Amino acid dipepetide frequency for Trichodesmium erythraeum (strain IMS101)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.023AlaAla: 5.023 ± 0.107	0.667AlaCys: 0.667 ± 0.023	3.258AlaAsp: 3.258 ± 0.073	4.635AlaGlu: 4.635 ± 0.08	2.386AlaPhe: 2.386 ± 0.044	4.429AlaGly: 4.429 ± 0.129	1.019AlaHis: 1.019 ± 0.031	6.145AlaIle: 6.145 ± 0.084	4.244AlaLys: 4.244 ± 0.063	6.782AlaLeu: 6.782 ± 0.116	1.299AlaMet: 1.299 ± 0.034	3.253AlaAsn: 3.253 ± 0.079	2.138AlaPro: 2.138 ± 0.057	2.969AlaGln: 2.969 ± 0.057	2.709AlaArg: 2.709 ± 0.058	3.733AlaSer: 3.733 ± 0.07	4.04AlaThr: 4.04 ± 0.093	4.354AlaVal: 4.354 ± 0.069	0.814AlaTrp: 0.814 ± 0.035	2.234AlaTyr: 2.234 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.497CysAla: 0.497 ± 0.019	0.167CysCys: 0.167 ± 0.011	0.449CysAsp: 0.449 ± 0.018	0.515CysGlu: 0.515 ± 0.019	0.448CysPhe: 0.448 ± 0.02	0.713CysGly: 0.713 ± 0.025	0.262CysHis: 0.262 ± 0.013	0.585CysIle: 0.585 ± 0.019	0.402CysLys: 0.402 ± 0.018	1.158CysLeu: 1.158 ± 0.029	0.157CysMet: 0.157 ± 0.011	0.417CysAsn: 0.417 ± 0.019	0.442CysPro: 0.442 ± 0.017	0.621CysGln: 0.621 ± 0.02	0.524CysArg: 0.524 ± 0.022	0.621CysSer: 0.621 ± 0.02	0.409CysThr: 0.409 ± 0.016	0.484CysVal: 0.484 ± 0.017	0.133CysTrp: 0.133 ± 0.009	0.439CysTyr: 0.439 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.821AspAla: 2.821 ± 0.051	0.401AspCys: 0.401 ± 0.017	2.518AspAsp: 2.518 ± 0.113	3.213AspGlu: 3.213 ± 0.068	2.699AspPhe: 2.699 ± 0.058	3.659AspGly: 3.659 ± 0.12	0.654AspHis: 0.654 ± 0.024	4.092AspIle: 4.092 ± 0.079	3.008AspLys: 3.008 ± 0.059	5.637AspLeu: 5.637 ± 0.076	0.816AspMet: 0.816 ± 0.025	2.742AspAsn: 2.742 ± 0.08	2.1AspPro: 2.1 ± 0.056	1.833AspGln: 1.833 ± 0.036	2.502AspArg: 2.502 ± 0.046	3.228AspSer: 3.228 ± 0.088	2.574AspThr: 2.574 ± 0.079	2.87AspVal: 2.87 ± 0.066	0.811AspTrp: 0.811 ± 0.034	2.023AspTyr: 2.023 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.256GluAla: 5.256 ± 0.089	0.48GluCys: 0.48 ± 0.021	2.926GluAsp: 2.926 ± 0.053	4.762GluGlu: 4.762 ± 0.076	2.642GluPhe: 2.642 ± 0.056	3.507GluGly: 3.507 ± 0.08	0.867GluHis: 0.867 ± 0.027	5.925GluIle: 5.925 ± 0.086	5.955GluLys: 5.955 ± 0.08	7.353GluLeu: 7.353 ± 0.101	1.367GluMet: 1.367 ± 0.035	4.262GluAsn: 4.262 ± 0.079	2.321GluPro: 2.321 ± 0.059	2.99GluGln: 2.99 ± 0.051	2.871GluArg: 2.871 ± 0.062	3.79GluSer: 3.79 ± 0.062	3.868GluThr: 3.868 ± 0.054	4.672GluVal: 4.672 ± 0.067	0.881GluTrp: 0.881 ± 0.027	2.253GluTyr: 2.253 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	2.565PheAla: 2.565 ± 0.052	0.59PheCys: 0.59 ± 0.02	2.325PheAsp: 2.325 ± 0.051	2.396PheGlu: 2.396 ± 0.052	1.837PhePhe: 1.837 ± 0.047	2.831PheGly: 2.831 ± 0.056	0.739PheHis: 0.739 ± 0.032	2.806PheIle: 2.806 ± 0.062	1.924PheLys: 1.924 ± 0.039	4.321PheLeu: 4.321 ± 0.078	0.733PheMet: 0.733 ± 0.021	2.176PheAsn: 2.176 ± 0.05	2.024PhePro: 2.024 ± 0.047	1.99PheGln: 1.99 ± 0.039	1.705PheArg: 1.705 ± 0.039	3.251PheSer: 3.251 ± 0.059	2.267PheThr: 2.267 ± 0.056	2.315PheVal: 2.315 ± 0.043	0.736PheTrp: 0.736 ± 0.03	1.642PheTyr: 1.642 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.071GlyAla: 4.071 ± 0.09	0.716GlyCys: 0.716 ± 0.024	3.762GlyAsp: 3.762 ± 0.137	4.426GlyGlu: 4.426 ± 0.077	2.77GlyPhe: 2.77 ± 0.057	4.772GlyGly: 4.772 ± 0.132	1.1GlyHis: 1.1 ± 0.029	5.328GlyIle: 5.328 ± 0.072	5.124GlyLys: 5.124 ± 0.071	6.245GlyLeu: 6.245 ± 0.085	1.323GlyMet: 1.323 ± 0.039	3.936GlyAsn: 3.936 ± 0.138	1.58GlyPro: 1.58 ± 0.248	2.506GlyGln: 2.506 ± 0.054	2.877GlyArg: 2.877 ± 0.058	4.079GlySer: 4.079 ± 0.081	3.542GlyThr: 3.542 ± 0.098	4.39GlyVal: 4.39 ± 0.079	1.056GlyTrp: 1.056 ± 0.038	2.342GlyTyr: 2.342 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.715HisAla: 0.715 ± 0.022	0.232HisCys: 0.232 ± 0.013	0.6HisAsp: 0.6 ± 0.023	0.773HisGlu: 0.773 ± 0.035	0.783HisPhe: 0.783 ± 0.025	1.003HisGly: 1.003 ± 0.029	0.501HisHis: 0.501 ± 0.026	1.07HisIle: 1.07 ± 0.031	0.976HisLys: 0.976 ± 0.027	1.943HisLeu: 1.943 ± 0.041	0.154HisMet: 0.154 ± 0.011	0.83HisAsn: 0.83 ± 0.028	1.176HisPro: 1.176 ± 0.037	1.085HisGln: 1.085 ± 0.037	0.818HisArg: 0.818 ± 0.024	1.089HisSer: 1.089 ± 0.031	0.747HisThr: 0.747 ± 0.024	0.659HisVal: 0.659 ± 0.024	0.283HisTrp: 0.283 ± 0.015	0.687HisTyr: 0.687 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.016IleAla: 6.016 ± 0.074	0.828IleCys: 0.828 ± 0.027	4.307IleAsp: 4.307 ± 0.072	5.268IleGlu: 5.268 ± 0.077	3.246IlePhe: 3.246 ± 0.052	4.7IleGly: 4.7 ± 0.081	1.171IleHis: 1.171 ± 0.025	5.38IleIle: 5.38 ± 0.073	4.594IleLys: 4.594 ± 0.068	7.459IleLeu: 7.459 ± 0.1	1.077IleMet: 1.077 ± 0.03	4.502IleAsn: 4.502 ± 0.085	3.678IlePro: 3.678 ± 0.06	3.063IleGln: 3.063 ± 0.056	2.881IleArg: 2.881 ± 0.047	5.672IleSer: 5.672 ± 0.075	4.313IleThr: 4.313 ± 0.14	4.275IleVal: 4.275 ± 0.066	0.959IleTrp: 0.959 ± 0.026	2.462IleTyr: 2.462 