Amino acid dipepetide frequency for Acipenser ruthenus (Sterlet sturgeon)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.872AlaAla: 5.872 ± 0.042	1.302AlaCys: 1.302 ± 0.014	3.067AlaAsp: 3.067 ± 0.02	4.622AlaGlu: 4.622 ± 0.039	2.432AlaPhe: 2.432 ± 0.019	4.257AlaGly: 4.257 ± 0.029	1.415AlaHis: 1.415 ± 0.015	2.834AlaIle: 2.834 ± 0.027	3.4AlaLys: 3.4 ± 0.027	6.355AlaLeu: 6.355 ± 0.04	1.593AlaMet: 1.593 ± 0.019	2.168AlaAsn: 2.168 ± 0.016	3.245AlaPro: 3.245 ± 0.033	2.865AlaGln: 2.865 ± 0.024	3.065AlaArg: 3.065 ± 0.028	5.491AlaSer: 5.491 ± 0.036	3.373AlaThr: 3.373 ± 0.027	5.076AlaVal: 5.076 ± 0.03	0.645AlaTrp: 0.645 ± 0.009	1.506AlaTyr: 1.506 ± 0.017	0.002AlaXaa: 0.002 ± 0.0
Cys	1.228CysAla: 1.228 ± 0.019	0.644CysCys: 0.644 ± 0.013	1.102CysAsp: 1.102 ± 0.014	1.292CysGlu: 1.292 ± 0.023	0.867CysPhe: 0.867 ± 0.011	1.466CysGly: 1.466 ± 0.023	0.602CysHis: 0.602 ± 0.009	1.048CysIle: 1.048 ± 0.013	1.266CysLys: 1.266 ± 0.014	2.081CysLeu: 2.081 ± 0.021	0.494CysMet: 0.494 ± 0.008	0.939CysAsn: 0.939 ± 0.015	1.254CysPro: 1.254 ± 0.02	1.027CysGln: 1.027 ± 0.014	1.271CysArg: 1.271 ± 0.018	2.104CysSer: 2.104 ± 0.022	1.299CysThr: 1.299 ± 0.019	1.368CysVal: 1.368 ± 0.017	0.277CysTrp: 0.277 ± 0.004	0.639CysTyr: 0.639 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.694AspAla: 2.694 ± 0.024	1.205AspCys: 1.205 ± 0.019	2.801AspAsp: 2.801 ± 0.022	3.719AspGlu: 3.719 ± 0.029	2.126AspPhe: 2.126 ± 0.02	3.264AspGly: 3.264 ± 0.028	1.184AspHis: 1.184 ± 0.014	2.798AspIle: 2.798 ± 0.019	2.816AspLys: 2.816 ± 0.019	4.981AspLeu: 4.981 ± 0.021	1.248AspMet: 1.248 ± 0.013	2.016AspAsn: 2.016 ± 0.019	2.82AspPro: 2.82 ± 0.02	1.963AspGln: 1.963 ± 0.017	2.588AspArg: 2.588 ± 0.018	4.665AspSer: 4.665 ± 0.031	2.695AspThr: 2.695 ± 0.023	3.108AspVal: 3.108 ± 0.024	0.662AspTrp: 0.662 ± 0.009	1.557AspTyr: 1.557 ± 0.014	0.001AspXaa: 0.001 ± 0.0
Glu	4.693GluAla: 4.693 ± 0.031	1.321GluCys: 1.321 ± 0.019	4.468GluAsp: 4.468 ± 0.031	8.184GluGlu: 8.184 ± 0.084	2.08GluPhe: 2.08 ± 0.016	4.271GluGly: 4.271 ± 0.037	1.598GluHis: 1.598 ± 0.015	3.255GluIle: 3.255 ± 0.027	5.265GluLys: 5.265 ± 0.045	6.257GluLeu: 6.257 ± 0.043	1.842GluMet: 1.842 ± 0.02	3.178GluAsn: 3.178 ± 0.028	2.913GluPro: 2.913 ± 0.023	3.375GluGln: 3.375 ± 0.034	4.177GluArg: 4.177 ± 0.042	4.865GluSer: 4.865 ± 0.033	3.817GluThr: 3.817 ± 0.036	4.287GluVal: 4.287 ± 0.027	0.7GluTrp: 0.7 ± 0.009	1.747GluTyr: 1.747 ± 0.018	0.003GluXaa: 0.003 ± 0.0
Phe	1.923PheAla: 1.923 ± 0.02	0.906PheCys: 0.906 ± 0.014	1.73PheAsp: 1.73 ± 0.012	2.045PheGlu: 2.045 ± 0.017	1.511PhePhe: 1.511 ± 0.015	2.116PheGly: 2.116 ± 0.018	0.998PheHis: 0.998 ± 0.014	1.915PheIle: 1.915 ± 0.016	1.93PheLys: 1.93 ± 0.016	3.739PheLeu: 3.739 ± 0.028	0.829PheMet: 0.829 ± 0.009	1.544PheAsn: 1.544 ± 0.02	1.785PhePro: 1.785 ± 0.015	1.759PheGln: 1.759 ± 0.013	1.827PheArg: 1.827 ± 0.018	3.265PheSer: 3.265 ± 0.019	2.195PheThr: 2.195 ± 0.02	2.215PheVal: 2.215 ± 0.019	0.431PheTrp: 0.431 ± 0.007	1.191PheTyr: 1.191 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	3.846GlyAla: 3.846 ± 0.031	1.266GlyCys: 1.266 ± 0.015	3.093GlyAsp: 3.093 ± 0.023	4.155GlyGlu: 4.155 ± 0.038	2.411GlyPhe: 2.411 ± 0.021	4.539GlyGly: 4.539 ± 0.041	1.518GlyHis: 1.518 ± 0.016	2.843GlyIle: 2.843 ± 0.021	3.823GlyLys: 3.823 ± 0.027	5.255GlyLeu: 5.255 ± 0.036	1.507GlyMet: 1.507 ± 0.017	2.628GlyAsn: 2.628 ± 0.023	2.831GlyPro: 2.831 ± 0.041	2.641GlyGln: 2.641 ± 0.022	3.329GlyArg: 3.329 ± 0.028	5.61GlySer: 5.61 ± 0.039	3.475GlyThr: 3.475 ± 0.025	3.749GlyVal: 3.749 ± 0.027	0.729GlyTrp: 0.729 ± 0.01	1.901GlyTyr: 1.901 ± 0.018	0.002GlyXaa: 0.002 ± 0.0
His	1.356HisAla: 1.356 ± 0.017	0.762HisCys: 0.762 ± 0.017	0.978HisAsp: 0.978 ± 0.018	1.273HisGlu: 1.273 ± 0.016	1.049HisPhe: 1.049 ± 0.01	1.465HisGly: 1.465 ± 0.014	0.963HisHis: 0.963 ± 0.018	1.295HisIle: 1.295 ± 0.015	1.36HisLys: 1.36 ± 0.011	2.578HisLeu: 2.578 ± 0.025	0.645HisMet: 0.645 ± 0.009	1.049HisAsn: 1.049 ± 0.016	1.527HisPro: 1.527 ± 0.025	1.232HisGln: 1.232 ± 0.013	1.575HisArg: 1.575 ± 0.019	2.497HisSer: 2.497 ± 0.025	1.518HisThr: 1.518 ± 0.027	1.413HisVal: 1.413 ± 0.015	0.335HisTrp: 0.335 ± 0.006	0.876HisTyr: 0.876 ± 0.024	0.001HisXaa: 0.001 ± 0.0
Ile	2.867IleAla: 2.867 ± 0.026	1.077IleCys: 1.077 ± 0.012	2.285IleAsp: 2.285 ± 0.02	2.789IleGlu: 2.789 ± 0.019	1.747IlePhe: 1.747 ± 0.017	2.393IleGly: 2.393 ± 0.017	1.31IleHis: 1.31 ± 0.021	2.411IleIle: 2.411 ± 0.023	2.792IleLys: 2.792 ± 0.023	4.421IleLeu: 4.421 ± 0.027	1.051IleMet: 1.051 ± 0.013	2.048IleAsn: 2.048 ± 0.021	2.655IlePro: 2.655 ± 0.023	2.349IleGln: 2.349 ± 0.026	2.384IleArg: 2.384 ± 0.02	3.857IleSer: 3.857 ± 0.026	2.831IleThr: 2.831 ± 0.025	2.815IleVal: 2.815 ± 0.02	0.49IleTrp: 0.49 ± 0.008	1.38IleTyr: 1.38 ± 0.023	0.001IleXaa: 0.001 ± 0.0
Lys	3.947LysAla: 3.947 ± 0.035	1.118LysCys: 1.118 ± 0.014	3.316LysAsp: 3.316 ± 0.023	5.411LysGlu: 5.411 ± 0.048	1.652LysPhe: 1.652 ± 0.017	3.416LysGly: 3.416 ± 0.031	1.585LysHis: 1.585 ± 0.026	2.733LysIle: 2.733 ± 0.021	5.018LysLys: 5.018 ± 0.053	5.299LysLeu: 5.299 ± 0.031	1.534LysMet: 1.534 ± 0.015	2.517LysAsn: 2.517 ± 0.02	3.097LysPro: 3.097 ± 0.031	3.059LysGln: 3.059 ± 0.038	3.527LysArg: 3.527 ± 0.024	4.122LysSer: 4.122 ± 0.035	3.464LysThr: 3.464 ± 0.023	3.596LysVal: 3.596 ± 0.025	0.616LysTrp: 0.616 ± 0.009	1.681LysTyr: 1.681 ± 0.022	0.001LysXaa: 0.001 ± 0.0
Leu	5.959LeuAla: 5.959 ± 0.036	2.183LeuCys: 2.183 ± 0.022	4.728LeuAsp: 4.728 ± 0.027	6.677LeuGlu: 6.677 ± 0.046	3.304LeuPhe: 3.304 ± 0.03	5.076LeuGly: 5.076 ± 0.031	2.708LeuHis: 2.708 ± 0.028	3.943LeuIle: 3.943 ± 0.033	6.001LeuLys: 6.001 ± 0.04	9.594LeuLeu: 9.594 ± 0.056	2.034LeuMet: 2.034 ± 0.017	3.854LeuAsn: 3.854 ± 0.026	5.183LeuPro: 5.183 ± 0.036	5.579LeuGln: 5.579 ± 0.037	5.14LeuArg: 5.14 ± 0.037	7.919LeuSer: 7.919 ± 0.036	4.993LeuThr: 4.993 ± 0.038	5.337LeuVal: 5.337 ± 0.031	1.006LeuTrp: 1.006 ± 0.011	2.723LeuTyr: 2.723 ± 0.033	0.002LeuXaa: 0.002 ± 0.0
Met	1.783MetAla: 1.783 ± 0.017	0.462MetCys: 0.462 ± 0.008	1.372MetAsp: 1.372 ± 0.013	1.968MetGlu: 1.968 ± 0.018	0.833MetPhe: 0.833 ± 0.008	1.407MetGly: 1.407 ± 0.017	0.56MetHis: 0.56 ± 0.009	0.93MetIle: 0.93 ± 0.013	1.628MetLys: 1.628 ± 0.024	2.1MetLeu: 2.1 ± 0.019	0.661MetMet: 0.661 ± 0.01	1.016MetAsn: 1.016 ± 0.011	1.132MetPro: 1.132 ± 0.017	1.115MetGln: 1.115 ± 0.013	1.128MetArg: 1.128 ± 0.014	1.778MetSer: 1.778 ± 0.015	1.217MetThr: 1.217 ± 0.012	1.47MetVal: 1.47 ± 0.016	0.246MetTrp: 0.246 ± 0.004	0.665MetTyr: 0.665 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.325AsnAla: 2.325 ± 0.016	0.944AsnCys: 0.944 ± 0.013	1.755AsnAsp: 1.755 ± 0.017	2.489AsnGlu: 2.489 ± 0.02	1.399AsnPhe: 1.399 ± 0.013	2.826AsnGly: 2.826 ± 0.027	1.048AsnHis: 1.048 ± 0.016	2.258AsnIle: 2.258 ± 0.018	2.512AsnLys: 2.512 ± 0.018	3.758AsnLeu: 3.758 ± 0.025	1.08AsnMet: 1.08 ± 0.018	1.944AsnAsn: 1.944 ± 0.027	2.368AsnPro: 2.368 ± 0.026	1.822AsnGln: 1.822 ± 0.018	2.076AsnArg: 2.076 ± 0.018	3.46AsnSer: 3.46 ± 0.025	2.46AsnThr: 2.46 ± 0.026	2.419AsnVal: 2.419 ± 0.019	0.46AsnTrp: 0.46 ± 0.008	1.222AsnTyr: 1.222 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	4.094ProAla: 4.094 ± 0.043	1.107ProCys: 1.107 ± 0.019	2.765ProAsp: 2.765 ± 0.023	3.87ProGlu: 3.87 ± 0.03	1.789ProPhe: 1.789 ± 0.015	3.943ProGly: 3.943 ± 0.057	1.367ProHis: 1.367 ± 0.025	1.91ProIle: 1.91 ± 0.015	2.71ProLys: 2.71 ± 0.032	4.646ProLeu: 4.646 ± 0.036	1.044ProMet: 1.044 ± 0.021	1.899ProAsn: 1.899 ± 0.016	4.646ProPro: 4.646 ± 0.051	2.614ProGln: 2.614 ± 0.035	2.632ProArg: 2.632 ± 0.024	5.285ProSer: 5.285 ± 0.042	2.84ProThr: 2.84 ± 0.027	3.882ProVal: 3.882 ± 0.035	0.547ProTrp: 0.547 ± 0.013	1.425ProTyr: 1.425 ± 0.016	0.003ProXaa: 0.003 ± 0.001
Gln	3.229GlnAla: 3.229 ± 0.023	1.048GlnCys: 1.048 ± 0.018	2.409GlnAsp: 2.409 ± 0.018	3.75GlnGlu: 3.75 ± 0.039	1.427GlnPhe: 1.427 ± 0.012	2.842GlnGly: 2.842 ± 0.027	1.428GlnHis: 1.428 ± 0.015	2.094GlnIle: 2.094 ± 0.019	2.904GlnLys: 2.904 ± 0.021	4.508GlnLeu: 4.508 ± 0.029	1.094GlnMet: 1.094 ± 0.012	2.02GlnAsn: 2.02 ± 0.018	2.538GlnPro: 2.538 ± 0.027	3.433GlnGln: 3.433 ± 0.04	2.909GlnArg: 2.909 ± 0.026	3.628GlnSer: 3.628 ± 0.038	2.601GlnThr: 2.601 ± 0.031	2.762GlnVal: 2.762 ± 0.019	0.55GlnTrp: 0.55 ± 0.011	1.369GlnTyr: 1.369 ± 0.02	0.002GlnXaa: 0.002 ± 0.0
Arg	3.262ArgAla: 3.262 ± 0.027	1.161ArgCys: 1.161 ± 0.016	2.79ArgAsp: 2.79 ± 0.026	3.943ArgGlu: 3.943 ± 0.045	1.863ArgPhe: 1.863 ± 0.015	3.217ArgGly: 3.217 ± 0.031	1.49ArgHis: 1.49 ± 0.019	2.427ArgIle: 2.427 ± 0.029	3.691ArgLys: 3.691 ± 0.027	4.908ArgLeu: 4.908 ± 0.031	1.26ArgMet: 1.26 ± 0.014	2.221ArgAsn: 2.221 ± 0.02	2.558ArgPro: 2.558 ± 0.021	2.62ArgGln: 2.62 ± 0.022	3.86ArgArg: 3.86 ± 0.029	4.303ArgSer: 4.303 ± 0.034	2.833ArgThr: 2.833 ± 0.02	3.089ArgVal: 3.089 ± 0.021	0.61ArgTrp: 0.61 ± 0.008	1.566ArgTyr: 1.566 ± 0.018	0.002ArgXaa: 0.002 ± 0.0
Ser	5.367SerAla: 5.367 ± 0.029	1.876SerCys: 1.876 ± 0.02	4.274SerAsp: 4.274 ± 0.031	5.495SerGlu: 5.495 ± 0.036	3.055SerPhe: 3.055 ± 0.025	5.306SerGly: 5.306 ± 0.031	2.08SerHis: 2.08 ± 0.022	3.573SerIle: 3.573 ± 0.029	4.523SerLys: 4.523 ± 0.034	8.165SerLeu: 8.165 ± 0.044	1.863SerMet: 1.863 ± 0.018	3.195SerAsn: 3.195 ± 0.025	5.663SerPro: 5.663 ± 0.051	3.936SerGln: 3.936 ± 0.028	4.356SerArg: 4.356 ± 0.036	9.639SerSer: 9.639 ± 0.071	5.047SerThr: 5.047 ± 0.045	5.376SerVal: 5.376 ± 0.043	0.925SerTrp: 0.925 ± 0.013	2.211SerTyr: 2.211 ± 0.024	0.003SerXaa: 0.003 ± 0.001
