Amino acid dipepetide frequency for Lasiodiplodia theobromae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.412AlaAla: 12.412 ± 0.085
1.131AlaCys: 1.131 ± 0.016
5.102AlaAsp: 5.102 ± 0.037
5.877AlaGlu: 5.877 ± 0.042
3.389AlaPhe: 3.389 ± 0.022
6.807AlaGly: 6.807 ± 0.048
1.993AlaHis: 1.993 ± 0.02
4.146AlaIle: 4.146 ± 0.027
4.259AlaLys: 4.259 ± 0.033
8.468AlaLeu: 8.468 ± 0.048
2.04AlaMet: 2.04 ± 0.019
3.173AlaAsn: 3.173 ± 0.024
5.586AlaPro: 5.586 ± 0.046
3.707AlaGln: 3.707 ± 0.031
5.453AlaArg: 5.453 ± 0.038
7.812AlaSer: 7.812 ± 0.051
5.842AlaThr: 5.842 ± 0.043
6.178AlaVal: 6.178 ± 0.043
1.333AlaTrp: 1.333 ± 0.015
2.404AlaTyr: 2.404 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
1.025CysAla: 1.025 ± 0.012
0.24CysCys: 0.24 ± 0.008
0.632CysAsp: 0.632 ± 0.011
0.595CysGlu: 0.595 ± 0.011
0.5CysPhe: 0.5 ± 0.009
0.966CysGly: 0.966 ± 0.016
0.282CysHis: 0.282 ± 0.007
0.615CysIle: 0.615 ± 0.01
0.473CysLys: 0.473 ± 0.009
1.099CysLeu: 1.099 ± 0.015
0.266CysMet: 0.266 ± 0.007
0.41CysAsn: 0.41 ± 0.009
0.617CysPro: 0.617 ± 0.013
0.383CysGln: 0.383 ± 0.008
0.713CysArg: 0.713 ± 0.012
0.836CysSer: 0.836 ± 0.013
0.689CysThr: 0.689 ± 0.011
0.805CysVal: 0.805 ± 0.012
0.205CysTrp: 0.205 ± 0.006
0.347CysTyr: 0.347 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.674AspAla: 5.674 ± 0.036
0.619AspCys: 0.619 ± 0.012
4.895AspAsp: 4.895 ± 0.048
4.782AspGlu: 4.782 ± 0.037
2.247AspPhe: 2.247 ± 0.021
4.526AspGly: 4.526 ± 0.027
1.179AspHis: 1.179 ± 0.017
2.74AspIle: 2.74 ± 0.022
2.291AspLys: 2.291 ± 0.024
4.801AspLeu: 4.801 ± 0.033
1.214AspMet: 1.214 ± 0.014
1.795AspAsn: 1.795 ± 0.021
3.454AspPro: 3.454 ± 0.027
1.811AspGln: 1.811 ± 0.019
2.996AspArg: 2.996 ± 0.028
3.945AspSer: 3.945 ± 0.032
2.826AspThr: 2.826 ± 0.024
4.02AspVal: 4.02 ± 0.029
0.942AspTrp: 0.942 ± 0.013
1.65AspTyr: 1.65 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
5.855GluAla: 5.855 ± 0.042
0.605GluCys: 0.605 ± 0.012
4.324GluAsp: 4.324 ± 0.034
6.051GluGlu: 6.051 ± 0.054
1.863GluPhe: 1.863 ± 0.018
4.172GluGly: 4.172 ± 0.036
1.416GluHis: 1.416 ± 0.014
2.72GluIle: 2.72 ± 0.028
3.836GluLys: 3.836 ± 0.036
5.239GluLeu: 5.239 ± 0.04
1.518GluMet: 1.518 ± 0.016
2.157GluAsn: 2.157 ± 0.019
2.817GluPro: 2.817 ± 0.034
2.641GluGln: 2.641 ± 0.028
4.279GluArg: 4.279 ± 0.034
3.869GluSer: 3.869 ± 0.032
3.253GluThr: 3.253 ± 0.025
3.667GluVal: 3.667 ± 0.023
