Amino acid dipepetide frequency for Halanaeroarchaeum sulfurireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.962AlaAla: 11.962 ± 0.194	0.501AlaCys: 0.501 ± 0.038	9.105AlaAsp: 9.105 ± 0.132	8.29AlaGlu: 8.29 ± 0.121	3.852AlaPhe: 3.852 ± 0.091	8.62AlaGly: 8.62 ± 0.147	1.782AlaHis: 1.782 ± 0.052	5.852AlaIle: 5.852 ± 0.111	2.126AlaLys: 2.126 ± 0.067	9.458AlaLeu: 9.458 ± 0.144	2.214AlaMet: 2.214 ± 0.07	2.688AlaAsn: 2.688 ± 0.066	3.732AlaPro: 3.732 ± 0.083	2.179AlaGln: 2.179 ± 0.059	6.097AlaArg: 6.097 ± 0.11	5.443AlaSer: 5.443 ± 0.107	7.019AlaThr: 7.019 ± 0.12	10.119AlaVal: 10.119 ± 0.145	0.954AlaTrp: 0.954 ± 0.037	2.504AlaTyr: 2.504 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.427CysAla: 0.427 ± 0.025	0.039CysCys: 0.039 ± 0.008	0.397CysAsp: 0.397 ± 0.025	0.499CysGlu: 0.499 ± 0.028	0.121CysPhe: 0.121 ± 0.015	0.716CysGly: 0.716 ± 0.04	0.149CysHis: 0.149 ± 0.019	0.204CysIle: 0.204 ± 0.02	0.133CysLys: 0.133 ± 0.017	0.342CysLeu: 0.342 ± 0.027	0.097CysMet: 0.097 ± 0.013	0.151CysAsn: 0.151 ± 0.014	0.505CysPro: 0.505 ± 0.034	0.137CysGln: 0.137 ± 0.015	0.369CysArg: 0.369 ± 0.029	0.421CysSer: 0.421 ± 0.031	0.323CysThr: 0.323 ± 0.023	0.317CysVal: 0.317 ± 0.02	0.046CysTrp: 0.046 ± 0.009	0.1CysTyr: 0.1 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	9.473AspAla: 9.473 ± 0.146	0.422AspCys: 0.422 ± 0.026	7.077AspAsp: 7.077 ± 0.131	8.256AspGlu: 8.256 ± 0.161	2.295AspPhe: 2.295 ± 0.056	7.287AspGly: 7.287 ± 0.123	1.86AspHis: 1.86 ± 0.067	3.656AspIle: 3.656 ± 0.086	1.068AspLys: 1.068 ± 0.047	7.637AspLeu: 7.637 ± 0.116	1.366AspMet: 1.366 ± 0.053	1.303AspAsn: 1.303 ± 0.043	4.612AspPro: 4.612 ± 0.084	1.841AspGln: 1.841 ± 0.065	6.848AspArg: 6.848 ± 0.12	3.309AspSer: 3.309 ± 0.082	4.265AspThr: 4.265 ± 0.086	8.608AspVal: 8.608 ± 0.134	1.022AspTrp: 1.022 ± 0.041	1.865AspTyr: 1.865 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	8.465GluAla: 8.465 ± 0.141	0.499GluCys: 0.499 ± 0.033	6.454GluAsp: 6.454 ± 0.136	7.527GluGlu: 7.527 ± 0.146	2.801GluPhe: 2.801 ± 0.076	5.645GluGly: 5.645 ± 0.111	2.008GluHis: 2.008 ± 0.052	4.179GluIle: 4.179 ± 0.1	2.163GluLys: 2.163 ± 0.068	7.019GluLeu: 7.019 ± 0.108	2.099GluMet: 2.099 ± 0.063	2.557GluAsn: 2.557 ± 0.07	3.904GluPro: 3.904 ± 0.089	2.651GluGln: 2.651 ± 0.065	7.746GluArg: 7.746 ± 0.129	5.424GluSer: 5.424 ± 0.104	6.885GluThr: 6.885 ± 0.11	5.7GluVal: 5.7 ± 0.099	0.992GluTrp: 0.992 ± 0.045	2.791GluTyr: 2.791 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.532PheAla: 3.532 ± 0.083	0.166PheCys: 0.166 ± 0.017	3.232PheAsp: 3.232 ± 0.075	3.311PheGlu: 3.311 ± 0.075	1.019PhePhe: 1.019 ± 0.046	3.013PheGly: 3.013 ± 0.084	0.678PheHis: 0.678 ± 0.032	1.116PheIle: 1.116 ± 0.043	0.543PheLys: 0.543 ± 0.028	2.736PheLeu: 2.736 ± 0.08	0.466PheMet: 0.466 ± 0.028	0.68PheAsn: 0.68 ± 0.03	1.287PhePro: 1.287 ± 0.044	0.846PheGln: 0.846 ± 0.035	1.776PheArg: 1.776 ± 0.053	1.653PheSer: 1.653 ± 0.05	1.885PheThr: 1.885 ± 0.053	3.261PheVal: 3.261 ± 0.08	0.372PheTrp: 0.372 ± 0.029	0.851PheTyr: 0.851 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.606GlyAla: 7.606 ± 0.138	0.485GlyCys: 0.485 ± 0.03	6.284GlyAsp: 6.284 ± 0.103	6.915GlyGlu: 6.915 ± 0.108	2.954GlyPhe: 2.954 ± 0.063	6.477GlyGly: 6.477 ± 0.139	1.738GlyHis: 1.738 ± 0.058	4.356GlyIle: 4.356 ± 0.085	1.956GlyLys: 1.956 ± 0.052	6.804GlyLeu: 6.804 ± 0.139	1.801GlyMet: 1.801 ± 0.062	1.909GlyAsn: 1.909 ± 0.056	3.352GlyPro: 3.352 ± 0.08	2.089GlyGln: 2.089 ± 0.06	5.044GlyArg: 5.044 ± 0.098	4.931GlySer: 4.931 ± 0.092	5.783GlyThr: 5.783 ± 0.091	7.212GlyVal: 7.212 ± 0.13	0.942GlyTrp: 0.942 ± 0.041	2.545GlyTyr: 2.545 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.992HisAla: 1.992 ± 0.054	0.162HisCys: 0.162 ± 0.015	1.743HisAsp: 1.743 ± 0.05	1.708HisGlu: 1.708 ± 0.05	0.603HisPhe: 0.603 ± 0.034	1.87HisGly: 1.87 ± 0.056	0.546HisHis: 0.546 ± 0.034	0.763HisIle: 0.763 ± 0.034	0.33HisLys: 0.33 ± 0.023	1.89HisLeu: 1.89 ± 0.062	0.3HisMet: 0.3 ± 0.02	0.477HisAsn: 0.477 ± 0.025	1.308HisPro: 1.308 ± 0.049	0.526HisGln: 0.526 ± 0.028	1.488HisArg: 1.488 ± 0.053	0.965HisSer: 0.965 ± 0.041	1.091HisThr: 1.091 ± 0.04	2.039HisVal: 2.039 ± 0.055	0.221HisTrp: 0.221 ± 0.019	0.557HisTyr: 0.557 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.257IleAla: 5.257 ± 0.104	0.223IleCys: 0.223 ± 0.017	4.476IleAsp: 4.476 ± 0.099	5.129IleGlu: 5.129 ± 0.087	1.121IlePhe: 1.121 ± 0.051	4.038IleGly: 4.038 ± 0.084	0.994IleHis: 0.994 ± 0.035	1.593IleIle: 1.593 ± 0.057	0.799IleLys: 0.799 ± 0.036	3.242IleLeu: 3.242 ± 0.087	0.592IleMet: 0.592 ± 0.03	1.027IleAsn: 1.027 ± 0.042	2.298IlePro: 2.298 ± 0.057	1.242IleGln: 1.242 ± 0.048	2.959IleArg: 2.959 ± 0.071	2.374IleSer: 2.374 ± 0.059	2.647IleThr: 2.647 ± 0.07	4.408IleVal: 4.408 ± 0.107	0.331IleTrp: 0.331 ± 0.024	0.948IleTyr: 0.948 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	2.028LysAla: 2.028 ± 0.057	0.133LysCys: 0.133 ± 0.015	1.182LysAsp: 1.182 ± 0.049	1.548LysGlu: 1.548 ± 0.065	0.581LysPhe: 0.581 ± 0.03	1.512LysGly: 1.512 ± 0.053	0.531LysHis: 0.531 ± 0.031	0.932LysIle: 0.932 ± 0.046	0.623LysLys: 0.623 ± 0.037	1.777LysLeu: 1.777 ± 0.061	0.402LysMet: 0.402 ± 0.026	0.675LysAsn: 0.675 ± 0.037	1.033LysPro: 1.033 ± 0.048	0.799LysGln: 0.799 ± 0.041	1.826LysArg: 1.826 ± 0.058	1.234LysSer: 1.234 ± 0.049	1.595LysThr: 1.595 ± 0.051	1.35LysVal: 1.35 ± 0.045	0.228LysTrp: 0.228 ± 0.02	0.67LysTyr: 0.67 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	10.173LeuAla: 10.173 ± 0.171	0.331LeuCys: 0.331 ± 0.023	7.879LeuAsp: 7.879 ± 0.115	7.25LeuGlu: 7.25 ± 0.119	2.95LeuPhe: 2.95 ± 0.093	7.03LeuGly: 7.03 ± 0.139	1.484LeuHis: 1.484 ± 0.048	3.166LeuIle: 3.166 ± 0.091	1.675LeuLys: 1.675 ± 0.057	7.703LeuLeu: 7.703 ± 0.146	1.361LeuMet: 1.361 ± 0.046	1.708LeuAsn: 1.708 ± 0.049	3.95LeuPro: 3.95 ± 0.083	2.309LeuGln: 2.309 ± 0.064	5.469LeuArg: 5.469 ± 0.101	5.551LeuSer: 5.551 ± 0.101	5.078LeuThr: 5.078 ± 0.086	7.915LeuVal: 7.915 ± 0.123	0.757LeuTrp: 0.757 ± 0.037	2.14LeuTyr: 2.14 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.986MetAla: 1.986 ± 0.052	0.075MetCys: 0.075 ± 0.01	1.54MetAsp: 1.54 ± 0.048	1.229MetGlu: 1.229 ± 0.047	0.516MetPhe: 0.516 ± 0.035	1.647MetGly: 1.647 ± 0.056	0.394MetHis: 0.394 ± 0.026	0.771MetIle: 0.771 ± 0.034	0.474MetLys: 0.474 ± 0.024	1.589MetLeu: 1.589 ± 0.053	0.355MetMet: 0.355 ± 0.026	0.642MetAsn: 0.642 ± 0.032	0.893MetPro: 0.893 ± 0.04	0.557MetGln: 0.557 ± 0.026	1.152MetArg: 1.152 ± 0.04	1.484MetSer: 1.484 ± 0.045	1.608MetThr: 1.608 ± 0.047	1.452MetVal: 1.452 ± 0.052	0.173MetTrp: 0.173 ± 0.016	0.402MetTyr: 0.402 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.725AsnAla: 2.725 ± 0.069	0.17AsnCys: 0.17 ± 0.017	1.826AsnAsp: 1.826 ± 0.055	1.951AsnGlu: 1.951 ± 0.063	0.651AsnPhe: 0.651 ± 0.033	2.046AsnGly: 2.046 ± 0.057	0.471AsnHis: 0.471 ± 0.029	0.978AsnIle: 0.978 ± 0.038	0.548AsnLys: 0.548 ± 0.031	2.002AsnLeu: 2.002 ± 0.053	0.43AsnMet: 0.43 ± 0.029	0.529AsnAsn: 0.529 ± 0.031	1.537AsnPro: 1.537 ± 0.051	0.626AsnGln: 0.626 ± 0.035	1.904AsnArg: 1.904 ± 0.06	1.075AsnSer: 1.075 ± 0.049	1.345AsnThr: 1.345 ± 0.047	2.419AsnVal: 2.419 ± 0.059	0.292AsnTrp: 0.292 ± 0.02	0.634AsnTyr: 0.634 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.474ProAla: 4.474 ± 0.083	0.214ProCys: 0.214 ± 0.02	4.689ProAsp: 4.689 ± 0.097	4.512ProGlu: 4.512 ± 0.089	1.659ProPhe: 1.659 ± 0.047	3.783ProGly: 3.783 ± 0.092	0.889ProHis: 0.889 ± 0.036	2.192ProIle: 2.192 ± 0.051	0.929ProLys: 0.929 ± 0.044	3.396ProLeu: 3.396 ± 0.081	0.882ProMet: 0.882 ± 0.037	1.168ProAsn: 1.168 ± 0.051	2.257ProPro: 2.257 ± 0.064	1.019ProGln: 1.019 ± 0.043	2.311ProArg: 2.311 ± 0.067	2.794ProSer: 2.794 ± 0.077	3.234ProThr: 3.234 ± 0.073	4.251ProVal: 4.251 ± 0.077	0.513ProTrp: 0.513 ± 0.026	1.133ProTyr: 1.133 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.549GlnAla: 2.549 ± 0.066	0.19GlnCys: 0.19 ± 0.019	1.604GlnAsp: 1.604 ± 0.058	1.903GlnGlu: 1.903 ± 0.062	0.998GlnPhe: 0.998 ± 0.041	1.705GlnGly: 1.705 ± 0.059	0.606GlnHis: 0.606 ± 0.029	1.33GlnIle: 1.33 ± 0.049	0.664GlnLys: 0.664 ± 0.037	2.223GlnLeu: 2.223 ± 0.061	0.601GlnMet: 0.601 ± 0.035	0.761GlnAsn: 0.761 ± 0.034	1.141GlnPro: 1.141 ± 0.04	1.027GlnGln: 1.027 ± 0.048	1.929GlnArg: 1.929 ± 0.056	1.73GlnSer: 1.73 ± 0.059	1.7GlnThr: 1.7 ± 0.049	2.038GlnVal: 2.038 ± 0.063	0.339GlnTrp: 0.339 ± 0.027	0.895GlnTyr: 0.895 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	6.338ArgAla: 6.338 ± 0.113	0.411ArgCys: 0.411 ± 0.034	5.418ArgAsp: 5.418 ± 0.101	6.498ArgGlu: 6.498 ± 0.096	2.309ArgPhe: 2.309 ± 0.062	4.664ArgGly: 4.664 ± 0.082	1.338ArgHis: 1.338 ± 0.045	3.424ArgIle: 3.424 ± 0.082	1.678ArgLys: 1.678 ± 0.051	5.945ArgLeu: 5.945 ± 0.092	1.41ArgMet: 1.41 ± 0.051	1.749ArgAsn: 1.749 ± 0.056	2.743ArgPro: 2.743 ± 0.075	1.882ArgGln: 1.882 ± 0.051	4.991ArgArg: 4.991 ± 0.108	3.937ArgSer: 3.937 ± 0.09	4.257ArgThr: 4.257 ± 0.102	5.471ArgVal: 5.471 ± 0.091	0.812ArgTrp: 0.812 ± 0.035	2.002ArgTyr: 2.002 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.32SerAla: 5.32 ± 0.102	0.325SerCys: 0.325 ± 0.022	4.298SerAsp: 4.298 ± 0.093	4.46SerGlu: 4.46 ± 0.093	1.882SerPhe: 1.882 ± 0.055	5.022SerGly: 5.022 ± 0.095	1.171SerHis: 1.171 ± 0.038	2.747SerIle: 2.747 ± 0.066	1.308SerLys: 1.308 ± 0.048	4.852SerLeu: 4.852 ± 0.102	1.272SerMet: 1.272 ± 0.048	1.339SerAsn: 1.339 ± 0.052	2.586SerPro: 2.586 ± 0.077	1.48SerGln: 1.48 ± 0.045	3.397SerArg: 3.397 ± 0.081	2.991SerSer: 2.991 ± 0.095	3.631SerThr: 3.631 ± 0.085	5.257SerVal: 5.257 ± 0.083	0.575SerTrp: 0.575 ± 0.033	1.421SerTyr: 1.421 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.967ThrAla: 6.967 ± 0.109	0.38ThrCys: 0.38 ± 0.027	5.545ThrAsp: 5.545 ± 0.1	4.757ThrGlu: 4.757 ± 0.086	2.058ThrPhe: 2.058 ± 0.06	5.673ThrGly: 5.673 ± 0.102	1.297ThrHis: 1.297 ± 0.047	3.505ThrIle: 3.505 ± 0.082	1.264ThrLys: 1.264 ± 0.046	5.761ThrLeu: 5.761 ± 0.092	1.217ThrMet: 1.217 ± 0.043	1.653ThrAsn: 1.653 ± 0.055	3.204ThrPro: 3.204 ± 0.072	1.473ThrGln: 1.473 ± 0.054	3.425ThrArg: 3.425 ± 0.068	2.931ThrSer: 2.931 ± 0.074	4.546ThrThr: 4.546 ± 0.107	7.407ThrVal: 7.407 ± 0.126	0.692ThrTrp: 0.692 ± 0.032	1.782ThrTyr: 1.782 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	9.827ValAla: 9.827 ± 0.157	0.515ValCys: 0.515 ± 0.028	7.931ValAsp: 7.931 ± 0.123	8.422ValGlu: 8.422 ± 0.134	2.845ValPhe: 2.845 ± 0.077	7.378ValGly: 7.378 ± 0.13	1.774ValHis: 1.774 ± 0.059	3.603ValIle: 3.603 ± 0.09	1.614ValLys: 1.614 ± 0.061	7.97ValLeu: 7.97 ± 0.154	1.438ValMet: 1.438 ± 0.047	2.146ValAsn: 2.146 ± 0.056	4.391ValPro: 4.391 ± 0.088	2.141ValGln: 2.141 ± 0.054	5.736ValArg: 5.736 ± 0.106	5.303ValSer: 5.303 ± 0.095	6.513ValThr: 6.513 ± 0.116	9.061ValVal: 9.061 ± 0.157	0.805ValTrp: 0.805 ± 0.032	2.083ValTyr: 2.083 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.9TrpAla: 0.9 ± 0.038	0.075TrpCys: 0.075 ± 0.012	0.73TrpAsp: 0.73 ± 0.033	0.797TrpGlu: 0.797 ± 0.038	0.391TrpPhe: 0.391 ± 0.025	0.774TrpGly: 0.774 ± 0.034	0.22TrpHis: 0.22 ± 0.019	0.513TrpIle: 0.513 ± 0.032	0.298TrpLys: 0.298 ± 0.023	1.011TrpLeu: 1.011 ± 0.043	0.246TrpMet: 0.246 ± 0.023	0.366TrpAsn: 0.366 ± 0.027	0.386TrpPro: 0.386 ± 0.027	0.359TrpGln: 0.359 ± 0.023	0.824TrpArg: 0.824 ± 0.041	0.595TrpSer: 0.595 ± 0.031	0.716TrpThr: 0.716 ± 0.03	0.87TrpVal: 0.87 ± 0.042	0.187TrpTrp: 0.187 ± 0.019	0.334TrpTyr: 0.334 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.496TyrAla: 2.496 ± 0.07	0.177TyrCys: 0.177 ± 0.017	2.661TyrAsp: 2.661 ± 0.063	2.548TyrGlu: 2.548 ± 0.065	0.816TyrPhe: 0.816 ± 0.039	2.284TyrGly: 2.284 ± 0.056	0.651TyrHis: 0.651 ± 0.032	0.815TyrIle: 0.815 ± 0.038	0.466TyrLys: 0.466 ± 0.029	2.521TyrLeu: 2.521 ± 0.066	0.389TyrMet: 0.389 ± 0.024	0.633TyrAsn: 0.633 ± 0.032	1.181TyrPro: 1.181 ± 0.044	0.749TyrGln: 0.749 ± 0.034	1.983TyrArg: 1.983 ± 0.061	1.192TyrSer: 1.192 ± 0.038	1.413TyrThr: 1.413 ± 0.042	2.342TyrVal: 2.342 ± 0.059	0.341TyrTrp: 0.341 ± 0.024	0.777TyrTyr: 0.777 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2225 proteins (637001 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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