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.192LysAla: 4.192 ± 0.066	0.491LysCys: 0.491 ± 0.019	2.733LysAsp: 2.733 ± 0.046	4.012LysGlu: 4.012 ± 0.063	2.684LysPhe: 2.684 ± 0.064	3.288LysGly: 3.288 ± 0.063	0.914LysHis: 0.914 ± 0.032	5.452LysIle: 5.452 ± 0.079	4.451LysLys: 4.451 ± 0.083	7.167LysLeu: 7.167 ± 0.106	1.185LysMet: 1.185 ± 0.028	3.926LysAsn: 3.926 ± 0.073	2.68LysPro: 2.68 ± 0.054	3.076LysGln: 3.076 ± 0.066	2.506LysArg: 2.506 ± 0.051	4.153LysSer: 4.153 ± 0.06	3.762LysThr: 3.762 ± 0.062	4.138LysVal: 4.138 ± 0.058	0.732LysTrp: 0.732 ± 0.026	2.303LysTyr: 2.303 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.767LeuAla: 7.767 ± 0.096	0.896LeuCys: 0.896 ± 0.027	5.303LeuAsp: 5.303 ± 0.069	8.397LeuGlu: 8.397 ± 0.108	3.822LeuPhe: 3.822 ± 0.066	7.46LeuGly: 7.46 ± 0.095	1.542LeuHis: 1.542 ± 0.037	7.111LeuIle: 7.111 ± 0.105	6.726LeuLys: 6.726 ± 0.107	10.47LeuLeu: 10.47 ± 0.144	1.99LeuMet: 1.99 ± 0.04	5.101LeuAsn: 5.101 ± 0.065	5.242LeuPro: 5.242 ± 0.069	4.835LeuGln: 4.835 ± 0.087	4.584LeuArg: 4.584 ± 0.074	7.342LeuSer: 7.342 ± 0.078	6.007LeuThr: 6.007 ± 0.066	6.631LeuVal: 6.631 ± 0.088	1.35LeuTrp: 1.35 ± 0.043	2.831LeuTyr: 2.831 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.457MetAla: 1.457 ± 0.036	0.116MetCys: 0.116 ± 0.009	0.701MetAsp: 0.701 ± 0.023	1.167MetGlu: 1.167 ± 0.031	0.582MetPhe: 0.582 ± 0.022	1.366MetGly: 1.366 ± 0.034	0.23MetHis: 0.23 ± 0.012	1.203MetIle: 1.203 ± 0.03	1.117MetLys: 1.117 ± 0.032	1.74MetLeu: 1.74 ± 0.037	0.411MetMet: 0.411 ± 0.016	0.922MetAsn: 0.922 ± 0.028	0.813MetPro: 0.813 ± 0.026	0.667MetGln: 0.667 ± 0.022	0.808MetArg: 0.808 ± 0.03	1.298MetSer: 1.298 ± 0.029	1.225MetThr: 1.225 ± 0.03	1.265MetVal: 1.265 ± 0.035	0.168MetTrp: 0.168 ± 0.011	0.359MetTyr: 0.359 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.759AsnAla: 2.759 ± 0.058	0.57AsnCys: 0.57 ± 0.022	2.449AsnAsp: 2.449 ± 0.114	2.31AsnGlu: 2.31 ± 0.05	2.73AsnPhe: 2.73 ± 0.052	2.973AsnGly: 2.973 ± 0.075	0.987AsnHis: 0.987 ± 0.034	4.599AsnIle: 4.599 ± 0.116	2.915AsnLys: 2.915 ± 0.054	6.776AsnLeu: 6.776 ± 0.094	0.861AsnMet: 0.861 ± 0.03	3.468AsnAsn: 3.468 ± 0.086	2.698AsnPro: 2.698 ± 0.048	3.182AsnGln: 3.182 ± 0.057	2.145AsnArg: 2.145 ± 0.046	4.324AsnSer: 4.324 ± 0.082	2.653AsnThr: 2.653 ± 0.077	2.527AsnVal: 2.527 ± 0.049	0.928AsnTrp: 0.928 ± 0.029	2.369AsnTyr: 2.369 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.3ProAla: 2.3 ± 0.075	0.297ProCys: 0.297 ± 0.014	2.532ProAsp: 2.532 ± 0.057	4.157ProGlu: 4.157 ± 0.069	1.595ProPhe: 1.595 ± 0.035	2.935ProGly: 2.935 ± 0.086	0.749ProHis: 0.749 ± 0.03	3.202ProIle: 3.202 ± 0.068	2.571ProLys: 2.571 ± 0.052	4.061ProLeu: 4.061 ± 0.062	0.695ProMet: 0.695 ± 0.026	2.396ProAsn: 2.396 ± 0.049	1.806ProPro: 1.806 ± 0.044	2.105ProGln: 2.105 ± 0.046	1.497ProArg: 1.497 ± 0.034	2.564ProSer: 2.564 ± 0.054	2.584ProThr: 2.584 ± 0.082	2.838ProVal: 2.838 ± 0.12	0.564ProTrp: 0.564 ± 0.017	1.342ProTyr: 1.342 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.407GlnAla: 3.407 ± 0.073	0.303GlnCys: 0.303 ± 0.015	2.088GlnAsp: 2.088 ± 0.037	3.988GlnGlu: 3.988 ± 0.074	1.541GlnPhe: 1.541 ± 0.036	3.118GlnGly: 3.118 ± 0.066	0.655GlnHis: 0.655 ± 0.023	3.608GlnIle: 3.608 ± 0.06	3.872GlnLys: 3.872 ± 0.073	5.038GlnLeu: 5.038 ± 0.087	0.816GlnMet: 0.816 ± 0.026	2.594GlnAsn: 2.594 ± 0.059	2.038GlnPro: 2.038 ± 0.045	2.855GlnGln: 2.855 ± 0.074	2.172GlnArg: 2.172 ± 0.051	2.357GlnSer: 2.357 ± 0.051	2.8GlnThr: 2.8 ± 0.071	3.204GlnVal: 3.204 ± 0.055	0.609GlnTrp: 0.609 ± 0.022	1.243GlnTyr: 1.243 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.499ArgAla: 2.499 ± 0.049	0.422ArgCys: 0.422 ± 0.015	2.212ArgAsp: 2.212 ± 0.044	3.12ArgGlu: 3.12 ± 0.057	1.795ArgPhe: 1.795 ± 0.039	2.751ArgGly: 2.751 ± 0.054	0.785ArgHis: 0.785 ± 0.028	2.969ArgIle: 2.969 ± 0.057	2.699ArgLys: 2.699 ± 0.054	4.862ArgLeu: 4.862 ± 0.078	0.833ArgMet: 0.833 ± 0.029	2.06ArgAsn: 2.06 ± 0.039	1.672ArgPro: 1.672 ± 0.038	2.487ArgGln: 2.487 ± 0.057	2.344ArgArg: 2.344 ± 0.057	2.707ArgSer: 2.707 ± 0.051	1.94ArgThr: 1.94 ± 0.037	2.766ArgVal: 2.766 ± 0.048	0.652ArgTrp: 0.652 ± 0.025	1.712ArgTyr: 1.712 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.649SerAla: 3.649 ± 0.072	0.68SerCys: 0.68 ± 0.021	3.445SerAsp: 3.445 ± 0.086	4.433SerGlu: 4.433 ± 0.071	2.799SerPhe: 2.799 ± 0.055	4.802SerGly: 4.802 ± 0.098	1.176SerHis: 1.176 ± 0.03	4.535SerIle: 4.535 ± 0.07	3.477SerLys: 3.477 ± 0.057	7.408SerLeu: 7.408 ± 0.089	1.135SerMet: 1.135 ± 0.034	3.341SerAsn: 3.341 ± 0.068	3.069SerPro: 3.069 ± 0.052	3.846SerGln: 3.846 ± 0.073	2.963SerArg: 2.963 ± 0.049	4.963SerSer: 4.963 ± 0.1	3.45SerThr: 3.45 ± 0.088	3.608SerVal: 3.608 ± 0.053	1.05SerTrp: 1.05 ± 0.036	2.247SerTyr: 2.247 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.828ThrAla: 3.828 ± 0.089	0.403ThrCys: 0.403 ± 0.018	2.798ThrAsp: 2.798 ± 0.085	3.8ThrGlu: 3.8 ± 0.062	2.194ThrPhe: 2.194 ± 0.068	4.111ThrGly: 4.111 ± 0.117	0.842ThrHis: 0.842 ± 0.027	4.378ThrIle: 4.378 ± 0.083	3.114ThrLys: 3.114 ± 0.053	5.59ThrLeu: 5.59 ± 0.101	0.808ThrMet: 0.808 ± 0.025	2.67ThrAsn: 2.67 ± 0.057	2.874ThrPro: 2.874 ± 0.074	2.623ThrGln: 2.623 ± 0.074	1.974ThrArg: 1.974 ± 0.046	3.454ThrSer: 3.454 ± 0.073	3.539ThrThr: 3.539 ± 0.162	3.718ThrVal: 3.718 ± 0.145	0.643ThrTrp: 0.643 ± 0.022	1.779ThrTyr: 1.779 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	4.79ValAla: 4.79 ± 0.081	0.608ValCys: 0.608 ± 0.02	3.355ValAsp: 3.355 ± 0.078	4.566ValGlu: 4.566 ± 0.081	2.426ValPhe: 2.426 ± 0.047	4.474ValGly: 4.474 ± 0.125	0.859ValHis: 0.859 ± 0.024	4.527ValIle: 4.527 ± 0.063	3.984ValLys: 3.984 ± 0.063	5.757ValLeu: 5.757 ± 0.078	1.183ValMet: 1.183 ± 0.031	3.216ValAsn: 3.216 ± 0.104	2.385ValPro: 2.385 ± 0.052	2.115ValGln: 2.115 ± 0.044	2.768ValArg: 2.768 ± 0.067	4.122ValSer: 4.122 ± 0.067	3.37ValThr: 3.37 ± 0.081	4.324ValVal: 4.324 ± 0.098	0.772ValTrp: 0.772 ± 0.026	1.896ValTyr: 1.896 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.804TrpAla: 0.804 ± 0.035	0.159TrpCys: 0.159 ± 0.012	0.69TrpAsp: 0.69 ± 0.034	1.04TrpGlu: 1.04 ± 0.034	0.57TrpPhe: 0.57 ± 0.028	0.903TrpGly: 0.903 ± 0.025	0.333TrpHis: 0.333 ± 0.016	0.804TrpIle: 0.804 ± 0.026	0.84TrpLys: 0.84 ± 0.042	1.774TrpLeu: 1.774 ± 0.046	0.294TrpMet: 0.294 ± 0.015	0.678TrpAsn: 0.678 ± 0.031	0.362TrpPro: 0.362 ± 0.017	1.039TrpGln: 1.039 ± 0.029	0.731TrpArg: 0.731 ± 0.024	0.861TrpSer: 0.861 ± 0.029	0.465TrpThr: 0.465 ± 0.019	0.921TrpVal: 0.921 ± 0.029	0.215TrpTrp: 0.215 ± 0.014	0.441TrpTyr: 0.441 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.712TyrAla: 1.712 ± 0.038	0.417TyrCys: 0.417 ± 0.018	1.753TyrAsp: 1.753 ± 0.05	1.972TyrGlu: 1.972 ± 0.057	1.623TyrPhe: 1.623 ± 0.038	2.152TyrGly: 2.152 ± 0.04	0.735TyrHis: 0.735 ± 0.024	2.134TyrIle: 2.134 ± 0.045	1.85TyrLys: 1.85 ± 0.05	3.868TyrLeu: 3.868 ± 0.063	0.477TyrMet: 0.477 ± 0.018	1.732TyrAsn: 1.732 ± 0.044	1.69TyrPro: 1.69 ± 0.03	2.424TyrGln: 2.424 ± 0.053	1.908TyrArg: 1.908 ± 0.05	2.466TyrSer: 2.466 ± 0.065	1.583TyrThr: 1.583 ± 0.044	1.536TyrVal: 1.536 ± 0.033	0.57TyrTrp: 0.57 ± 0.02	1.483TyrTyr: 1.483 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4342 proteins (1524108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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