0.963GluTrp: 0.963 ± 0.012
1.622GluTyr: 1.622 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.363PheAla: 3.363 ± 0.024
0.53PheCys: 0.53 ± 0.01
2.343PheAsp: 2.343 ± 0.021
2.128PheGlu: 2.128 ± 0.02
1.65PhePhe: 1.65 ± 0.021
2.909PheGly: 2.909 ± 0.026
0.849PheHis: 0.849 ± 0.013
1.612PheIle: 1.612 ± 0.018
1.445PheLys: 1.445 ± 0.018
3.265PheLeu: 3.265 ± 0.026
0.74PheMet: 0.74 ± 0.012
1.378PheAsn: 1.378 ± 0.015
1.918PhePro: 1.918 ± 0.02
1.26PheGln: 1.26 ± 0.014
1.889PheArg: 1.889 ± 0.02
2.823PheSer: 2.823 ± 0.023
2.134PheThr: 2.134 ± 0.031
2.506PheVal: 2.506 ± 0.025
0.661PheTrp: 0.661 ± 0.012
1.084PheTyr: 1.084 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
6.374GlyAla: 6.374 ± 0.037
0.897GlyCys: 0.897 ± 0.014
3.873GlyAsp: 3.873 ± 0.032
4.101GlyGlu: 4.101 ± 0.028
2.871GlyPhe: 2.871 ± 0.023
7.161GlyGly: 7.161 ± 0.068
1.638GlyHis: 1.638 ± 0.019
3.302GlyIle: 3.302 ± 0.028
3.412GlyLys: 3.412 ± 0.028
6.075GlyLeu: 6.075 ± 0.058
1.66GlyMet: 1.66 ± 0.024
2.514GlyAsn: 2.514 ± 0.02
3.466GlyPro: 3.466 ± 0.031
2.474GlyGln: 2.474 ± 0.023
4.263GlyArg: 4.263 ± 0.033
5.95GlySer: 5.95 ± 0.051
4.096GlyThr: 4.096 ± 0.046
4.761GlyVal: 4.761 ± 0.036
1.272GlyTrp: 1.272 ± 0.016
2.144GlyTyr: 2.144 ± 0.021
0.0GlyXaa: 0.0 ± 0.0
His
2.116HisAla: 2.116 ± 0.021
0.312HisCys: 0.312 ± 0.008
1.31HisAsp: 1.31 ± 0.017
1.313HisGlu: 1.313 ± 0.013
0.926HisPhe: 0.926 ± 0.013
1.715HisGly: 1.715 ± 0.016
1.003HisHis: 1.003 ± 0.02
1.045HisIle: 1.045 ± 0.013
0.846HisLys: 0.846 ± 0.013
2.117HisLeu: 2.117 ± 0.02
0.456HisMet: 0.456 ± 0.009
0.789HisAsn: 0.789 ± 0.012
1.653HisPro: 1.653 ± 0.019
0.969HisGln: 0.969 ± 0.014
1.517HisArg: 1.517 ± 0.02
1.669HisSer: 1.669 ± 0.019
1.223HisThr: 1.223 ± 0.016
1.45HisVal: 1.45 ± 0.016
0.348HisTrp: 0.348 ± 0.009
0.692HisTyr: 0.692 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
4.124IleAla: 4.124 ± 0.029
0.643IleCys: 0.643 ± 0.011
2.654IleAsp: 2.654 ± 0.023
2.597IleGlu: 2.597 ± 0.022
1.782IlePhe: 1.782 ± 0.019
3.002IleGly: 3.002 ± 0.023
1.056IleHis: 1.056 ± 0.013
2.176IleIle: 2.176 ± 0.023
1.965IleLys: 1.965 ± 0.019
3.944IleLeu: 3.944 ± 0.028
0.911IleMet: 0.911 ± 0.012
1.625IleAsn: 1.625 ± 0.018
2.76IlePro: 2.76 ± 0.026
1.6IleGln: 1.6 ± 0.017
2.492IleArg: 2.492 ± 0.019
3.296IleSer: 3.296 ± 0.025
2.688IleThr: 2.688 ± 0.041
3.007IleVal: 3.007 ± 0.028
0.672IleTrp: 0.672 ± 0.01
1.246IleTyr: 1.246 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
