Amino acid dipepetide frequency for Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.068AlaAla: 10.068 ± 0.07
0.898AlaCys: 0.898 ± 0.015
4.212AlaAsp: 4.212 ± 0.029
5.36AlaGlu: 5.36 ± 0.047
2.797AlaPhe: 2.797 ± 0.025
6.086AlaGly: 6.086 ± 0.046
1.765AlaHis: 1.765 ± 0.02
3.875AlaIle: 3.875 ± 0.031
4.395AlaLys: 4.395 ± 0.038
7.189AlaLeu: 7.189 ± 0.049
1.979AlaMet: 1.979 ± 0.02
2.994AlaAsn: 2.994 ± 0.026
5.414AlaPro: 5.414 ± 0.056
3.514AlaGln: 3.514 ± 0.038
4.854AlaArg: 4.854 ± 0.041
7.33AlaSer: 7.33 ± 0.056
5.511AlaThr: 5.511 ± 0.041
5.37AlaVal: 5.37 ± 0.036
1.057AlaTrp: 1.057 ± 0.016
1.996AlaTyr: 1.996 ± 0.024
0.001AlaXaa: 0.001 ± 0.0
Cys
0.828CysAla: 0.828 ± 0.015
0.225CysCys: 0.225 ± 0.008
0.566CysAsp: 0.566 ± 0.01
0.548CysGlu: 0.548 ± 0.01
0.456CysPhe: 0.456 ± 0.009
0.869CysGly: 0.869 ± 0.015
0.291CysHis: 0.291 ± 0.007
0.564CysIle: 0.564 ± 0.01
0.496CysLys: 0.496 ± 0.012
1.088CysLeu: 1.088 ± 0.017
0.227CysMet: 0.227 ± 0.006
0.427CysAsn: 0.427 ± 0.01
0.639CysPro: 0.639 ± 0.014
0.398CysGln: 0.398 ± 0.008
0.637CysArg: 0.637 ± 0.014
0.806CysSer: 0.806 ± 0.016
0.608CysThr: 0.608 ± 0.014
0.691CysVal: 0.691 ± 0.014
0.186CysTrp: 0.186 ± 0.006
0.311CysTyr: 0.311 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
4.484AspAla: 4.484 ± 0.039
0.57AspCys: 0.57 ± 0.01
4.775AspAsp: 4.775 ± 0.054
4.821AspGlu: 4.821 ± 0.051
2.066AspPhe: 2.066 ± 0.02
4.222AspGly: 4.222 ± 0.031
1.302AspHis: 1.302 ± 0.017
2.807AspIle: 2.807 ± 0.027
2.629AspLys: 2.629 ± 0.024
4.766AspLeu: 4.766 ± 0.038
1.309AspMet: 1.309 ± 0.015
2.087AspAsn: 2.087 ± 0.021
3.334AspPro: 3.334 ± 0.025
1.881AspGln: 1.881 ± 0.02
3.004AspArg: 3.004 ± 0.035
3.946AspSer: 3.946 ± 0.034
2.858AspThr: 2.858 ± 0.026
3.539AspVal: 3.539 ± 0.031
0.85AspTrp: 0.85 ± 0.013
1.574AspTyr: 1.574 ± 0.019
0.0AspXaa: 0.0 ± 0.0
Glu
5.644GluAla: 5.644 ± 0.046
0.567GluCys: 0.567 ± 0.011
4.617GluAsp: 4.617 ± 0.047
6.953GluGlu: 6.953 ± 0.079
1.89GluPhe: 1.89 ± 0.021
4.261GluGly: 4.261 ± 0.034
1.381GluHis: 1.381 ± 0.018
2.814GluIle: 2.814 ± 0.026
4.209GluLys: 4.209 ± 0.044
5.122GluLeu: 5.122 ± 0.049
1.512GluMet: 1.512 ± 0.019
2.251GluAsn: 2.251 ± 0.02
2.923GluPro: 2.923 ± 0.039
2.732GluGln: 2.732 ± 0.028
4.217GluArg: 4.217 ± 0.04
4.02GluSer: 4.02 ± 0.032
3.466GluThr: 3.466 ± 0.03
3.833GluVal: 3.833 ± 0.035
0.905GluTrp: 0.905 ± 0.015
1.615GluTyr: 1.615 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.813PheAla: 2.813 ± 0.028
0.478PheCys: 0.478 ± 0.011
2.125PheAsp: 2.125 ± 0.024
2.024PheGlu: 2.024 ± 0.023
1.44PhePhe: 1.44 ± 0.02
2.739PheGly: 2.739 ± 0.029
0.84PheHis: 0.84 ± 0.014
1.551PheIle: 1.551 ± 0.021
1.497PheLys: 1.497 ± 0.018
3.099PheLeu: 3.099 ± 0.027
0.741PheMet: 0.741 ± 0.014
1.401PheAsn: 1.401 ± 0.016
1.878PhePro: 1.878 ± 0.017
1.235PheGln: 1.235 ± 0.018
1.817PheArg: 1.817 ± 0.019
2.729PheSer: 2.729 ± 0.028
2.042PheThr: 2.042 ± 0.019
2.175PheVal: 2.175 ± 0.025
0.571PheTrp: 0.571 ± 0.012
0.986PheTyr: 0.986 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
5.525GlyAla: 5.525 ± 0.044
0.805GlyCys: 0.805 ± 0.016
3.716GlyAsp: 3.716 ± 0.033
4.067GlyGlu: 4.067 ± 0.033
2.668GlyPhe: 2.668 ± 0.028
7.473GlyGly: 7.473 ± 0.075
1.864GlyHis: 1.864 ± 0.025
3.237GlyIle: 3.237 ± 0.029
3.727GlyLys: 3.727 ± 0.034
5.84GlyLeu: 5.84 ± 0.043
1.694GlyMet: 1.694 ± 0.023
2.871GlyAsn: 2.871 ± 0.034
3.706GlyPro: 3.706 ± 0.037
2.869GlyGln: 2.869 ± 0.034
4.268GlyArg: 4.268 ± 0.035
6.131GlySer: 6.131 ± 0.045
4.25GlyThr: 4.25 ± 0.04
4.363GlyVal: 4.363 ± 0.03
1.146GlyTrp: 1.146 ± 0.017
2.123GlyTyr: 2.123 ± 0.025
0.002GlyXaa: 0.002 ± 0.001
His
1.773HisAla: 1.773 ± 0.02
0.288HisCys: 0.288 ± 0.007
1.348HisAsp: 1.348 ± 0.017
1.318HisGlu: 1.318 ± 0.018
0.848HisPhe: 0.848 ± 0.014
1.825HisGly: 1.825 ± 0.02
1.165HisHis: 1.165 ± 0.021
1.091HisIle: 1.091 ± 0.015
0.968HisLys: 0.968 ± 0.014
2.127HisLeu: 2.127 ± 0.022
0.504HisMet: 0.504 ± 0.009
0.942HisAsn: 0.942 ± 0.013
1.76HisPro: 1.76 ± 0.022
1.25HisGln: 1.25 ± 0.022
1.509HisArg: 1.509 ± 0.019
1.833HisSer: 1.833 ± 0.026
1.246HisThr: 1.246 ± 0.018
1.376HisVal: 1.376 ± 0.017
0.316HisTrp: 0.316 ± 0.008
0.712HisTyr: 0.712 ± 0.012
0.001HisXaa: 0.001 ± 0.0
Ile
3.761IleAla: 3.761 ± 0.031
0.614IleCys: 0.614 ± 0.013
2.644IleAsp: 2.644 ± 0.025
2.648IleGlu: 2.648 ± 0.026
1.718IlePhe: 1.718 ± 0.023
2.822IleGly: 2.822 ± 0.029
1.093IleHis: 1.093 ± 0.016
2.27IleIle: 2.27 ± 0.025
2.256IleLys: 2.256 ± 0.019
3.948IleLeu: 3.948 ± 0.037
0.941IleMet: 0.941 ± 0.016
1.747IleAsn: 1.747 ± 0.019
3.055IlePro: 3.055 ± 0.029
1.716IleGln: 1.716 ± 0.018
2.596IleArg: 2.596 ± 0.025
3.395IleSer: 3.395 ± 0.029
2.834IleThr: 2.834 ± 0.026
2.788IleVal: 2.788 ± 0.028
0.654IleTrp: 0.654 ± 0.012
1.221IleTyr: 1.221 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
4.644LysAla: 4.644 ± 0.041
0.477LysCys: 0.477 ± 0.011
2.942LysAsp: 2.942 ± 0.028
4.105LysGlu: 4.105 ± 0.043
1.469LysPhe: 1.469 ± 0.019
3.352LysGly: 3.352 ± 0.029
1.116LysHis: 1.116 ± 0.015
2.211LysIle: 2.211 ± 0.024
4.05LysLys: 4.05 ± 0.053
4.092LysLeu: 4.092 ± 0.034
1.079LysMet: 1.079 ± 0.016
1.852LysAsn: 1.852 ± 0.021
3.032LysPro: 3.032 ± 0.032
2.015LysGln: 2.015 ± 0.024
3.593LysArg: 3.593 ± 0.032
3.425LysSer: 3.425 ± 0.033
3.049LysThr: 3.049 ± 0.031
2.98LysVal: 2.98 ± 0.025
0.72LysTrp: 0.72 ± 0.013
1.324LysTyr: 1.324 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
7.36LeuAla: 7.36 ± 0.047
1.038LeuCys: 1.038 ± 0.016
4.852LeuAsp: 4.852 ± 0.034
5.293LeuGlu: 5.293 ± 0.043
2.996LeuPhe: 2.996 ± 0.033
5.647LeuGly: 5.647 ± 0.047
1.996LeuHis: 1.996 ± 0.02
3.476LeuIle: 3.476 ± 0.031
4.165LeuLys: 4.165 ± 0.037
7.641LeuLeu: 7.641 ± 0.06
1.674LeuMet: 1.674 ± 0.019
3.034LeuAsn: 3.034 ± 0.027
5.584LeuPro: 5.584 ± 0.055
3.494LeuGln: 3.494 ± 0.033
5.382LeuArg: 5.382 ± 0.039
6.72LeuSer: 6.72 ± 0.048
4.702LeuThr: 4.702 ± 0.037
5.052LeuVal: 5.052 ± 0.034
1.109LeuTrp: 1.109 ± 0.018
2.102LeuTyr: 2.102 ± 0.021
0.001LeuXaa: 0.001 ± 0.0
Met
2.232MetAla: 2.232 ± 0.024
0.221MetCys: 0.221 ± 0.007
1.297MetAsp: 1.297 ± 0.014
1.366MetGlu: 1.366 ± 0.015
0.694MetPhe: 0.694 ± 0.013
1.645MetGly: 1.645 ± 0.021
0.445MetHis: 0.445 ± 0.011
0.891MetIle: 0.891 ± 0.015
1.012MetLys: 1.012 ± 0.014
1.704MetLeu: 1.704 ± 0.02
0.616MetMet: 0.616 ± 0.013
0.766MetAsn: 0.766 ± 0.013
1.3MetPro: 1.3 ± 0.018
0.797MetGln: 0.797 ± 0.013
1.248MetArg: 1.248 ± 0.017
1.883MetSer: 1.883 ± 0.023
1.319MetThr: 1.319 ± 0.015
1.348MetVal: 1.348 ± 0.016
0.253MetTrp: 0.253 ± 0.007
0.479MetTyr: 0.479 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.007AsnAla: 3.007 ± 0.026
0.406AsnCys: 0.406 ± 0.009
2.034AsnAsp: 2.034 ± 0.023
1.999AsnGlu: 1.999 ± 0.024
1.3AsnPhe: 1.3 ± 0.017
3.321AsnGly: 3.321 ± 0.04
0.951AsnHis: 0.951 ± 0.014
1.891AsnIle: 1.891 ± 0.02
1.869AsnLys: 1.869 ± 0.023
3.098AsnLeu: 3.098 ± 0.028
0.883AsnMet: 0.883 ± 0.016
2.105AsnAsn: 2.105 ± 0.035
2.626AsnPro: 2.626 ± 0.025
1.43AsnGln: 1.43 ± 0.022
1.994AsnArg: 1.994 ± 0.021
2.826AsnSer: 2.826 ± 0.028
2.334AsnThr: 2.334 ± 0.025
2.152AsnVal: 2.152 ± 0.023
0.541AsnTrp: 0.541 ± 0.01
1.037AsnTyr: 1.037 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
5.844ProAla: 5.844 ± 0.062
0.482ProCys: 0.482 ± 0.01
3.173ProAsp: 3.173 ± 0.029
3.953ProGlu: 3.953 ± 0.046
2.003ProPhe: 2.003 ± 0.022
4.312ProGly: 4.312 ± 0.037
1.397ProHis: 1.397 ± 0.018
2.586ProIle: 2.586 ± 0.021
3.031ProLys: 3.031 ± 0.034
4.78ProLeu: 4.78 ± 0.038
1.144ProMet: 1.144 ± 0.016
2.337ProAsn: 2.337 ± 0.023
6.119ProPro: 6.119 ± 0.087
2.771ProGln: 2.771 ± 0.042
3.567ProArg: 3.567 ± 0.037
6.566ProSer: 6.566 ± 0.055
4.562ProThr: 4.562 ± 0.043
3.944ProVal: 3.944 ± 0.037
0.706ProTrp: 0.706 ± 0.011
1.5ProTyr: 1.5 ± 0.017
0.001ProXaa: 0.001 ± 0.0
Gln
3.596GlnAla: 3.596 ± 0.039
0.398GlnCys: 0.398 ± 0.01
2.031GlnAsp: 2.031 ± 0.021
2.622GlnGlu: 2.622 ± 0.029
1.219GlnPhe: 1.219 ± 0.016
2.552GlnGly: 2.552 ± 0.029
1.302GlnHis: 1.302 ± 0.024
1.722GlnIle: 1.722 ± 0.018
2.092GlnLys: 2.092 ± 0.024
3.318GlnLeu: 3.318 ± 0.032
0.882GlnMet: 0.882 ± 0.017
1.523GlnAsn: 1.523 ± 0.022
3.01GlnPro: 3.01 ± 0.044
4.002GlnGln: 4.002 ± 0.098
2.663GlnArg: 2.663 ± 0.022
3.002GlnSer: 3.002 ± 0.029
2.353GlnThr: 2.353 ± 0.023
2.173GlnVal: 2.173 ± 0.022
0.508GlnTrp: 0.508 ± 0.009
1.137GlnTyr: 1.137 ± 0.016
0.001GlnXaa: 0.001 ± 0.0
Arg
4.6ArgAla: 4.6 ± 0.031
0.636ArgCys: 0.636 ± 0.012
3.363ArgAsp: 3.363 ± 0.037
4.096ArgGlu: 4.096 ± 0.036
2.016ArgPhe: 2.016 ± 0.02
3.969ArgGly: 3.969 ± 0.036
1.583ArgHis: 1.583 ± 0.018
2.64ArgIle: 2.64 ± 0.025
3.572ArgLys: 3.572 ± 0.03
5.112ArgLeu: 5.112 ± 0.033
1.322ArgMet: 1.322 ± 0.017
2.251ArgAsn: 2.251 ± 0.022
3.667ArgPro: 3.667 ± 0.038
2.679ArgGln: 2.679 ± 0.029
5.181ArgArg: 5.181 ± 0.045
4.705ArgSer: 4.705 ± 0.047
3.276ArgThr: 3.276 ± 0.024
3.259ArgVal: 3.259 ± 0.027
0.875ArgTrp: 0.875 ± 0.013
1.567ArgTyr: 1.567 ± 0.02
0.001ArgXaa: 0.001 ± 0.0
Ser
6.733SerAla: 6.733 ± 0.052
0.769SerCys: 0.769 ± 0.013
4.098SerAsp: 4.098 ± 0.042
4.034SerGlu: 4.034 ± 0.033
2.757SerPhe: 2.757 ± 0.024
5.896SerGly: 5.896 ± 0.041
1.996SerHis: 1.996 ± 0.027
3.506SerIle: 3.506 ± 0.028
3.659SerLys: 3.659 ± 0.032
6.669SerLeu: 6.669 ± 0.041
1.609SerMet: 1.609 ± 0.021
3.076SerAsn: 3.076 ± 0.029
6.005SerPro: 6.005 ± 0.076
3.283SerGln: 3.283 ± 0.031
4.871SerArg: 4.871 ± 0.046
9.843SerSer: 9.843 ± 0.097
5.851SerThr: 5.851 ± 0.047
4.444SerVal: 4.444 ± 0.033
1.01SerTrp: 1.01 ± 0.016
1.957SerTyr: 1.957 ± 0.023
0.001SerXaa: 0.001 ± 0.0
Thr
5.535ThrAla: 5.535 ± 0.038
0.692ThrCys: 0.692 ± 0.012
2.866ThrAsp: 2.866 ± 0.023
3.274ThrGlu: 3.274 ± 0.031
2.084ThrPhe: 2.084 ± 0.021
4.42ThrGly: 4.42 ± 0.038
1.298ThrHis: 1.298 ± 0.018
2.964ThrIle: 2.964 ± 0.027
2.868ThrLys: 2.868 ± 0.024
4.94ThrLeu: 4.94 ± 0.037
1.157ThrMet: 1.157 ± 0.014
2.224ThrAsn: 2.224 ± 0.023
4.843ThrPro: 4.843 ± 0.045
2.167ThrGln: 2.167 ± 0.026
3.142ThrArg: 3.142 ± 0.03
5.671ThrSer: 5.671 ± 0.044
5.551ThrThr: 5.551 ± 0.064
3.752ThrVal: 3.752 ± 0.034
0.777ThrTrp: 0.777 ± 0.012
1.486ThrTyr: 1.486 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
5.168ValAla: 5.168 ± 0.041
0.732ValCys: 0.732 ± 0.015
3.694ValAsp: 3.694 ± 0.03
4.06ValGlu: 4.06 ± 0.037
2.184ValPhe: 2.184 ± 0.025
3.956ValGly: 3.956 ± 0.035
1.321ValHis: 1.321 ± 0.017
2.758ValIle: 2.758 ± 0.025
3.102ValLys: 3.102 ± 0.025
5.129ValLeu: 5.129 ± 0.036
1.326ValMet: 1.326 ± 0.019
2.222ValAsn: 2.222 ± 0.022
3.832ValPro: 3.832 ± 0.035
2.264ValGln: 2.264 ± 0.019
3.383ValArg: 3.383 ± 0.027
4.442ValSer: 4.442 ± 0.036
3.544ValThr: 3.544 ± 0.032
4.334ValVal: 4.334 ± 0.04
0.834ValTrp: 0.834 ± 0.015
1.624ValTyr: 1.624 ± 0.018
0.001ValXaa: 0.001 ± 0.0
Trp
1.068TrpAla: 1.068 ± 0.016
0.191TrpCys: 0.191 ± 0.006
0.862TrpAsp: 0.862 ± 0.014
0.875TrpGlu: 0.875 ± 0.015
0.514TrpPhe: 0.514 ± 0.01
0.925TrpGly: 0.925 ± 0.015
0.33TrpHis: 0.33 ± 0.009
0.654TrpIle: 0.654 ± 0.012
0.818TrpLys: 0.818 ± 0.013
1.223TrpLeu: 1.223 ± 0.019
0.347TrpMet: 0.347 ± 0.008
0.576TrpAsn: 0.576 ± 0.012
0.582TrpPro: 0.582 ± 0.012
0.525TrpGln: 0.525 ± 0.01
0.9TrpArg: 0.9 ± 0.014
0.936TrpSer: 0.936 ± 0.015
0.851TrpThr: 0.851 ± 0.013
0.84TrpVal: 0.84 ± 0.014
0.272TrpTrp: 0.272 ± 0.008
0.399TrpTyr: 0.399 ± 0.008
0.001TrpXaa: 0.001 ± 0.0
Tyr
1.983TyrAla: 1.983 ± 0.022
0.373TyrCys: 0.373 ± 0.009
1.608TyrAsp: 1.608 ± 0.02
1.514TyrGlu: 1.514 ± 0.018
1.059TyrPhe: 1.059 ± 0.015
2.051TyrGly: 2.051 ± 0.028
0.763TyrHis: 0.763 ± 0.013
1.218TyrIle: 1.218 ± 0.018
1.111TyrLys: 1.111 ± 0.018
2.432TyrLeu: 2.432 ± 0.025
0.57TyrMet: 0.57 ± 0.012
1.119TyrAsn: 1.119 ± 0.015
1.468TyrPro: 1.468 ± 0.023
1.082TyrGln: 1.082 ± 0.016
1.541TyrArg: 1.541 ± 0.021
1.858TyrSer: 1.858 ± 0.022
1.504TyrThr: 1.504 ± 0.018
1.497TyrVal: 1.497 ± 0.017
0.401TyrTrp: 0.401 ± 0.009
0.901TyrTyr: 0.901 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.0
0.001XaaHis: 0.001 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.001XaaMet: 0.001 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.001
0.001XaaGln: 0.001 ± 0.0
0.001XaaArg: 0.001 ± 0.0
0.002XaaSer: 0.002 ± 0.001
0.001XaaThr: 0.001 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.399XaaXaa: 0.399 ± 0.066
Statistics based on 9890 proteins (5012912 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski