Amino acid dipepetide frequency for Babesia microti (strain RI)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.113AlaAla: 3.113 ± 0.09	1.0AlaCys: 1.0 ± 0.027	2.338AlaAsp: 2.338 ± 0.043	2.726AlaGlu: 2.726 ± 0.056	2.029AlaPhe: 2.029 ± 0.04	2.317AlaGly: 2.317 ± 0.059	1.179AlaHis: 1.179 ± 0.032	4.293AlaIle: 4.293 ± 0.056	3.945AlaLys: 3.945 ± 0.059	5.265AlaLeu: 5.265 ± 0.1	1.193AlaMet: 1.193 ± 0.028	3.089AlaAsn: 3.089 ± 0.043	1.698AlaPro: 1.698 ± 0.052	1.73AlaGln: 1.73 ± 0.034	2.315AlaArg: 2.315 ± 0.055	4.074AlaSer: 4.074 ± 0.064	2.873AlaThr: 2.873 ± 0.05	2.774AlaVal: 2.774 ± 0.056	0.425AlaTrp: 0.425 ± 0.018	1.676AlaTyr: 1.676 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.998CysAla: 0.998 ± 0.03	0.459CysCys: 0.459 ± 0.022	1.319CysAsp: 1.319 ± 0.032	1.063CysGlu: 1.063 ± 0.029	0.767CysPhe: 0.767 ± 0.022	1.33CysGly: 1.33 ± 0.038	0.537CysHis: 0.537 ± 0.017	1.817CysIle: 1.817 ± 0.036	1.678CysLys: 1.678 ± 0.04	2.044CysLeu: 2.044 ± 0.04	0.424CysMet: 0.424 ± 0.019	1.482CysAsn: 1.482 ± 0.032	0.831CysPro: 0.831 ± 0.03	0.666CysGln: 0.666 ± 0.021	0.91CysArg: 0.91 ± 0.024	1.536CysSer: 1.536 ± 0.034	1.118CysThr: 1.118 ± 0.027	1.214CysVal: 1.214 ± 0.03	0.221CysTrp: 0.221 ± 0.015	0.836CysTyr: 0.836 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.748AspAla: 2.748 ± 0.046	1.213AspCys: 1.213 ± 0.036	3.626AspAsp: 3.626 ± 0.07	3.842AspGlu: 3.842 ± 0.07	2.584AspPhe: 2.584 ± 0.045	2.979AspGly: 2.979 ± 0.059	1.139AspHis: 1.139 ± 0.027	4.947AspIle: 4.947 ± 0.065	4.555AspLys: 4.555 ± 0.073	5.023AspLeu: 5.023 ± 0.064	1.363AspMet: 1.363 ± 0.034	3.734AspAsn: 3.734 ± 0.053	2.198AspPro: 2.198 ± 0.033	1.584AspGln: 1.584 ± 0.032	2.353AspArg: 2.353 ± 0.049	4.769AspSer: 4.769 ± 0.059	3.214AspThr: 3.214 ± 0.05	3.282AspVal: 3.282 ± 0.045	0.542AspTrp: 0.542 ± 0.019	2.417AspTyr: 2.417 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	2.885GluAla: 2.885 ± 0.058	1.299GluCys: 1.299 ± 0.028	2.899GluAsp: 2.899 ± 0.055	3.35GluGlu: 3.35 ± 0.078	2.852GluPhe: 2.852 ± 0.041	2.327GluGly: 2.327 ± 0.055	1.223GluHis: 1.223 ± 0.029	4.753GluIle: 4.753 ± 0.067	3.933GluLys: 3.933 ± 0.064	6.023GluLeu: 6.023 ± 0.067	1.498GluMet: 1.498 ± 0.034	3.406GluAsn: 3.406 ± 0.059	1.66GluPro: 1.66 ± 0.031	1.884GluGln: 1.884 ± 0.035	2.697GluArg: 2.697 ± 0.049	4.659GluSer: 4.659 ± 0.06	2.761GluThr: 2.761 ± 0.041	2.539GluVal: 2.539 ± 0.045	0.655GluTrp: 0.655 ± 0.02	2.337GluTyr: 2.337 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.194PheAla: 2.194 ± 0.038	0.927PheCys: 0.927 ± 0.024	3.079PheAsp: 3.079 ± 0.046	2.496PheGlu: 2.496 ± 0.04	1.724PhePhe: 1.724 ± 0.038	2.617PheGly: 2.617 ± 0.053	1.048PheHis: 1.048 ± 0.026	3.57PheIle: 3.57 ± 0.058	3.22PheLys: 3.22 ± 0.051	3.722PheLeu: 3.722 ± 0.047	0.965PheMet: 0.965 ± 0.024	2.837PheAsn: 2.837 ± 0.048	1.616PhePro: 1.616 ± 0.036	1.385PheGln: 1.385 ± 0.032	1.759PheArg: 1.759 ± 0.03	3.782PheSer: 3.782 ± 0.056	2.717PheThr: 2.717 ± 0.039	2.67PheVal: 2.67 ± 0.044	0.458PheTrp: 0.458 ± 0.017	1.917PheTyr: 1.917 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	2.256GlyAla: 2.256 ± 0.06	0.977GlyCys: 0.977 ± 0.029	3.015GlyAsp: 3.015 ± 0.051	2.578GlyGlu: 2.578 ± 0.051	2.286GlyPhe: 2.286 ± 0.044	3.016GlyGly: 3.016 ± 0.085	1.26GlyHis: 1.26 ± 0.033	4.064GlyIle: 4.064 ± 0.049	3.861GlyLys: 3.861 ± 0.053	4.454GlyLeu: 4.454 ± 0.064	1.111GlyMet: 1.111 ± 0.026	3.03GlyAsn: 3.03 ± 0.049	1.567GlyPro: 1.567 ± 0.042	1.526GlyGln: 1.526 ± 0.036	2.301GlyArg: 2.301 ± 0.043	3.714GlySer: 3.714 ± 0.066	2.746GlyThr: 2.746 ± 0.05	2.893GlyVal: 2.893 ± 0.052	0.533GlyTrp: 0.533 ± 0.019	2.077GlyTyr: 2.077 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.035HisAla: 1.035 ± 0.029	0.46HisCys: 0.46 ± 0.02	1.147HisAsp: 1.147 ± 0.03	1.138HisGlu: 1.138 ± 0.027	1.205HisPhe: 1.205 ± 0.027	1.214HisGly: 1.214 ± 0.029	0.554HisHis: 0.554 ± 0.021	1.992HisIle: 1.992 ± 0.036	1.688HisLys: 1.688 ± 0.043	2.714HisLeu: 2.714 ± 0.043	0.584HisMet: 0.584 ± 0.017	1.433HisAsn: 1.433 ± 0.033	1.065HisPro: 1.065 ± 0.026	0.782HisGln: 0.782 ± 0.022	1.107HisArg: 1.107 ± 0.031	2.213HisSer: 2.213 ± 0.039	1.214HisThr: 1.214 ± 0.03	1.352HisVal: 1.352 ± 0.028	0.253HisTrp: 0.253 ± 0.011	0.929HisTyr: 0.929 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.497IleAla: 4.497 ± 0.057	1.912IleCys: 1.912 ± 0.036	5.122IleAsp: 5.122 ± 0.069	4.47IleGlu: 4.47 ± 0.059	3.516IlePhe: 3.516 ± 0.055	3.904IleGly: 3.904 ± 0.052	1.947IleHis: 1.947 ± 0.04	5.925IleIle: 5.925 ± 0.091	5.859IleLys: 5.859 ± 0.077	7.356IleLeu: 7.356 ± 0.083	1.45IleMet: 1.45 ± 0.031	5.143IleAsn: 5.143 ± 0.074	3.269IlePro: 3.269 ± 0.053	2.491IleGln: 2.491 ± 0.039	3.29IleArg: 3.29 ± 0.047	7.355IleSer: 7.355 ± 0.082	4.589IleThr: 4.589 ± 0.064	4.465IleVal: 4.465 ± 0.063	0.69IleTrp: 0.69 ± 0.027	3.331IleTyr: 3.331 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	3.069LysAla: 3.069 ± 0.048	1.7LysCys: 1.7 ± 0.039	3.446LysAsp: 3.446 ± 0.061	3.598LysGlu: 3.598 ± 0.066	3.68LysPhe: 3.68 ± 0.051	3.133LysGly: 3.133 ± 0.053	1.855LysHis: 1.855 ± 0.032	6.081LysIle: 6.081 ± 0.072	4.882LysLys: 4.882 ± 0.083	8.276LysLeu: 8.276 ± 0.091	1.787LysMet: 1.787 ± 0.032	4.586LysAsn: 4.586 ± 0.071	2.46LysPro: 2.46 ± 0.041	2.513LysGln: 2.513 ± 0.043	3.677LysArg: 3.677 ± 0.055	6.08LysSer: 6.08 ± 0.072	3.457LysThr: 3.457 ± 0.059	3.717LysVal: 3.717 ± 0.053	0.815LysTrp: 0.815 ± 0.025	3.276LysTyr: 3.276 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	5.409LeuAla: 5.409 ± 0.089	2.159LeuCys: 2.159 ± 0.036	6.131LeuAsp: 6.131 ± 0.068	6.062LeuGlu: 6.062 ± 0.066	4.457LeuPhe: 4.457 ± 0.072	4.499LeuGly: 4.499 ± 0.073	2.474LeuHis: 2.474 ± 0.042	7.023LeuIle: 7.023 ± 0.085	7.131LeuLys: 7.131 ± 0.077	10.393LeuLeu: 10.393 ± 0.131	2.021LeuMet: 2.021 ± 0.034	5.933LeuAsn: 5.933 ± 0.072	4.332LeuPro: 4.332 ± 0.068	3.453LeuGln: 3.453 ± 0.048	4.138LeuArg: 4.138 ± 0.058	8.937LeuSer: 8.937 ± 0.089	5.047LeuThr: 5.047 ± 0.06	5.669LeuVal: 5.669 ± 0.065	0.914LeuTrp: 0.914 ± 0.027	3.913LeuTyr: 3.913 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.481MetAla: 1.481 ± 0.031	0.452MetCys: 0.452 ± 0.016	1.648MetAsp: 1.648 ± 0.033	1.453MetGlu: 1.453 ± 0.029	0.817MetPhe: 0.817 ± 0.025	1.334MetGly: 1.334 ± 0.032	0.496MetHis: 0.496 ± 0.019	1.544MetIle: 1.544 ± 0.029	1.411MetLys: 1.411 ± 0.031	2.174MetLeu: 2.174 ± 0.042	0.5MetMet: 0.5 ± 0.018	1.211MetAsn: 1.211 ± 0.031	1.001MetPro: 1.001 ± 0.023	0.76MetGln: 0.76 ± 0.025	0.95MetArg: 0.95 ± 0.022	1.738MetSer: 1.738 ± 0.037	0.943MetThr: 0.943 ± 0.025	1.159MetVal: 1.159 ± 0.028	0.171MetTrp: 0.171 ± 0.01	0.819MetTyr: 0.819 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.985AsnAla: 2.985 ± 0.043	1.482AsnCys: 1.482 ± 0.028	3.993AsnAsp: 3.993 ± 0.066	3.724AsnGlu: 3.724 ± 0.066	2.908AsnPhe: 2.908 ± 0.042	3.067AsnGly: 3.067 ± 0.051	1.276AsnHis: 1.276 ± 0.028	5.363AsnIle: 5.363 ± 0.072	4.553AsnLys: 4.553 ± 0.071	6.014AsnLeu: 6.014 ± 0.073	1.444AsnMet: 1.444 ± 0.037	4.448AsnAsn: 4.448 ± 0.081	2.488AsnPro: 2.488 ± 0.041	1.746AsnGln: 1.746 ± 0.044	2.501AsnArg: 2.501 ± 0.038	5.303AsnSer: 5.303 ± 0.07	3.42AsnThr: 3.42 ± 0.051	3.98AsnVal: 3.98 ± 0.054	0.609AsnTrp: 0.609 ± 0.022	2.776AsnTyr: 2.776 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.593ProAla: 1.593 ± 0.049	0.704ProCys: 0.704 ± 0.026	1.897ProAsp: 1.897 ± 0.039	2.256ProGlu: 2.256 ± 0.039	1.903ProPhe: 1.903 ± 0.04	1.79ProGly: 1.79 ± 0.042	0.967ProHis: 0.967 ± 0.028	3.243ProIle: 3.243 ± 0.053	2.717ProLys: 2.717 ± 0.044	3.974ProLeu: 3.974 ± 0.055	0.788ProMet: 0.788 ± 0.025	2.544ProAsn: 2.544 ± 0.044	2.117ProPro: 2.117 ± 0.055	1.496ProGln: 1.496 ± 0.032	1.525ProArg: 1.525 ± 0.032	3.31ProSer: 3.31 ± 0.056	2.177ProThr: 2.177 ± 0.037	2.065ProVal: 2.065 ± 0.044	0.398ProTrp: 0.398 ± 0.018	1.342ProTyr: 1.342 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.567GlnAla: 1.567 ± 0.032	0.661GlnCys: 0.661 ± 0.021	1.431GlnAsp: 1.431 ± 0.031	1.658GlnGlu: 1.658 ± 0.034	1.597GlnPhe: 1.597 ± 0.032	1.351GlnGly: 1.351 ± 0.034	0.9GlnHis: 0.9 ± 0.023	2.991GlnIle: 2.991 ± 0.044	2.029GlnLys: 2.029 ± 0.036	4.229GlnLeu: 4.229 ± 0.058	0.892GlnMet: 0.892 ± 0.022	2.041GlnAsn: 2.041 ± 0.038	1.199GlnPro: 1.199 ± 0.041	1.525GlnGln: 1.525 ± 0.04	1.538GlnArg: 1.538 ± 0.032	2.788GlnSer: 2.788 ± 0.044	1.635GlnThr: 1.635 ± 0.032	1.797GlnVal: 1.797 ± 0.035	0.294GlnTrp: 0.294 ± 0.012	1.254GlnTyr: 1.254 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.244ArgAla: 2.244 ± 0.053	0.915ArgCys: 0.915 ± 0.029	2.456ArgAsp: 2.456 ± 0.039	2.395ArgGlu: 2.395 ± 0.042	1.961ArgPhe: 1.961 ± 0.035	2.281ArgGly: 2.281 ± 0.052	1.265ArgHis: 1.265 ± 0.031	3.532ArgIle: 3.532 ± 0.048	3.073ArgLys: 3.073 ± 0.051	4.663ArgLeu: 4.663 ± 0.066	1.021ArgMet: 1.021 ± 0.027	2.597ArgAsn: 2.597 ± 0.044	1.49ArgPro: 1.49 ± 0.032	1.602ArgGln: 1.602 ± 0.033	2.549ArgArg: 2.549 ± 0.052	3.251ArgSer: 3.251 ± 0.06	1.879ArgThr: 1.879 ± 0.036	2.511ArgVal: 2.511 ± 0.048	0.481ArgTrp: 0.481 ± 0.017	1.75ArgTyr: 1.75 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.02SerAla: 4.02 ± 0.067	1.573SerCys: 1.573 ± 0.035	5.151SerAsp: 5.151 ± 0.064	4.285SerGlu: 4.285 ± 0.056	3.668SerPhe: 3.668 ± 0.054	4.304SerGly: 4.304 ± 0.068	2.103SerHis: 2.103 ± 0.043	6.835SerIle: 6.835 ± 0.086	6.008SerLys: 6.008 ± 0.074	8.488SerLeu: 8.488 ± 0.092	1.749SerMet: 1.749 ± 0.037	5.812SerAsn: 5.812 ± 0.077	3.13SerPro: 3.13 ± 0.061	3.007SerGln: 3.007 ± 0.042	3.505SerArg: 3.505 ± 0.06	7.196SerSer: 7.196 ± 0.086	4.896SerThr: 4.896 ± 0.067	4.569SerVal: 4.569 ± 0.058	0.657SerTrp: 0.657 ± 0.022	2.876SerTyr: 2.876 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	2.675ThrAla: 2.675 ± 0.048	1.213ThrCys: 1.213 ± 0.032	2.847ThrAsp: 2.847 ± 0.044	2.469ThrGlu: 2.469 ± 0.034	2.494ThrPhe: 2.494 ± 0.04	2.749ThrGly: 2.749 ± 0.051	1.383ThrHis: 1.383 ± 0.033	4.522ThrIle: 4.522 ± 0.058	3.522ThrLys: 3.522 ± 0.065	5.546ThrLeu: 5.546 ± 0.067	1.092ThrMet: 1.092 ± 0.027	3.871ThrAsn: 3.871 ± 0.059	2.469ThrPro: 2.469 ± 0.044	1.771ThrGln: 1.771 ± 0.035	2.222ThrArg: 2.222 ± 0.041	4.617ThrSer: 4.617 ± 0.053	3.158ThrThr: 3.158 ± 0.066	2.927ThrVal: 2.927 ± 0.05	0.409ThrTrp: 0.409 ± 0.017	1.817ThrTyr: 1.817 ± 0.035	0.001ThrXaa: 0.001 ± 0.001
Val	3.05ValAla: 3.05 ± 0.057	1.136ValCys: 1.136 ± 0.029	3.726ValAsp: 3.726 ± 0.051	3.55ValGlu: 3.55 ± 0.056	2.203ValPhe: 2.203 ± 0.036	2.69ValGly: 2.69 ± 0.049	1.191ValHis: 1.191 ± 0.031	4.031ValIle: 4.031 ± 0.054	4.274ValLys: 4.274 ± 0.051	4.875ValLeu: 4.875 ± 0.068	1.095ValMet: 1.095 ± 0.026	3.369ValAsn: 3.369 ± 0.052	2.365ValPro: 2.365 ± 0.044	1.774ValGln: 1.774 ± 0.033	2.113ValArg: 2.113 ± 0.04	4.574ValSer: 4.574 ± 0.056	3.25ValThr: 3.25 ± 0.053	3.054ValVal: 3.054 ± 0.054	0.538ValTrp: 0.538 ± 0.022	2.201ValTyr: 2.201 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.48TrpAla: 0.48 ± 0.019	0.203TrpCys: 0.203 ± 0.011	0.629TrpAsp: 0.629 ± 0.026	0.483TrpGlu: 0.483 ± 0.017	0.369TrpPhe: 0.369 ± 0.017	0.447TrpGly: 0.447 ± 0.019	0.278TrpHis: 0.278 ± 0.015	0.802TrpIle: 0.802 ± 0.02	0.714TrpLys: 0.714 ± 0.021	0.946TrpLeu: 0.946 ± 0.024	0.207TrpMet: 0.207 ± 0.012	0.659TrpAsn: 0.659 ± 0.022	0.373TrpPro: 0.373 ± 0.016	0.331TrpGln: 0.331 ± 0.014	0.492TrpArg: 0.492 ± 0.021	0.718TrpSer: 0.718 ± 0.023	0.448TrpThr: 0.448 ± 0.018	0.511TrpVal: 0.511 ± 0.017	0.128TrpTrp: 0.128 ± 0.01	0.345TrpTyr: 0.345 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.755TyrAla: 1.755 ± 0.037	0.806TyrCys: 0.806 ± 0.023	2.21TyrAsp: 2.21 ± 0.037	2.043TyrGlu: 2.043 ± 0.042	1.681TyrPhe: 1.681 ± 0.037	1.916TyrGly: 1.916 ± 0.036	1.004TyrHis: 1.004 ± 0.022	3.252TyrIle: 3.252 ± 0.046	3.035TyrLys: 3.035 ± 0.05	3.919TyrLeu: 3.919 ± 0.058	0.874TyrMet: 0.874 ± 0.026	2.854TyrAsn: 2.854 ± 0.048	1.481TyrPro: 1.481 ± 0.031	1.35TyrGln: 1.35 ± 0.029	1.974TyrArg: 1.974 ± 0.032	3.223TyrSer: 3.223 ± 0.053	2.232TyrThr: 2.232 ± 0.04	1.911TyrVal: 1.911 ± 0.036	0.371TyrTrp: 0.371 ± 0.018	1.773TyrTyr: 1.773 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3595 proteins (1580787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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