Amino acid dipepetide frequency for Valsa malicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.064AlaAla: 10.064 ± 0.069
1.018AlaCys: 1.018 ± 0.014
4.609AlaAsp: 4.609 ± 0.031
5.509AlaGlu: 5.509 ± 0.043
3.039AlaPhe: 3.039 ± 0.03
6.463AlaGly: 6.463 ± 0.043
1.81AlaHis: 1.81 ± 0.017
4.014AlaIle: 4.014 ± 0.031
4.165AlaLys: 4.165 ± 0.037
7.585AlaLeu: 7.585 ± 0.047
2.153AlaMet: 2.153 ± 0.024
2.973AlaAsn: 2.973 ± 0.027
5.073AlaPro: 5.073 ± 0.048
3.461AlaGln: 3.461 ± 0.033
5.162AlaArg: 5.162 ± 0.041
7.318AlaSer: 7.318 ± 0.051
5.508AlaThr: 5.508 ± 0.036
5.728AlaVal: 5.728 ± 0.039
1.21AlaTrp: 1.21 ± 0.015
2.187AlaTyr: 2.187 ± 0.023
0.0AlaXaa: 0.0 ± 0.0
Cys
0.881CysAla: 0.881 ± 0.016
0.228CysCys: 0.228 ± 0.007
0.65CysAsp: 0.65 ± 0.012
0.576CysGlu: 0.576 ± 0.01
0.494CysPhe: 0.494 ± 0.01
0.918CysGly: 0.918 ± 0.013
0.299CysHis: 0.299 ± 0.008
0.642CysIle: 0.642 ± 0.011
0.465CysLys: 0.465 ± 0.011
1.177CysLeu: 1.177 ± 0.018
0.259CysMet: 0.259 ± 0.008
0.407CysAsn: 0.407 ± 0.009
0.634CysPro: 0.634 ± 0.011
0.402CysGln: 0.402 ± 0.008
0.667CysArg: 0.667 ± 0.012
0.814CysSer: 0.814 ± 0.015
0.621CysThr: 0.621 ± 0.013
0.76CysVal: 0.76 ± 0.013
0.19CysTrp: 0.19 ± 0.006
0.338CysTyr: 0.338 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.981AspAla: 4.981 ± 0.036
0.619AspCys: 0.619 ± 0.012
4.99AspAsp: 4.99 ± 0.052
4.901AspGlu: 4.901 ± 0.041
2.283AspPhe: 2.283 ± 0.022
4.667AspGly: 4.667 ± 0.032
1.326AspHis: 1.326 ± 0.017
2.981AspIle: 2.981 ± 0.023
2.473AspLys: 2.473 ± 0.026
5.156AspLeu: 5.156 ± 0.035
1.438AspMet: 1.438 ± 0.017
2.004AspAsn: 2.004 ± 0.018
3.474AspPro: 3.474 ± 0.027
1.929AspGln: 1.929 ± 0.021
3.116AspArg: 3.116 ± 0.03
4.077AspSer: 4.077 ± 0.031
3.114AspThr: 3.114 ± 0.023
3.96AspVal: 3.96 ± 0.028
0.944AspTrp: 0.944 ± 0.014
1.656AspTyr: 1.656 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
5.904GluAla: 5.904 ± 0.04
0.592GluCys: 0.592 ± 0.011
4.711GluAsp: 4.711 ± 0.04
5.783GluGlu: 5.783 ± 0.058
1.882GluPhe: 1.882 ± 0.02
4.198GluGly: 4.198 ± 0.038
1.401GluHis: 1.401 ± 0.02
2.796GluIle: 2.796 ± 0.025
3.654GluLys: 3.654 ± 0.032
5.201GluLeu: 5.201 ± 0.041
1.536GluMet: 1.536 ± 0.02
2.129GluAsn: 2.129 ± 0.022
2.947GluPro: 2.947 ± 0.032
2.479GluGln: 2.479 ± 0.026
3.938GluArg: 3.938 ± 0.036
3.963GluSer: 3.963 ± 0.028
3.516GluThr: 3.516 ± 0.03
3.866GluVal: 3.866 ± 0.029
0.898GluTrp: 0.898 ± 0.014
1.654GluTyr: 1.654 ± 0.019
