 0.784
1.993AspCys: 1.993 ± 0.708
2.658AspAsp: 2.658 ± 0.745
2.99AspGlu: 2.99 ± 1.044
2.658AspPhe: 2.658 ± 1.105
4.651AspGly: 4.651 ± 0.917
0.332AspHis: 0.332 ± 0.278
0.997AspIle: 0.997 ± 0.666
2.326AspLys: 2.326 ± 1.547
5.648AspLeu: 5.648 ± 1.512
1.329AspMet: 1.329 ± 0.635
2.326AspAsn: 2.326 ± 0.635
1.661AspPro: 1.661 ± 0.545
1.993AspGln: 1.993 ± 0.42
4.319AspArg: 4.319 ± 1.273
5.648AspSer: 5.648 ± 1.079
2.658AspThr: 2.658 ± 1.33
2.658AspVal: 2.658 ± 0.725
0.332AspTrp: 0.332 ± 0.29
1.661AspTyr: 1.661 ± 0.697
0.0AspXaa: 0.0 ± 0.0
Glu
3.987GluAla: 3.987 ± 0.959
3.654GluCys: 3.654 ± 0.797
4.319GluAsp: 4.319 ± 1.373
2.658GluGlu: 2.658 ± 0.906
2.658GluPhe: 2.658 ± 1.266
4.319GluGly: 4.319 ± 1.104
0.997GluHis: 0.997 ± 0.637
3.654GluIle: 3.654 ± 1.109
1.993GluLys: 1.993 ± 0.646
5.98GluLeu: 5.98 ± 2.054
0.997GluMet: 0.997 ± 0.663
1.993GluAsn: 1.993 ± 0.945
0.664GluPro: 0.664 ± 0.413
1.661GluGln: 1.661 ± 0.698
4.319GluArg: 4.319 ± 0.952
5.648GluSer: 5.648 ± 1.311
2.326GluThr: 2.326 ± 0.543
4.983GluVal: 4.983 ± 1.436
1.329GluTrp: 1.329 ± 0.744
1.993GluTyr: 1.993 ± 0.587
0.0GluXaa: 0.0 ± 0.0
Phe
2.326PheAla: 2.326 ± 0.627
1.993PheCys: 1.993 ± 0.647
0.664PheAsp: 0.664 ± 0.378
2.658PheGlu: 2.658 ± 1.194
1.329PhePhe: 1.329 ± 0.475
1.993PheGly: 1.993 ± 0.742
0.997PheHis: 0.997 ± 0.438
0.664PheIle: 0.664 ± 0.347
2.99PheLys: 2.99 ± 0.767
4.651PheLeu: 4.651 ± 0.768
0.332PheMet: 0.332 ± 0.315
2.658PheAsn: 2.658 ± 0.915
1.329PhePro: 1.329 ± 0.53
1.661PheGln: 1.661 ± 0.891
3.654PheArg: 3.654 ± 0.784
1.993PheSer: 1.993 ± 1.23
0.997PheThr: 0.997 ± 0.511
2.658PheVal: 2.658 ± 1.024
0.997PheTrp: 0.997 ± 0.575
2.326PheTyr: 2.326 ± 0.874
0.0PheXaa: 0.0 ± 0.0
Gly
2.658GlyAla: 2.658 ± 1.354
1.329GlyCys: 1.329 ± 0.643
5.316GlyAsp: 5.316 ± 1.051
4.319GlyGlu: 4.319 ± 0.579
3.322GlyPhe: 3.322 ± 1.375
3.654GlyGly: 3.654 ± 0.57
0.997GlyHis: 0.997 ± 0.589
1.661GlyIle: 1.661 ± 0.856
4.651GlyLys: 4.651 ± 0.783
7.641GlyLeu: 7.641 ± 0.909
3.322GlyMet: 3.322 ± 1.354
0.664GlyAsn: 0.664 ± 0.368
2.658GlyPro: 2.658 ± 0.807
2.326GlyGln: 2.326 ± 0.81
3.322GlyArg: 3.322 ± 0.752
6.312GlySer: 6.312 ± 1.486
2.658GlyThr: 2.658 ± 0.893
4.651GlyVal: 4.651 ± 1.549
0.664GlyTrp: 0.664 ± 0.378
2.658GlyTyr: 2.658 ± 1.118
0.0GlyXaa: 0.0 ± 0.0
His
0.997HisAla: 0.997 ± 0.445
0.664HisCys: 0.664 ± 0.463
0.332HisAsp: 0.332 ± 0.3
0.0HisGlu: 0.0 ± 0.0
1.661HisPhe: 1.661 ± 0.771
0.997HisGly: 0.997 ± 0.459
0.664HisHis: 0.664 ± 0.397
0.332HisIle: 0.332 ± 0.292
0.664HisLys: 0.664 ± 0.6
1.993HisLeu: 1.993 ± 0.688
0.332HisMet: 0.332 ± 0.292
0.664HisAsn: 0.664 ± 0.368
1.993HisPro: 1.993 ± 0.947
0.332HisGln: 0.332 ± 0.315
2.658HisArg: 2.658 ± 0.893
1.993HisSer: 1.993 ± 0.548
1.661HisThr: 1.661 ± 0.633
0.997HisVal: 0.997 ± 0.393
0.332HisTrp: 0.332 ± 0.368
0.997HisTyr: 0.997 ± 0.612
0.0HisXaa: 0.0 ± 0.0
Ile
2.658IleAla: 2.658 ± 0.88
0.997IleCys: 0.997 ± 0.365
2.99IleAsp: 2.99 ± 1.108
3.322IleGlu: 3.322 ± 0.618
0.664IlePhe: 0.664 ± 0.356
4.651IleGly: 4.651 ± 0.985
0.332IleHis: 0.332 ± 0.292
1.993IleIle: 1.993 ± 0.784
4.319IleLys: 4.319 ± 1.147
4.651IleLeu: 4.651 ± 1.808
0.332IleMet: 0.332 ± 0.285
1.329IleAsn: 1.329 ± 0.719
2.658IlePro: 2.658 ± 0.773
1.329IleGln: 1.329 ± 0.841
1.993IleArg: 1.993 ± 0.567
5.316IleSer: 5.316 ± 1.061
2.326IleThr: 2.326 ± 0.944
1.329IleVal: 1.329 ± 0.645
0.332IleTrp: 0.332 ± 0.29
0.664IleTyr: 0.664 ± 0.356
0.0IleXaa: 0.0 ± 0.0
Lys
4.651LysAla: 4.651 ± 0.989
1.329LysCys: 1.329 ± 0.561
3.322LysAsp: 3.322 ± 1.012
1.993LysGlu: 1.993 ± 0.304
2.99LysPhe: 2.99 ± 0.872
3.987LysGly: 3.987 ± 1.418
1.661LysHis: 1.661 ± 0.704
3.322LysIle: 3.322 ± 1.127
4.983LysLys: 4.983 ± 1.64
3.987LysLeu: 3.987 ± 1.054
1.661LysMet: 1.661 ± 0.841
1.661LysAsn: 1.661 ± 0.859
1.661LysPro: 1.661 ± 0.836
2.658LysGln: 2.658 ± 0.715
5.98LysArg: 5.98 ± 1.511
6.312LysSer: 6.312 ± 1.413
1.993LysThr: 1.993 ± 0.794
4.983LysVal: 4.983 ± 0.786
1.329LysTrp: 1.329 ± 0.493
1.993LysTyr: 1.993 ± 0.885
0.0LysXaa: 0.0 ± 0.0
Leu
8.97LeuAla: 8.97 ± 1.463
3.322LeuCys: 3.322 ± 1.339
6.645LeuAsp: 6.645 ± 1.63
9.302LeuGlu: 9.302 ± 1.526
2.658LeuPhe: 2.658 ± 0.873
3.987LeuGly: 3.987 ± 0.963
1.329LeuHis: 1.329 ± 0.592
3.654LeuIle: 3.654 ± 0.585
4.651LeuLys: 4.651 ± 1.403
9.635LeuLeu: 9.635 ± 1.494
2.326LeuMet: 2.326 ± 0.828
4.651LeuAsn: 4.651 ± 1.056
5.98LeuPro: 5.98 ± 0.823
2.326LeuGln: 2.326 ± 0.65
5.648LeuArg: 5.648 ± 0.8
11.628LeuSer: 11.628 ± 2.305
4.651LeuThr: 4.651 ± 0.79
7.641LeuVal: 7.641 ± 1.533
0.0LeuTrp: 0.0 ± 0.0
1.993LeuTyr: 1.993 ± 0.371
0.0LeuXaa: 0.0 ± 0.0
Met
1.661MetAla: 1.661 ± 0.641
0.0MetCys: 0.0 ± 0.0
1.329MetAsp: 1.329 ± 0.479
0.332MetGlu: 0.332 ± 0.29
0.664MetPhe: 0.664 ± 0.381
1.661MetGly: 1.661 ± 0.707
1.329MetHis: 1.329 ± 0.534
0.332MetIle: 0.332 ± 0.278
1.661MetLys: 1.661 ± 0.823
3.654MetLeu: 3.654 ± 0.828
0.997MetMet: 0.997 ± 0.379
0.0MetAsn: 0.0 ± 0.0
0.332MetPro: 0.332 ± 0.285
0.664MetGln: 0.664 ± 0.425
1.329MetArg: 1.329 ± 0.431
2.326MetSer: 2.326 ± 1.18
2.658MetThr: 2.658 ± 0.759
1.661MetVal: 1.661 ± 0.827
0.997MetTrp: 0.997 ± 0.454
0.664MetTyr: 0.664 ± 0.413
0.0MetXaa: 0.0 ± 0.0
Asn
1.993AsnAla: 1.993 ± 0.558
0.997AsnCys: 0.997 ± 0.743
0.664AsnAsp: 0.664 ± 0.378
2.658AsnGlu: 2.658 ± 0.538
1.661AsnPhe: 1.661 ± 0.751
1.993AsnGly: 1.993 ± 0.479
0.997AsnHis: 0.997 ± 0.535
1.329AsnIle: 1.329 ± 0.438
0.997AsnLys: 0.997 ± 0.443
2.658AsnLeu: 2.658 ± 1.148
0.664AsnMet: 0.664 ± 0.413
0.997AsnAsn: 0.997 ± 0.399
1.329AsnPro: 1.329 ± 0.679
1.329AsnGln: 1.329 ± 0.574
1.661AsnArg: 1.661 ± 0.717
1.993AsnSer: 1.993 ± 0.714
2.658AsnThr: 2.658 ± 0.816
0.997AsnVal: 0.997 ± 0.415
0.0AsnTrp: 0.0 ± 0.0
1.329AsnTyr: 1.329 ± 0.458
0.0AsnXaa: 0.0 ± 0.0
Pro
2.658ProAla: 2.658 ± 0.571
0.664ProCys: 0.664 ± 0.585
1.329ProAsp: 1.329 ± 0.875
1.329ProGlu: 1.329 ± 0.651
2.326ProPhe: 2.326 ± 1.007
4.319ProGly: 4.319 ± 0.717
0.997ProHis: 0.997 ± 0.486
1.661ProIle: 1.661 ± 0.461
4.651ProLys: 4.651 ± 1.532
4.319ProLeu: 4.319 ± 1.054
0.332ProMet: 0.332 ± 0.315
1.661ProAsn: 1.661 ± 0.431
2.326ProPro: 2.326 ± 0.753
0.664ProGln: 0.664 ± 0.585
1.993ProArg: 1.993 ± 1.035
2.326ProSer: 2.326 ± 0.686
4.651ProThr: 4.651 ± 1.081
2.658ProVal: 2.658 ± 1.062
0.332ProTrp: 0.332 ± 0.406
0.997ProTyr: 0.997 ± 0.638
0.0ProXaa: 0.0 ± 0.0
Gln
3.322GlnAla: 3.322 ± 0.707
0.997GlnCys: 0.997 ± 0.689
1.993GlnAsp: 1.993 ± 0.719
3.654GlnGlu: 3.654 ± 0.867
1.329GlnPhe: 1.329 ± 0.586
2.326GlnGly: 2.326 ± 0.873
0.664GlnHis: 0.664 ± 0.378
1.329GlnIle: 1.329 ± 0.436
1.661GlnLys: 1.661 ± 0.316
1.329GlnLeu: 1.329 ± 0.634
0.664GlnMet: 0.664 ± 0.359
0.0GlnAsn: 0.0 ± 0.0
1.993GlnPro: 1.993 ± 0.869
0.997GlnGln: 0.997 ± 0.365
0.997GlnArg: 0.997 ± 0.444
1.993GlnSer: 1.993 ± 0.784
1.661GlnThr: 1.661 ± 0.715
2.326GlnVal: 2.326 ± 0.945
0.332GlnTrp: 0.332 ± 0.278
0.664GlnTyr: 0.664 ± 0.421
0.0GlnXaa: 0.0 ± 0.0
Arg
4.651ArgAla: 4.651 ± 1.298
1.329ArgCys: 1.329 ± 0.413
2.99ArgAsp: 2.99 ± 0.581
5.98ArgGlu: 5.98 ± 1.362
2.658ArgPhe: 2.658 ± 0.56
4.651ArgGly: 4.651 ± 0.8
0.664ArgHis: 0.664 ± 0.397
3.654ArgIle: 3.654 ± 0.963
6.312ArgLys: 6.312 ± 1.586
5.98ArgLeu: 5.98 ± 0.866
1.661ArgMet: 1.661 ± 0.63
1.661ArgAsn: 1.661 ± 0.532
2.326ArgPro: 2.326 ± 0.677
1.329ArgGln: 1.329 ± 0.514
5.316ArgArg: 5.316 ± 1.174
5.648ArgSer: 5.648 ± 1.546
3.322ArgThr: 3.322 ± 1.744
4.983ArgVal: 4.983 ± 1.086
0.997ArgTrp: 0.997 ± 0.527
1.993ArgTyr: 1.993 ± 0.57
0.0ArgXaa: 0.0 ± 0.0
Ser
4.983SerAla: 4.983 ± 0.779
3.322SerCys: 3.322 ± 1.044
4.651SerAsp: 4.651 ± 1.349
5.98SerGlu: 5.98 ± 1.525
4.319SerPhe: 4.319 ± 1.651
6.977SerGly: 6.977 ± 0.938
2.326SerHis: 2.326 ± 0.501
3.322SerIle: 3.322 ± 0.783
6.312SerLys: 6.312 ± 0.738
8.638SerLeu: 8.638 ± 1.415
0.997SerMet: 0.997 ± 0.487
1.329SerAsn: 1.329 ± 0.983
4.651SerPro: 4.651 ± 1.036
3.654SerGln: 3.654 ± 1.105
7.973SerArg: 7.973 ± 1.024
5.316SerSer: 5.316 ± 1.128
4.983SerThr: 4.983 ± 1.517
5.316SerVal: 5.316 ± 1.057
1.329SerTrp: 1.329 ± 0.78
3.654SerTyr: 3.654 ± 0.878
0.0SerXaa: 0.0 ± 0.0
Thr
5.648ThrAla: 5.648 ± 1.471
1.329ThrCys: 1.329 ± 0.381
1.661ThrAsp: 1.661 ± 0.864
2.99ThrGlu: 2.99 ± 0.982
1.661ThrPhe: 1.661 ± 0.725
3.654ThrGly: 3.654 ± 1.299
0.997ThrHis: 0.997 ± 0.393
2.326ThrIle: 2.326 ± 0.777
1.993ThrLys: 1.993 ± 0.721
6.977ThrLeu: 6.977 ± 1.511
0.664ThrMet: 0.664 ± 0.579
1.661ThrAsn: 1.661 ± 0.544
2.326ThrPro: 2.326 ± 0.898
0.997ThrGln: 0.997 ± 0.616
5.316ThrArg: 5.316 ± 1.818
4.983ThrSer: 4.983 ± 1.377
2.99ThrThr: 2.99 ± 1.16
5.316ThrVal: 5.316 ± 1.368
0.997ThrTrp: 0.997 ± 0.582
2.326ThrTyr: 2.326 ± 0.483
0.0ThrXaa: 0.0 ± 0.0
Val
6.312ValAla: 6.312 ± 1.167
2.658ValCys: 2.658 ± 0.964
2.658ValAsp: 2.658 ± 1.034
4.319ValGlu: 4.319 ± 1.36
1.661ValPhe: 1.661 ± 0.787
2.99ValGly: 2.99 ± 1.19
1.993ValHis: 1.993 ± 0.615
4.651ValIle: 4.651 ± 1.131
1.661ValLys: 1.661 ± 0.646
7.641ValLeu: 7.641 ± 1.788
1.993ValMet: 1.993 ± 0.96
1.661ValAsn: 1.661 ± 0.792
3.654ValPro: 3.654 ± 0.902
2.326ValGln: 2.326 ± 0.529
3.987ValArg: 3.987 ± 0.771
4.651ValSer: 4.651 ± 0.719
4.319ValThr: 4.319 ± 1.043
5.98ValVal: 5.98 ± 0.71
1.661ValTrp: 1.661 ± 0.576
1.661ValTyr: 1.661 ± 0.839
0.0ValXaa: 0.0 ± 0.0
Trp
0.664TrpAla: 0.664 ± 0.451
0.332TrpCys: 0.332 ± 0.368
0.997TrpAsp: 0.997 ± 0.571
0.664TrpGlu: 0.664 ± 0.364
0.664TrpPhe: 0.664 ± 0.472
0.664TrpGly: 0.664 ± 0.434
0.332TrpHis: 0.332 ± 0.292
1.993TrpIle: 1.993 ± 1.074
0.997TrpLys: 0.997 ± 0.604
0.997TrpLeu: 0.997 ± 0.483
0.332TrpMet: 0.332 ± 0.292
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.332TrpGln: 0.332 ± 0.406
0.997TrpArg: 0.997 ± 0.569
1.329TrpSer: 1.329 ± 0.704
0.664TrpThr: 0.664 ± 0.472
1.329TrpVal: 1.329 ± 0.484
0.0TrpTrp: 0.0 ± 0.0
0.332TrpTyr: 0.332 ± 0.285
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.661TyrAla: 1.661 ± 0.518
0.664TyrCys: 0.664 ± 0.368
1.993TyrAsp: 1.993 ± 0.826
0.664TyrGlu: 0.664 ± 0.41
0.664TyrPhe: 0.664 ± 0.368
1.329TyrGly: 1.329 ± 0.489
0.997TyrHis: 0.997 ± 0.477
1.329TyrIle: 1.329 ± 0.585
3.322TyrLys: 3.322 ± 1.094
4.319TyrLeu: 4.319 ± 1.169
1.329TyrMet: 1.329 ± 0.902
1.993TyrAsn: 1.993 ± 0.905
0.664TyrPro: 0.664 ± 0.49
1.329TyrGln: 1.329 ± 0.594
1.329TyrArg: 1.329 ± 0.365
3.322TyrSer: 3.322 ± 0.796
2.326TyrThr: 2.326 ± 0.619
0.997TyrVal: 0.997 ± 0.527
0.332TyrTrp: 0.332 ± 0.368
0.997TyrTyr: 0.997 ± 0.454
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (3011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski