Amino acid dipepetide frequency for Halohasta litchfieldiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.625AlaAla: 11.625 ± 0.142	0.636AlaCys: 0.636 ± 0.029	8.511AlaAsp: 8.511 ± 0.115	8.431AlaGlu: 8.431 ± 0.122	3.448AlaPhe: 3.448 ± 0.07	8.26AlaGly: 8.26 ± 0.1	1.716AlaHis: 1.716 ± 0.042	5.087AlaIle: 5.087 ± 0.087	2.107AlaLys: 2.107 ± 0.052	8.37AlaLeu: 8.37 ± 0.105	1.877AlaMet: 1.877 ± 0.05	2.443AlaAsn: 2.443 ± 0.052	3.139AlaPro: 3.139 ± 0.06	2.258AlaGln: 2.258 ± 0.048	4.732AlaArg: 4.732 ± 0.076	5.136AlaSer: 5.136 ± 0.069	6.447AlaThr: 6.447 ± 0.087	9.678AlaVal: 9.678 ± 0.12	0.906AlaTrp: 0.906 ± 0.032	2.382AlaTyr: 2.382 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.555CysAla: 0.555 ± 0.026	0.112CysCys: 0.112 ± 0.011	0.557CysAsp: 0.557 ± 0.026	0.665CysGlu: 0.665 ± 0.025	0.228CysPhe: 0.228 ± 0.017	0.862CysGly: 0.862 ± 0.036	0.2CysHis: 0.2 ± 0.017	0.327CysIle: 0.327 ± 0.02	0.16CysLys: 0.16 ± 0.015	0.638CysLeu: 0.638 ± 0.027	0.123CysMet: 0.123 ± 0.011	0.216CysAsn: 0.216 ± 0.016	0.469CysPro: 0.469 ± 0.026	0.187CysGln: 0.187 ± 0.014	0.495CysArg: 0.495 ± 0.026	0.499CysSer: 0.499 ± 0.022	0.421CysThr: 0.421 ± 0.023	0.543CysVal: 0.543 ± 0.022	0.12CysTrp: 0.12 ± 0.011	0.218CysTyr: 0.218 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.742AspAla: 7.742 ± 0.111	0.761AspCys: 0.761 ± 0.037	7.226AspAsp: 7.226 ± 0.12	8.111AspGlu: 8.111 ± 0.124	1.855AspPhe: 1.855 ± 0.046	6.985AspGly: 6.985 ± 0.099	2.116AspHis: 2.116 ± 0.053	3.894AspIle: 3.894 ± 0.066	1.454AspLys: 1.454 ± 0.039	6.905AspLeu: 6.905 ± 0.111	1.24AspMet: 1.24 ± 0.037	1.954AspAsn: 1.954 ± 0.05	4.156AspPro: 4.156 ± 0.065	2.576AspGln: 2.576 ± 0.059	6.15AspArg: 6.15 ± 0.08	5.215AspSer: 5.215 ± 0.088	4.698AspThr: 4.698 ± 0.072	6.176AspVal: 6.176 ± 0.09	1.011AspTrp: 1.011 ± 0.032	1.917AspTyr: 1.917 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	8.795GluAla: 8.795 ± 0.109	0.51GluCys: 0.51 ± 0.028	5.054GluAsp: 5.054 ± 0.094	6.127GluGlu: 6.127 ± 0.136	3.034GluPhe: 3.034 ± 0.064	5.015GluGly: 5.015 ± 0.082	1.559GluHis: 1.559 ± 0.046	5.023GluIle: 5.023 ± 0.079	1.953GluLys: 1.953 ± 0.05	8.218GluLeu: 8.218 ± 0.108	1.899GluMet: 1.899 ± 0.047	2.402GluAsn: 2.402 ± 0.056	4.105GluPro: 4.105 ± 0.071	3.326GluGln: 3.326 ± 0.063	5.383GluArg: 5.383 ± 0.078	5.813GluSer: 5.813 ± 0.08	7.438GluThr: 7.438 ± 0.105	5.15GluVal: 5.15 ± 0.09	1.078GluTrp: 1.078 ± 0.036	2.5GluTyr: 2.5 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.107PheAla: 3.107 ± 0.067	0.294PheCys: 0.294 ± 0.019	3.185PheAsp: 3.185 ± 0.059	3.257PheGlu: 3.257 ± 0.067	1.089PhePhe: 1.089 ± 0.036	3.35PheGly: 3.35 ± 0.062	0.605PheHis: 0.605 ± 0.024	1.453PheIle: 1.453 ± 0.039	0.636PheLys: 0.636 ± 0.027	2.695PheLeu: 2.695 ± 0.065	0.536PheMet: 0.536 ± 0.022	0.835PheAsn: 0.835 ± 0.034	1.274PhePro: 1.274 ± 0.037	0.87PheGln: 0.87 ± 0.029	1.767PheArg: 1.767 ± 0.043	1.915PheSer: 1.915 ± 0.04	1.885PheThr: 1.885 ± 0.049	3.05PheVal: 3.05 ± 0.059	0.404PheTrp: 0.404 ± 0.02	0.882PheTyr: 0.882 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.443GlyAla: 6.443 ± 0.11	0.726GlyCys: 0.726 ± 0.029	5.73GlyAsp: 5.73 ± 0.09	6.509GlyGlu: 6.509 ± 0.1	3.104GlyPhe: 3.104 ± 0.067	6.762GlyGly: 6.762 ± 0.114	1.557GlyHis: 1.557 ± 0.044	4.795GlyIle: 4.795 ± 0.085	1.953GlyLys: 1.953 ± 0.046	7.364GlyLeu: 7.364 ± 0.112	1.595GlyMet: 1.595 ± 0.047	2.051GlyAsn: 2.051 ± 0.063	3.026GlyPro: 3.026 ± 0.05	2.344GlyGln: 2.344 ± 0.047	4.454GlyArg: 4.454 ± 0.07	5.482GlySer: 5.482 ± 0.094	5.354GlyThr: 5.354 ± 0.07	6.868GlyVal: 6.868 ± 0.092	1.024GlyTrp: 1.024 ± 0.038	2.61GlyTyr: 2.61 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.821HisAla: 1.821 ± 0.046	0.214HisCys: 0.214 ± 0.016	1.704HisAsp: 1.704 ± 0.047	1.625HisGlu: 1.625 ± 0.042	0.468HisPhe: 0.468 ± 0.025	1.866HisGly: 1.866 ± 0.05	0.586HisHis: 0.586 ± 0.024	0.924HisIle: 0.924 ± 0.033	0.402HisLys: 0.402 ± 0.02	1.711HisLeu: 1.711 ± 0.047	0.282HisMet: 0.282 ± 0.019	0.573HisAsn: 0.573 ± 0.022	1.132HisPro: 1.132 ± 0.039	0.634HisGln: 0.634 ± 0.029	1.345HisArg: 1.345 ± 0.043	1.116HisSer: 1.116 ± 0.039	1.215HisThr: 1.215 ± 0.036	1.565HisVal: 1.565 ± 0.044	0.231HisTrp: 0.231 ± 0.016	0.557HisTyr: 0.557 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.227IleAla: 5.227 ± 0.086	0.35IleCys: 0.35 ± 0.019	4.174IleAsp: 4.174 ± 0.071	5.499IleGlu: 5.499 ± 0.076	1.225IlePhe: 1.225 ± 0.042	4.474IleGly: 4.474 ± 0.078	1.053IleHis: 1.053 ± 0.036	2.274IleIle: 2.274 ± 0.059	1.151IleLys: 1.151 ± 0.038	3.685IleLeu: 3.685 ± 0.081	0.671IleMet: 0.671 ± 0.027	1.468IleAsn: 1.468 ± 0.042	2.434IlePro: 2.434 ± 0.051	1.593IleGln: 1.593 ± 0.043	2.857IleArg: 2.857 ± 0.062	3.056IleSer: 3.056 ± 0.054	3.273IleThr: 3.273 ± 0.056	4.295IleVal: 4.295 ± 0.069	0.414IleTrp: 0.414 ± 0.022	1.193IleTyr: 1.193 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	2.031LysAla: 2.031 ± 0.055	0.137LysCys: 0.137 ± 0.013	1.269LysAsp: 1.269 ± 0.045	1.601LysGlu: 1.601 ± 0.045	0.616LysPhe: 0.616 ± 0.025	1.514LysGly: 1.514 ± 0.04	0.59LysHis: 0.59 ± 0.026	1.163LysIle: 1.163 ± 0.042	0.735LysLys: 0.735 ± 0.037	2.119LysLeu: 2.119 ± 0.046	0.446LysMet: 0.446 ± 0.021	0.72LysAsn: 0.72 ± 0.033	1.129LysPro: 1.129 ± 0.036	1.221LysGln: 1.221 ± 0.039	1.833LysArg: 1.833 ± 0.042	1.493LysSer: 1.493 ± 0.043	1.708LysThr: 1.708 ± 0.042	1.277LysVal: 1.277 ± 0.038	0.262LysTrp: 0.262 ± 0.017	0.652LysTyr: 0.652 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	9.642LeuAla: 9.642 ± 0.13	0.701LeuCys: 0.701 ± 0.025	7.264LeuAsp: 7.264 ± 0.095	6.132LeuGlu: 6.132 ± 0.099	3.297LeuPhe: 3.297 ± 0.07	7.232LeuGly: 7.232 ± 0.105	1.519LeuHis: 1.519 ± 0.04	4.077LeuIle: 4.077 ± 0.083	2.034LeuLys: 2.034 ± 0.044	8.754LeuLeu: 8.754 ± 0.141	1.378LeuMet: 1.378 ± 0.041	2.249LeuAsn: 2.249 ± 0.053	4.027LeuPro: 4.027 ± 0.073	2.537LeuGln: 2.537 ± 0.058	5.185LeuArg: 5.185 ± 0.079	6.607LeuSer: 6.607 ± 0.093	5.898LeuThr: 5.898 ± 0.098	7.669LeuVal: 7.669 ± 0.115	0.883LeuTrp: 0.883 ± 0.031	2.345LeuTyr: 2.345 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.822MetAla: 1.822 ± 0.04	0.117MetCys: 0.117 ± 0.012	1.296MetAsp: 1.296 ± 0.04	1.131MetGlu: 1.131 ± 0.039	0.524MetPhe: 0.524 ± 0.023	1.389MetGly: 1.389 ± 0.042	0.302MetHis: 0.302 ± 0.019	0.836MetIle: 0.836 ± 0.031	0.515MetLys: 0.515 ± 0.023	1.531MetLeu: 1.531 ± 0.043	0.346MetMet: 0.346 ± 0.019	0.626MetAsn: 0.626 ± 0.024	0.787MetPro: 0.787 ± 0.031	0.558MetGln: 0.558 ± 0.023	0.955MetArg: 0.955 ± 0.034	1.682MetSer: 1.682 ± 0.04	1.527MetThr: 1.527 ± 0.04	1.361MetVal: 1.361 ± 0.038	0.16MetTrp: 0.16 ± 0.016	0.391MetTyr: 0.391 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.557AsnAla: 2.557 ± 0.06	0.301AsnCys: 0.301 ± 0.021	1.867AsnAsp: 1.867 ± 0.038	2.189AsnGlu: 2.189 ± 0.052	0.749AsnPhe: 0.749 ± 0.029	2.219AsnGly: 2.219 ± 0.057	0.603AsnHis: 0.603 ± 0.026	1.366AsnIle: 1.366 ± 0.037	0.698AsnLys: 0.698 ± 0.029	2.098AsnLeu: 2.098 ± 0.051	0.503AsnMet: 0.503 ± 0.023	0.734AsnAsn: 0.734 ± 0.031	1.706AsnPro: 1.706 ± 0.046	0.947AsnGln: 0.947 ± 0.035	1.89AsnArg: 1.89 ± 0.043	1.53AsnSer: 1.53 ± 0.044	1.685AsnThr: 1.685 ± 0.046	2.168AsnVal: 2.168 ± 0.052	0.354AsnTrp: 0.354 ± 0.019	0.77AsnTyr: 0.77 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.217ProAla: 4.217 ± 0.068	