Amino acid dipepetide frequency for TM7 phylum sp. oral taxon 350

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.782AlaAla: 3.782 ± 0.224
0.431AlaCys: 0.431 ± 0.065
3.641AlaAsp: 3.641 ± 0.166
3.776AlaGlu: 3.776 ± 0.185
2.773AlaPhe: 2.773 ± 0.163
4.402AlaGly: 4.402 ± 0.221
1.036AlaHis: 1.036 ± 0.058
6.198AlaIle: 6.198 ± 0.215
6.75AlaLys: 6.75 ± 0.256
6.69AlaLeu: 6.69 ± 0.228
1.683AlaMet: 1.683 ± 0.107
3.432AlaAsn: 3.432 ± 0.159
1.918AlaPro: 1.918 ± 0.128
1.487AlaGln: 1.487 ± 0.11
2.881AlaArg: 2.881 ± 0.165
4.953AlaSer: 4.953 ± 0.182
3.459AlaThr: 3.459 ± 0.165
4.402AlaVal: 4.402 ± 0.219
0.505AlaTrp: 0.505 ± 0.066
2.322AlaTyr: 2.322 ± 0.121
0.0AlaXaa: 0.0 ± 0.0
Cys
0.397CysAla: 0.397 ± 0.09
0.047CysCys: 0.047 ± 0.018
0.417CysAsp: 0.417 ± 0.053
0.377CysGlu: 0.377 ± 0.05
0.242CysPhe: 0.242 ± 0.047
0.424CysGly: 0.424 ± 0.055
0.168CysHis: 0.168 ± 0.037
0.37CysIle: 0.37 ± 0.055
0.498CysLys: 0.498 ± 0.059
0.68CysLeu: 0.68 ± 0.069
0.054CysMet: 0.054 ± 0.019
0.357CysAsn: 0.357 ± 0.05
0.283CysPro: 0.283 ± 0.045
0.135CysGln: 0.135 ± 0.032
0.222CysArg: 0.222 ± 0.038
0.357CysSer: 0.357 ± 0.048
0.276CysThr: 0.276 ± 0.039
0.283CysVal: 0.283 ± 0.05
0.249CysTrp: 0.249 ± 0.143
0.31CysTyr: 0.31 ± 0.051
0.0CysXaa: 0.0 ± 0.0
Asp
3.284AspAla: 3.284 ± 0.165
0.33AspCys: 0.33 ± 0.048
3.405AspAsp: 3.405 ± 0.194
4.462AspGlu: 4.462 ± 0.18
3.062AspPhe: 3.062 ± 0.144
3.439AspGly: 3.439 ± 0.174
1.016AspHis: 1.016 ± 0.09
4.953AspIle: 4.953 ± 0.169
5.674AspLys: 5.674 ± 0.238
6.118AspLeu: 6.118 ± 0.254
1.124AspMet: 1.124 ± 0.089
3.23AspAsn: 3.23 ± 0.139
1.952AspPro: 1.952 ± 0.121
1.999AspGln: 1.999 ± 0.132
2.322AspArg: 2.322 ± 0.135
3.735AspSer: 3.735 ± 0.144
2.746AspThr: 2.746 ± 0.13
3.466AspVal: 3.466 ± 0.144
0.444AspTrp: 0.444 ± 0.057
2.645AspTyr: 2.645 ± 0.116
0.0AspXaa: 0.0 ± 0.0
Glu
5.216GluAla: 5.216 ± 0.228
0.316GluCys: 0.316 ± 0.047
4.402GluAsp: 4.402 ± 0.206
4.967GluGlu: 4.967 ± 0.253
2.228GluPhe: 2.228 ± 0.129
2.961GluGly: 2.961 ± 0.149
1.003GluHis: 1.003 ± 0.088
5.916GluIle: 5.916 ± 0.238
6.764GluLys: 6.764 ± 0.272
6.972GluLeu: 6.972 ± 0.28
1.481GluMet: 1.481 ± 0.1
3.843GluAsn: 3.843 ± 0.152
1.716GluPro: 1.716 ± 0.105
2.113GluGln: 2.113 ± 0.116
2.571GluArg: 2.571 ± 0.141
3.156GluSer: 3.156 ± 0.145
3.13GluThr: 3.13 ± 0.166
4.321GluVal: 4.321 ± 0.204
0.384GluTrp: 0.384 ± 0.051
2.14GluTyr: 2.14 ± 0.136
0.0GluXaa: 0.0 ± 0.0
Phe
2.685PheAla: 2.685 ± 0.169
0.377PheCys: 0.377 ± 0.048
2.382PheAsp: 2.382 ± 0.144
2.14PheGlu: 2.14 ± 0.113
1.992PhePhe: 1.992 ± 0.154
2.638PheGly: 2.638 ± 0.13
0.559PheHis: 0.559 ± 0.061
3.782PheIle: 3.782 ± 0.196
3.567PheLys: 3.567 ± 0.175
4.166PheLeu: 4.166 ± 0.23
1.003PheMet: 1.003 ± 0.091
2.477PheAsn: 2.477 ± 0.135
1.07PhePro: 1.07 ± 0.09
0.767PheGln: 0.767 ± 0.066
1.662PheArg: 1.662 ± 0.096
3.661PheSer: 3.661 ± 0.18
2.12PheThr: 2.12 ± 0.13
2.598PheVal: 2.598 ± 0.172
0.431PheTrp: 0.431 ± 0.052
1.615PheTyr: 1.615 ± 0.106
0.0PheXaa: 0.0 ± 0.0
Gly
4.099GlyAla: 4.099 ± 0.197
0.337GlyCys: 0.337 ± 0.049
3.103GlyAsp: 3.103 ± 0.158
3.607GlyGlu: 3.607 ± 0.174
2.78GlyPhe: 2.78 ± 0.154
4.2GlyGly: 4.2 ± 0.242
0.983GlyHis: 0.983 ± 0.086
4.778GlyIle: 4.778 ± 0.184
5.229GlyLys: 5.229 ± 0.236
5.68GlyLeu: 5.68 ± 0.215
1.346GlyMet: 1.346 ± 0.092
2.753GlyAsn: 2.753 ± 0.18
1.218GlyPro: 1.218 ± 0.094
1.925GlyGln: 1.925 ± 0.121
2.726GlyArg: 2.726 ± 0.16
4.227GlySer: 4.227 ± 0.241
3.533GlyThr: 3.533 ± 0.235
4.314GlyVal: 4.314 ± 0.193
0.545GlyTrp: 0.545 ± 0.067
2.463GlyTyr: 2.463 ± 0.134
0.0GlyXaa: 0.0 ± 0.0
His
0.942HisAla: 0.942 ± 0.074
0.121HisCys: 0.121 ± 0.027
0.969HisAsp: 0.969 ± 0.082
0.983HisGlu: 0.983 ± 0.094
0.68HisPhe: 0.68 ± 0.074
1.036HisGly: 1.036 ± 0.086
0.323HisHis: 0.323 ± 0.049
1.218HisIle: 1.218 ± 0.093
1.137HisLys: 1.137 ± 0.099
1.575HisLeu: 1.575 ± 0.102
0.377HisMet: 0.377 ± 0.053
0.781HisAsn: 0.781 ± 0.071
0.707HisPro: 0.707 ± 0.079
0.525HisGln: 0.525 ± 0.056
0.586HisArg: 0.586 ± 0.077
0.922HisSer: 0.922 ± 0.077
0.713HisThr: 0.713 ± 0.076
0.942HisVal: 0.942 ± 0.077
0.128HisTrp: 0.128 ± 0.03
0.458HisTyr: 0.458 ± 0.056
0.0HisXaa: 0.0 ± 0.0
Ile
6.38IleAla: 6.38 ± 0.264
0.565IleCys: 0.565 ± 0.068
5.31IleAsp: 5.31 ± 0.203
5.236IleGlu: 5.236 ± 0.213
3.547IlePhe: 3.547 ± 0.213
5.088IleGly: 5.088 ± 0.214
1.063IleHis: 1.063 ± 0.092
6.892IleIle: 6.892 ± 0.278
7.645IleLys: 7.645 ± 0.263
8.002IleLeu: 8.002 ± 0.29
1.494IleMet: 1.494 ± 0.104
5.061IleAsn: 5.061 ± 0.187
2.773IlePro: 2.773 ± 0.162
1.918IleGln: 1.918 ± 0.112
3.365IleArg: 3.365 ± 0.152
6.212IleSer: 6.212 ± 0.2
4.805IleThr: 4.805 ± 0.204
5.418IleVal: 5.418 ± 0.198
0.498IleTrp: 0.498 ± 0.063
2.773IleTyr: 2.773 ± 0.129
0.0IleXaa: 0.0 ± 0.0
Lys
5.7LysAla: 5.7 ± 0.222
0.33LysCys: 0.33 ± 0.049
6.643LysAsp: 6.643 ± 0.267
8.278LysGlu: 8.278 ± 0.336
2.409LysPhe: 2.409 ± 0.124
3.829LysGly: 3.829 ± 0.161
1.312LysHis: 1.312 ± 0.103
7.484LysIle: 7.484 ± 0.275
9.51LysLys: 9.51 ± 0.415
7.76LysLeu: 7.76 ± 0.27
2.187LysMet: 2.187 ± 0.12
6.293LysAsn: 6.293 ± 0.248
2.531LysPro: 2.531 ± 0.156
3.224LysGln: 3.224 ± 0.168
4.341LysArg: 4.341 ± 0.196
5.209LysSer: 5.209 ± 0.205
5.647LysThr: 5.647 ± 0.234
5.694LysVal: 5.694 ± 0.166
0.592LysTrp: 0.592 ± 0.063
3.224LysTyr: 3.224 ± 0.158
0.0LysXaa: 0.0 ± 0.0
Leu
7.349LeuAla: 7.349 ± 0.248
0.559LeuCys: 0.559 ± 0.063
6.118LeuAsp: 6.118 ± 0.233
6.158LeuGlu: 6.158 ± 0.27
3.897LeuPhe: 3.897 ± 0.194
5.727LeuGly: 5.727 ± 0.234
1.306LeuHis: 1.306 ± 0.097
8.332LeuIle: 8.332 ± 0.36
8.965LeuLys: 8.965 ± 0.319
8.978LeuLeu: 8.978 ± 0.357
2.187LeuMet: 2.187 ± 0.121
5.303LeuAsn: 5.303 ± 0.189
3.749LeuPro: 3.749 ± 0.145
2.221LeuGln: 2.221 ± 0.124
3.803LeuArg: 3.803 ± 0.174
7.679LeuSer: 7.679 ± 0.237
5.048LeuThr: 5.048 ± 0.154
6.158LeuVal: 6.158 ± 0.219
0.666LeuTrp: 0.666 ± 0.079
2.766LeuTyr: 2.766 ± 0.122
0.0LeuXaa: 0.0 ± 0.0
Met
1.709MetAla: 1.709 ± 0.114
0.094MetCys: 0.094 ± 0.025
1.09MetAsp: 1.09 ± 0.098
1.104MetGlu: 1.104 ± 0.091
0.828MetPhe: 0.828 ± 0.073
1.144MetGly: 1.144 ± 0.082
0.35MetHis: 0.35 ± 0.049
1.81MetIle: 1.81 ± 0.134
1.804MetLys: 1.804 ± 0.1
1.925MetLeu: 1.925 ± 0.112
0.552MetMet: 0.552 ± 0.067
1.312MetAsn: 1.312 ± 0.099
1.03MetPro: 1.03 ± 0.092
0.942MetGln: 0.942 ± 0.082
1.117MetArg: 1.117 ± 0.084
1.878MetSer: 1.878 ± 0.12
1.245MetThr: 1.245 ± 0.096
1.413MetVal: 1.413 ± 0.106
0.128MetTrp: 0.128 ± 0.031
0.545MetTyr: 0.545 ± 0.064
0.0MetXaa: 0.0 ± 0.0
Asn
3.103AsnAla: 3.103 ± 0.162
0.39AsnCys: 0.39 ± 0.053
2.611AsnAsp: 2.611 ± 0.154
3.405AsnGlu: 3.405 ± 0.159
2.403AsnPhe: 2.403 ± 0.132
3.52AsnGly: 3.52 ± 0.194
0.787AsnHis: 0.787 ± 0.071
4.778AsnIle: 4.778 ± 0.224
5.391AsnLys: 5.391 ± 0.209
5.795AsnLeu: 5.795 ± 0.214
1.326AsnMet: 1.326 ± 0.1
3.823AsnAsn: 3.823 ± 0.171
2.382AsnPro: 2.382 ± 0.137
2.093AsnGln: 2.093 ± 0.142
2.47AsnArg: 2.47 ± 0.142
3.668AsnSer: 3.668 ± 0.181
2.759AsnThr: 2.759 ± 0.157
3.52AsnVal: 3.52 ± 0.151
0.397AsnTrp: 0.397 ± 0.052
2.14AsnTyr: 2.14 ± 0.133
0.0AsnXaa: 0.0 ± 0.0
Pro
2.08ProAla: 2.08 ± 0.142
0.141ProCys: 0.141 ± 0.031
2.073ProAsp: 2.073 ± 0.122
2.537ProGlu: 2.537 ± 0.139
1.521ProPhe: 1.521 ± 0.101
1.575ProGly: 1.575 ± 0.112
0.572ProHis: 0.572 ± 0.06
2.483ProIle: 2.483 ± 0.138
3.224ProLys: 3.224 ± 0.156
2.584ProLeu: 2.584 ± 0.126
0.673ProMet: 0.673 ± 0.073
1.992ProAsn: 1.992 ± 0.118
0.781ProPro: 0.781 ± 0.089
0.942ProGln: 0.942 ± 0.104
1.265ProArg: 1.265 ± 0.089
2.403ProSer: 2.403 ± 0.119
2.066ProThr: 2.066 ± 0.122
2.255ProVal: 2.255 ± 0.148
0.303ProTrp: 0.303 ± 0.047
1.185ProTyr: 1.185 ± 0.088
0.0ProXaa: 0.0 ± 0.0
Gln
2.194GlnAla: 2.194 ± 0.16
0.114GlnCys: 0.114 ± 0.033
1.575GlnAsp: 1.575 ± 0.121
2.147GlnGlu: 2.147 ± 0.13
1.057GlnPhe: 1.057 ± 0.091
1.548GlnGly: 1.548 ± 0.108
0.431GlnHis: 0.431 ± 0.063
2.551GlnIle: 2.551 ± 0.124
2.981GlnLys: 2.981 ± 0.137
2.894GlnLeu: 2.894 ± 0.15
0.707GlnMet: 0.707 ± 0.059
1.669GlnAsn: 1.669 ± 0.131
0.996GlnPro: 0.996 ± 0.125
0.929GlnGln: 0.929 ± 0.115
1.225GlnArg: 1.225 ± 0.102
1.494GlnSer: 1.494 ± 0.134
1.582GlnThr: 1.582 ± 0.127
1.985GlnVal: 1.985 ± 0.139
0.222GlnTrp: 0.222 ± 0.038
0.996GlnTyr: 0.996 ± 0.093
0.0GlnXaa: 0.0 ± 0.0
Arg
2.719ArgAla: 2.719 ± 0.147
0.175ArgCys: 0.175 ± 0.027
2.611ArgAsp: 2.611 ± 0.126
2.753ArgGlu: 2.753 ± 0.154
1.871ArgPhe: 1.871 ± 0.125
2.376ArgGly: 2.376 ± 0.159
0.612ArgHis: 0.612 ± 0.063
3.345ArgIle: 3.345 ± 0.169
3.803ArgLys: 3.803 ± 0.184
4.011ArgLeu: 4.011 ± 0.181
1.124ArgMet: 1.124 ± 0.096
1.985ArgAsn: 1.985 ± 0.116
1.561ArgPro: 1.561 ± 0.124
1.508ArgGln: 1.508 ± 0.102
2.207ArgArg: 2.207 ± 0.122
2.531ArgSer: 2.531 ± 0.142
1.952ArgThr: 1.952 ± 0.128
2.753ArgVal: 2.753 ± 0.148
0.269ArgTrp: 0.269 ± 0.047
1.703ArgTyr: 1.703 ± 0.098
0.0ArgXaa: 0.0 ± 0.0
Ser
3.984SerAla: 3.984 ± 0.186
0.498SerCys: 0.498 ± 0.07
4.132SerAsp: 4.132 ± 0.156
4.206SerGlu: 4.206 ± 0.208
3.237SerPhe: 3.237 ± 0.14
4.617SerGly: 4.617 ± 0.231
1.07SerHis: 1.07 ± 0.094
5.425SerIle: 5.425 ± 0.227
5.633SerLys: 5.633 ± 0.16
7.107SerLeu: 7.107 ± 0.266
1.44SerMet: 1.44 ± 0.099
4.132SerAsn: 4.132 ± 0.203
1.911SerPro: 1.911 ± 0.101
2.228SerGln: 2.228 ± 0.135
2.739SerArg: 2.739 ± 0.143
5.324SerSer: 5.324 ± 0.178
3.52SerThr: 3.52 ± 0.184
4.078SerVal: 4.078 ± 0.172
0.599SerTrp: 0.599 ± 0.084
2.773SerTyr: 2.773 ± 0.157
0.0SerXaa: 0.0 ± 0.0
Thr
3.217ThrAla: 3.217 ± 0.161
0.377ThrCys: 0.377 ± 0.068
2.833ThrAsp: 2.833 ± 0.157
2.941ThrGlu: 2.941 ± 0.147
2.409ThrPhe: 2.409 ± 0.147
3.944ThrGly: 3.944 ± 0.177
0.781ThrHis: 0.781 ± 0.069
4.731ThrIle: 4.731 ± 0.216
4.704ThrLys: 4.704 ± 0.184
5.068ThrLeu: 5.068 ± 0.163
0.962ThrMet: 0.962 ± 0.087
3.055ThrAsn: 3.055 ± 0.166
2.416ThrPro: 2.416 ± 0.154
1.198ThrGln: 1.198 ± 0.094
1.851ThrArg: 1.851 ± 0.122
3.614ThrSer: 3.614 ± 0.191
3.345ThrThr: 3.345 ± 0.215
3.459ThrVal: 3.459 ± 0.178
0.478ThrTrp: 0.478 ± 0.079
2.154ThrTyr: 2.154 ± 0.133
0.007ThrXaa: 0.007 ± 0.006
Val
5.027ValAla: 5.027 ± 0.196
0.397ValCys: 0.397 ± 0.051
3.479ValAsp: 3.479 ± 0.156
4.004ValGlu: 4.004 ± 0.18
2.806ValPhe: 2.806 ± 0.149
4.294ValGly: 4.294 ± 0.187
0.902ValHis: 0.902 ± 0.074
5.896ValIle: 5.896 ± 0.209
5.175ValLys: 5.175 ± 0.212
6.259ValLeu: 6.259 ± 0.215
1.467ValMet: 1.467 ± 0.103
3.17ValAsn: 3.17 ± 0.154
2.181ValPro: 2.181 ± 0.128
1.326ValGln: 1.326 ± 0.112
2.369ValArg: 2.369 ± 0.131
4.704ValSer: 4.704 ± 0.197
3.614ValThr: 3.614 ± 0.165
4.415ValVal: 4.415 ± 0.22
0.451ValTrp: 0.451 ± 0.062
2.019ValTyr: 2.019 ± 0.112
0.0ValXaa: 0.0 ± 0.0
Trp
0.451TrpAla: 0.451 ± 0.063
0.067TrpCys: 0.067 ± 0.022
0.363TrpAsp: 0.363 ± 0.055
0.296TrpGlu: 0.296 ± 0.049
0.337TrpPhe: 0.337 ± 0.049
0.761TrpGly: 0.761 ± 0.167
0.188TrpHis: 0.188 ± 0.036
0.586TrpIle: 0.586 ± 0.069
0.511TrpLys: 0.511 ± 0.055
0.855TrpLeu: 0.855 ± 0.088
0.188TrpMet: 0.188 ± 0.031
0.471TrpAsn: 0.471 ± 0.068
0.222TrpPro: 0.222 ± 0.041
0.471TrpGln: 0.471 ± 0.053
0.363TrpArg: 0.363 ± 0.05
0.458TrpSer: 0.458 ± 0.055
0.35TrpThr: 0.35 ± 0.048
0.35TrpVal: 0.35 ± 0.044
0.114TrpTrp: 0.114 ± 0.032
0.316TrpTyr: 0.316 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.201TyrAla: 2.201 ± 0.108
0.478TyrCys: 0.478 ± 0.14
2.248TyrAsp: 2.248 ± 0.134
2.221TyrGlu: 2.221 ± 0.126
1.615TyrPhe: 1.615 ± 0.117
2.322TyrGly: 2.322 ± 0.136
0.66TyrHis: 0.66 ± 0.078
2.524TyrIle: 2.524 ± 0.13
3.23TyrLys: 3.23 ± 0.141
3.85TyrLeu: 3.85 ± 0.175
0.646TyrMet: 0.646 ± 0.063
1.622TyrAsn: 1.622 ± 0.103
1.259TyrPro: 1.259 ± 0.099
1.346TyrGln: 1.346 ± 0.113
1.783TyrArg: 1.783 ± 0.125
2.47TyrSer: 2.47 ± 0.135
1.635TyrThr: 1.635 ± 0.119
2.133TyrVal: 2.133 ± 0.142
0.303TyrTrp: 0.303 ± 0.047
1.413TyrTyr: 1.413 ± 0.113
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.007XaaTrp: 0.007 ± 0.006
0.0XaaTyr: 0.0 ± 0.0
0.013XaaXaa: 0.013 ± 0.013
Statistics based on 481 proteins (148586 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski