Amino acid dipepetide frequency for Emmonsia sp. CAC-2015a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.278AlaAla: 8.278 ± 0.067	0.912AlaCys: 0.912 ± 0.018	3.929AlaAsp: 3.929 ± 0.037	4.947AlaGlu: 4.947 ± 0.044	2.805AlaPhe: 2.805 ± 0.029	5.452AlaGly: 5.452 ± 0.044	1.674AlaHis: 1.674 ± 0.021	4.077AlaIle: 4.077 ± 0.034	3.988AlaLys: 3.988 ± 0.037	7.144AlaLeu: 7.144 ± 0.05	1.716AlaMet: 1.716 ± 0.022	2.914AlaAsn: 2.914 ± 0.028	4.406AlaPro: 4.406 ± 0.041	3.117AlaGln: 3.117 ± 0.03	4.726AlaArg: 4.726 ± 0.036	6.948AlaSer: 6.948 ± 0.046	5.087AlaThr: 5.087 ± 0.036	4.852AlaVal: 4.852 ± 0.037	0.925AlaTrp: 0.925 ± 0.018	1.89AlaTyr: 1.89 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.845CysAla: 0.845 ± 0.015	0.23CysCys: 0.23 ± 0.009	0.621CysAsp: 0.621 ± 0.012	0.612CysGlu: 0.612 ± 0.012	0.502CysPhe: 0.502 ± 0.013	0.876CysGly: 0.876 ± 0.019	0.33CysHis: 0.33 ± 0.009	0.66CysIle: 0.66 ± 0.013	0.52CysLys: 0.52 ± 0.014	1.2CysLeu: 1.2 ± 0.02	0.252CysMet: 0.252 ± 0.008	0.412CysAsn: 0.412 ± 0.013	0.68CysPro: 0.68 ± 0.018	0.454CysGln: 0.454 ± 0.011	0.739CysArg: 0.739 ± 0.015	0.922CysSer: 0.922 ± 0.018	0.627CysThr: 0.627 ± 0.014	0.73CysVal: 0.73 ± 0.015	0.182CysTrp: 0.182 ± 0.007	0.332CysTyr: 0.332 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.189AspAla: 4.189 ± 0.037	0.608AspCys: 0.608 ± 0.012	4.438AspAsp: 4.438 ± 0.061	4.471AspGlu: 4.471 ± 0.045	2.09AspPhe: 2.09 ± 0.025	4.056AspGly: 4.056 ± 0.038	1.235AspHis: 1.235 ± 0.02	3.386AspIle: 3.386 ± 0.03	2.409AspLys: 2.409 ± 0.028	4.882AspLeu: 4.882 ± 0.042	1.263AspMet: 1.263 ± 0.019	2.059AspAsn: 2.059 ± 0.022	3.354AspPro: 3.354 ± 0.032	1.805AspGln: 1.805 ± 0.023	3.119AspArg: 3.119 ± 0.038	4.236AspSer: 4.236 ± 0.036	2.909AspThr: 2.909 ± 0.027	3.472AspVal: 3.472 ± 0.038	0.761AspTrp: 0.761 ± 0.014	1.508AspTyr: 1.508 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	4.978GluAla: 4.978 ± 0.041	0.611GluCys: 0.611 ± 0.014	4.09GluAsp: 4.09 ± 0.037	5.572GluGlu: 5.572 ± 0.058	2.006GluPhe: 2.006 ± 0.022	3.779GluGly: 3.779 ± 0.034	1.398GluHis: 1.398 ± 0.016	3.248GluIle: 3.248 ± 0.031	3.886GluLys: 3.886 ± 0.036	5.306GluLeu: 5.306 ± 0.041	1.462GluMet: 1.462 ± 0.02	2.649GluAsn: 2.649 ± 0.029	2.868GluPro: 2.868 ± 0.043	2.491GluGln: 2.491 ± 0.028	4.1GluArg: 4.1 ± 0.036	4.4GluSer: 4.4 ± 0.039	3.416GluThr: 3.416 ± 0.03	3.415GluVal: 3.415 ± 0.031	0.835GluTrp: 0.835 ± 0.016	1.711GluTyr: 1.711 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.764PheAla: 2.764 ± 0.028	0.539PheCys: 0.539 ± 0.013	2.224PheAsp: 2.224 ± 0.027	2.148PheGlu: 2.148 ± 0.025	1.469PhePhe: 1.469 ± 0.023	2.676PheGly: 2.676 ± 0.03	0.926PheHis: 0.926 ± 0.014	1.78PheIle: 1.78 ± 0.023	1.549PheLys: 1.549 ± 0.021	3.395PheLeu: 3.395 ± 0.032	0.722PheMet: 0.722 ± 0.014	1.427PheAsn: 1.427 ± 0.019	2.081PhePro: 2.081 ± 0.027	1.385PheGln: 1.385 ± 0.017	2.065PheArg: 2.065 ± 0.026	3.15PheSer: 3.15 ± 0.029	2.082PheThr: 2.082 ± 0.025	2.256PheVal: 2.256 ± 0.029	0.563PheTrp: 0.563 ± 0.014	1.055PheTyr: 1.055 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.892GlyAla: 4.892 ± 0.047	0.806GlyCys: 0.806 ± 0.017	3.747GlyAsp: 3.747 ± 0.031	3.856GlyGlu: 3.856 ± 0.039	2.609GlyPhe: 2.609 ± 0.03	6.136GlyGly: 6.136 ± 0.073	1.612GlyHis: 1.612 ± 0.027	3.517GlyIle: 3.517 ± 0.035	3.587GlyLys: 3.587 ± 0.035	5.565GlyLeu: 5.565 ± 0.042	1.592GlyMet: 1.592 ± 0.021	2.748GlyAsn: 2.748 ± 0.03	3.229GlyPro: 3.229 ± 0.033	2.449GlyGln: 2.449 ± 0.027	4.165GlyArg: 4.165 ± 0.037	5.795GlySer: 5.795 ± 0.049	3.769GlyThr: 3.769 ± 0.032	4.207GlyVal: 4.207 ± 0.043	1.064GlyTrp: 1.064 ± 0.018	2.008GlyTyr: 2.008 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.769HisAla: 1.769 ± 0.024	0.327HisCys: 0.327 ± 0.01	1.322HisAsp: 1.322 ± 0.021	1.311HisGlu: 1.311 ± 0.02	0.925HisPhe: 0.925 ± 0.018	1.663HisGly: 1.663 ± 0.021	0.999HisHis: 0.999 ± 0.02	1.309HisIle: 1.309 ± 0.02	0.924HisLys: 0.924 ± 0.015	2.314HisLeu: 2.314 ± 0.024	0.483HisMet: 0.483 ± 0.01	0.953HisAsn: 0.953 ± 0.017	1.866HisPro: 1.866 ± 0.023	1.137HisGln: 1.137 ± 0.021	1.609HisArg: 1.609 ± 0.02	2.102HisSer: 2.102 ± 0.025	1.333HisThr: 1.333 ± 0.019	1.352HisVal: 1.352 ± 0.021	0.293HisTrp: 0.293 ± 0.01	0.668HisTyr: 0.668 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.931IleAla: 3.931 ± 0.034	0.758IleCys: 0.758 ± 0.014	2.968IleAsp: 2.968 ± 0.023	2.922IleGlu: 2.922 ± 0.031	2.106IlePhe: 2.106 ± 0.028	3.064IleGly: 3.064 ± 0.031	1.318IleHis: 1.318 ± 0.019	2.677IleIle: 2.677 ± 0.033	2.282IleLys: 2.282 ± 0.025	4.857IleLeu: 4.857 ± 0.037	1.006IleMet: 1.006 ± 0.016	1.967IleAsn: 1.967 ± 0.023	3.413IlePro: 3.413 ± 0.029	1.971IleGln: 1.971 ± 0.022	2.988IleArg: 2.988 ± 0.03	4.544IleSer: 4.544 ± 0.042	2.89IleThr: 2.89 ± 0.028	3.046IleVal: 3.046 ± 0.033	0.688IleTrp: 0.688 ± 0.015	1.453IleTyr: 1.453 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.957LysAla: 3.957 ± 0.038	0.52LysCys: 0.52 ± 0.012	2.686LysAsp: 2.686 ± 0.028	3.479LysGlu: 3.479 ± 0.036	1.614LysPhe: 1.614 ± 0.021	3.093LysGly: 3.093 ± 0.029	1.188LysHis: 1.188 ± 0.019	2.532LysIle: 2.532 ± 0.026	3.473LysLys: 3.473 ± 0.054	4.392LysLeu: 4.392 ± 0.033	1.055LysMet: 1.055 ± 0.017	1.965LysAsn: 1.965 ± 0.02	3.01LysPro: 3.01 ± 0.029	2.032LysGln: 2.032 ± 0.026	3.77LysArg: 3.77 ± 0.04	3.838LysSer: 3.838 ± 0.032	2.747LysThr: 2.747 ± 0.025	2.761LysVal: 2.761 ± 0.031	0.652LysTrp: 0.652 ± 0.014	1.455LysTyr: 1.455 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.276LeuAla: 7.276 ± 0.047	1.155LeuCys: 1.155 ± 0.021	5.057LeuAsp: 5.057 ± 0.04	5.589LeuGlu: 5.589 ± 0.049	3.283LeuPhe: 3.283 ± 0.035	5.598LeuGly: 5.598 ± 0.041	2.267LeuHis: 2.267 ± 0.025	4.017LeuIle: 4.017 ± 0.043	4.507LeuLys: 4.507 ± 0.04	8.355LeuLeu: 8.355 ± 0.06	1.693LeuMet: 1.693 ± 0.022	3.332LeuAsn: 3.332 ± 0.031	5.632LeuPro: 5.632 ± 0.036	3.809LeuGln: 3.809 ± 0.039	5.877LeuArg: 5.877 ± 0.049	7.717LeuSer: 7.717 ± 0.054	4.744LeuThr: 4.744 ± 0.037	5.05LeuVal: 5.05 ± 0.036	1.068LeuTrp: 1.068 ± 0.022	2.267LeuTyr: 2.267 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.061MetAla: 2.061 ± 0.024	0.234MetCys: 0.234 ± 0.008	1.23MetAsp: 1.23 ± 0.018	1.362MetGlu: 1.362 ± 0.019	0.698MetPhe: 0.698 ± 0.013	1.402MetGly: 1.402 ± 0.024	0.434MetHis: 0.434 ± 0.01	1.003MetIle: 1.003 ± 0.015	1.078MetLys: 1.078 ± 0.017	1.743MetLeu: 1.743 ± 0.022	0.546MetMet: 0.546 ± 0.014	0.832MetAsn: 0.832 ± 0.016	1.193MetPro: 1.193 ± 0.017	0.809MetGln: 0.809 ± 0.014	1.218MetArg: 1.218 ± 0.02	1.791MetSer: 1.791 ± 0.02	1.218MetThr: 1.218 ± 0.018	1.237MetVal: 1.237 ± 0.022	0.243MetTrp: 0.243 ± 0.008	0.471MetTyr: 0.471 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.047AsnAla: 3.047 ± 0.026	0.471AsnCys: 0.471 ± 0.011	2.179AsnAsp: 2.179 ± 0.023	2.261AsnGlu: 2.261 ± 0.024	1.434AsnPhe: 1.434 ± 0.021	3.098AsnGly: 3.098 ± 0.036	0.994AsnHis: 0.994 ± 0.017	2.335AsnIle: 2.335 ± 0.027	1.739AsnLys: 1.739 ± 0.021	3.463AsnLeu: 3.463 ± 0.037	0.874AsnMet: 0.874 ± 0.015	2.166AsnAsn: 2.166 ± 0.039	2.76AsnPro: 2.76 ± 0.035	1.472AsnGln: 1.472 ± 0.02	2.196AsnArg: 2.196 ± 0.023	3.263AsnSer: 3.263 ± 0.03	2.334AsnThr: 2.334 ± 0.024	2.284AsnVal: 2.284 ± 0.028	0.489AsnTrp: 0.489 ± 0.01	1.045AsnTyr: 1.045 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.023ProAla: 5.023 ± 0.042	0.527ProCys: 0.527 ± 0.013	3.243ProAsp: 3.243 ± 0.03	3.807ProGlu: 3.807 ± 0.04	2.132ProPhe: 2.132 ± 0.027	3.914ProGly: 3.914 ± 0.035	1.518ProHis: 1.518 ± 0.021	2.781ProIle: 2.781 ± 0.028	2.804ProLys: 2.804 ± 0.027	5.047ProLeu: 5.047 ± 0.036	1.021ProMet: 1.021 ± 0.018	2.513ProAsn: 2.513 ± 0.03	6.098ProPro: 6.098 ± 0.083	2.763ProGln: 2.763 ± 0.035	3.562ProArg: 3.562 ± 0.041	6.812ProSer: 6.812 ± 0.059	4.349ProThr: 4.349 ± 0.045	3.437ProVal: 3.437 ± 0.031	0.665ProTrp: 0.665 ± 0.015	1.537ProTyr: 1.537 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.142GlnAla: 3.142 ± 0.033	0.416GlnCys: 0.416 ± 0.01	1.931GlnAsp: 1.931 ± 0.024	2.392GlnGlu: 2.392 ± 0.025	1.316GlnPhe: 1.316 ± 0.02	2.297GlnGly: 2.297 ± 0.029	1.219GlnHis: 1.219 ± 0.022	1.977GlnIle: 1.977 ± 0.02	2.156GlnLys: 2.156 ± 0.025	3.55GlnLeu: 3.55 ± 0.036	0.843GlnMet: 0.843 ± 0.017	1.737GlnAsn: 1.737 ± 0.023	2.829GlnPro: 2.829 ± 0.034	3.133GlnGln: 3.133 ± 0.084	2.749GlnArg: 2.749 ± 0.03	3.313GlnSer: 3.313 ± 0.03	2.33GlnThr: 2.33 ± 0.026	2.04GlnVal: 2.04 ± 0.022	0.475GlnTrp: 0.475 ± 0.012	1.104GlnTyr: 1.104 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.621ArgAla: 4.621 ± 0.034	0.738ArgCys: 0.738 ± 0.015	3.461ArgAsp: 3.461 ± 0.034	4.059ArgGlu: 4.059 ± 0.039	2.137ArgPhe: 2.137 ± 0.027	3.956ArgGly: 3.956 ± 0.045	1.623ArgHis: 1.623 ± 0.022	3.075ArgIle: 3.075 ± 0.03	3.775ArgLys: 3.775 ± 0.036	5.439ArgLeu: 5.439 ± 0.04	1.3ArgMet: 1.3 ± 0.022	2.54ArgAsn: 2.54 ± 0.028	3.616ArgPro: 3.616 ± 0.041	2.751ArgGln: 2.751 ± 0.029	5.456ArgArg: 5.456 ± 0.053	5.127ArgSer: 5.127 ± 0.047	3.335ArgThr: 3.335 ± 0.032	3.366ArgVal: 3.366 ± 0.028	0.859ArgTrp: 0.859 ± 0.016	1.702ArgTyr: 1.702 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.557SerAla: 6.557 ± 0.049	0.873SerCys: 0.873 ± 0.017	4.282SerAsp: 4.282 ± 0.038	4.219SerGlu: 4.219 ± 0.034	3.124SerPhe: 3.124 ± 0.03	5.739SerGly: 5.739 ± 0.043	2.202SerHis: 2.202 ± 0.025	4.259SerIle: 4.259 ± 0.035	4.093SerLys: 4.093 ± 0.038	7.576SerLeu: 7.576 ± 0.054	1.726SerMet: 1.726 ± 0.023	3.538SerAsn: 3.538 ± 0.038	6.416SerPro: 6.416 ± 0.059	3.532SerGln: 3.532 ± 0.034	5.546SerArg: 5.546 ± 0.044	10.377SerSer: 10.377 ± 0.097	6.022SerThr: 6.022 ± 0.051	4.499SerVal: 4.499 ± 0.036	1.053SerTrp: 1.053 ± 0.016	2.051SerTyr: 2.051 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.935ThrAla: 4.935 ± 0.03	0.707ThrCys: 0.707 ± 0.015	2.823ThrAsp: 2.823 ± 0.026	3.07ThrGlu: 3.07 ± 0.033	2.141ThrPhe: 2.141 ± 0.026	4.023ThrGly: 4.023 ± 0.037	1.346ThrHis: 1.346 ± 0.022	3.124ThrIle: 3.124 ± 0.034	2.668ThrLys: 2.668 ± 0.029	5.116ThrLeu: 5.116 ± 0.036	1.102ThrMet: 1.102 ± 0.016	2.303ThrAsn: 2.303 ± 0.028	4.57ThrPro: 4.57 ± 0.043	2.091ThrGln: 2.091 ± 0.026	3.233ThrArg: 3.233 ± 0.028	5.777ThrSer: 5.777 ± 0.052	4.77ThrThr: 4.77 ± 0.055	3.43ThrVal: 3.43 ± 0.031	0.7ThrTrp: 0.7 ± 0.012	1.488ThrTyr: 1.488 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.654ValAla: 4.654 ± 0.036	0.739ValCys: 0.739 ± 0.014	3.618ValAsp: 3.618 ± 0.032	3.841ValGlu: 3.841 ± 0.034	2.236ValPhe: 2.236 ± 0.026	3.842ValGly: 3.842 ± 0.041	1.317ValHis: 1.317 ± 0.017	2.953ValIle: 2.953 ± 0.033	2.921ValLys: 2.921 ± 0.028	5.184ValLeu: 5.184 ± 0.041	1.236ValMet: 1.236 ± 0.018	2.193ValAsn: 2.193 ± 0.025	3.431ValPro: 3.431 ± 0.028	2.163ValGln: 2.163 ± 0.022	3.345ValArg: 3.345 ± 0.03	4.536ValSer: 4.536 ± 0.033	3.234ValThr: 3.234 ± 0.031	3.971ValVal: 3.971 ± 0.034	0.754ValTrp: 0.754 ± 0.014	1.557ValTyr: 1.557 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.001TrpAla: 1.001 ± 0.019	0.17TrpCys: 0.17 ± 0.007	0.809TrpAsp: 0.809 ± 0.014	0.822TrpGlu: 0.822 ± 0.014	0.452TrpPhe: 0.452 ± 0.011	0.808TrpGly: 0.808 ± 0.015	0.313TrpHis: 0.313 ± 0.01	0.698TrpIle: 0.698 ± 0.015	0.776TrpLys: 0.776 ± 0.012	1.163TrpLeu: 1.163 ± 0.018	0.33TrpMet: 0.33 ± 0.009	0.574TrpAsn: 0.574 ± 0.012	0.53TrpPro: 0.53 ± 0.012	0.496TrpGln: 0.496 ± 0.011	0.893TrpArg: 0.893 ± 0.016	0.926TrpSer: 0.926 ± 0.016	0.747TrpThr: 0.747 ± 0.014	0.778TrpVal: 0.778 ± 0.016	0.236TrpTrp: 0.236 ± 0.009	0.355TrpTyr: 0.355 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.867TyrAla: 1.867 ± 0.022	0.382TyrCys: 0.382 ± 0.01	1.593TyrAsp: 1.593 ± 0.021	1.48TyrGlu: 1.48 ± 0.02	1.175TyrPhe: 1.175 ± 0.019	1.882TyrGly: 1.882 ± 0.025	0.747TyrHis: 0.747 ± 0.014	1.439TyrIle: 1.439 ± 0.019	1.086TyrLys: 1.086 ± 0.018	2.602TyrLeu: 2.602 ± 0.026	0.583TyrMet: 0.583 ± 0.013	1.081TyrAsn: 1.081 ± 0.016	1.572TyrPro: 1.572 ± 0.028	1.09TyrGln: 1.09 ± 0.017	1.583TyrArg: 1.583 ± 0.022	2.112TyrSer: 2.112 ± 0.028	1.471TyrThr: 1.471 ± 0.021	1.541TyrVal: 1.541 ± 0.022	0.372TyrTrp: 0.372 ± 0.01	0.881TyrTyr: 0.881 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8745 proteins (3939199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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