Amino acid dipepetide frequency for Glarea lozoyensis (strain ATCC 20868 / MF5171)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.927AlaAla: 7.927 ± 0.05	1.03AlaCys: 1.03 ± 0.012	3.813AlaAsp: 3.813 ± 0.022	4.866AlaGlu: 4.866 ± 0.032	3.029AlaPhe: 3.029 ± 0.022	5.469AlaGly: 5.469 ± 0.035	1.611AlaHis: 1.611 ± 0.016	4.347AlaIle: 4.347 ± 0.031	4.281AlaLys: 4.281 ± 0.028	7.225AlaLeu: 7.225 ± 0.041	1.841AlaMet: 1.841 ± 0.017	3.04AlaAsn: 3.04 ± 0.024	4.424AlaPro: 4.424 ± 0.037	3.14AlaGln: 3.14 ± 0.024	4.361AlaArg: 4.361 ± 0.026	6.904AlaSer: 6.904 ± 0.039	5.196AlaThr: 5.196 ± 0.032	5.028AlaVal: 5.028 ± 0.031	1.078AlaTrp: 1.078 ± 0.015	2.088AlaTyr: 2.088 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.889CysAla: 0.889 ± 0.012	0.259CysCys: 0.259 ± 0.007	0.637CysAsp: 0.637 ± 0.011	0.64CysGlu: 0.64 ± 0.013	0.54CysPhe: 0.54 ± 0.009	0.977CysGly: 0.977 ± 0.016	0.316CysHis: 0.316 ± 0.008	0.709CysIle: 0.709 ± 0.013	0.607CysLys: 0.607 ± 0.012	1.195CysLeu: 1.195 ± 0.016	0.266CysMet: 0.266 ± 0.007	0.468CysAsn: 0.468 ± 0.009	0.66CysPro: 0.66 ± 0.012	0.448CysGln: 0.448 ± 0.009	0.697CysArg: 0.697 ± 0.013	0.939CysSer: 0.939 ± 0.014	0.73CysThr: 0.73 ± 0.012	0.793CysVal: 0.793 ± 0.013	0.221CysTrp: 0.221 ± 0.006	0.378CysTyr: 0.378 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.265AspAla: 4.265 ± 0.028	0.657AspCys: 0.657 ± 0.011	3.953AspAsp: 3.953 ± 0.034	4.504AspGlu: 4.504 ± 0.035	2.3AspPhe: 2.3 ± 0.021	4.032AspGly: 4.032 ± 0.025	1.193AspHis: 1.193 ± 0.013	3.154AspIle: 3.154 ± 0.024	2.411AspLys: 2.411 ± 0.022	4.931AspLeu: 4.931 ± 0.033	1.266AspMet: 1.266 ± 0.015	1.963AspAsn: 1.963 ± 0.019	3.081AspPro: 3.081 ± 0.024	1.761AspGln: 1.761 ± 0.019	2.785AspArg: 2.785 ± 0.023	4.162AspSer: 4.162 ± 0.03	2.959AspThr: 2.959 ± 0.022	3.641AspVal: 3.641 ± 0.025	0.867AspTrp: 0.867 ± 0.013	1.585AspTyr: 1.585 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.083GluAla: 5.083 ± 0.036	0.654GluCys: 0.654 ± 0.011	4.335GluAsp: 4.335 ± 0.032	5.802GluGlu: 5.802 ± 0.05	2.091GluPhe: 2.091 ± 0.022	4.072GluGly: 4.072 ± 0.03	1.357GluHis: 1.357 ± 0.014	3.484GluIle: 3.484 ± 0.024	4.184GluLys: 4.184 ± 0.037	5.146GluLeu: 5.146 ± 0.038	1.582GluMet: 1.582 ± 0.017	2.646GluAsn: 2.646 ± 0.024	2.614GluPro: 2.614 ± 0.022	2.3GluGln: 2.3 ± 0.023	3.923GluArg: 3.923 ± 0.032	4.478GluSer: 4.478 ± 0.031	3.513GluThr: 3.513 ± 0.028	3.888GluVal: 3.888 ± 0.031	0.913GluTrp: 0.913 ± 0.013	1.724GluTyr: 1.724 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.992PheAla: 2.992 ± 0.022	0.585PheCys: 0.585 ± 0.011	2.315PheAsp: 2.315 ± 0.019	2.333PheGlu: 2.333 ± 0.02	1.58PhePhe: 1.58 ± 0.017	2.933PheGly: 2.933 ± 0.027	0.867PheHis: 0.867 ± 0.012	1.848PheIle: 1.848 ± 0.02	1.701PheLys: 1.701 ± 0.018	3.414PheLeu: 3.414 ± 0.028	0.799PheMet: 0.799 ± 0.01	1.542PheAsn: 1.542 ± 0.016	1.949PhePro: 1.949 ± 0.019	1.444PheGln: 1.444 ± 0.016	1.876PheArg: 1.876 ± 0.017	3.113PheSer: 3.113 ± 0.024	2.27PheThr: 2.27 ± 0.02	2.381PheVal: 2.381 ± 0.024	0.656PheTrp: 0.656 ± 0.012	1.111PheTyr: 1.111 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.937GlyAla: 4.937 ± 0.031	0.909GlyCys: 0.909 ± 0.012	3.561GlyAsp: 3.561 ± 0.025	3.855GlyGlu: 3.855 ± 0.029	2.884GlyPhe: 2.884 ± 0.025	6.076GlyGly: 6.076 ± 0.052	1.566GlyHis: 1.566 ± 0.018	3.68GlyIle: 3.68 ± 0.029	3.861GlyLys: 3.861 ± 0.03	5.907GlyLeu: 5.907 ± 0.033	1.689GlyMet: 1.689 ± 0.016	2.817GlyAsn: 2.817 ± 0.023	3.11GlyPro: 3.11 ± 0.024	2.333GlyGln: 2.333 ± 0.023	4.002GlyArg: 4.002 ± 0.027	5.696GlySer: 5.696 ± 0.036	4.021GlyThr: 4.021 ± 0.029	4.47GlyVal: 4.47 ± 0.031	1.178GlyTrp: 1.178 ± 0.016	2.14GlyTyr: 2.14 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.631HisAla: 1.631 ± 0.016	0.321HisCys: 0.321 ± 0.007	1.23HisAsp: 1.23 ± 0.012	1.312HisGlu: 1.312 ± 0.015	0.917HisPhe: 0.917 ± 0.011	1.594HisGly: 1.594 ± 0.018	0.772HisHis: 0.772 ± 0.014	1.217HisIle: 1.217 ± 0.014	0.992HisLys: 0.992 ± 0.014	2.103HisLeu: 2.103 ± 0.02	0.482HisMet: 0.482 ± 0.009	0.909HisAsn: 0.909 ± 0.013	1.534HisPro: 1.534 ± 0.018	0.947HisGln: 0.947 ± 0.011	1.365HisArg: 1.365 ± 0.016	1.834HisSer: 1.834 ± 0.018	1.304HisThr: 1.304 ± 0.016	1.31HisVal: 1.31 ± 0.017	0.328HisTrp: 0.328 ± 0.008	0.669HisTyr: 0.669 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.273IleAla: 4.273 ± 0.029	0.777IleCys: 0.777 ± 0.011	3.001IleAsp: 3.001 ± 0.022	3.162IleGlu: 3.162 ± 0.024	2.118IlePhe: 2.118 ± 0.022	3.314IleGly: 3.314 ± 0.03	1.231IleHis: 1.231 ± 0.012	2.775IleIle: 2.775 ± 0.025	2.498IleLys: 2.498 ± 0.021	4.78IleLeu: 4.78 ± 0.034	1.06IleMet: 1.06 ± 0.014	2.011IleAsn: 2.011 ± 0.017	3.261IlePro: 3.261 ± 0.024	2.007IleGln: 2.007 ± 0.02	2.761IleArg: 2.761 ± 0.021	4.335IleSer: 4.335 ± 0.028	3.141IleThr: 3.141 ± 0.024	3.228IleVal: 3.228 ± 0.024	0.776IleTrp: 0.776 ± 0.012	1.511IleTyr: 1.511 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.441LysAla: 4.441 ± 0.031	0.576LysCys: 0.576 ± 0.011	3.038LysAsp: 3.038 ± 0.024	3.795LysGlu: 3.795 ± 0.03	1.696LysPhe: 1.696 ± 0.016	3.31LysGly: 3.31 ± 0.024	1.2LysHis: 1.2 ± 0.014	2.699LysIle: 2.699 ± 0.024	3.838LysLys: 3.838 ± 0.038	4.352LysLeu: 4.352 ± 0.027	1.145LysMet: 1.145 ± 0.012	2.062LysAsn: 2.062 ± 0.02	2.899LysPro: 2.899 ± 0.028	1.903LysGln: 1.903 ± 0.021	3.521LysArg: 3.521 ± 0.027	4.216LysSer: 4.216 ± 0.035	3.224LysThr: 3.224 ± 0.024	3.116LysVal: 3.116 ± 0.025	0.747LysTrp: 0.747 ± 0.01	1.514LysTyr: 1.514 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.313LeuAla: 7.313 ± 0.04	1.177LeuCys: 1.177 ± 0.015	4.925LeuAsp: 4.925 ± 0.032	5.628LeuGlu: 5.628 ± 0.04	3.208LeuPhe: 3.208 ± 0.029	5.787LeuGly: 5.787 ± 0.034	2.073LeuHis: 2.073 ± 0.019	4.066LeuIle: 4.066 ± 0.03	4.591LeuLys: 4.591 ± 0.028	8.029LeuLeu: 8.029 ± 0.059	1.719LeuMet: 1.719 ± 0.018	3.303LeuAsn: 3.303 ± 0.02	5.37LeuPro: 5.37 ± 0.026	3.644LeuGln: 3.644 ± 0.03	5.261LeuArg: 5.261 ± 0.037	7.275LeuSer: 7.275 ± 0.038	4.895LeuThr: 4.895 ± 0.03	5.108LeuVal: 5.108 ± 0.033	1.167LeuTrp: 1.167 ± 0.017	2.275LeuTyr: 2.275 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.156MetAla: 2.156 ± 0.018	0.254MetCys: 0.254 ± 0.006	1.264MetAsp: 1.264 ± 0.014	1.356MetGlu: 1.356 ± 0.018	0.781MetPhe: 0.781 ± 0.011	1.519MetGly: 1.519 ± 0.018	0.446MetHis: 0.446 ± 0.008	1.096MetIle: 1.096 ± 0.014	1.162MetLys: 1.162 ± 0.015	1.775MetLeu: 1.775 ± 0.017	0.573MetMet: 0.573 ± 0.011	0.896MetAsn: 0.896 ± 0.013	1.198MetPro: 1.198 ± 0.014	0.816MetGln: 0.816 ± 0.01	1.24MetArg: 1.24 ± 0.014	1.962MetSer: 1.962 ± 0.02	1.294MetThr: 1.294 ± 0.014	1.299MetVal: 1.299 ± 0.015	0.273MetTrp: 0.273 ± 0.007	0.526MetTyr: 0.526 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.151AsnAla: 3.151 ± 0.024	0.502AsnCys: 0.502 ± 0.01	2.099AsnAsp: 2.099 ± 0.02	2.209AsnGlu: 2.209 ± 0.02	1.571AsnPhe: 1.571 ± 0.017	3.251AsnGly: 3.251 ± 0.031	0.934AsnHis: 0.934 ± 0.013	2.265AsnIle: 2.265 ± 0.017	1.749AsnLys: 1.749 ± 0.017	3.492AsnLeu: 3.492 ± 0.022	0.882AsnMet: 0.882 ± 0.013	1.707AsnAsn: 1.707 ± 0.021	2.617AsnPro: 2.617 ± 0.022	1.458AsnGln: 1.458 ± 0.016	1.976AsnArg: 1.976 ± 0.018	3.309AsnSer: 3.309 ± 0.03	2.577AsnThr: 2.577 ± 0.022	2.454AsnVal: 2.454 ± 0.019	0.595AsnTrp: 0.595 ± 0.01	1.141AsnTyr: 1.141 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.71ProAla: 4.71 ± 0.04	