Amino acid dipepetide frequency for Akanthomyces lecanii RCEF 1005

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.371AlaAla: 12.371 ± 0.079	1.175AlaCys: 1.175 ± 0.016	5.122AlaAsp: 5.122 ± 0.031	5.496AlaGlu: 5.496 ± 0.042	3.305AlaPhe: 3.305 ± 0.028	6.712AlaGly: 6.712 ± 0.046	2.008AlaHis: 2.008 ± 0.02	4.339AlaIle: 4.339 ± 0.033	4.489AlaLys: 4.489 ± 0.038	8.448AlaLeu: 8.448 ± 0.049	2.294AlaMet: 2.294 ± 0.025	3.152AlaAsn: 3.152 ± 0.027	5.258AlaPro: 5.258 ± 0.038	3.773AlaGln: 3.773 ± 0.032	5.355AlaArg: 5.355 ± 0.035	7.927AlaSer: 7.927 ± 0.041	5.997AlaThr: 5.997 ± 0.04	6.318AlaVal: 6.318 ± 0.04	1.303AlaTrp: 1.303 ± 0.019	2.259AlaTyr: 2.259 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.016	0.253CysCys: 0.253 ± 0.009	0.695CysAsp: 0.695 ± 0.011	0.578CysGlu: 0.578 ± 0.009	0.55CysPhe: 0.55 ± 0.01	0.993CysGly: 0.993 ± 0.015	0.318CysHis: 0.318 ± 0.007	0.712CysIle: 0.712 ± 0.011	0.531CysLys: 0.531 ± 0.01	1.218CysLeu: 1.218 ± 0.018	0.272CysMet: 0.272 ± 0.007	0.424CysAsn: 0.424 ± 0.01	0.652CysPro: 0.652 ± 0.013	0.453CysGln: 0.453 ± 0.009	0.761CysArg: 0.761 ± 0.011	0.876CysSer: 0.876 ± 0.012	0.696CysThr: 0.696 ± 0.013	0.813CysVal: 0.813 ± 0.013	0.206CysTrp: 0.206 ± 0.007	0.338CysTyr: 0.338 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.772AspAla: 5.772 ± 0.032	0.677AspCys: 0.677 ± 0.012	4.707AspAsp: 4.707 ± 0.049	4.618AspGlu: 4.618 ± 0.037	2.238AspPhe: 2.238 ± 0.022	4.659AspGly: 4.659 ± 0.033	1.194AspHis: 1.194 ± 0.013	2.917AspIle: 2.917 ± 0.025	2.679AspLys: 2.679 ± 0.025	4.814AspLeu: 4.814 ± 0.032	1.467AspMet: 1.467 ± 0.018	1.938AspAsn: 1.938 ± 0.021	2.985AspPro: 2.985 ± 0.022	1.764AspGln: 1.764 ± 0.019	3.012AspArg: 3.012 ± 0.031	4.13AspSer: 4.13 ± 0.031	2.976AspThr: 2.976 ± 0.024	3.9AspVal: 3.9 ± 0.032	0.888AspTrp: 0.888 ± 0.014	1.576AspTyr: 1.576 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.71GluAla: 5.71 ± 0.037	0.608GluCys: 0.608 ± 0.012	4.084GluAsp: 4.084 ± 0.036	4.953GluGlu: 4.953 ± 0.063	1.897GluPhe: 1.897 ± 0.019	3.374GluGly: 3.374 ± 0.028	1.401GluHis: 1.401 ± 0.016	2.674GluIle: 2.674 ± 0.024	3.32GluLys: 3.32 ± 0.034	5.136GluLeu: 5.136 ± 0.038	1.518GluMet: 1.518 ± 0.016	2.085GluAsn: 2.085 ± 0.02	2.767GluPro: 2.767 ± 0.032	2.498GluGln: 2.498 ± 0.023	3.674GluArg: 3.674 ± 0.03	3.985GluSer: 3.985 ± 0.034	3.42GluThr: 3.42 ± 0.029	3.264GluVal: 3.264 ± 0.031	0.827GluTrp: 0.827 ± 0.013	1.568GluTyr: 1.568 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.38PheAla: 3.38 ± 0.029	0.556PheCys: 0.556 ± 0.011	2.368PheAsp: 2.368 ± 0.024	1.997PheGlu: 1.997 ± 0.022	1.613PhePhe: 1.613 ± 0.023	2.919PheGly: 2.919 ± 0.029	0.869PheHis: 0.869 ± 0.014	1.692PheIle: 1.692 ± 0.021	1.449PheLys: 1.449 ± 0.019	3.38PheLeu: 3.38 ± 0.028	0.829PheMet: 0.829 ± 0.014	1.385PheAsn: 1.385 ± 0.018	1.804PhePro: 1.804 ± 0.02	1.379PheGln: 1.379 ± 0.016	1.914PheArg: 1.914 ± 0.019	2.866PheSer: 2.866 ± 0.025	2.102PheThr: 2.102 ± 0.02	2.46PheVal: 2.46 ± 0.024	0.67PheTrp: 0.67 ± 0.013	1.109PheTyr: 1.109 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	6.21GlyAla: 6.21 ± 0.043	0.904GlyCys: 0.904 ± 0.014	3.924GlyAsp: 3.924 ± 0.031	3.622GlyGlu: 3.622 ± 0.031	2.791GlyPhe: 2.791 ± 0.025	6.492GlyGly: 6.492 ± 0.064	1.776GlyHis: 1.776 ± 0.023	3.465GlyIle: 3.465 ± 0.023	3.526GlyLys: 3.526 ± 0.027	6.084GlyLeu: 6.084 ± 0.04	1.655GlyMet: 1.655 ± 0.019	2.652GlyAsn: 2.652 ± 0.038	3.29GlyPro: 3.29 ± 0.032	2.703GlyGln: 2.703 ± 0.03	4.292GlyArg: 4.292 ± 0.029	5.83GlySer: 5.83 ± 0.048	4.027GlyThr: 4.027 ± 0.031	4.402GlyVal: 4.402 ± 0.034	1.197GlyTrp: 1.197 ± 0.015	2.171GlyTyr: 2.171 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.041HisAla: 2.041 ± 0.02	0.333HisCys: 0.333 ± 0.009	1.416HisAsp: 1.416 ± 0.016	1.311HisGlu: 1.311 ± 0.014	0.907HisPhe: 0.907 ± 0.014	1.865HisGly: 1.865 ± 0.021	0.866HisHis: 0.866 ± 0.018	1.186HisIle: 1.186 ± 0.015	0.908HisLys: 0.908 ± 0.015	2.141HisLeu: 2.141 ± 0.02	0.546HisMet: 0.546 ± 0.011	0.841HisAsn: 0.841 ± 0.014	1.496HisPro: 1.496 ± 0.019	0.948HisGln: 0.948 ± 0.016	1.542HisArg: 1.542 ± 0.017	1.734HisSer: 1.734 ± 0.023	1.202HisThr: 1.202 ± 0.015	1.466HisVal: 1.466 ± 0.015	0.351HisTrp: 0.351 ± 0.009	0.675HisTyr: 0.675 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.353IleAla: 4.353 ± 0.031	0.702IleCys: 0.702 ± 0.013	2.781IleAsp: 2.781 ± 0.025	2.575IleGlu: 2.575 ± 0.021	1.92IlePhe: 1.92 ± 0.023	3.171IleGly: 3.171 ± 0.027	1.096IleHis: 1.096 ± 0.014	2.347IleIle: 2.347 ± 0.025	2.061IleLys: 2.061 ± 0.021	4.314IleLeu: 4.314 ± 0.035	1.069IleMet: 1.069 ± 0.016	1.627IleAsn: 1.627 ± 0.019	2.661IlePro: 2.661 ± 0.023	1.735IleGln: 1.735 ± 0.018	2.597IleArg: 2.597 ± 0.02	3.459IleSer: 3.459 ± 0.031	2.661IleThr: 2.661 ± 0.024	3.201IleVal: 3.201 ± 0.024	0.687IleTrp: 0.687 ± 0.013	1.303IleTyr: 1.303 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.382LysAla: 