Amino acid dipepetide frequency for Sporothrix insectorum RCEF 264

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.424AlaAla: 19.424 ± 0.139	1.187AlaCys: 1.187 ± 0.015	6.175AlaAsp: 6.175 ± 0.042	5.628AlaGlu: 5.628 ± 0.049	3.555AlaPhe: 3.555 ± 0.03	8.598AlaGly: 8.598 ± 0.051	2.393AlaHis: 2.393 ± 0.024	3.546AlaIle: 3.546 ± 0.03	3.875AlaLys: 3.875 ± 0.037	9.114AlaLeu: 9.114 ± 0.057	2.056AlaMet: 2.056 ± 0.021	3.389AlaAsn: 3.389 ± 0.028	6.433AlaPro: 6.433 ± 0.052	3.923AlaGln: 3.923 ± 0.036	6.682AlaArg: 6.682 ± 0.04	9.055AlaSer: 9.055 ± 0.053	7.656AlaThr: 7.656 ± 0.054	7.733AlaVal: 7.733 ± 0.05	1.396AlaTrp: 1.396 ± 0.018	2.485AlaTyr: 2.485 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.018	0.245CysCys: 0.245 ± 0.009	0.592CysAsp: 0.592 ± 0.013	0.466CysGlu: 0.466 ± 0.011	0.485CysPhe: 0.485 ± 0.009	0.897CysGly: 0.897 ± 0.017	0.286CysHis: 0.286 ± 0.007	0.544CysIle: 0.544 ± 0.012	0.353CysLys: 0.353 ± 0.01	1.168CysLeu: 1.168 ± 0.017	0.232CysMet: 0.232 ± 0.007	0.352CysAsn: 0.352 ± 0.008	0.623CysPro: 0.623 ± 0.011	0.374CysGln: 0.374 ± 0.009	0.757CysArg: 0.757 ± 0.013	0.734CysSer: 0.734 ± 0.014	0.642CysThr: 0.642 ± 0.013	0.767CysVal: 0.767 ± 0.012	0.184CysTrp: 0.184 ± 0.007	0.322CysTyr: 0.322 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.645AspAla: 6.645 ± 0.048	0.552AspCys: 0.552 ± 0.012	6.529AspAsp: 6.529 ± 0.078	4.596AspGlu: 4.596 ± 0.043	1.894AspPhe: 1.894 ± 0.021	5.458AspGly: 5.458 ± 0.042	1.319AspHis: 1.319 ± 0.018	2.181AspIle: 2.181 ± 0.021	2.104AspLys: 2.104 ± 0.023	4.659AspLeu: 4.659 ± 0.028	1.128AspMet: 1.128 ± 0.017	2.247AspAsn: 2.247 ± 0.025	3.17AspPro: 3.17 ± 0.03	1.589AspGln: 1.589 ± 0.018	3.479AspArg: 3.479 ± 0.035	3.345AspSer: 3.345 ± 0.03	2.995AspThr: 2.995 ± 0.024	4.159AspVal: 4.159 ± 0.03	0.801AspTrp: 0.801 ± 0.013	1.452AspTyr: 1.452 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.938GluAla: 5.938 ± 0.055	0.471GluCys: 0.471 ± 0.011	3.823GluAsp: 3.823 ± 0.039	4.381GluGlu: 4.381 ± 0.054	1.459GluPhe: 1.459 ± 0.018	3.139GluGly: 3.139 ± 0.025	1.258GluHis: 1.258 ± 0.017	2.014GluIle: 2.014 ± 0.023	2.611GluLys: 2.611 ± 0.032	4.35GluLeu: 4.35 ± 0.042	1.08GluMet: 1.08 ± 0.016	1.794GluAsn: 1.794 ± 0.022	2.596GluPro: 2.596 ± 0.033	2.255GluGln: 2.255 ± 0.028	3.765GluArg: 3.765 ± 0.033	3.002GluSer: 3.002 ± 0.027	3.195GluThr: 3.195 ± 0.026	2.84GluVal: 2.84 ± 0.023	0.651GluTrp: 0.651 ± 0.012	1.267GluTyr: 1.267 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.526PheAla: 3.526 ± 0.034	0.524PheCys: 0.524 ± 0.012	2.095PheAsp: 2.095 ± 0.018	1.632PheGlu: 1.632 ± 0.019	1.497PhePhe: 1.497 ± 0.02	2.785PheGly: 2.785 ± 0.032	0.828PheHis: 0.828 ± 0.014	1.169PheIle: 1.169 ± 0.018	0.991PheLys: 0.991 ± 0.016	3.185PheLeu: 3.185 ± 0.03	0.641PheMet: 0.641 ± 0.013	1.09PheAsn: 1.09 ± 0.016	1.815PhePro: 1.815 ± 0.021	1.158PheGln: 1.158 ± 0.015	2.037PheArg: 2.037 ± 0.019	2.574PheSer: 2.574 ± 0.025	1.79PheThr: 1.79 ± 0.018	2.608PheVal: 2.608 ± 0.023	0.572PheTrp: 0.572 ± 0.011	1.009PheTyr: 1.009 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	7.614GlyAla: 7.614 ± 0.052	0.827GlyCys: 0.827 ± 0.014	4.588GlyAsp: 4.588 ± 0.034	3.301GlyGlu: 3.301 ± 0.029	2.663GlyPhe: 2.663 ± 0.026	10.505GlyGly: 10.505 ± 0.105	2.005GlyHis: 2.005 ± 0.023	2.799GlyIle: 2.799 ± 0.029	2.724GlyLys: 2.724 ± 0.03	6.092GlyLeu: 6.092 ± 0.038	1.455GlyMet: 1.455 ± 0.022	2.847GlyAsn: 2.847 ± 0.03	4.077GlyPro: 4.077 ± 0.036	2.513GlyGln: 2.513 ± 0.021	5.221GlyArg: 5.221 ± 0.037	6.76GlySer: 6.76 ± 0.05	4.565GlyThr: 4.565 ± 0.034	4.873GlyVal: 4.873 ± 0.04	1.078GlyTrp: 1.078 ± 0.015	1.997GlyTyr: 1.997 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.45HisAla: 2.45 ± 0.022	0.284HisCys: 0.284 ± 0.008	1.526HisAsp: 1.526 ± 0.018	1.212HisGlu: 1.212 ± 0.015	0.817HisPhe: 0.817 ± 0.014	2.147HisGly: 2.147 ± 0.025	1.278HisHis: 1.278 ± 0.028	0.966HisIle: 0.966 ± 0.015	0.757HisLys: 0.757 ± 0.013	2.125HisLeu: 2.125 ± 0.021	0.48HisMet: 0.48 ± 0.01	0.905HisAsn: 0.905 ± 0.013	1.722HisPro: 1.722 ± 0.021	1.143HisGln: 1.143 ± 0.021	1.772HisArg: 1.772 ± 0.021	1.577HisSer: 1.577 ± 0.018	1.341HisThr: 1.341 ± 0.016	1.547HisVal: 1.547 ± 0.021	0.322HisTrp: 0.322 ± 0.008	0.675HisTyr: 0.675 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.468IleAla: 3.468 ± 0.029	0.522IleCys: 0.522 ± 0.01	2.235IleAsp: 2.235 ± 0.024	1.937IleGlu: 1.937 ± 0.021	1.371IlePhe: 1.371 ± 0.018	2.531IleGly: 2.531 ± 0.028	0.903IleHis: 0.903 ± 0.013	1.452IleIle: 1.452 ± 0.021	1.377IleLys: 1.377 ± 0.019	3.257IleLeu: 3.257 ± 0.03	0.749IleMet: 0.749 ± 0.011	1.308IleAsn: 1.308 ± 0.017	2.122IlePro: 2.122 ± 0.021	1.327IleGln: 1.327 ± 0.016	2.263IleArg: 2.263 ± 0.022	2.308IleSer: 2.308 ± 0.024	2.043IleThr: 2.043 ± 0.023	2.807IleVal: 2.807 ± 0.023	0.506IleTrp: 0.506 ± 0.012	0.974IleTyr: 0.974 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.911LysAla: 3.911 ± 0.03	0.328LysCys: 0.328 ± 0.009	2.087LysAsp: 2.087 ± 0.023	2.261LysGlu: 2.261 ± 0.029	0.932LysPhe: 0.932 ± 0.014	2.202LysGly: 2.202 ± 0.023	0.883LysHis: 0.883 ± 0.013	1.463LysIle: 1.463 ± 0.019	2.584LysLys: 2.584 ± 0.089	2.966LysLeu: 2.966 ± 0.029	0.762LysMet: 0.762 ± 0.013	1.337LysAsn: 1.337 ± 0.019	2.189LysPro: 2.189 ± 0.025	1.527LysGln: 1.527 ± 0.021	2.912LysArg: 2.912 ± 0.029	2.264LysSer: 2.264 ± 0.021	2.503LysThr: 2.503 ± 0.024	2.018LysVal: 2.018 ± 0.025	0.444LysTrp: 0.444 ± 0.01	0.948LysTyr: 0.948 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	9.591LeuAla: 9.591 ± 0.062	1.131LeuCys: 1.131 ± 0.016	4.988LeuAsp: 4.988 ± 0.034	4.398LeuGlu: 4.398 ± 0.035	3.18LeuPhe: 3.18 ± 0.032	5.894LeuGly: 5.894 ± 0.042	2.272LeuHis: 2.272 ± 0.024	2.671LeuIle: 2.671 ± 0.034	2.863LeuLys: 2.863 ± 0.027	8.56LeuLeu: 8.56 ± 0.067	1.479LeuMet: 1.479 ± 0.016	2.407LeuAsn: 2.407 ± 0.025	6.003LeuPro: 6.003 ± 0.039	3.797LeuGln: 3.797 ± 0.036	6.382LeuArg: 6.382 ± 0.05	6.27LeuSer: 6.27 ± 0.041	4.423LeuThr: 4.423 ± 0.039	5.934LeuVal: 5.934 ± 0.043	1.144LeuTrp: 1.144 ± 0.016	2.215LeuTyr: 2.215 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.472MetAla: 2.472 ± 0.022	0.198MetCys: 0.198 ± 0.006	1.098MetAsp: 1.098 ± 0.018	0.967MetGlu: 0.967 ± 0.014	0.61MetPhe: 0.61 ± 0.011	1.293MetGly: 1.293 ± 0.02	0.438MetHis: 0.438 ± 0.01	0.63MetIle: 0.63 ± 0.011	0.615MetLys: 0.615 ± 0.012	1.681MetLeu: 1.681 ± 0.019	0.444MetMet: 0.444 ± 0.011	0.566MetAsn: 0.566 ± 0.01	1.25MetPro: 1.25 ± 0.015	0.782MetGln: 0.782 ± 0.013	1.211MetArg: 1.211 ± 0.013	1.453MetSer: 1.453 ± 0.018	1.139MetThr: 1.139 ± 0.016	1.189MetVal: 1.189 ± 0.015	0.219MetTrp: 0.219 ± 0.007	0.432MetTyr: 0.432 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.372AsnAla: 3.372 ± 0.026	0.346AsnCys: 0.346 ± 0.008	2.221AsnAsp: 2.221 ± 0.022	1.652AsnGlu: 1.652 ± 0.02	1.05AsnPhe: 1.05 ± 0.017	3.573AsnGly: 3.573 ± 0.035	0.836AsnHis: 0.836 ± 0.014	1.382AsnIle: 1.382 ± 0.018	1.28AsnLys: 1.28 ± 0.017	2.606AsnLeu: 2.606 ± 0.024	0.661AsnMet: 0.661 ± 0.011	2.233AsnAsn: 2.233 ± 0.037	1.938AsnPro: 1.938 ± 0.023	1.061AsnGln: 1.061 ± 0.018	1.88AsnArg: 1.88 ± 0.019	2.331AsnSer: 2.331 ± 0.026	2.056AsnThr: 2.056 ± 0.024	2.125AsnVal: 2.125 ± 0.023	0.432AsnTrp: 0.432 ± 0.01	0.851AsnTyr: 0.851 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	7.655ProAla: 7.655 ± 0.058	0.509ProCys: 0.509 ± 0.011	3.306ProAsp: 3.306 ± 0.031	3.092ProGlu: 3.092 ± 0.032	2.033ProPhe: 2.033 ± 0.022	4.569ProGly: 4.569 ± 0.037	1.48ProHis: 1.48 ± 0.019	1.868ProIle: 1.868 ± 0.021	1.917ProLys: 1.917 ± 0.022	5.268ProLeu: 5.268 ± 0.029	0.981ProMet: 0.981 ± 0.014	1.838ProAsn: 1.838 ± 0.021	7.572ProPro: 7.572 ± 0.093	2.637ProGln: 2.637 ± 0.039	3.908ProArg: 3.908 ± 0.031	6.184ProSer: 6.184 ± 0.046	4.28ProThr: 4.28 ± 0.036	4.071ProVal: 4.071 ± 0.031	0.73ProTrp: 0.73 ± 0.012	1.508ProTyr: 1.508 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	4.005GlnAla: 4.005 ± 0.038	0.384GlnCys: 0.384 ± 0.009	1.752GlnAsp: 1.752 ± 0.021	1.91GlnGlu: 1.91 ± 0.025	1.134GlnPhe: 1.134 ± 0.017	2.155GlnGly: 2.155 ± 0.022	1.384GlnHis: 1.384 ± 0.027	1.433GlnIle: 1.433 ± 0.017	1.546GlnLys: 1.546 ± 0.018	3.474GlnLeu: 3.474 ± 0.027	0.79GlnMet: 0.79 ± 0.014	1.253GlnAsn: 1.253 ± 0.017	3.066GlnPro: 3.066 ± 0.038	5.293GlnGln: 5.293 ± 0.133	3.033GlnArg: 3.033 ± 0.031	2.426GlnSer: 2.426 ± 0.027	2.31GlnThr: 2.31 ± 0.025	1.874GlnVal: 1.874 ± 0.019	0.503GlnTrp: 0.503 ± 0.011	1.011GlnTyr: 1.011 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	6.372ArgAla: 6.372 ± 0.042	0.789ArgCys: 0.789 ± 0.014	3.772ArgAsp: 3.772 ± 0.041	3.446ArgGlu: 3.446 ± 0.033	2.199ArgPhe: 2.199 ± 0.019	4.413ArgGly: 4.413 ± 0.032	1.882ArgHis: 1.882 ± 0.02	2.543ArgIle: 2.543 ± 0.019	2.894ArgLys: 2.894 ± 0.028	6.118ArgLeu: 6.118 ± 0.038	1.27ArgMet: 1.27 ± 0.018	2.152ArgAsn: 2.152 ± 0.023	4.393ArgPro: 4.393 ± 0.037	2.969ArgGln: 2.969 ± 0.026	6.638ArgArg: 6.638 ± 0.051	4.807ArgSer: 4.807 ± 0.042	3.747ArgThr: 3.747 ± 0.027	3.763ArgVal: 3.763 ± 0.031	0.979ArgTrp: 0.979 ± 0.017	1.686ArgTyr: 1.686 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.902SerAla: 7.902 ± 0.047	0.7SerCys: 0.7 ± 0.013	3.809SerAsp: 3.809 ± 0.032	3.022SerGlu: 3.022 ± 0.03	2.597SerPhe: 2.597 ± 0.024	6.311SerGly: 6.311 ± 0.047	1.692SerHis: 1.692 ± 0.021	2.741SerIle: 2.741 ± 0.025	2.498SerLys: 2.498 ± 0.025	6.278SerLeu: 6.278 ± 0.039	1.404SerMet: 1.404 ± 0.017	2.704SerAsn: 2.704 ± 0.026	5.608SerPro: 5.608 ± 0.05	2.576SerGln: 2.576 ± 0.026	4.736SerArg: 4.736 ± 0.034	10.26SerSer: 10.26 ± 0.099	5.237SerThr: 5.237 ± 0.043	4.569SerVal: 4.569 ± 0.039	0.893SerTrp: 0.893 ± 0.014	1.673SerTyr: 1.673 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	7.83ThrAla: 7.83 ± 0.048	0.656ThrCys: 0.656 ± 0.013	3.025ThrAsp: 3.025 ± 0.028	2.676ThrGlu: 2.676 ± 0.024	1.991ThrPhe: 1.991 ± 0.025	4.653ThrGly: 4.653 ± 0.038	1.255ThrHis: 1.255 ± 0.016	2.333ThrIle: 2.333 ± 0.026	2.189ThrLys: 2.189 ± 0.024	4.862ThrLeu: 4.862 ± 0.029	1.121ThrMet: 1.121 ± 0.015	2.102ThrAsn: 2.102 ± 0.021	4.574ThrPro: 4.574 ± 0.04	1.907ThrGln: 1.907 ± 0.019	3.318ThrArg: 3.318 ± 0.031	4.96ThrSer: 4.96 ± 0.035	6.16ThrThr: 6.16 ± 0.064	4.136ThrVal: 4.136 ± 0.034	0.747ThrTrp: 0.747 ± 0.012	1.459ThrTyr: 1.459 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	7.434ValAla: 7.434 ± 0.047	0.859ValCys: 0.859 ± 0.014	4.218ValAsp: 4.218 ± 0.026	3.334ValGlu: 3.334 ± 0.033	2.53ValPhe: 2.53 ± 0.027	4.468ValGly: 4.468 ± 0.038	1.597ValHis: 1.597 ± 0.018	2.174ValIle: 2.174 ± 0.022	2.006ValLys: 2.006 ± 0.021	6.227ValLeu: 6.227 ± 0.045	1.104ValMet: 1.104 ± 0.016	1.942ValAsn: 1.942 ± 0.023	4.263ValPro: 4.263 ± 0.031	2.404ValGln: 2.404 ± 0.022	4.219ValArg: 4.219 ± 0.031	4.48ValSer: 4.48 ± 0.035	3.598ValThr: 3.598 ± 0.035	5.33ValVal: 5.33 ± 0.045	0.889ValTrp: 0.889 ± 0.014	1.802ValTyr: 1.802 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.19TrpAla: 1.19 ± 0.014	0.189TrpCys: 0.189 ± 0.006	0.816TrpAsp: 0.816 ± 0.014	0.644TrpGlu: 0.644 ± 0.011	0.466TrpPhe: 0.466 ± 0.01	0.815TrpGly: 0.815 ± 0.016	0.365TrpHis: 0.365 ± 0.008	0.553TrpIle: 0.553 ± 0.012	0.537TrpLys: 0.537 ± 0.01	1.292TrpLeu: 1.292 ± 0.019	0.321TrpMet: 0.321 ± 0.009	0.489TrpAsn: 0.489 ± 0.01	0.676TrpPro: 0.676 ± 0.014	0.548TrpGln: 0.548 ± 0.01	1.004TrpArg: 1.004 ± 0.014	0.907TrpSer: 0.907 ± 0.015	0.88TrpThr: 0.88 ± 0.016	0.81TrpVal: 0.81 ± 0.013	0.266TrpTrp: 0.266 ± 0.008	0.382TrpTyr: 0.382 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.456TyrAla: 2.456 ± 0.026	0.368TyrCys: 0.368 ± 0.008	1.649TyrAsp: 1.649 ± 0.019	1.335TyrGlu: 1.335 ± 0.018	1.063TyrPhe: 1.063 ± 0.016	2.098TyrGly: 2.098 ± 0.023	0.693TyrHis: 0.693 ± 0.012	0.997TyrIle: 0.997 ± 0.015	0.801TyrLys: 0.801 ± 0.014	2.321TyrLeu: 2.321 ± 0.025	0.527TyrMet: 0.527 ± 0.01	0.929TyrAsn: 0.929 ± 0.016	1.316TyrPro: 1.316 ± 0.017	0.954TyrGln: 0.954 ± 0.016	1.614TyrArg: 1.614 ± 0.019	1.514TyrSer: 1.514 ± 0.018	1.395TyrThr: 1.395 ± 0.021	1.725TyrVal: 1.725 ± 0.02	0.393TyrTrp: 0.393 ± 0.008	0.891TyrTyr: 0.891 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9495 proteins (5161090 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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