0.488ProCys: 0.488 ± 0.01	2.893ProAsp: 2.893 ± 0.024	3.679ProGlu: 3.679 ± 0.028	1.992ProPhe: 1.992 ± 0.02	3.645ProGly: 3.645 ± 0.033	1.241ProHis: 1.241 ± 0.017	2.764ProIle: 2.764 ± 0.023	3.004ProLys: 3.004 ± 0.026	4.602ProLeu: 4.602 ± 0.028	1.043ProMet: 1.043 ± 0.015	2.362ProAsn: 2.362 ± 0.022	4.905ProPro: 4.905 ± 0.065	2.449ProGln: 2.449 ± 0.025	3.139ProArg: 3.139 ± 0.026	5.882ProSer: 5.882 ± 0.043	4.188ProThr: 4.188 ± 0.037	3.438ProVal: 3.438 ± 0.025	0.699ProTrp: 0.699 ± 0.011	1.505ProTyr: 1.505 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.134GlnAla: 3.134 ± 0.026	0.43GlnCys: 0.43 ± 0.007	1.992GlnAsp: 1.992 ± 0.018	2.358GlnGlu: 2.358 ± 0.022	1.303GlnPhe: 1.303 ± 0.015	2.173GlnGly: 2.173 ± 0.018	0.995GlnHis: 0.995 ± 0.014	2.015GlnIle: 2.015 ± 0.017	2.192GlnLys: 2.192 ± 0.021	3.21GlnLeu: 3.21 ± 0.023	0.89GlnMet: 0.89 ± 0.015	1.805GlnAsn: 1.805 ± 0.018	2.324GlnPro: 2.324 ± 0.024	2.175GlnGln: 2.175 ± 0.037	2.394GlnArg: 2.394 ± 0.025	3.148GlnSer: 3.148 ± 0.025	2.385GlnThr: 2.385 ± 0.019	2.062GlnVal: 2.062 ± 0.018	0.53GlnTrp: 0.53 ± 0.008	1.192GlnTyr: 1.192 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.182ArgAla: 4.182 ± 0.027	0.663ArgCys: 0.663 ± 0.011	3.197ArgAsp: 3.197 ± 0.026	3.819ArgGlu: 3.819 ± 0.033	2.021ArgPhe: 2.021 ± 0.017	3.697ArgGly: 3.697 ± 0.031	1.366ArgHis: 1.366 ± 0.016	2.855ArgIle: 2.855 ± 0.024	3.589ArgLys: 3.589 ± 0.027	4.95ArgLeu: 4.95 ± 0.034	1.283ArgMet: 1.283 ± 0.013	2.403ArgAsn: 2.403 ± 0.022	3.125ArgPro: 3.125 ± 0.025	2.374ArgGln: 2.374 ± 0.024	4.506ArgArg: 4.506 ± 0.037	4.601ArgSer: 4.601 ± 0.042	3.179ArgThr: 3.179 ± 0.023	3.191ArgVal: 3.191 ± 0.024	0.848ArgTrp: 0.848 ± 0.013	1.569ArgTyr: 1.569 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.422SerAla: 6.422 ± 0.034	0.913SerCys: 0.913 ± 0.015	4.188SerAsp: 4.188 ± 0.034	4.455SerGlu: 4.455 ± 0.03	3.115SerPhe: 3.115 ± 0.021	5.506SerGly: 5.506 ± 0.034	1.939SerHis: 1.939 ± 0.018	4.339SerIle: 4.339 ± 0.026	4.36SerLys: 4.36 ± 0.032	7.096SerLeu: 7.096 ± 0.036	1.798SerMet: 1.798 ± 0.018	3.475SerAsn: 3.475 ± 0.028	5.534SerPro: 5.534 ± 0.052	3.398SerGln: 3.398 ± 0.027	4.869SerArg: 4.869 ± 0.037	9.296SerSer: 9.296 ± 0.076	6.151SerThr: 6.151 ± 0.045	4.67SerVal: 4.67 ± 0.035	1.132SerTrp: 1.132 ± 0.014	2.203SerTyr: 2.203 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.081ThrAla: 5.081 ± 0.03	0.786ThrCys: 0.786 ± 0.013	2.814ThrAsp: 2.814 ± 0.022	3.223ThrGlu: 3.223 ± 0.023	2.41ThrPhe: 2.41 ± 0.021	4.129ThrGly: 4.129 ± 0.03	1.316ThrHis: 1.316 ± 0.016	3.479ThrIle: 3.479 ± 0.027	2.99ThrLys: 2.99 ± 0.024	5.334ThrLeu: 5.334 ± 0.031	1.207ThrMet: 1.207 ± 0.013	2.364ThrAsn: 2.364 ± 0.02	4.571ThrPro: 4.571 ± 0.04	2.188ThrGln: 2.188 ± 0.02	3.136ThrArg: 3.136 ± 0.023	5.969ThrSer: 5.969 ± 0.044	4.807ThrThr: 4.807 ± 0.047	3.658ThrVal: 3.658 ± 0.029	0.851ThrTrp: 0.851 ± 0.012	1.695ThrTyr: 1.695 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.026ValAla: 5.026 ± 0.037	0.772ValCys: 0.772 ± 0.013	3.677ValAsp: 3.677 ± 0.025	4.219ValGlu: 4.219 ± 0.029	2.41ValPhe: 2.41 ± 0.024	4.153ValGly: 4.153 ± 0.027	1.262ValHis: 1.262 ± 0.015	2.977ValIle: 2.977 ± 0.023	3.209ValLys: 3.209 ± 0.024	5.395ValLeu: 5.395 ± 0.035	1.363ValMet: 1.363 ± 0.015	2.296ValAsn: 2.296 ± 0.02	3.413ValPro: 3.413 ± 0.023	2.223ValGln: 2.223 ± 0.02	3.176ValArg: 3.176 ± 0.023	4.561ValSer: 4.561 ± 0.03	3.509ValThr: 3.509 ± 0.025	4.42ValVal: 4.42 ± 0.036	0.883ValTrp: 0.883 ± 0.014	1.68ValTyr: 1.68 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.046TrpAla: 1.046 ± 0.014	0.192TrpCys: 0.192 ± 0.006	0.889TrpAsp: 0.889 ± 0.014	0.913TrpGlu: 0.913 ± 0.012	0.534TrpPhe: 0.534 ± 0.01	0.968TrpGly: 0.968 ± 0.016	0.342TrpHis: 0.342 ± 0.008	0.809TrpIle: 0.809 ± 0.012	0.869TrpLys: 0.869 ± 0.012	1.273TrpLeu: 1.273 ± 0.015	0.38TrpMet: 0.38 ± 0.007	0.669TrpAsn: 0.669 ± 0.011	0.566TrpPro: 0.566 ± 0.01	0.557TrpGln: 0.557 ± 0.009	0.902TrpArg: 0.902 ± 0.013	1.061TrpSer: 1.061 ± 0.013	0.902TrpThr: 0.902 ± 0.013	0.88TrpVal: 0.88 ± 0.014	0.271TrpTrp: 0.271 ± 0.007	0.429TrpTyr: 0.429 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.045TyrAla: 2.045 ± 0.018	0.424TyrCys: 0.424 ± 0.008	1.648TyrAsp: 1.648 ± 0.019	1.662TyrGlu: 1.662 ± 0.016	1.207TyrPhe: 1.207 ± 0.016	2.087TyrGly: 2.087 ± 0.023	0.744TyrHis: 0.744 ± 0.012	1.439TyrIle: 1.439 ± 0.018	1.205TyrLys: 1.205 ± 0.013	2.609TyrLeu: 2.609 ± 0.021	0.619TyrMet: 0.619 ± 0.01	1.199TyrAsn: 1.199 ± 0.015	1.474TyrPro: 1.474 ± 0.019	1.144TyrGln: 1.144 ± 0.014	1.528TyrArg: 1.528 ± 0.016	2.116TyrSer: 2.116 ± 0.021	1.762TyrThr: 1.762 ± 0.019	1.589TyrVal: 1.589 ± 0.019	0.438TyrTrp: 0.438 ± 0.01	0.922TyrTyr: 0.922 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13082 proteins (6275584 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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