Amino acid dipepetide frequency for Malassezia vespertilionis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.353AlaAla: 12.353 ± 0.138	1.362AlaCys: 1.362 ± 0.032	5.121AlaAsp: 5.121 ± 0.053	6.309AlaGlu: 6.309 ± 0.075	3.63AlaPhe: 3.63 ± 0.047	5.425AlaGly: 5.425 ± 0.055	3.348AlaHis: 3.348 ± 0.054	3.85AlaIle: 3.85 ± 0.051	4.446AlaLys: 4.446 ± 0.063	11.968AlaLeu: 11.968 ± 0.127	2.948AlaMet: 2.948 ± 0.049	3.113AlaAsn: 3.113 ± 0.036	7.617AlaPro: 7.617 ± 0.09	5.783AlaGln: 5.783 ± 0.071	7.348AlaArg: 7.348 ± 0.082	8.34AlaSer: 8.34 ± 0.067	5.495AlaThr: 5.495 ± 0.059	6.314AlaVal: 6.314 ± 0.059	1.587AlaTrp: 1.587 ± 0.035	2.749AlaTyr: 2.749 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.504CysAla: 1.504 ± 0.036	0.17CysCys: 0.17 ± 0.009	0.686CysAsp: 0.686 ± 0.017	0.577CysGlu: 0.577 ± 0.016	0.463CysPhe: 0.463 ± 0.016	0.855CysGly: 0.855 ± 0.023	0.271CysHis: 0.271 ± 0.011	0.763CysIle: 0.763 ± 0.018	0.452CysLys: 0.452 ± 0.016	1.063CysLeu: 1.063 ± 0.029	0.368CysMet: 0.368 ± 0.012	0.384CysAsn: 0.384 ± 0.012	0.522CysPro: 0.522 ± 0.018	0.317CysGln: 0.317 ± 0.012	0.616CysArg: 0.616 ± 0.02	0.765CysSer: 0.765 ± 0.02	0.868CysThr: 0.868 ± 0.025	0.98CysVal: 0.98 ± 0.022	0.154CysTrp: 0.154 ± 0.009	0.303CysTyr: 0.303 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.427AspAla: 8.427 ± 0.082	0.495AspCys: 0.495 ± 0.015	3.814AspAsp: 3.814 ± 0.069	4.584AspGlu: 4.584 ± 0.059	1.734AspPhe: 1.734 ± 0.03	3.726AspGly: 3.726 ± 0.046	1.078AspHis: 1.078 ± 0.025	2.346AspIle: 2.346 ± 0.033	2.152AspLys: 2.152 ± 0.042	4.592AspLeu: 4.592 ± 0.051	1.633AspMet: 1.633 ± 0.03	1.438AspAsn: 1.438 ± 0.029	3.214AspPro: 3.214 ± 0.046	1.728AspGln: 1.728 ± 0.032	2.765AspArg: 2.765 ± 0.043	3.122AspSer: 3.122 ± 0.046	3.96AspThr: 3.96 ± 0.051	4.181AspVal: 4.181 ± 0.051	0.772AspTrp: 0.772 ± 0.02	1.307AspTyr: 1.307 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.194GluAla: 6.194 ± 0.063	0.638GluCys: 0.638 ± 0.017	3.535GluAsp: 3.535 ± 0.047	5.316GluGlu: 5.316 ± 0.09	1.632GluPhe: 1.632 ± 0.028	2.938GluGly: 2.938 ± 0.045	2.184GluHis: 2.184 ± 0.034	2.381GluIle: 2.381 ± 0.037	3.064GluLys: 3.064 ± 0.048	5.752GluLeu: 5.752 ± 0.063	1.718GluMet: 1.718 ± 0.03	2.012GluAsn: 2.012 ± 0.034	2.956GluPro: 2.956 ± 0.041	3.323GluGln: 3.323 ± 0.051	4.783GluArg: 4.783 ± 0.069	3.861GluSer: 3.861 ± 0.047	3.348GluThr: 3.348 ± 0.049	3.033GluVal: 3.033 ± 0.045	0.748GluTrp: 0.748 ± 0.019	1.681GluTyr: 1.681 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.708PheAla: 3.708 ± 0.046	0.533PheCys: 0.533 ± 0.016	2.146PheAsp: 2.146 ± 0.033	1.821PheGlu: 1.821 ± 0.03	1.475PhePhe: 1.475 ± 0.03	2.668PheGly: 2.668 ± 0.046	0.887PheHis: 0.887 ± 0.022	1.292PheIle: 1.292 ± 0.027	1.073PheLys: 1.073 ± 0.026	3.388PheLeu: 3.388 ± 0.051	0.733PheMet: 0.733 ± 0.018	0.994PheAsn: 0.994 ± 0.027	1.686PhePro: 1.686 ± 0.031	1.28PheGln: 1.28 ± 0.024	1.918PheArg: 1.918 ± 0.029	2.727PheSer: 2.727 ± 0.039	1.825PheThr: 1.825 ± 0.031	2.639PheVal: 2.639 ± 0.037	0.487PheTrp: 0.487 ± 0.018	0.994PheTyr: 0.994 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	6.938GlyAla: 6.938 ± 0.071	0.681GlyCys: 0.681 ± 0.02	3.243GlyAsp: 3.243 ± 0.045	3.441GlyGlu: 3.441 ± 0.042	2.205GlyPhe: 2.205 ± 0.037	4.386GlyGly: 4.386 ± 0.087	1.582GlyHis: 1.582 ± 0.034	2.972GlyIle: 2.972 ± 0.046	2.994GlyLys: 2.994 ± 0.047	5.197GlyLeu: 5.197 ± 0.058	1.821GlyMet: 1.821 ± 0.035	1.999GlyAsn: 1.999 ± 0.047	2.626GlyPro: 2.626 ± 0.037	2.136GlyGln: 2.136 ± 0.049	3.504GlyArg: 3.504 ± 0.048	4.401GlySer: 4.401 ± 0.068	4.075GlyThr: 4.075 ± 0.043	4.151GlyVal: 4.151 ± 0.047	0.902GlyTrp: 0.902 ± 0.025	1.713GlyTyr: 1.713 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	4.063HisAla: 4.063 ± 0.063	0.342HisCys: 0.342 ± 0.014	1.691HisAsp: 1.691 ± 0.027	1.609HisGlu: 1.609 ± 0.031	0.979HisPhe: 0.979 ± 0.022	2.205HisGly: 2.205 ± 0.033	0.765HisHis: 0.765 ± 0.024	1.366HisIle: 1.366 ± 0.024	0.971HisLys: 0.971 ± 0.02	2.518HisLeu: 2.518 ± 0.036	0.716HisMet: 0.716 ± 0.018	0.798HisAsn: 0.798 ± 0.019	1.601HisPro: 1.601 ± 0.03	0.803HisGln: 0.803 ± 0.019	1.675HisArg: 1.675 ± 0.035	1.866HisSer: 1.866 ± 0.037	2.09HisThr: 2.09 ± 0.038	2.236HisVal: 2.236 ± 0.032	0.34HisTrp: 0.34 ± 0.012	0.684HisTyr: 0.684 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.52IleAla: 4.52 ± 0.052	0.559IleCys: 0.559 ± 0.016	2.43IleAsp: 2.43 ± 0.04	2.353IleGlu: 2.353 ± 0.037	1.471IlePhe: 1.471 ± 0.03	2.586IleGly: 2.586 ± 0.044	1.06IleHis: 1.06 ± 0.021	1.478IleIle: 1.478 ± 0.028	1.523IleLys: 1.523 ± 0.03	3.947IleLeu: 3.947 ± 0.047	0.912IleMet: 0.912 ± 0.021	1.166IleAsn: 1.166 ± 0.024	2.611IlePro: 2.611 ± 0.036	1.718IleGln: 1.718 ± 0.029	2.377IleArg: 2.377 ± 0.032	2.766IleSer: 2.766 ± 0.038	2.086IleThr: 2.086 ± 0.032	3.212IleVal: 3.212 ± 0.05	0.534IleTrp: 0.534 ± 0.018	1.014IleTyr: 1.014 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.642LysAla: 3.642 ± 0.061	0.39LysCys: 0.39 ± 0.014	2.277LysAsp: 2.277 ± 0.041	2.823LysGlu: 2.823 ± 0.048	1.081LysPhe: 1.081 ± 0.024	2.233LysGly: 2.233 ± 0.04	1.302LysHis: 1.302 ± 0.028	1.604LysIle: 1.604 ± 0.031	2.359LysLys: 2.359 ± 0.054	3.661LysLeu: 3.661 ± 0.042	0.987LysMet: 0.987 ± 0.023	1.418LysAsn: 1.418 ± 0.028	2.299LysPro: 2.299 ± 0.044	1.968LysGln: 1.968 ± 0.029	3.412LysArg: 3.412 ± 0.046	2.645LysSer: 2.645 ± 0.043	2.219LysThr: 2.219 ± 0.037	2.278LysVal: 2.278 ± 0.04	0.406LysTrp: 0.406 ± 0.015	1.128LysTyr: 1.128 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.501LeuAla: 10.501 ± 0.11	1.582LeuCys: 1.582 ± 0.032	6.231LeuAsp: 6.231 ± 0.067	5.803LeuGlu: 5.803 ± 0.076	3.587LeuPhe: 3.587 ± 0.047	6.302LeuGly: 6.302 ± 0.06	3.341LeuHis: 3.341 ± 0.047	3.097LeuIle: 3.097 ± 0.041	3.105LeuLys: 3.105 ± 0.052	10.328LeuLeu: 10.328 ± 0.121	1.842LeuMet: 1.842 ± 0.033	2.702LeuAsn: 2.702 ± 0.04	5.757LeuPro: 5.757 ± 0.061	4.74LeuGln: 4.74 ± 0.051	7.269LeuArg: 7.269 ± 0.07	6.801LeuSer: 6.801 ± 0.067	4.362LeuThr: 4.362 ± 0.049	6.481LeuVal: 6.481 ± 0.063	1.214LeuTrp: 1.214 ± 0.028	2.74LeuTyr: 2.74 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.339MetAla: 2.339 ± 0.033	0.29MetCys: 0.29 ± 0.014	1.688MetAsp: 1.688 ± 0.027	1.518MetGlu: 1.518 ± 0.03	0.771MetPhe: 0.771 ± 0.023	1.492MetGly: 1.492 ± 0.026	1.042MetHis: 1.042 ± 0.024	0.887MetIle: 0.887 ± 0.023	0.695MetLys: 0.695 ± 0.02	2.872MetLeu: 2.872 ± 0.043	0.568MetMet: 0.568 ± 0.017	0.77MetAsn: 0.77 ± 0.02	1.723MetPro: 1.723 ± 0.034	1.441MetGln: 1.441 ± 0.028	2.029MetArg: 2.029 ± 0.031	1.806MetSer: 1.806 ± 0.03	1.108MetThr: 1.108 ± 0.023	1.456MetVal: 1.456 ± 0.032	0.262MetTrp: 0.262 ± 0.011	0.797MetTyr: 0.797 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.943AsnAla: 3.943 ± 0.049	0.27AsnCys: 0.27 ± 0.013	1.717AsnAsp: 1.717 ± 0.034	1.857AsnGlu: 1.857 ± 0.028	1.006AsnPhe: 1.006 ± 0.02	2.072AsnGly: 2.072 ± 0.047	0.554AsnHis: 0.554 ± 0.017	1.443AsnIle: 1.443 ± 0.024	1.287AsnLys: 1.287 ± 0.029	2.582AsnLeu: 2.582 ± 0.044	0.936AsnMet: 0.936 ± 0.024	0.978AsnAsn: 0.978 ± 0.029	1.757AsnPro: 1.757 ± 0.032	0.979AsnGln: 0.979 ± 0.022	1.532AsnArg: 1.532 ± 0.028	1.776AsnSer: 1.776 ± 0.034	2.016AsnThr: 2.016 ± 0.032	2.545AsnVal: 2.545 ± 0.031	0.389AsnTrp: 0.389 ± 0.013	0.785AsnTyr: 0.785 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.966ProAla: 5.966 ± 0.074	0.587ProCys: 0.587 ± 0.017	3.099ProAsp: 3.099 ± 0.042	3.459ProGlu: 3.459 ± 0.044	2.096ProPhe: 2.096 ± 0.037	3.45ProGly: 3.45 ± 0.048	1.713ProHis: 1.713 ± 0.032	2.253ProIle: 2.253 ± 0.033	2.418ProLys: 2.418 ± 0.041	5.467ProLeu: 5.467 ± 0.057	1.481ProMet: 1.481 ± 0.032	1.926ProAsn: 1.926 ± 0.035	4.477ProPro: 4.477 ± 0.079	2.43ProGln: 2.43 ± 0.044	3.639ProArg: 3.639 ± 0.053	5.348ProSer: 5.348 ± 0.06	3.501ProThr: 3.501 ± 0.043	3.794ProVal: 3.794 ± 0.05	0.753ProTrp: 0.753 ± 0.019	1.489ProTyr: 1.489 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.218GlnAla: 4.218 ± 0.051	0.559GlnCys: 0.559 ± 0.017	2.394GlnAsp: 2.394 ± 0.042	2.635GlnGlu: 2.635 ± 0.041	1.326GlnPhe: 1.326 ± 0.025	2.717GlnGly: 2.717 ± 0.045	1.514GlnHis: 1.514 ± 0.025	1.62GlnIle: 1.62 ± 0.028	1.647GlnLys: 1.647 ± 0.031	4.439GlnLeu: 4.439 ± 0.051	1.021GlnMet: 1.021 ± 0.024	1.315GlnAsn: 1.315 ± 0.024	2.308GlnPro: 2.308 ± 0.049	2.317GlnGln: 2.317 ± 0.056	3.681GlnArg: 3.681 ± 0.05	2.884GlnSer: 2.884 ± 0.044	2.21GlnThr: 2.21 ± 0.032	2.638GlnVal: 2.638 ± 0.037	0.557GlnTrp: 0.557 ± 0.014	1.198GlnTyr: 1.198 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.683ArgAla: 7.683 ± 0.081	0.735ArgCys: 0.735 ± 0.02	3.635ArgAsp: 3.635 ± 0.042	3.962ArgGlu: 3.962 ± 0.056	2.274ArgPhe: 2.274 ± 0.034	3.829ArgGly: 3.829 ± 0.046	1.808ArgHis: 1.808 ± 0.028	3.275ArgIle: 3.275 ± 0.042	3.069ArgLys: 3.069 ± 0.048	6.052ArgLeu: 6.052 ± 0.059	1.785ArgMet: 1.785 ± 0.033	2.196ArgAsn: 2.196 ± 0.034	3.18ArgPro: 3.18 ± 0.048	2.366ArgGln: 2.366 ± 0.032	5.294ArgArg: 5.294 ± 0.07	4.591ArgSer: 4.591 ± 0.05	4.223ArgThr: 4.223 ± 0.049	4.326ArgVal: 4.326 ± 0.047	0.853ArgTrp: 0.853 ± 0.02	1.627ArgTyr: 1.627 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.696SerAla: 7.696 ± 0.07	0.669SerCys: 0.669 ± 0.02	3.972SerAsp: 3.972 ± 0.048	3.757SerGlu: 3.757 ± 0.043	2.552SerPhe: 2.552 ± 0.041	4.465SerGly: 4.465 ± 0.066	1.718SerHis: 1.718 ± 0.029	3.116SerIle: 3.116 ± 0.039	2.936SerLys: 2.936 ± 0.039	6.854SerLeu: 6.854 ± 0.062	2.099SerMet: 2.099 ± 0.035	2.198SerAsn: 2.198 ± 0.033	4.339SerPro: 4.339 ± 0.072	2.538SerGln: 2.538 ± 0.037	4.064SerArg: 4.064 ± 0.052	5.925SerSer: 5.925 ± 0.076	4.556SerThr: 4.556 ± 0.054	4.941SerVal: 4.941 ± 0.049	0.812SerTrp: 0.812 ± 0.02	1.642SerTyr: 1.642 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.332ThrAla: 5.332 ± 0.058	0.673ThrCys: 0.673 ± 0.018	2.871ThrAsp: 2.871 ± 0.042	3.208ThrGlu: 3.208 ± 0.044	2.031ThrPhe: 2.031 ± 0.032	3.437ThrGly: 3.437 ± 0.052	1.695ThrHis: 1.695 ± 0.032	2.425ThrIle: 2.425 ± 0.039	2.165ThrLys: 2.165 ± 0.037	6.086ThrLeu: 6.086 ± 0.061	1.499ThrMet: 1.499 ± 0.027	1.776ThrAsn: 1.776 ± 0.032	4.273ThrPro: 4.273 ± 0.053	2.516ThrGln: 2.516 ± 0.041	3.43ThrArg: 3.43 ± 0.042	4.213ThrSer: 4.213 ± 0.051	3.086ThrThr: 3.086 ± 0.041	3.53ThrVal: 3.53 ± 0.037	0.765ThrTrp: 0.765 ± 0.019	1.512ThrTyr: 1.512 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	6.084ValAla: 6.084 ± 0.055	0.993ValCys: 0.993 ± 0.022	3.908ValAsp: 3.908 ± 0.047	3.794ValGlu: 3.794 ± 0.045	2.432ValPhe: 2.432 ± 0.033	3.627ValGly: 3.627 ± 0.045	2.374ValHis: 2.374 ± 0.032	2.325ValIle: 2.325 ± 0.041	2.238ValLys: 2.238 ± 0.036	7.152ValLeu: 7.152 ± 0.065	1.438ValMet: 1.438 ± 0.026	1.778ValAsn: 1.778 ± 0.029	4.589ValPro: 4.589 ± 0.048	3.421ValGln: 3.421 ± 0.04	4.915ValArg: 4.915 ± 0.055	4.402ValSer: 4.402 ± 0.054	2.957ValThr: 2.957 ± 0.039	4.348ValVal: 4.348 ± 0.054	0.92ValTrp: 0.92 ± 0.024	1.955ValTyr: 1.955 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.114TrpAla: 1.114 ± 0.024	0.208TrpCys: 0.208 ± 0.009	0.928TrpAsp: 0.928 ± 0.022	0.727TrpGlu: 0.727 ± 0.017	0.444TrpPhe: 0.444 ± 0.015	0.689TrpGly: 0.689 ± 0.019	0.429TrpHis: 0.429 ± 0.015	0.66TrpIle: 0.66 ± 0.02	0.534TrpLys: 0.534 ± 0.017	1.288TrpLeu: 1.288 ± 0.031	0.312TrpMet: 0.312 ± 0.012	0.543TrpAsn: 0.543 ± 0.018	0.548TrpPro: 0.548 ± 0.017	0.526TrpGln: 0.526 ± 0.017	0.988TrpArg: 0.988 ± 0.021	0.999TrpSer: 0.999 ± 0.022	0.767TrpThr: 0.767 ± 0.021	0.718TrpVal: 0.718 ± 0.018	0.208TrpTrp: 0.208 ± 0.011	0.383TrpTyr: 0.383 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.882TyrAla: 2.882 ± 0.045	0.344TyrCys: 0.344 ± 0.013	1.681TyrAsp: 1.681 ± 0.037	1.545TyrGlu: 1.545 ± 0.034	1.084TyrPhe: 1.084 ± 0.025	1.865TyrGly: 1.865 ± 0.04	0.652TyrHis: 0.652 ± 0.017	1.171TyrIle: 1.171 ± 0.026	1.003TyrLys: 1.003 ± 0.026	2.579TyrLeu: 2.579 ± 0.033	0.735TyrMet: 0.735 ± 0.02	0.921TyrAsn: 0.921 ± 0.021	1.262TyrPro: 1.262 ± 0.029	0.87TyrGln: 0.87 ± 0.021	1.524TyrArg: 1.524 ± 0.03	1.609TyrSer: 1.609 ± 0.029	1.772TyrThr: 1.772 ± 0.031	1.851TyrVal: 1.851 ± 0.032	0.351TyrTrp: 0.351 ± 0.013	0.829TyrTyr: 0.829 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3791 proteins (2125182 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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