Thr	4.261ThrAla: 4.261 ± 0.037	1.309ThrCys: 1.309 ± 0.021	2.902ThrAsp: 2.902 ± 0.023	4.067ThrGlu: 4.067 ± 0.034	2.048ThrPhe: 2.048 ± 0.015	3.813ThrGly: 3.813 ± 0.029	1.266ThrHis: 1.266 ± 0.02	2.469ThrIle: 2.469 ± 0.02	2.808ThrLys: 2.808 ± 0.021	5.268ThrLeu: 5.268 ± 0.047	1.206ThrMet: 1.206 ± 0.014	1.974ThrAsn: 1.974 ± 0.019	3.57ThrPro: 3.57 ± 0.034	2.372ThrGln: 2.372 ± 0.026	2.482ThrArg: 2.482 ± 0.021	4.79ThrSer: 4.79 ± 0.041	3.257ThrThr: 3.257 ± 0.034	4.243ThrVal: 4.243 ± 0.032	0.625ThrTrp: 0.625 ± 0.011	1.428ThrTyr: 1.428 ± 0.014	0.002ThrXaa: 0.002 ± 0.0
Val	3.869ValAla: 3.869 ± 0.023	1.585ValCys: 1.585 ± 0.017	3.07ValAsp: 3.07 ± 0.022	4.117ValGlu: 4.117 ± 0.028	2.604ValPhe: 2.604 ± 0.019	3.249ValGly: 3.249 ± 0.022	1.577ValHis: 1.577 ± 0.015	3.117ValIle: 3.117 ± 0.028	3.84ValLys: 3.84 ± 0.03	6.227ValLeu: 6.227 ± 0.035	1.49ValMet: 1.49 ± 0.015	2.562ValAsn: 2.562 ± 0.019	3.41ValPro: 3.41 ± 0.04	2.954ValGln: 2.954 ± 0.021	3.027ValArg: 3.027 ± 0.018	5.274ValSer: 5.274 ± 0.033	3.849ValThr: 3.849 ± 0.027	4.204ValVal: 4.204 ± 0.052	0.735ValTrp: 0.735 ± 0.011	1.858ValTyr: 1.858 ± 0.02	0.002ValXaa: 0.002 ± 0.001
Trp	0.613TrpAla: 0.613 ± 0.01	0.247TrpCys: 0.247 ± 0.013	0.628TrpAsp: 0.628 ± 0.01	0.745TrpGlu: 0.745 ± 0.011	0.438TrpPhe: 0.438 ± 0.008	0.633TrpGly: 0.633 ± 0.011	0.265TrpHis: 0.265 ± 0.006	0.556TrpIle: 0.556 ± 0.009	0.789TrpLys: 0.789 ± 0.011	1.104TrpLeu: 1.104 ± 0.014	0.307TrpMet: 0.307 ± 0.006	0.55TrpAsn: 0.55 ± 0.01	0.41TrpPro: 0.41 ± 0.006	0.513TrpGln: 0.513 ± 0.012	0.648TrpArg: 0.648 ± 0.011	0.869TrpSer: 0.869 ± 0.013	0.639TrpThr: 0.639 ± 0.012	0.671TrpVal: 0.671 ± 0.013	0.168TrpTrp: 0.168 ± 0.004	0.358TrpTyr: 0.358 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.397TyrAla: 1.397 ± 0.013	0.742TyrCys: 0.742 ± 0.011	1.381TyrAsp: 1.381 ± 0.014	1.682TyrGlu: 1.682 ± 0.018	1.222TyrPhe: 1.222 ± 0.019	1.649TyrGly: 1.649 ± 0.015	0.785TyrHis: 0.785 ± 0.015	1.541TyrIle: 1.541 ± 0.019	1.633TyrLys: 1.633 ± 0.029	2.696TyrLeu: 2.696 ± 0.018	0.688TyrMet: 0.688 ± 0.009	1.303TyrAsn: 1.303 ± 0.014	1.408TyrPro: 1.408 ± 0.019	1.315TyrGln: 1.315 ± 0.021	1.668TyrArg: 1.668 ± 0.019	2.502TyrSer: 2.502 ± 0.032	1.755TyrThr: 1.755 ± 0.031	1.54TyrVal: 1.54 ± 0.014	0.395TyrTrp: 0.395 ± 0.012	1.015TyrTyr: 1.015 ± 0.015	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.002XaaThr: 0.002 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	1.039XaaXaa: 1.039 ± 0.257

Statistics based on 22004 proteins (11239965 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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