4.347LysAla: 4.347 ± 0.038
0.455LysCys: 0.455 ± 0.009
2.739LysAsp: 2.739 ± 0.028
3.396LysGlu: 3.396 ± 0.032
1.372LysPhe: 1.372 ± 0.016
2.944LysGly: 2.944 ± 0.028
1.097LysHis: 1.097 ± 0.015
1.99LysIle: 1.99 ± 0.023
3.491LysLys: 3.491 ± 0.046
3.843LysLeu: 3.843 ± 0.033
0.989LysMet: 0.989 ± 0.013
1.634LysAsn: 1.634 ± 0.019
2.625LysPro: 2.625 ± 0.03
1.802LysGln: 1.802 ± 0.019
3.357LysArg: 3.357 ± 0.026
3.056LysSer: 3.056 ± 0.027
2.628LysThr: 2.628 ± 0.023
2.7LysVal: 2.7 ± 0.022
0.656LysTrp: 0.656 ± 0.01
1.269LysTyr: 1.269 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
8.277LeuAla: 8.277 ± 0.047
1.144LeuCys: 1.144 ± 0.016
5.06LeuAsp: 5.06 ± 0.028
5.318LeuGlu: 5.318 ± 0.042
3.221LeuPhe: 3.221 ± 0.027
5.799LeuGly: 5.799 ± 0.034
2.217LeuHis: 2.217 ± 0.022
3.489LeuIle: 3.489 ± 0.03
3.897LeuLys: 3.897 ± 0.033
8.082LeuLeu: 8.082 ± 0.046
1.707LeuMet: 1.707 ± 0.018
2.944LeuAsn: 2.944 ± 0.022
5.527LeuPro: 5.527 ± 0.065
3.566LeuGln: 3.566 ± 0.03
5.771LeuArg: 5.771 ± 0.034
6.727LeuSer: 6.727 ± 0.036
4.641LeuThr: 4.641 ± 0.036
5.361LeuVal: 5.361 ± 0.034
1.205LeuTrp: 1.205 ± 0.015
2.242LeuTyr: 2.242 ± 0.019
0.0LeuXaa: 0.0 ± 0.0
Met
2.279MetAla: 2.279 ± 0.021
0.224MetCys: 0.224 ± 0.006
1.248MetAsp: 1.248 ± 0.016
1.255MetGlu: 1.255 ± 0.016
0.711MetPhe: 0.711 ± 0.012
1.461MetGly: 1.461 ± 0.019
0.503MetHis: 0.503 ± 0.01
0.876MetIle: 0.876 ± 0.013
0.959MetLys: 0.959 ± 0.01
1.811MetLeu: 1.811 ± 0.018
0.55MetMet: 0.55 ± 0.011
0.74MetAsn: 0.74 ± 0.011
1.293MetPro: 1.293 ± 0.018
0.855MetGln: 0.855 ± 0.013
1.315MetArg: 1.315 ± 0.015
1.697MetSer: 1.697 ± 0.018
1.213MetThr: 1.213 ± 0.012
1.275MetVal: 1.275 ± 0.014
0.286MetTrp: 0.286 ± 0.008
0.505MetTyr: 0.505 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.369AsnAla: 3.369 ± 0.023
0.413AsnCys: 0.413 ± 0.009
1.972AsnAsp: 1.972 ± 0.02
1.92AsnGlu: 1.92 ± 0.018
1.347AsnPhe: 1.347 ± 0.016
3.06AsnGly: 3.06 ± 0.028
0.782AsnHis: 0.782 ± 0.012
1.804AsnIle: 1.804 ± 0.02
1.467AsnLys: 1.467 ± 0.018
2.944AsnLeu: 2.944 ± 0.026
0.775AsnMet: 0.775 ± 0.012
1.556AsnAsn: 1.556 ± 0.024
2.298AsnPro: 2.298 ± 0.021
1.189AsnGln: 1.189 ± 0.015
1.775AsnArg: 1.775 ± 0.019
2.54AsnSer: 2.54 ± 0.022
2.096AsnThr: 2.096 ± 0.023
2.269AsnVal: 2.269 ± 0.02
0.54AsnTrp: 0.54 ± 0.011
1.019AsnTyr: 1.019 ± 0.011
0.0AsnXaa: 0.0 ± 0.0
Pro
6.221ProAla: 6.221 ± 0.051
0.476ProCys: 0.476 ± 0.01
3.408ProAsp: 3.408 ± 0.026
3.796ProGlu: 3.796 ± 0.036
2.075ProPhe: 2.075 ± 0.024
4.095ProGly: 4.095 ± 0.042
1.412ProHis: 1.412 ± 0.018
2.281ProIle: 2.281 ± 0.021
2.523ProLys: 2.523 ± 0.024
4.731ProLeu: 4.731 ± 0.028
1.038ProMet: 1.038 ± 0.013
2.069ProAsn: 2.069 ± 0.02
5.836ProPro: 5.836 ± 0.073
2.509ProGln: 2.509 ± 0.029
3.382ProArg: 3.382 ± 0.033
5.899ProSer: 5.899 ± 0.067
4.102ProThr: 4.102 ± 0.076
3.603ProVal: 3.603 ± 0.033
0.759ProTrp: 0.759 ± 0.011
1.542ProTyr: 1.542 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.551GlnAla: 3.551 ± 0.03
0.395GlnCys: 0.395 ± 0.009
1.972GlnAsp: 1.972 ± 0.02
2.36GlnGlu: 2.36 ± 0.022
1.165GlnPhe: 1.165 ± 0.015
2.261GlnGly: 2.261 ± 0.024
1.148GlnHis: 1.148 ± 0.018
1.61GlnIle: 1.61 ± 0.015
1.871GlnLys: 1.871 ± 0.022
3.347GlnLeu: 3.347 ± 0.025
0.881GlnMet: 0.881 ± 0.015
1.404GlnAsn: 1.404 ± 0.018
2.672GlnPro: 2.672 ± 0.032
2.88GlnGln: 2.88 ± 0.05
2.676GlnArg: 2.676 ± 0.024
2.755GlnSer: 2.755 ± 0.026
2.162GlnThr: 2.162 ± 0.018
2.025GlnVal: 2.025 ± 0.019
0.577GlnTrp: 0.577 ± 0.01
1.084GlnTyr: 1.084 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
5.235ArgAla: 5.235 ± 0.031
0.703ArgCys: 0.703 ± 0.012
3.375ArgAsp: 3.375 ± 0.027
3.956ArgGlu: 3.956 ± 0.033
2.134ArgPhe: 2.134 ± 0.019
3.88ArgGly: 3.88 ± 0.036
1.5ArgHis: 1.5 ± 0.017
2.712ArgIle: 2.712 ± 0.021
3.398ArgLys: 3.398 ± 0.028
5.409ArgLeu: 5.409 ± 0.034
1.331ArgMet: 1.331 ± 0.016
2.175ArgAsn: 2.175 ± 0.022
3.488ArgPro: 3.488 ± 0.032
2.47ArgGln: 2.47 ± 0.023
5.248ArgArg: 5.248 ± 0.049
4.479ArgSer: 4.479 ± 0.039
3.283ArgThr: 3.283 ± 0.025
3.473ArgVal: 3.473 ± 0.028
1.013ArgTrp: 1.013 ± 0.014
1.607ArgTyr: 1.607 ± 0.019
0.0ArgXaa: 0.0 ± 0.0
Ser
7.419SerAla: 7.419 ± 0.059
0.778SerCys: 0.778 ± 0.012
4.096SerAsp: 4.096 ± 0.032
3.885SerGlu: 3.885 ± 0.033
2.841SerPhe: 2.841 ± 0.023
5.769SerGly: 5.769 ± 0.083
1.686SerHis: 1.686 ± 0.018
3.544SerIle: 3.544 ± 0.029
3.233SerLys: 3.233 ± 0.028
6.456SerLeu: 6.456 ± 0.041
1.54SerMet: 1.54 ± 0.016
2.859SerAsn: 2.859 ± 0.028
5.404SerPro: 5.404 ± 0.054
2.802SerGln: 2.802 ± 0.024
4.473SerArg: 4.473 ± 0.039
9.102SerSer: 9.102 ± 0.076
5.523SerThr: 5.523 ± 0.05
4.424SerVal: 4.424 ± 0.027
1.089SerTrp: 1.089 ± 0.015
1.993SerTyr: 1.993 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
5.94ThrAla: 5.94 ± 0.05
0.696ThrCys: 0.696 ± 0.012
2.894ThrAsp: 2.894 ± 0.022
2.928ThrGlu: 2.928 ± 0.025
2.224ThrPhe: 2.224 ± 0.02
4.208ThrGly: 4.208 ± 0.054
1.251ThrHis: 1.251 ± 0.015
2.873ThrIle: 2.873 ± 0.033
2.384ThrLys: 2.384 ± 0.021
5.089ThrLeu: 5.089 ± 0.038
1.118ThrMet: 1.118 ± 0.013
2.095ThrAsn: 2.095 ± 0.019
4.491ThrPro: 4.491 ± 0.05
1.959ThrGln: 1.959 ± 0.019
2.973ThrArg: 2.973 ± 0.023
5.073ThrSer: 5.073 ± 0.053
4.791ThrThr: 4.791 ± 0.071
3.795ThrVal: 3.795 ± 0.037
0.865ThrTrp: 0.865 ± 0.012
1.621ThrTyr: 1.621 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
5.889ValAla: 5.889 ± 0.037
0.828ValCys: 0.828 ± 0.012
3.876ValAsp: 3.876 ± 0.026
4.18ValGlu: 4.18 ± 0.033
2.462ValPhe: 2.462 ± 0.021
4.396ValGly: 4.396 ± 0.029
1.364ValHis: 1.364 ± 0.015
2.714ValIle: 2.714 ± 0.027
2.82ValLys: 2.82 ± 0.026
5.624ValLeu: 5.624 ± 0.034
1.336ValMet: 1.336 ± 0.015
2.148ValAsn: 2.148 ± 0.019
3.73ValPro: 3.73 ± 0.043
2.34ValGln: 2.34 ± 0.019
3.705ValArg: 3.705 ± 0.029
4.415ValSer: 4.415 ± 0.032
3.455ValThr: 3.455 ± 0.04
4.798ValVal: 4.798 ± 0.039
0.942ValTrp: 0.942 ± 0.013
1.721ValTyr: 1.721 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
1.265TrpAla: 1.265 ± 0.015
0.21TrpCys: 0.21 ± 0.006
0.94TrpAsp: 0.94 ± 0.012
0.898TrpGlu: 0.898 ± 0.014
0.555TrpPhe: 0.555 ± 0.01
0.995TrpGly: 0.995 ± 0.015
0.376TrpHis: 0.376 ± 0.008
0.724TrpIle: 0.724 ± 0.012
0.799TrpLys: 0.799 ± 0.011
1.375TrpLeu: 1.375 ± 0.016
0.386TrpMet: 0.386 ± 0.009
0.61TrpAsn: 0.61 ± 0.01
0.646TrpPro: 0.646 ± 0.011
0.574TrpGln: 0.574 ± 0.009
1.04TrpArg: 1.04 ± 0.013
1.042TrpSer: 1.042 ± 0.015
0.974TrpThr: 0.974 ± 0.013
0.946TrpVal: 0.946 ± 0.014
0.305TrpTrp: 0.305 ± 0.008
0.445TrpTyr: 0.445 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.378TyrAla: 2.378 ± 0.018
0.4TyrCys: 0.4 ± 0.008
1.692TyrAsp: 1.692 ± 0.02
1.532TyrGlu: 1.532 ± 0.019
1.156TyrPhe: 1.156 ± 0.013
2.181TyrGly: 2.181 ± 0.023
0.718TyrHis: 0.718 ± 0.011
1.267TyrIle: 1.267 ± 0.016
1.018TyrLys: 1.018 ± 0.012
2.472TyrLeu: 2.472 ± 0.02
0.596TyrMet: 0.596 ± 0.01
1.059TyrAsn: 1.059 ± 0.015
1.478TyrPro: 1.478 ± 0.018
1.007TyrGln: 1.007 ± 0.012
1.553TyrArg: 1.553 ± 0.017
1.929TyrSer: 1.929 ± 0.019
1.649TyrThr: 1.649 ± 0.023
1.681TyrVal: 1.681 ± 0.017
0.469TyrTrp: 0.469 ± 0.009
0.952TyrTyr: 0.952 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.008XaaXaa: 0.008 ± 0.004
Statistics based on 12895 proteins (6232502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski