Amino acid dipepetide frequency for Haladaptatus litoreus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.223AlaAla: 8.223 ± 0.115	0.72AlaCys: 0.72 ± 0.023	7.291AlaAsp: 7.291 ± 0.08	7.689AlaGlu: 7.689 ± 0.101	3.65AlaPhe: 3.65 ± 0.067	7.75AlaGly: 7.75 ± 0.084	1.725AlaHis: 1.725 ± 0.037	5.15AlaIle: 5.15 ± 0.066	2.444AlaLys: 2.444 ± 0.047	8.88AlaLeu: 8.88 ± 0.099	2.046AlaMet: 2.046 ± 0.043	2.837AlaAsn: 2.837 ± 0.047	3.347AlaPro: 3.347 ± 0.055	2.349AlaGln: 2.349 ± 0.045	5.228AlaArg: 5.228 ± 0.073	5.087AlaSer: 5.087 ± 0.06	5.939AlaThr: 5.939 ± 0.059	8.473AlaVal: 8.473 ± 0.109	1.015AlaTrp: 1.015 ± 0.03	2.448AlaTyr: 2.448 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.585CysAla: 0.585 ± 0.022	0.119CysCys: 0.119 ± 0.009	0.682CysAsp: 0.682 ± 0.023	0.662CysGlu: 0.662 ± 0.022	0.235CysPhe: 0.235 ± 0.014	0.847CysGly: 0.847 ± 0.025	0.216CysHis: 0.216 ± 0.013	0.351CysIle: 0.351 ± 0.017	0.179CysLys: 0.179 ± 0.014	0.574CysLeu: 0.574 ± 0.022	0.138CysMet: 0.138 ± 0.011	0.224CysAsn: 0.224 ± 0.015	0.561CysPro: 0.561 ± 0.024	0.196CysGln: 0.196 ± 0.013	0.505CysArg: 0.505 ± 0.02	0.523CysSer: 0.523 ± 0.02	0.435CysThr: 0.435 ± 0.019	0.548CysVal: 0.548 ± 0.022	0.123CysTrp: 0.123 ± 0.009	0.223CysTyr: 0.223 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.543AspAla: 7.543 ± 0.089	0.807AspCys: 0.807 ± 0.032	6.481AspAsp: 6.481 ± 0.091	7.612AspGlu: 7.612 ± 0.092	2.354AspPhe: 2.354 ± 0.046	6.81AspGly: 6.81 ± 0.091	1.636AspHis: 1.636 ± 0.04	3.584AspIle: 3.584 ± 0.058	1.408AspLys: 1.408 ± 0.037	5.747AspLeu: 5.747 ± 0.086	1.311AspMet: 1.311 ± 0.033	1.672AspAsn: 1.672 ± 0.042	3.414AspPro: 3.414 ± 0.05	1.603AspGln: 1.603 ± 0.04	4.418AspArg: 4.418 ± 0.062	4.581AspSer: 4.581 ± 0.06	4.12AspThr: 4.12 ± 0.065	6.596AspVal: 6.596 ± 0.081	1.015AspTrp: 1.015 ± 0.033	1.986AspTyr: 1.986 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.497GluAla: 6.497 ± 0.082	0.547GluCys: 0.547 ± 0.024	5.262GluAsp: 5.262 ± 0.075	6.8GluGlu: 6.8 ± 0.103	3.155GluPhe: 3.155 ± 0.052	4.852GluGly: 4.852 ± 0.065	2.072GluHis: 2.072 ± 0.05	4.47GluIle: 4.47 ± 0.079	2.651GluLys: 2.651 ± 0.052	7.631GluLeu: 7.631 ± 0.085	2.16GluMet: 2.16 ± 0.04	3.29GluAsn: 3.29 ± 0.052	3.419GluPro: 3.419 ± 0.06	3.382GluGln: 3.382 ± 0.055	6.452GluArg: 6.452 ± 0.086	5.707GluSer: 5.707 ± 0.082	6.625GluThr: 6.625 ± 0.077	5.203GluVal: 5.203 ± 0.079	1.178GluTrp: 1.178 ± 0.034	2.748GluTyr: 2.748 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.648PheAla: 3.648 ± 0.06	0.321PheCys: 0.321 ± 0.016	3.395PheAsp: 3.395 ± 0.055	3.263PheGlu: 3.263 ± 0.048	1.349PhePhe: 1.349 ± 0.039	3.491PheGly: 3.491 ± 0.06	0.77PheHis: 0.77 ± 0.023	1.523PheIle: 1.523 ± 0.035	0.657PheLys: 0.657 ± 0.026	3.172PheLeu: 3.172 ± 0.062	0.625PheMet: 0.625 ± 0.023	0.862PheAsn: 0.862 ± 0.026	1.559PhePro: 1.559 ± 0.039	0.956PheGln: 0.956 ± 0.027	1.977PheArg: 1.977 ± 0.041	2.332PheSer: 2.332 ± 0.045	2.099PheThr: 2.099 ± 0.042	3.535PheVal: 3.535 ± 0.058	0.457PheTrp: 0.457 ± 0.02	1.004PheTyr: 1.004 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	6.804GlyAla: 6.804 ± 0.105	0.743GlyCys: 0.743 ± 0.026	5.724GlyAsp: 5.724 ± 0.078	6.621GlyGlu: 6.621 ± 0.083	3.344GlyPhe: 3.344 ± 0.053	6.895GlyGly: 6.895 ± 0.091	1.687GlyHis: 1.687 ± 0.04	4.812GlyIle: 4.812 ± 0.067	2.597GlyLys: 2.597 ± 0.048	6.851GlyLeu: 6.851 ± 0.097	1.866GlyMet: 1.866 ± 0.036	2.586GlyAsn: 2.586 ± 0.053	2.58GlyPro: 2.58 ± 0.051	2.211GlyGln: 2.211 ± 0.048	4.189GlyArg: 4.189 ± 0.063	5.104GlySer: 5.104 ± 0.066	5.663GlyThr: 5.663 ± 0.075	6.946GlyVal: 6.946 ± 0.073	1.137GlyTrp: 1.137 ± 0.033	2.703GlyTyr: 2.703 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.921HisAla: 1.921 ± 0.041	0.223HisCys: 0.223 ± 0.015	1.841HisAsp: 1.841 ± 0.041	1.811HisGlu: 1.811 ± 0.036	0.714HisPhe: 0.714 ± 0.024	2.014HisGly: 2.014 ± 0.044	0.587HisHis: 0.587 ± 0.024	0.942HisIle: 0.942 ± 0.026	0.407HisLys: 0.407 ± 0.018	1.834HisLeu: 1.834 ± 0.041	0.324HisMet: 0.324 ± 0.014	0.502HisAsn: 0.502 ± 0.018	1.326HisPro: 1.326 ± 0.034	0.577HisGln: 0.577 ± 0.022	1.33HisArg: 1.33 ± 0.033	1.106HisSer: 1.106 ± 0.028	1.125HisThr: 1.125 ± 0.031	1.798HisVal: 1.798 ± 0.037	0.253HisTrp: 0.253 ± 0.012	0.598HisTyr: 0.598 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.151IleAla: 5.151 ± 0.066	0.347IleCys: 0.347 ± 0.015	4.2IleAsp: 4.2 ± 0.064	4.542IleGlu: 4.542 ± 0.061	1.387IlePhe: 1.387 ± 0.035	4.405IleGly: 4.405 ± 0.072	1.031IleHis: 1.031 ± 0.03	2.077IleIle: 2.077 ± 0.048	0.96IleLys: 0.96 ± 0.029	3.935IleLeu: 3.935 ± 0.063	0.634IleMet: 0.634 ± 0.022	1.318IleAsn: 1.318 ± 0.039	2.599IlePro: 2.599 ± 0.044	1.391IleGln: 1.391 ± 0.035	2.994IleArg: 2.994 ± 0.049	3.071IleSer: 3.071 ± 0.049	2.912IleThr: 2.912 ± 0.053	4.19IleVal: 4.19 ± 0.068	0.401IleTrp: 0.401 ± 0.02	1.081IleTyr: 1.081 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.254LysAla: 2.254 ± 0.047	0.168LysCys: 0.168 ± 0.013	1.348LysAsp: 1.348 ± 0.034	1.993LysGlu: 1.993 ± 0.048	0.823LysPhe: 0.823 ± 0.027	1.645LysGly: 1.645 ± 0.039	0.686LysHis: 0.686 ± 0.02	1.262LysIle: 1.262 ± 0.029	1.028LysLys: 1.028 ± 0.037	2.266LysLeu: 2.266 ± 0.045	0.6LysMet: 0.6 ± 0.021	1.028LysAsn: 1.028 ± 0.031	1.298LysPro: 1.298 ± 0.038	1.2LysGln: 1.2 ± 0.036	2.056LysArg: 2.056 ± 0.042	1.803LysSer: 1.803 ± 0.042	2.001LysThr: 2.001 ± 0.046	1.56LysVal: 1.56 ± 0.034	0.348LysTrp: 0.348 ± 0.018	0.888LysTyr: 0.888 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	9.426LeuAla: 9.426 ± 0.13	0.604LeuCys: 0.604 ± 0.026	6.694LeuAsp: 6.694 ± 0.101	6.181LeuGlu: 6.181 ± 0.08	3.607LeuPhe: 3.607 ± 0.065	7.293LeuGly: 7.293 ± 0.091	1.674LeuHis: 1.674 ± 0.031	3.518LeuIle: 3.518 ± 0.069	2.047LeuLys: 2.047 ± 0.043	8.696LeuLeu: 8.696 ± 0.122	1.488LeuMet: 1.488 ± 0.037	2.346LeuAsn: 2.346 ± 0.048	4.156LeuPro: 4.156 ± 0.065	2.476LeuGln: 2.476 ± 0.048	5.055LeuArg: 5.055 ± 0.068	6.459LeuSer: 6.459 ± 0.076	5.395LeuThr: 5.395 ± 0.072	7.925LeuVal: 7.925 ± 0.116	0.983LeuTrp: 0.983 ± 0.032	2.47LeuTyr: 2.47 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.983MetAla: 1.983 ± 0.037	0.131MetCys: 0.131 ± 0.012	1.273MetAsp: 1.273 ± 0.034	1.289MetGlu: 1.289 ± 0.034	0.61MetPhe: 0.61 ± 0.023	1.596MetGly: 1.596 ± 0.031	0.394MetHis: 0.394 ± 0.016	0.781MetIle: 0.781 ± 0.026	0.645MetLys: 0.645 ± 0.023	1.764MetLeu: 1.764 ± 0.038	0.405MetMet: 0.405 ± 0.02	0.877MetAsn: 0.877 ± 0.025	0.9MetPro: 0.9 ± 0.026	0.677MetGln: 0.677 ± 0.022	1.139MetArg: 1.139 ± 0.027	1.671MetSer: 1.671 ± 0.031	1.638MetThr: 1.638 ± 0.034	1.442MetVal: 1.442 ± 0.037	0.178MetTrp: 0.178 ± 0.012	0.466MetTyr: 0.466 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.976AsnAla: 2.976 ± 0.052	0.32AsnCys: 0.32 ± 0.016	2.196AsnAsp: 2.196 ± 0.042	2.481AsnGlu: 2.481 ± 0.048	0.882AsnPhe: 0.882 ± 0.025	2.596AsnGly: 2.596 ± 0.055	0.773AsnHis: 0.773 ± 0.024	1.394AsnIle: 1.394 ± 0.036	0.642AsnLys: 0.642 ± 0.027	2.617AsnLeu: 2.617 ± 0.042	0.577AsnMet: 0.577 ± 0.021	0.879AsnAsn: 0.879 ± 0.035	2.077AsnPro: 2.077 ± 0.046	1.035AsnGln: 1.035 ± 0.034	2.224AsnArg: 2.224 ± 0.043	1.672AsnSer: 1.672 ± 0.036	1.777AsnThr: 1.777 ± 0.043	2.762AsnVal: 2.762 ± 0.057	0.463AsnTrp: 0.463 ± 0.02	0.896AsnTyr: 0.896 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.673ProAla: 3.673 ± 0.058	0.3ProCys: 0.3 ± 0.016	4.081ProAsp: 4.081 ± 0.069	4.431ProGlu: 4.431 ± 0.065	1.645ProPhe: 1.645 ± 0.034	3.278ProGly: 3.278 ± 0.056	0.935ProHis: 0.935 ± 0.026	2.159ProIle: 2.159 ± 0.039	1.305ProLys: 1.305 ± 0.033	3.632ProLeu: 3.632 ± 0.061	0.893ProMet: 0.893 ± 0.026	1.603ProAsn: 1.603 ± 0.037	2.013ProPro: 2.013 ± 0.044	1.174ProGln: 1.174 ± 0.028	2.106ProArg: 2.106 ± 0.04	2.651ProSer: 2.651 ± 0.042	3.179ProThr: 3.179 ± 0.056	3.62ProVal: 3.62 ± 0.063	0.527ProTrp: 0.527 ± 0.02	1.158ProTyr: 1.158 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.543GlnAla: 2.543 ± 0.052	0.201GlnCys: 0.201 ± 0.012	1.448GlnAsp: 1.448 ± 0.04	1.943GlnGlu: 1.943 ± 0.043	1.358GlnPhe: 1.358 ± 0.029	1.8GlnGly: 1.8 ± 0.038	0.683GlnHis: 0.683 ± 0.026	1.459GlnIle: 1.459 ± 0.037	0.89GlnLys: 0.89 ± 0.031	2.605GlnLeu: 2.605 ± 0.049	0.711GlnMet: 0.711 ± 0.024	1.199GlnAsn: 1.199 ± 0.042	1.234GlnPro: 1.234 ± 0.03	1.412GlnGln: 1.412 ± 0.042	2.044GlnArg: 2.044 ± 0.043	2.202GlnSer: 2.202 ± 0.05	2.146GlnThr: 2.146 ± 0.055	2.036GlnVal: 2.036 ± 0.042	0.475GlnTrp: 0.475 ± 0.02	1.087GlnTyr: 1.087 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.119ArgAla: 5.119 ± 0.076	0.513ArgCys: 0.513 ± 0.024	4.439ArgAsp: 4.439 ± 0.059	6.03ArgGlu: 6.03 ± 0.079	2.303ArgPhe: 2.303 ± 0.045	4.061ArgGly: 4.061 ± 0.069	1.163ArgHis: 1.163 ± 0.03	3.228ArgIle: 3.228 ± 0.056	2.025ArgLys: 2.025 ± 0.042	5.186ArgLeu: 5.186 ± 0.075	1.402ArgMet: 1.402 ± 0.03	2.179ArgAsn: 2.179 ± 0.044	2.258ArgPro: 2.258 ± 0.046	1.862ArgGln: 1.862 ± 0.044	4.108ArgArg: 4.108 ± 0.064	3.267ArgSer: 3.267 ± 0.059	3.834ArgThr: 3.834 ± 0.061	4.589ArgVal: 4.589 ± 0.069	0.744ArgTrp: 0.744 ± 0.026	1.895ArgTyr: 1.895 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.845SerAla: 5.845 ± 0.064	0.426SerCys: 0.426 ± 0.021	4.754SerAsp: 4.754 ± 0.072	4.917SerGlu: 4.917 ± 0.069	2.363SerPhe: 2.363 ± 0.042	5.852SerGly: 5.852 ± 0.078	1.262SerHis: 1.262 ± 0.03	2.982SerIle: 2.982 ± 0.05	1.819SerLys: 1.819 ± 0.041	5.544SerLeu: 5.544 ± 0.068	1.315SerMet: 1.315 ± 0.031	2.105SerAsn: 2.105 ± 0.039	2.805SerPro: 2.805 ± 0.047	1.765SerGln: 1.765 ± 0.043	3.433SerArg: 3.433 ± 0.063	3.85SerSer: 3.85 ± 0.066	3.729SerThr: 3.729 ± 0.058	5.311SerVal: 5.311 ± 0.066	0.778SerTrp: 0.778 ± 0.026	1.635SerTyr: 1.635 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.364ThrAla: 6.364 ± 0.083	0.421ThrCys: 0.421 ± 0.018	5.056ThrAsp: 5.056 ± 0.068	5.05ThrGlu: 5.05 ± 0.069	2.29ThrPhe: 2.29 ± 0.041	5.408ThrGly: 5.408 ± 0.074	1.302ThrHis: 1.302 ± 0.032	3.548ThrIle: 3.548 ± 0.055	1.677ThrLys: 1.677 ± 0.036	5.895ThrLeu: 5.895 ± 0.075	1.252ThrMet: 1.252 ± 0.029	2.083ThrAsn: 2.083 ± 0.045	3.244ThrPro: 3.244 ± 0.059	1.739ThrGln: 1.739 ± 0.038	3.211ThrArg: 3.211 ± 0.052	3.397ThrSer: 3.397 ± 0.048	5.157ThrThr: 5.157 ± 0.114	6.458ThrVal: 6.458 ± 0.079	0.662ThrTrp: 0.662 ± 0.024	1.726ThrTyr: 1.726 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.316ValAla: 8.316 ± 0.091	0.657ValCys: 0.657 ± 0.024	5.127ValAsp: 5.127 ± 0.07	7.417ValGlu: 7.417 ± 0.084	3.282ValPhe: 3.282 ± 0.062	7.246ValGly: 7.246 ± 0.084	1.642ValHis: 1.642 ± 0.035	3.735ValIle: 3.735 ± 0.061	1.865ValLys: 1.865 ± 0.046	7.772ValLeu: 7.772 ± 0.106	1.435ValMet: 1.435 ± 0.034	2.315ValAsn: 2.315 ± 0.042	3.759ValPro: 3.759 ± 0.063	2.168ValGln: 2.168 ± 0.044	4.922ValArg: 4.922 ± 0.058	5.672ValSer: 5.672 ± 0.072	5.786ValThr: 5.786 ± 0.073	7.943ValVal: 7.943 ± 0.097	0.872ValTrp: 0.872 ± 0.029	2.121ValTyr: 2.121 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.853TrpAla: 0.853 ± 0.03	0.108TrpCys: 0.108 ± 0.009	0.772TrpAsp: 0.772 ± 0.027	0.94TrpGlu: 0.94 ± 0.025	0.565TrpPhe: 0.565 ± 0.019	0.909TrpGly: 0.909 ± 0.025	0.274TrpHis: 0.274 ± 0.015	0.563TrpIle: 0.563 ± 0.022	0.464TrpLys: 0.464 ± 0.022	1.201TrpLeu: 1.201 ± 0.036	0.256TrpMet: 0.256 ± 0.014	0.527TrpAsn: 0.527 ± 0.02	0.486TrpPro: 0.486 ± 0.02	0.458TrpGln: 0.458 ± 0.016	0.828TrpArg: 0.828 ± 0.024	0.71TrpSer: 0.71 ± 0.026	0.767TrpThr: 0.767 ± 0.027	0.928TrpVal: 0.928 ± 0.029	0.233TrpTrp: 0.233 ± 0.014	0.391TrpTyr: 0.391 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.565TyrAla: 2.565 ± 0.049	0.252TyrCys: 0.252 ± 0.014	2.635TyrAsp: 2.635 ± 0.05	2.429TyrGlu: 2.429 ± 0.046	1.079TyrPhe: 1.079 ± 0.025	2.317TyrGly: 2.317 ± 0.043	0.722TyrHis: 0.722 ± 0.025	1.089TyrIle: 1.089 ± 0.029	0.546TyrLys: 0.546 ± 0.023	2.692TyrLeu: 2.692 ± 0.051	0.424TyrMet: 0.424 ± 0.017	0.805TyrAsn: 0.805 ± 0.025	1.325TyrPro: 1.325 ± 0.032	0.845TyrGln: 0.845 ± 0.025	1.987TyrArg: 1.987 ± 0.041	1.624TyrSer: 1.624 ± 0.045	1.609TyrThr: 1.609 ± 0.034	2.189TyrVal: 2.189 ± 0.044	0.39TyrTrp: 0.39 ± 0.018	0.943TyrTyr: 0.943 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4885 proteins (1295187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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