4.382 ± 0.031	0.5LysCys: 0.5 ± 0.011	2.784LysAsp: 2.784 ± 0.026	3.015LysGlu: 3.015 ± 0.03	1.47LysPhe: 1.47 ± 0.016	2.779LysGly: 2.779 ± 0.024	1.12LysHis: 1.12 ± 0.016	2.129LysIle: 2.129 ± 0.022	3.266LysLys: 3.266 ± 0.078	4.101LysLeu: 4.101 ± 0.033	1.079LysMet: 1.079 ± 0.015	1.696LysAsn: 1.696 ± 0.021	2.67LysPro: 2.67 ± 0.029	1.939LysGln: 1.939 ± 0.02	3.165LysArg: 3.165 ± 0.031	3.415LysSer: 3.415 ± 0.029	2.956LysThr: 2.956 ± 0.025	2.689LysVal: 2.689 ± 0.024	0.669LysTrp: 0.669 ± 0.012	1.323LysTyr: 1.323 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.662LeuAla: 8.662 ± 0.046	1.228LeuCys: 1.228 ± 0.016	5.273LeuAsp: 5.273 ± 0.036	5.102LeuGlu: 5.102 ± 0.034	3.339LeuPhe: 3.339 ± 0.032	6.04LeuGly: 6.04 ± 0.035	2.228LeuHis: 2.228 ± 0.021	3.656LeuIle: 3.656 ± 0.03	3.839LeuLys: 3.839 ± 0.032	8.424LeuLeu: 8.424 ± 0.058	1.829LeuMet: 1.829 ± 0.016	2.902LeuAsn: 2.902 ± 0.024	5.361LeuPro: 5.361 ± 0.038	3.841LeuGln: 3.841 ± 0.032	5.809LeuArg: 5.809 ± 0.041	6.895LeuSer: 6.895 ± 0.043	4.644LeuThr: 4.644 ± 0.027	5.652LeuVal: 5.652 ± 0.044	1.224LeuTrp: 1.224 ± 0.018	2.309LeuTyr: 2.309 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.542MetAla: 2.542 ± 0.024	0.263MetCys: 0.263 ± 0.006	1.335MetAsp: 1.335 ± 0.016	1.317MetGlu: 1.317 ± 0.015	0.756MetPhe: 0.756 ± 0.013	1.539MetGly: 1.539 ± 0.019	0.534MetHis: 0.534 ± 0.011	0.951MetIle: 0.951 ± 0.016	0.998MetLys: 0.998 ± 0.013	2.004MetLeu: 2.004 ± 0.022	0.631MetMet: 0.631 ± 0.012	0.795MetAsn: 0.795 ± 0.014	1.433MetPro: 1.433 ± 0.018	0.953MetGln: 0.953 ± 0.014	1.374MetArg: 1.374 ± 0.017	1.918MetSer: 1.918 ± 0.021	1.404MetThr: 1.404 ± 0.018	1.388MetVal: 1.388 ± 0.017	0.268MetTrp: 0.268 ± 0.008	0.562MetTyr: 0.562 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.274AsnAla: 3.274 ± 0.031	0.444AsnCys: 0.444 ± 0.009	1.914AsnAsp: 1.914 ± 0.02	1.852AsnGlu: 1.852 ± 0.018	1.309AsnPhe: 1.309 ± 0.015	3.049AsnGly: 3.049 ± 0.042	0.799AsnHis: 0.799 ± 0.012	1.912AsnIle: 1.912 ± 0.019	1.574AsnLys: 1.574 ± 0.018	3.017AsnLeu: 3.017 ± 0.025	0.901AsnMet: 0.901 ± 0.014	1.429AsnAsn: 1.429 ± 0.023	2.146AsnPro: 2.146 ± 0.024	1.216AsnGln: 1.216 ± 0.016	1.828AsnArg: 1.828 ± 0.022	2.546AsnSer: 2.546 ± 0.026	2.023AsnThr: 2.023 ± 0.021	2.306AsnVal: 2.306 ± 0.021	0.54AsnTrp: 0.54 ± 0.011	1.005AsnTyr: 1.005 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.752ProAla: 5.752 ± 0.041	0.521ProCys: 0.521 ± 0.012	3.197ProAsp: 3.197 ± 0.026	3.593ProGlu: 3.593 ± 0.033	1.934ProPhe: 1.934 ± 0.019	3.987ProGly: 3.987 ± 0.038	1.213ProHis: 1.213 ± 0.017	2.272ProIle: 2.272 ± 0.022	2.55ProLys: 2.55 ± 0.026	4.529ProLeu: 4.529 ± 0.035	1.119ProMet: 1.119 ± 0.015	2.005ProAsn: 2.005 ± 0.022	4.896ProPro: 4.896 ± 0.062	2.353ProGln: 2.353 ± 0.031	3.352ProArg: 3.352 ± 0.031	5.426ProSer: 5.426 ± 0.048	3.701ProThr: 3.701 ± 0.033	3.586ProVal: 3.586 ± 0.033	0.737ProTrp: 0.737 ± 0.01	1.377ProTyr: 1.377 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.698GlnAla: 3.698 ± 0.032	0.443GlnCys: 0.443 ± 0.011	2.201GlnAsp: 2.201 ± 0.019	2.25GlnGlu: 2.25 ± 0.022	1.304GlnPhe: 1.304 ± 0.017	2.452GlnGly: 2.452 ± 0.026	1.156GlnHis: 1.156 ± 0.017	1.746GlnIle: 1.746 ± 0.018	1.887GlnLys: 1.887 ± 0.025	3.568GlnLeu: 3.568 ± 0.026	0.95GlnMet: 0.95 ± 0.015	1.456GlnAsn: 1.456 ± 0.018	2.533GlnPro: 2.533 ± 0.036	2.782GlnGln: 2.782 ± 0.055	2.735GlnArg: 2.735 ± 0.025	3.006GlnSer: 3.006 ± 0.027	2.243GlnThr: 2.243 ± 0.019	2.183GlnVal: 2.183 ± 0.023	0.576GlnTrp: 0.576 ± 0.01	1.118GlnTyr: 1.118 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.149ArgAla: 5.149 ± 0.036	0.735ArgCys: 0.735 ± 0.012	3.54ArgAsp: 3.54 ± 0.032	3.55ArgGlu: 3.55 ± 0.027	2.129ArgPhe: 2.129 ± 0.02	3.889ArgGly: 3.889 ± 0.033	1.651ArgHis: 1.651 ± 0.021	2.782ArgIle: 2.782 ± 0.025	3.176ArgLys: 3.176 ± 0.03	5.465ArgLeu: 5.465 ± 0.043	1.336ArgMet: 1.336 ± 0.018	2.141ArgAsn: 2.141 ± 0.022	3.39ArgPro: 3.39 ± 0.028	2.721ArgGln: 2.721 ± 0.022	5.212ArgArg: 5.212 ± 0.045	4.561ArgSer: 4.561 ± 0.04	3.175ArgThr: 3.175 ± 0.027	3.37ArgVal: 3.37 ± 0.026	0.943ArgTrp: 0.943 ± 0.014	1.611ArgTyr: 1.611 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.211SerAla: 7.211 ± 0.05	0.868SerCys: 0.868 ± 0.015	4.213SerAsp: 4.213 ± 0.032	3.799SerGlu: 3.799 ± 0.035	2.904SerPhe: 2.904 ± 0.026	5.667SerGly: 5.667 ± 0.044	1.858SerHis: 1.858 ± 0.023	3.734SerIle: 3.734 ± 0.028	3.599SerLys: 3.599 ± 0.032	6.828SerLeu: 6.828 ± 0.039	1.774SerMet: 1.774 ± 0.019	2.757SerAsn: 2.757 ± 0.028	4.996SerPro: 4.996 ± 0.051	3.119SerGln: 3.119 ± 0.028	4.85SerArg: 4.85 ± 0.037	8.461SerSer: 8.461 ± 0.083	5.292SerThr: 5.292 ± 0.051	4.613SerVal: 4.613 ± 0.035	1.098SerTrp: 1.098 ± 0.015	1.963SerTyr: 1.963 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.832ThrAla: 5.832 ± 0.039	0.709ThrCys: 0.709 ± 0.012	2.891ThrAsp: 2.891 ± 0.024	3.098ThrGlu: 3.098 ± 0.027	2.168ThrPhe: 2.168 ± 0.021	4.224ThrGly: 4.224 ± 0.032	1.225ThrHis: 1.225 ± 0.015	2.944ThrIle: 2.944 ± 0.03	2.629ThrLys: 2.629 ± 0.023	5.166ThrLeu: 5.166 ± 0.032	1.262ThrMet: 1.262 ± 0.015	1.951ThrAsn: 1.951 ± 0.019	4.114ThrPro: 4.114 ± 0.038	2.046ThrGln: 2.046 ± 0.022	3.032ThrArg: 3.032 ± 0.026	5.109ThrSer: 5.109 ± 0.048	4.385ThrThr: 4.385 ± 0.045	3.858ThrVal: 3.858 ± 0.032	0.818ThrTrp: 0.818 ± 0.013	1.529ThrTyr: 1.529 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	6.162ValAla: 6.162 ± 0.042	0.881ValCys: 0.881 ± 0.014	3.917ValAsp: 3.917 ± 0.029	3.757ValGlu: 3.757 ± 0.035	2.495ValPhe: 2.495 ± 0.024	4.169ValGly: 4.169 ± 0.034	1.373ValHis: 1.373 ± 0.016	2.837ValIle: 2.837 ± 0.028	2.777ValLys: 2.777 ± 0.024	5.766ValLeu: 5.766 ± 0.038	1.4ValMet: 1.4 ± 0.017	2.162ValAsn: 2.162 ± 0.019	3.634ValPro: 3.634 ± 0.03	2.413ValGln: 2.413 ± 0.02	3.505ValArg: 3.505 ± 0.032	4.494ValSer: 4.494 ± 0.031	3.613ValThr: 3.613 ± 0.024	4.554ValVal: 4.554 ± 0.037	0.885ValTrp: 0.885 ± 0.014	1.724ValTyr: 1.724 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.245TrpAla: 1.245 ± 0.015	0.198TrpCys: 0.198 ± 0.005	0.887TrpAsp: 0.887 ± 0.013	0.808TrpGlu: 0.808 ± 0.012	0.549TrpPhe: 0.549 ± 0.011	0.935TrpGly: 0.935 ± 0.014	0.376TrpHis: 0.376 ± 0.009	0.707TrpIle: 0.707 ± 0.013	0.75TrpLys: 0.75 ± 0.012	1.388TrpLeu: 1.388 ± 0.017	0.38TrpMet: 0.38 ± 0.008	0.606TrpAsn: 0.606 ± 0.011	0.635TrpPro: 0.635 ± 0.011	0.611TrpGln: 0.611 ± 0.009	0.983TrpArg: 0.983 ± 0.016	1.031TrpSer: 1.031 ± 0.014	0.919TrpThr: 0.919 ± 0.016	0.885TrpVal: 0.885 ± 0.013	0.285TrpTrp: 0.285 ± 0.008	0.436TrpTyr: 0.436 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.282TyrAla: 2.282 ± 0.024	0.413TyrCys: 0.413 ± 0.009	1.661TyrAsp: 1.661 ± 0.021	1.473TyrGlu: 1.473 ± 0.018	1.162TyrPhe: 1.162 ± 0.016	2.096TyrGly: 2.096 ± 0.026	0.714TyrHis: 0.714 ± 0.012	1.321TyrIle: 1.321 ± 0.016	1.136TyrLys: 1.136 ± 0.014	2.467TyrLeu: 2.467 ± 0.023	0.655TyrMet: 0.655 ± 0.011	1.079TyrAsn: 1.079 ± 0.013	1.378TyrPro: 1.378 ± 0.018	1.041TyrGln: 1.041 ± 0.019	1.535TyrArg: 1.535 ± 0.018	1.933TyrSer: 1.933 ± 0.023	1.556TyrThr: 1.556 ± 0.019	1.612TyrVal: 1.612 ± 0.018	0.441TyrTrp: 0.441 ± 0.009	0.919TyrTyr: 0.919 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11019 proteins (5350041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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