Amino acid dipepetide frequency for Linderina pennispora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.121AlaAla: 11.121 ± 0.107	1.334AlaCys: 1.334 ± 0.021	5.12AlaAsp: 5.12 ± 0.044	5.417AlaGlu: 5.417 ± 0.055	3.035AlaPhe: 3.035 ± 0.03	6.305AlaGly: 6.305 ± 0.047	2.199AlaHis: 2.199 ± 0.025	4.487AlaIle: 4.487 ± 0.04	4.483AlaLys: 4.483 ± 0.048	8.482AlaLeu: 8.482 ± 0.057	2.615AlaMet: 2.615 ± 0.032	3.228AlaAsn: 3.228 ± 0.035	4.856AlaPro: 4.856 ± 0.093	3.949AlaGln: 3.949 ± 0.037	5.481AlaArg: 5.481 ± 0.043	7.532AlaSer: 7.532 ± 0.064	5.668AlaThr: 5.668 ± 0.051	6.446AlaVal: 6.446 ± 0.057	1.119AlaTrp: 1.119 ± 0.017	2.347AlaTyr: 2.347 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.269CysAla: 1.269 ± 0.023	0.401CysCys: 0.401 ± 0.016	0.735CysAsp: 0.735 ± 0.014	0.693CysGlu: 0.693 ± 0.016	0.566CysPhe: 0.566 ± 0.014	1.14CysGly: 1.14 ± 0.023	0.404CysHis: 0.404 ± 0.012	0.835CysIle: 0.835 ± 0.017	0.612CysLys: 0.612 ± 0.014	1.44CysLeu: 1.44 ± 0.024	0.448CysMet: 0.448 ± 0.011	0.49CysAsn: 0.49 ± 0.014	0.788CysPro: 0.788 ± 0.016	0.601CysGln: 0.601 ± 0.015	1.016CysArg: 1.016 ± 0.019	1.166CysSer: 1.166 ± 0.021	0.879CysThr: 0.879 ± 0.017	1.019CysVal: 1.019 ± 0.019	0.213CysTrp: 0.213 ± 0.009	0.402CysTyr: 0.402 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.987AspAla: 4.987 ± 0.046	0.695AspCys: 0.695 ± 0.018	4.07AspAsp: 4.07 ± 0.054	3.909AspGlu: 3.909 ± 0.043	2.015AspPhe: 2.015 ± 0.028	3.837AspGly: 3.837 ± 0.04	1.15AspHis: 1.15 ± 0.021	3.362AspIle: 3.362 ± 0.04	2.54AspLys: 2.54 ± 0.03	4.668AspLeu: 4.668 ± 0.04	1.638AspMet: 1.638 ± 0.022	1.954AspAsn: 1.954 ± 0.034	2.756AspPro: 2.756 ± 0.028	1.848AspGln: 1.848 ± 0.03	2.865AspArg: 2.865 ± 0.031	4.425AspSer: 4.425 ± 0.039	3.121AspThr: 3.121 ± 0.031	3.597AspVal: 3.597 ± 0.036	0.69AspTrp: 0.69 ± 0.016	1.631AspTyr: 1.631 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	4.806GluAla: 4.806 ± 0.05	0.758GluCys: 0.758 ± 0.016	3.314GluAsp: 3.314 ± 0.042	4.114GluGlu: 4.114 ± 0.069	2.232GluPhe: 2.232 ± 0.024	2.812GluGly: 2.812 ± 0.029	1.481GluHis: 1.481 ± 0.023	2.786GluIle: 2.786 ± 0.033	2.662GluLys: 2.662 ± 0.035	5.505GluLeu: 5.505 ± 0.056	1.509GluMet: 1.509 ± 0.028	1.834GluAsn: 1.834 ± 0.024	2.607GluPro: 2.607 ± 0.04	2.654GluGln: 2.654 ± 0.031	3.6GluArg: 3.6 ± 0.044	4.082GluSer: 4.082 ± 0.046	2.982GluThr: 2.982 ± 0.042	3.228GluVal: 3.228 ± 0.047	0.706GluTrp: 0.706 ± 0.014	1.757GluTyr: 1.757 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.457PheAla: 3.457 ± 0.032	0.633PheCys: 0.633 ± 0.014	2.269PheAsp: 2.269 ± 0.025	1.917PheGlu: 1.917 ± 0.026	1.484PhePhe: 1.484 ± 0.028	2.878PheGly: 2.878 ± 0.037	0.879PheHis: 0.879 ± 0.018	1.823PheIle: 1.823 ± 0.024	1.411PheLys: 1.411 ± 0.021	3.162PheLeu: 3.162 ± 0.036	0.918PheMet: 0.918 ± 0.017	1.417PheAsn: 1.417 ± 0.02	1.727PhePro: 1.727 ± 0.025	1.179PheGln: 1.179 ± 0.019	1.93PheArg: 1.93 ± 0.024	3.014PheSer: 3.014 ± 0.033	2.021PheThr: 2.021 ± 0.024	2.82PheVal: 2.82 ± 0.029	0.535PheTrp: 0.535 ± 0.014	1.192PheTyr: 1.192 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.386GlyAla: 5.386 ± 0.048	1.044GlyCys: 1.044 ± 0.02	3.529GlyAsp: 3.529 ± 0.034	3.308GlyGlu: 3.308 ± 0.038	2.639GlyPhe: 2.639 ± 0.032	5.073GlyGly: 5.073 ± 0.067	1.741GlyHis: 1.741 ± 0.023	3.557GlyIle: 3.557 ± 0.033	3.234GlyLys: 3.234 ± 0.033	5.49GlyLeu: 5.49 ± 0.044	1.794GlyMet: 1.794 ± 0.023	2.465GlyAsn: 2.465 ± 0.031	2.694GlyPro: 2.694 ± 0.044	2.516GlyGln: 2.516 ± 0.035	3.977GlyArg: 3.977 ± 0.047	5.898GlySer: 5.898 ± 0.05	3.75GlyThr: 3.75 ± 0.046	4.306GlyVal: 4.306 ± 0.036	0.951GlyTrp: 0.951 ± 0.016	2.165GlyTyr: 2.165 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.128HisAla: 2.128 ± 0.027	0.445HisCys: 0.445 ± 0.011	1.217HisAsp: 1.217 ± 0.019	1.138HisGlu: 1.138 ± 0.02	0.884HisPhe: 0.884 ± 0.014	1.817HisGly: 1.817 ± 0.023	0.882HisHis: 0.882 ± 0.025	1.43HisIle: 1.43 ± 0.02	0.938HisLys: 0.938 ± 0.017	2.193HisLeu: 2.193 ± 0.026	0.755HisMet: 0.755 ± 0.015	0.839HisAsn: 0.839 ± 0.016	1.471HisPro: 1.471 ± 0.021	1.078HisGln: 1.078 ± 0.023	1.689HisArg: 1.689 ± 0.024	1.996HisSer: 1.996 ± 0.026	1.509HisThr: 1.509 ± 0.023	1.766HisVal: 1.766 ± 0.023	0.369HisTrp: 0.369 ± 0.01	0.749HisTyr: 0.749 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.642IleAla: 4.642 ± 0.044	0.81IleCys: 0.81 ± 0.015	3.122IleAsp: 3.122 ± 0.034	2.882IleGlu: 2.882 ± 0.033	1.741IlePhe: 1.741 ± 0.025	3.395IleGly: 3.395 ± 0.04	1.186IleHis: 1.186 ± 0.017	2.364IleIle: 2.364 ± 0.026	2.125IleLys: 2.125 ± 0.028	4.194IleLeu: 4.194 ± 0.044	1.177IleMet: 1.177 ± 0.018	1.828IleAsn: 1.828 ± 0.03	2.659IlePro: 2.659 ± 0.027	1.784IleGln: 1.784 ± 0.025	2.839IleArg: 2.839 ± 0.029	3.968IleSer: 3.968 ± 0.041	2.694IleThr: 2.694 ± 0.034	3.391IleVal: 3.391 ± 0.035	0.548IleTrp: 0.548 ± 0.013	1.483IleTyr: 1.483 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.954LysAla: 3.954 ± 0.045	0.603LysCys: 0.603 ± 0.014	2.424LysAsp: 2.424 ± 0.029	2.666LysGlu: 2.666 ± 0.036	1.468LysPhe: 1.468 ± 0.022	2.413LysGly: 2.413 ± 0.031	1.255LysHis: 1.255 ± 0.021	2.014LysIle: 2.014 ± 0.026	2.6LysLys: 2.6 ± 0.049	3.985LysLeu: 3.985 ± 0.039	1.028LysMet: 1.028 ± 0.02	1.497LysAsn: 1.497 ± 0.023	2.499LysPro: 2.499 ± 0.034	2.086LysGln: 2.086 ± 0.03	3.216LysArg: 3.216 ± 0.033	3.058LysSer: 3.058 ± 0.032	2.462LysThr: 2.462 ± 0.025	2.751LysVal: 2.751 ± 0.034	0.581LysTrp: 0.581 ± 0.014	1.525LysTyr: 1.525 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	9.256LeuAla: 9.256 ± 0.058	1.52LeuCys: 1.52 ± 0.022	5.163LeuAsp: 5.163 ± 0.044	4.918LeuGlu: 4.918 ± 0.05	3.479LeuPhe: 3.479 ± 0.035	5.842LeuGly: 5.842 ± 0.052	2.363LeuHis: 2.363 ± 0.028	3.685LeuIle: 3.685 ± 0.038	3.827LeuLys: 3.827 ± 0.041	8.689LeuLeu: 8.689 ± 0.077	2.082LeuMet: 2.082 ± 0.024	2.974LeuAsn: 2.974 ± 0.033	5.149LeuPro: 5.149 ± 0.045	3.785LeuGln: 3.785 ± 0.03	5.858LeuArg: 5.858 ± 0.051	6.924LeuSer: 6.924 ± 0.047	4.859LeuThr: 4.859 ± 0.053	6.642LeuVal: 6.642 ± 0.057	1.08LeuTrp: 1.08 ± 0.019	2.465LeuTyr: 2.465 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.754MetAla: 2.754 ± 0.032	0.42MetCys: 0.42 ± 0.012	1.48MetAsp: 1.48 ± 0.022	1.241MetGlu: 1.241 ± 0.019	0.993MetPhe: 0.993 ± 0.017	1.534MetGly: 1.534 ± 0.023	0.747MetHis: 0.747 ± 0.014	0.958MetIle: 0.958 ± 0.017	0.913MetLys: 0.913 ± 0.017	2.523MetLeu: 2.523 ± 0.029	0.669MetMet: 0.669 ± 0.012	0.789MetAsn: 0.789 ± 0.014	1.597MetPro: 1.597 ± 0.026	1.221MetGln: 1.221 ± 0.021	1.77MetArg: 1.77 ± 0.023	2.171MetSer: 2.171 ± 0.026	1.388MetThr: 1.388 ± 0.021	1.74MetVal: 1.74 ± 0.024	0.321MetTrp: 0.321 ± 0.01	0.798MetTyr: 0.798 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.064AsnAla: 3.064 ± 0.03	0.47AsnCys: 0.47 ± 0.013	1.858AsnAsp: 1.858 ± 0.025	1.849AsnGlu: 1.849 ± 0.024	1.158AsnPhe: 1.158 ± 0.02	2.523AsnGly: 2.523 ± 0.034	0.736AsnHis: 0.736 ± 0.014	2.128AsnIle: 2.128 ± 0.025	1.538AsnLys: 1.538 ± 0.023	2.799AsnLeu: 2.799 ± 0.035	1.074AsnMet: 1.074 ± 0.016	1.311AsnAsn: 1.311 ± 0.023	2.02AsnPro: 2.02 ± 0.029	1.271AsnGln: 1.271 ± 0.024	1.884AsnArg: 1.884 ± 0.023	2.736AsnSer: 2.736 ± 0.029	2.173AsnThr: 2.173 ± 0.037	2.418AsnVal: 2.418 ± 0.045	0.449AsnTrp: 0.449 ± 0.012	1.09AsnTyr: 1.09 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	5.944ProAla: 5.944 ± 0.091	0.655ProCys: 0.655 ± 0.016	2.693ProAsp: 2.693 ± 0.025	3.281ProGlu: 3.281 ± 0.034	1.887ProPhe: 1.887 ± 0.026	3.572ProGly: 3.572 ± 0.041	1.295ProHis: 1.295 ± 0.024	2.263ProIle: 2.263 ± 0.026	2.22ProLys: 2.22 ± 0.028	4.488ProLeu: 4.488 ± 0.039	1.299ProMet: 1.299 ± 0.019	1.782ProAsn: 1.782 ± 0.024	3.747ProPro: 3.747 ± 0.059	2.241ProGln: 2.241 ± 0.034	2.993ProArg: 2.993 ± 0.031	4.495ProSer: 4.495 ± 0.05	3.477ProThr: 3.477 ± 0.042	4.031ProVal: 4.031 ± 0.045	0.602ProTrp: 0.602 ± 0.015	1.405ProTyr: 1.405 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.822GlnAla: 3.822 ± 0.046	0.598GlnCys: 0.598 ± 0.013	1.77GlnAsp: 1.77 ± 0.023	2.02GlnGlu: 2.02 ± 0.026	1.537GlnPhe: 1.537 ± 0.022	2.255GlnGly: 2.255 ± 0.027	1.311GlnHis: 1.311 ± 0.025	1.953GlnIle: 1.953 ± 0.024	1.741GlnLys: 1.741 ± 0.028	4.17GlnLeu: 4.17 ± 0.039	1.147GlnMet: 1.147 ± 0.02	1.259GlnAsn: 1.259 ± 0.017	2.518GlnPro: 2.518 ± 0.041	3.663GlnGln: 3.663 ± 0.093	3.071GlnArg: 3.071 ± 0.037	2.931GlnSer: 2.931 ± 0.038	2.276GlnThr: 2.276 ± 0.027	2.465GlnVal: 2.465 ± 0.032	0.614GlnTrp: 0.614 ± 0.012	1.311GlnTyr: 1.311 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	5.249ArgAla: 5.249 ± 0.044	0.933ArgCys: 0.933 ± 0.019	3.071ArgAsp: 3.071 ± 0.031	3.275ArgGlu: 3.275 ± 0.037	2.279ArgPhe: 2.279 ± 0.029	3.478ArgGly: 3.478 ± 0.041	1.77ArgHis: 1.77 ± 0.024	3.271ArgIle: 3.271 ± 0.031	2.911ArgLys: 2.911 ± 0.03	6.03ArgLeu: 6.03 ± 0.046	1.628ArgMet: 1.628 ± 0.023	2.201ArgAsn: 2.201 ± 0.027	3.128ArgPro: 3.128 ± 0.036	2.995ArgGln: 2.995 ± 0.036	5.281ArgArg: 5.281 ± 0.054	4.672ArgSer: 4.672 ± 0.051	3.474ArgThr: 3.474 ± 0.034	3.92ArgVal: 3.92 ± 0.036	0.877ArgTrp: 0.877 ± 0.016	1.768ArgTyr: 1.768 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.794SerAla: 7.794 ± 0.059	1.043SerCys: 1.043 ± 0.021	4.506SerAsp: 4.506 ± 0.04	4.065SerGlu: 4.065 ± 0.037	2.671SerPhe: 2.671 ± 0.029	5.78SerGly: 5.78 ± 0.057	1.794SerHis: 1.794 ± 0.025	3.775SerIle: 3.775 ± 0.036	3.303SerLys: 3.303 ± 0.034	7.108SerLeu: 7.108 ± 0.063	2.024SerMet: 2.024 ± 0.024	2.764SerAsn: 2.764 ± 0.03	4.52SerPro: 4.52 ± 0.059	3.134SerGln: 3.134 ± 0.04	4.632SerArg: 4.632 ± 0.044	8.049SerSer: 8.049 ± 0.079	5.184SerThr: 5.184 ± 0.053	5.177SerVal: 5.177 ± 0.048	0.955SerTrp: 0.955 ± 0.017	1.951SerTyr: 1.951 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	5.749ThrAla: 5.749 ± 0.06	0.848ThrCys: 0.848 ± 0.018	2.927ThrAsp: 2.927 ± 0.034	2.844ThrGlu: 2.844 ± 0.035	1.984ThrPhe: 1.984 ± 0.028	4.041ThrGly: 4.041 ± 0.039	1.394ThrHis: 1.394 ± 0.022	2.94ThrIle: 2.94 ± 0.036	2.497ThrLys: 2.497 ± 0.03	5.211ThrLeu: 5.211 ± 0.038	1.418ThrMet: 1.418 ± 0.024	2.01ThrAsn: 2.01 ± 0.029	3.695ThrPro: 3.695 ± 0.04	2.16ThrGln: 2.16 ± 0.028	3.263ThrArg: 3.263 ± 0.03	4.721ThrSer: 4.721 ± 0.045	3.998ThrThr: 3.998 ± 0.063	4.034ThrVal: 4.034 ± 0.043	0.695ThrTrp: 0.695 ± 0.019	1.538ThrTyr: 1.538 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	6.415ValAla: 6.415 ± 0.053	1.186ValCys: 1.186 ± 0.022	4.147ValAsp: 4.147 ± 0.044	3.797ValGlu: 3.797 ± 0.044	2.822ValPhe: 2.822 ± 0.033	4.157ValGly: 4.157 ± 0.037	1.649ValHis: 1.649 ± 0.021	3.031ValIle: 3.031 ± 0.035	2.694ValLys: 2.694 ± 0.031	6.378ValLeu: 6.378 ± 0.053	1.555ValMet: 1.555 ± 0.022	2.275ValAsn: 2.275 ± 0.032	3.895ValPro: 3.895 ± 0.04	2.593ValGln: 2.593 ± 0.026	4.128ValArg: 4.128 ± 0.039	5.235ValSer: 5.235 ± 0.046	3.567ValThr: 3.567 ± 0.042	5.354ValVal: 5.354 ± 0.054	0.895ValTrp: 0.895 ± 0.017	2.07ValTyr: 2.07 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.001TrpAla: 1.001 ± 0.017	0.227TrpCys: 0.227 ± 0.008	0.751TrpAsp: 0.751 ± 0.015	0.598TrpGlu: 0.598 ± 0.014	0.532TrpPhe: 0.532 ± 0.014	0.687TrpGly: 0.687 ± 0.013	0.336TrpHis: 0.336 ± 0.01	0.664TrpIle: 0.664 ± 0.015	0.558TrpLys: 0.558 ± 0.016	1.302TrpLeu: 1.302 ± 0.022	0.372TrpMet: 0.372 ± 0.009	0.502TrpAsn: 0.502 ± 0.013	0.583TrpPro: 0.583 ± 0.013	0.563TrpGln: 0.563 ± 0.014	0.951TrpArg: 0.951 ± 0.018	0.98TrpSer: 0.98 ± 0.018	0.776TrpThr: 0.776 ± 0.013	0.846TrpVal: 0.846 ± 0.016	0.223TrpTrp: 0.223 ± 0.008	0.387TrpTyr: 0.387 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.428TyrAla: 2.428 ± 0.031	0.493TyrCys: 0.493 ± 0.011	1.591TyrAsp: 1.591 ± 0.022	1.494TyrGlu: 1.494 ± 0.023	1.259TyrPhe: 1.259 ± 0.018	1.981TyrGly: 1.981 ± 0.03	0.722TyrHis: 0.722 ± 0.015	1.507TyrIle: 1.507 ± 0.022	1.278TyrLys: 1.278 ± 0.023	2.743TyrLeu: 2.743 ± 0.034	0.875TyrMet: 0.875 ± 0.016	1.13TyrAsn: 1.13 ± 0.019	1.458TyrPro: 1.458 ± 0.023	1.111TyrGln: 1.111 ± 0.017	1.768TyrArg: 1.768 ± 0.022	2.176TyrSer: 2.176 ± 0.028	1.71TyrThr: 1.71 ± 0.025	1.89TyrVal: 1.89 ± 0.026	0.417TyrTrp: 0.417 ± 0.012	1.027TyrTyr: 1.027 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9274 proteins (3585573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---