0.243ProCys: 0.243 ± 0.015	4.286ProAsp: 4.286 ± 0.079	4.558ProGlu: 4.558 ± 0.065	1.561ProPhe: 1.561 ± 0.042	3.133ProGly: 3.133 ± 0.06	0.847ProHis: 0.847 ± 0.034	2.229ProIle: 2.229 ± 0.044	1.032ProLys: 1.032 ± 0.034	3.587ProLeu: 3.587 ± 0.066	0.781ProMet: 0.781 ± 0.032	1.324ProAsn: 1.324 ± 0.046	2.045ProPro: 2.045 ± 0.054	1.308ProGln: 1.308 ± 0.036	2.053ProArg: 2.053 ± 0.053	2.816ProSer: 2.816 ± 0.062	3.344ProThr: 3.344 ± 0.062	3.96ProVal: 3.96 ± 0.066	0.46ProTrp: 0.46 ± 0.024	1.096ProTyr: 1.096 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.778GlnAla: 2.778 ± 0.053	0.224GlnCys: 0.224 ± 0.015	1.568GlnAsp: 1.568 ± 0.045	1.977GlnGlu: 1.977 ± 0.055	1.333GlnPhe: 1.333 ± 0.032	1.748GlnGly: 1.748 ± 0.049	0.683GlnHis: 0.683 ± 0.028	1.622GlnIle: 1.622 ± 0.046	0.774GlnLys: 0.774 ± 0.028	3.379GlnLeu: 3.379 ± 0.064	0.713GlnMet: 0.713 ± 0.026	0.96GlnAsn: 0.96 ± 0.035	1.605GlnPro: 1.605 ± 0.044	1.793GlnGln: 1.793 ± 0.055	2.279GlnArg: 2.279 ± 0.052	2.381GlnSer: 2.381 ± 0.059	2.248GlnThr: 2.248 ± 0.049	1.918GlnVal: 1.918 ± 0.047	0.481GlnTrp: 0.481 ± 0.025	1.11GlnTyr: 1.11 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.967ArgAla: 4.967 ± 0.079	0.417ArgCys: 0.417 ± 0.019	4.041ArgAsp: 4.041 ± 0.06	5.747ArgGlu: 5.747 ± 0.089	2.19ArgPhe: 2.19 ± 0.053	3.906ArgGly: 3.906 ± 0.065	1.165ArgHis: 1.165 ± 0.036	3.165ArgIle: 3.165 ± 0.059	1.551ArgLys: 1.551 ± 0.046	6.117ArgLeu: 6.117 ± 0.1	1.211ArgMet: 1.211 ± 0.036	1.73ArgAsn: 1.73 ± 0.044	2.394ArgPro: 2.394 ± 0.057	2.244ArgGln: 2.244 ± 0.05	4.175ArgArg: 4.175 ± 0.08	3.691ArgSer: 3.691 ± 0.068	3.602ArgThr: 3.602 ± 0.059	4.388ArgVal: 4.388 ± 0.069	0.698ArgTrp: 0.698 ± 0.03	1.752ArgTyr: 1.752 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.178SerAla: 5.178 ± 0.077	0.434SerCys: 0.434 ± 0.025	4.799SerAsp: 4.799 ± 0.084	5.325SerGlu: 5.325 ± 0.082	2.031SerPhe: 2.031 ± 0.052	5.421SerGly: 5.421 ± 0.1	1.291SerHis: 1.291 ± 0.035	2.946SerIle: 2.946 ± 0.052	1.58SerLys: 1.58 ± 0.042	5.443SerLeu: 5.443 ± 0.08	1.226SerMet: 1.226 ± 0.04	1.686SerAsn: 1.686 ± 0.043	2.671SerPro: 2.671 ± 0.057	1.993SerGln: 1.993 ± 0.045	3.557SerArg: 3.557 ± 0.073	3.519SerSer: 3.519 ± 0.071	5.348SerThr: 5.348 ± 0.1	5.754SerVal: 5.754 ± 0.083	0.628SerTrp: 0.628 ± 0.03	1.759SerTyr: 1.759 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	7.441ThrAla: 7.441 ± 0.096	0.334ThrCys: 0.334 ± 0.02	6.201ThrAsp: 6.201 ± 0.094	5.834ThrGlu: 5.834 ± 0.088	2.086ThrPhe: 2.086 ± 0.054	5.734ThrGly: 5.734 ± 0.076	1.359ThrHis: 1.359 ± 0.041	3.496ThrIle: 3.496 ± 0.054	1.426ThrLys: 1.426 ± 0.044	6.001ThrLeu: 6.001 ± 0.082	1.076ThrMet: 1.076 ± 0.038	1.991ThrAsn: 1.991 ± 0.048	3.439ThrPro: 3.439 ± 0.067	1.908ThrGln: 1.908 ± 0.047	3.092ThrArg: 3.092 ± 0.057	3.194ThrSer: 3.194 ± 0.056	4.785ThrThr: 4.785 ± 0.085	7.432ThrVal: 7.432 ± 0.107	0.562ThrTrp: 0.562 ± 0.027	1.621ThrTyr: 1.621 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	8.086ValAla: 8.086 ± 0.1	0.733ValCys: 0.733 ± 0.029	10.271ValAsp: 10.271 ± 0.111	6.407ValGlu: 6.407 ± 0.099	2.917ValPhe: 2.917 ± 0.057	6.932ValGly: 6.932 ± 0.101	1.369ValHis: 1.369 ± 0.038	4.061ValIle: 4.061 ± 0.072	1.471ValLys: 1.471 ± 0.037	6.95ValLeu: 6.95 ± 0.112	1.333ValMet: 1.333 ± 0.035	1.794ValAsn: 1.794 ± 0.052	3.605ValPro: 3.605 ± 0.058	1.913ValGln: 1.913 ± 0.053	4.389ValArg: 4.389 ± 0.072	5.345ValSer: 5.345 ± 0.079	5.722ValThr: 5.722 ± 0.076	7.615ValVal: 7.615 ± 0.111	0.764ValTrp: 0.764 ± 0.024	1.992ValTyr: 1.992 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.859TrpAla: 0.859 ± 0.031	0.093TrpCys: 0.093 ± 0.009	0.678TrpAsp: 0.678 ± 0.031	0.867TrpGlu: 0.867 ± 0.032	0.482TrpPhe: 0.482 ± 0.025	0.725TrpGly: 0.725 ± 0.028	0.209TrpHis: 0.209 ± 0.016	0.582TrpIle: 0.582 ± 0.027	0.295TrpLys: 0.295 ± 0.016	1.235TrpLeu: 1.235 ± 0.04	0.214TrpMet: 0.214 ± 0.016	0.386TrpAsn: 0.386 ± 0.022	0.424TrpPro: 0.424 ± 0.022	0.423TrpGln: 0.423 ± 0.02	0.725TrpArg: 0.725 ± 0.029	0.632TrpSer: 0.632 ± 0.027	0.734TrpThr: 0.734 ± 0.028	0.811TrpVal: 0.811 ± 0.029	0.164TrpTrp: 0.164 ± 0.013	0.395TrpTyr: 0.395 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.057	0.262TyrCys: 0.262 ± 0.018	2.462TyrAsp: 2.462 ± 0.059	2.391TyrGlu: 2.391 ± 0.05	0.851TyrPhe: 0.851 ± 0.033	2.225TyrGly: 2.225 ± 0.053	0.643TyrHis: 0.643 ± 0.028	1.046TyrIle: 1.046 ± 0.034	0.584TyrLys: 0.584 ± 0.026	2.629TyrLeu: 2.629 ± 0.052	0.404TyrMet: 0.404 ± 0.02	0.796TyrAsn: 0.796 ± 0.032	1.312TyrPro: 1.312 ± 0.038	0.94TyrGln: 0.94 ± 0.03	1.837TyrArg: 1.837 ± 0.045	1.468TyrSer: 1.468 ± 0.041	1.68TyrThr: 1.68 ± 0.047	1.989TyrVal: 1.989 ± 0.04	0.329TyrTrp: 0.329 ± 0.02	0.82TyrTyr: 0.82 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3425 proteins (947826 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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