0.0GluXaa: 0.0 ± 0.0
Phe
2.912PheAla: 2.912 ± 0.027
0.492PheCys: 0.492 ± 0.01
2.277PheAsp: 2.277 ± 0.021
2.148PheGlu: 2.148 ± 0.019
1.496PhePhe: 1.496 ± 0.022
2.841PheGly: 2.841 ± 0.031
0.842PheHis: 0.842 ± 0.013
1.682PheIle: 1.682 ± 0.023
1.446PheLys: 1.446 ± 0.019
3.218PheLeu: 3.218 ± 0.028
0.82PheMet: 0.82 ± 0.013
1.336PheAsn: 1.336 ± 0.017
1.88PhePro: 1.88 ± 0.021
1.323PheGln: 1.323 ± 0.015
1.883PheArg: 1.883 ± 0.022
2.76PheSer: 2.76 ± 0.024
2.089PheThr: 2.089 ± 0.021
2.334PheVal: 2.334 ± 0.021
0.62PheTrp: 0.62 ± 0.012
1.056PheTyr: 1.056 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
5.897GlyAla: 5.897 ± 0.046
0.848GlyCys: 0.848 ± 0.014
4.2GlyAsp: 4.2 ± 0.03
4.067GlyGlu: 4.067 ± 0.033
2.782GlyPhe: 2.782 ± 0.026
7.207GlyGly: 7.207 ± 0.061
1.858GlyHis: 1.858 ± 0.022
3.384GlyIle: 3.384 ± 0.029
3.523GlyLys: 3.523 ± 0.029
6.393GlyLeu: 6.393 ± 0.045
1.754GlyMet: 1.754 ± 0.021
2.674GlyAsn: 2.674 ± 0.025
3.733GlyPro: 3.733 ± 0.031
2.743GlyGln: 2.743 ± 0.027
4.419GlyArg: 4.419 ± 0.034
6.085GlySer: 6.085 ± 0.044
4.291GlyThr: 4.291 ± 0.035
4.639GlyVal: 4.639 ± 0.036
1.219GlyTrp: 1.219 ± 0.018
2.163GlyTyr: 2.163 ± 0.025
0.0GlyXaa: 0.0 ± 0.0
His
1.826HisAla: 1.826 ± 0.019
0.315HisCys: 0.315 ± 0.007
1.385HisAsp: 1.385 ± 0.017
1.352HisGlu: 1.352 ± 0.015
0.87HisPhe: 0.87 ± 0.012
1.812HisGly: 1.812 ± 0.018
0.924HisHis: 0.924 ± 0.019
1.149HisIle: 1.149 ± 0.016
0.936HisLys: 0.936 ± 0.014
2.13HisLeu: 2.13 ± 0.024
0.528HisMet: 0.528 ± 0.01
0.851HisAsn: 0.851 ± 0.011
1.615HisPro: 1.615 ± 0.019
0.979HisGln: 0.979 ± 0.017
1.476HisArg: 1.476 ± 0.019
1.665HisSer: 1.665 ± 0.021
1.215HisThr: 1.215 ± 0.016
1.467HisVal: 1.467 ± 0.018
0.341HisTrp: 0.341 ± 0.008
0.679HisTyr: 0.679 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.869IleAla: 3.869 ± 0.034
0.689IleCys: 0.689 ± 0.012
2.755IleAsp: 2.755 ± 0.021
2.682IleGlu: 2.682 ± 0.026
1.789IlePhe: 1.789 ± 0.022
3.01IleGly: 3.01 ± 0.029
1.087IleHis: 1.087 ± 0.014
2.293IleIle: 2.293 ± 0.026
2.06IleLys: 2.06 ± 0.021
4.142IleLeu: 4.142 ± 0.032
1.059IleMet: 1.059 ± 0.017
1.702IleAsn: 1.702 ± 0.016
2.871IlePro: 2.871 ± 0.025
1.755IleGln: 1.755 ± 0.017
2.606IleArg: 2.606 ± 0.024
3.409IleSer: 3.409 ± 0.031
2.759IleThr: 2.759 ± 0.024
3.007IleVal: 3.007 ± 0.027
0.713IleTrp: 0.713 ± 0.013
1.287IleTyr: 1.287 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
4.448LysAla: 4.448 ± 0.035
0.454LysCys: 0.454 ± 0.01
2.845LysAsp: 2.845 ± 0.028
3.381LysGlu: 3.381 ± 0.029
1.382LysPhe: 1.382 ± 0.017
3.126LysGly: 3.126 ± 0.026
1.094LysHis: 1.094 ± 0.016
2.041LysIle: 2.041 ± 0.02
3.39LysLys: 3.39 ± 0.049
3.846LysLeu: 3.846 ± 0.032
1.04LysMet: 1.04 ± 0.013
1.626LysAsn: 1.626 ± 0.017
2.728LysPro: 2.728 ± 0.027
1.806LysGln: 1.806 ± 0.021
3.276LysArg: 3.276 ± 0.039
3.302LysSer: 3.302 ± 0.028
2.852LysThr: 2.852 ± 0.026
2.87LysVal: 2.87 ± 0.026
0.672LysTrp: 0.672 ± 0.013
1.339LysTyr: 1.339 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
7.903LeuAla: 7.903 ± 0.046
1.129LeuCys: 1.129 ± 0.015
5.294LeuAsp: 5.294 ± 0.036
5.415LeuGlu: 5.415 ± 0.039
3.053LeuPhe: 3.053 ± 0.028
6.167LeuGly: 6.167 ± 0.044
2.073LeuHis: 2.073 ± 0.024
3.548LeuIle: 3.548 ± 0.031
4.012LeuLys: 4.012 ± 0.032
7.887LeuLeu: 7.887 ± 0.056
1.813LeuMet: 1.813 ± 0.019
2.964LeuAsn: 2.964 ± 0.025
5.268LeuPro: 5.268 ± 0.037
3.61LeuGln: 3.61 ± 0.034
5.597LeuArg: 5.597 ± 0.041
6.689LeuSer: 6.689 ± 0.038
4.631LeuThr: 4.631 ± 0.033
5.52LeuVal: 5.52 ± 0.042
1.196LeuTrp: 1.196 ± 0.017
2.238LeuTyr: 2.238 ± 0.025
0.0LeuXaa: 0.0 ± 0.0
Met
2.508MetAla: 2.508 ± 0.02
0.248MetCys: 0.248 ± 0.007
1.416MetAsp: 1.416 ± 0.017
1.362MetGlu: 1.362 ± 0.017
0.77MetPhe: 0.77 ± 0.015
1.633MetGly: 1.633 ± 0.017
0.477MetHis: 0.477 ± 0.009
0.966MetIle: 0.966 ± 0.013
1.013MetLys: 1.013 ± 0.017
1.858MetLeu: 1.858 ± 0.02
0.642MetMet: 0.642 ± 0.013
0.806MetAsn: 0.806 ± 0.013
1.387MetPro: 1.387 ± 0.019
0.848MetGln: 0.848 ± 0.014
1.32MetArg: 1.32 ± 0.016
1.986MetSer: 1.986 ± 0.02
1.352MetThr: 1.352 ± 0.016
1.42MetVal: 1.42 ± 0.018
0.301MetTrp: 0.301 ± 0.008
0.552MetTyr: 0.552 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.993AsnAla: 2.993 ± 0.029
0.418AsnCys: 0.418 ± 0.01
1.969AsnAsp: 1.969 ± 0.019
1.937AsnGlu: 1.937 ± 0.021
1.324AsnPhe: 1.324 ± 0.016
3.056AsnGly: 3.056 ± 0.031
0.838AsnHis: 0.838 ± 0.012
1.905AsnIle: 1.905 ± 0.023
1.592AsnLys: 1.592 ± 0.017
3.098AsnLeu: 3.098 ± 0.026
0.861AsnMet: 0.861 ± 0.014
1.713AsnAsn: 1.713 ± 0.025
2.331AsnPro: 2.331 ± 0.021
1.227AsnGln: 1.227 ± 0.017
1.821AsnArg: 1.821 ± 0.02
2.656AsnSer: 2.656 ± 0.024
2.215AsnThr: 2.215 ± 0.023
2.258AsnVal: 2.258 ± 0.024
0.545AsnTrp: 0.545 ± 0.011
1.041AsnTyr: 1.041 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
5.56ProAla: 5.56 ± 0.047
0.465ProCys: 0.465 ± 0.008
3.414ProAsp: 3.414 ± 0.025
3.997ProGlu: 3.997 ± 0.033
1.996ProPhe: 1.996 ± 0.019
4.414ProGly: 4.414 ± 0.041
1.296ProHis: 1.296 ± 0.018
2.356ProIle: 2.356 ± 0.023
2.654ProLys: 2.654 ± 0.028
4.532ProLeu: 4.532 ± 0.034
1.195ProMet: 1.195 ± 0.019
2.087ProAsn: 2.087 ± 0.023
5.358ProPro: 5.358 ± 0.063
2.534ProGln: 2.534 ± 0.034
3.561ProArg: 3.561 ± 0.033
5.764ProSer: 5.764 ± 0.049
3.968ProThr: 3.968 ± 0.04
3.75ProVal: 3.75 ± 0.032
0.744ProTrp: 0.744 ± 0.011
1.519ProTyr: 1.519 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
3.583GlnAla: 3.583 ± 0.03
0.407GlnCys: 0.407 ± 0.01
2.17GlnAsp: 2.17 ± 0.022
2.45GlnGlu: 2.45 ± 0.028
1.161GlnPhe: 1.161 ± 0.014
2.57GlnGly: 2.57 ± 0.025
1.103GlnHis: 1.103 ± 0.018
1.678GlnIle: 1.678 ± 0.021
1.885GlnLys: 1.885 ± 0.021
3.276GlnLeu: 3.276 ± 0.032
0.914GlnMet: 0.914 ± 0.015
1.449GlnAsn: 1.449 ± 0.022
2.596GlnPro: 2.596 ± 0.03
2.721GlnGln: 2.721 ± 0.052
2.597GlnArg: 2.597 ± 0.026
2.882GlnSer: 2.882 ± 0.03
2.2GlnThr: 2.2 ± 0.023
2.252GlnVal: 2.252 ± 0.02
0.572GlnTrp: 0.572 ± 0.012
1.132GlnTyr: 1.132 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
4.767ArgAla: 4.767 ± 0.036
0.641ArgCys: 0.641 ± 0.011
3.516ArgAsp: 3.516 ± 0.033
3.88ArgGlu: 3.88 ± 0.035
2.028ArgPhe: 2.028 ± 0.021
4.006ArgGly: 4.006 ± 0.035
1.56ArgHis: 1.56 ± 0.019
2.674ArgIle: 2.674 ± 0.025
3.381ArgLys: 3.381 ± 0.036
5.409ArgLeu: 5.409 ± 0.034
1.372ArgMet: 1.372 ± 0.017
2.181ArgAsn: 2.181 ± 0.021
3.671ArgPro: 3.671 ± 0.031
2.608ArgGln: 2.608 ± 0.024
5.206ArgArg: 5.206 ± 0.046
4.504ArgSer: 4.504 ± 0.039
3.211ArgThr: 3.211 ± 0.025
3.418ArgVal: 3.418 ± 0.028
0.931ArgTrp: 0.931 ± 0.013
1.607ArgTyr: 1.607 ± 0.019
0.0ArgXaa: 0.0 ± 0.0
Ser
6.581SerAla: 6.581 ± 0.045
0.778SerCys: 0.778 ± 0.014
4.131SerAsp: 4.131 ± 0.038
3.958SerGlu: 3.958 ± 0.031
2.767SerPhe: 2.767 ± 0.025
5.92SerGly: 5.92 ± 0.049
1.801SerHis: 1.801 ± 0.021
3.627SerIle: 3.627 ± 0.027
3.524SerLys: 3.524 ± 0.03
6.602SerLeu: 6.602 ± 0.044
1.796SerMet: 1.796 ± 0.018
2.86SerAsn: 2.86 ± 0.026
5.433SerPro: 5.433 ± 0.052
3.148SerGln: 3.148 ± 0.029
4.76SerArg: 4.76 ± 0.037
8.841SerSer: 8.841 ± 0.086
5.445SerThr: 5.445 ± 0.047
4.516SerVal: 4.516 ± 0.037
1.087SerTrp: 1.087 ± 0.015
2.029SerTyr: 2.029 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
5.508ThrAla: 5.508 ± 0.038
0.693ThrCys: 0.693 ± 0.011
2.997ThrAsp: 2.997 ± 0.025
3.144ThrGlu: 3.144 ± 0.031
2.19ThrPhe: 2.19 ± 0.026
4.449ThrGly: 4.449 ± 0.032
1.236ThrHis: 1.236 ± 0.017
2.963ThrIle: 2.963 ± 0.026
2.596ThrLys: 2.596 ± 0.023
4.9ThrLeu: 4.9 ± 0.029
1.263ThrMet: 1.263 ± 0.017
2.115ThrAsn: 2.115 ± 0.023
4.331ThrPro: 4.331 ± 0.039
2.05ThrGln: 2.05 ± 0.022
3.143ThrArg: 3.143 ± 0.025
5.309ThrSer: 5.309 ± 0.046
4.741ThrThr: 4.741 ± 0.056
3.876ThrVal: 3.876 ± 0.032
0.875ThrTrp: 0.875 ± 0.014
1.621ThrTyr: 1.621 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
5.541ValAla: 5.541 ± 0.038
0.791ValCys: 0.791 ± 0.013
4.082ValAsp: 4.082 ± 0.029
4.03ValGlu: 4.03 ± 0.03
2.459ValPhe: 2.459 ± 0.023
4.287ValGly: 4.287 ± 0.036
1.398ValHis: 1.398 ± 0.017
2.845ValIle: 2.845 ± 0.029
2.906ValLys: 2.906 ± 0.024
5.718ValLeu: 5.718 ± 0.042
1.385ValMet: 1.385 ± 0.017
2.182ValAsn: 2.182 ± 0.022
3.756ValPro: 3.756 ± 0.026
2.376ValGln: 2.376 ± 0.022
3.5ValArg: 3.5 ± 0.026
4.555ValSer: 4.555 ± 0.033
3.711ValThr: 3.711 ± 0.034
4.654ValVal: 4.654 ± 0.039
0.902ValTrp: 0.902 ± 0.016
1.782ValTyr: 1.782 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
1.198TrpAla: 1.198 ± 0.016
0.2TrpCys: 0.2 ± 0.007
0.97TrpAsp: 0.97 ± 0.014
0.887TrpGlu: 0.887 ± 0.013
0.544TrpPhe: 0.544 ± 0.01
0.981TrpGly: 0.981 ± 0.016
0.352TrpHis: 0.352 ± 0.009
0.687TrpIle: 0.687 ± 0.013
0.766TrpLys: 0.766 ± 0.011
1.355TrpLeu: 1.355 ± 0.02
0.394TrpMet: 0.394 ± 0.008
0.612TrpAsn: 0.612 ± 0.011
0.636TrpPro: 0.636 ± 0.01
0.558TrpGln: 0.558 ± 0.01
0.952TrpArg: 0.952 ± 0.013
1.031TrpSer: 1.031 ± 0.016
0.949TrpThr: 0.949 ± 0.014
0.906TrpVal: 0.906 ± 0.015
0.278TrpTrp: 0.278 ± 0.008
0.444TrpTyr: 0.444 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.128TyrAla: 2.128 ± 0.023
0.398TyrCys: 0.398 ± 0.009
1.709TyrAsp: 1.709 ± 0.02
1.59TyrGlu: 1.59 ± 0.017
1.144TyrPhe: 1.144 ± 0.016
2.151TyrGly: 2.151 ± 0.028
0.741TyrHis: 0.741 ± 0.012
1.316TyrIle: 1.316 ± 0.019
1.077TyrLys: 1.077 ± 0.014
2.524TyrLeu: 2.524 ± 0.022
0.64TyrMet: 0.64 ± 0.011
1.126TyrAsn: 1.126 ± 0.017
1.442TyrPro: 1.442 ± 0.017
1.04TyrGln: 1.04 ± 0.016
1.571TyrArg: 1.571 ± 0.018
1.995TyrSer: 1.995 ± 0.021
1.61TyrThr: 1.61 ± 0.019
1.658TyrVal: 1.658 ± 0.02
0.464TyrTrp: 0.464 ± 0.01
0.965TyrTyr: 0.965 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.023XaaXaa: 0.023 ± 0.009
Statistics based on 10560 proteins (5240010 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski