Amino acid dipepetide frequency for Caulochytrium protostelioides

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	33.025AlaAla: 33.025 ± 0.357	1.37AlaCys: 1.37 ± 0.022	7.966AlaAsp: 7.966 ± 0.076	5.852AlaGlu: 5.852 ± 0.069	3.398AlaPhe: 3.398 ± 0.039	9.086AlaGly: 9.086 ± 0.075	3.68AlaHis: 3.68 ± 0.046	3.931AlaIle: 3.931 ± 0.036	3.431AlaLys: 3.431 ± 0.046	11.955AlaLeu: 11.955 ± 0.086	3.274AlaMet: 3.274 ± 0.034	2.459AlaAsn: 2.459 ± 0.031	11.329AlaPro: 11.329 ± 0.122	4.974AlaGln: 4.974 ± 0.07	8.684AlaArg: 8.684 ± 0.079	13.248AlaSer: 13.248 ± 0.122	10.24AlaThr: 10.24 ± 0.085	9.2AlaVal: 9.2 ± 0.074	1.8AlaTrp: 1.8 ± 0.027	2.416AlaTyr: 2.416 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.021	0.195CysCys: 0.195 ± 0.009	0.566CysAsp: 0.566 ± 0.014	0.486CysGlu: 0.486 ± 0.012	0.421CysPhe: 0.421 ± 0.013	0.826CysGly: 0.826 ± 0.021	0.374CysHis: 0.374 ± 0.011	0.424CysIle: 0.424 ± 0.011	0.284CysLys: 0.284 ± 0.011	1.109CysLeu: 1.109 ± 0.021	0.236CysMet: 0.236 ± 0.01	0.249CysAsn: 0.249 ± 0.009	0.634CysPro: 0.634 ± 0.017	0.398CysGln: 0.398 ± 0.01	0.858CysArg: 0.858 ± 0.018	0.613CysSer: 0.613 ± 0.014	0.566CysThr: 0.566 ± 0.013	0.741CysVal: 0.741 ± 0.016	0.147CysTrp: 0.147 ± 0.007	0.289CysTyr: 0.289 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	10.413AspAla: 10.413 ± 0.094	0.426AspCys: 0.426 ± 0.01	5.394AspAsp: 5.394 ± 0.099	3.092AspGlu: 3.092 ± 0.044	1.439AspPhe: 1.439 ± 0.029	5.112AspGly: 5.112 ± 0.056	1.619AspHis: 1.619 ± 0.024	1.698AspIle: 1.698 ± 0.027	1.167AspLys: 1.167 ± 0.023	4.705AspLeu: 4.705 ± 0.039	1.07AspMet: 1.07 ± 0.019	1.016AspAsn: 1.016 ± 0.024	4.135AspPro: 4.135 ± 0.039	1.486AspGln: 1.486 ± 0.024	3.694AspArg: 3.694 ± 0.04	2.576AspSer: 2.576 ± 0.036	2.643AspThr: 2.643 ± 0.033	4.009AspVal: 4.009 ± 0.041	0.644AspTrp: 0.644 ± 0.015	1.084AspTyr: 1.084 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.362GluAla: 6.362 ± 0.067	0.43GluCys: 0.43 ± 0.012	2.49GluAsp: 2.49 ± 0.035	2.251GluGlu: 2.251 ± 0.038	1.096GluPhe: 1.096 ± 0.023	2.376GluGly: 2.376 ± 0.029	1.227GluHis: 1.227 ± 0.019	1.832GluIle: 1.832 ± 0.028	1.526GluLys: 1.526 ± 0.031	3.915GluLeu: 3.915 ± 0.048	1.097GluMet: 1.097 ± 0.021	1.112GluAsn: 1.112 ± 0.018	2.554GluPro: 2.554 ± 0.037	1.878GluGln: 1.878 ± 0.037	3.603GluArg: 3.603 ± 0.047	2.626GluSer: 2.626 ± 0.032	3.268GluThr: 3.268 ± 0.039	2.278GluVal: 2.278 ± 0.029	0.499GluTrp: 0.499 ± 0.012	0.953GluTyr: 0.953 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.85PheAla: 2.85 ± 0.032	0.429PheCys: 0.429 ± 0.011	1.709PheAsp: 1.709 ± 0.026	1.405PheGlu: 1.405 ± 0.026	0.972PhePhe: 0.972 ± 0.02	2.04PheGly: 2.04 ± 0.037	0.858PheHis: 0.858 ± 0.016	0.947PheIle: 0.947 ± 0.022	0.843PheLys: 0.843 ± 0.02	2.714PheLeu: 2.714 ± 0.035	0.678PheMet: 0.678 ± 0.015	0.742PheAsn: 0.742 ± 0.017	1.461PhePro: 1.461 ± 0.022	1.039PheGln: 1.039 ± 0.02	1.814PheArg: 1.814 ± 0.026	1.771PheSer: 1.771 ± 0.026	1.468PheThr: 1.468 ± 0.024	1.938PheVal: 1.938 ± 0.026	0.433PheTrp: 0.433 ± 0.01	0.786PheTyr: 0.786 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	9.038GlyAla: 9.038 ± 0.084	0.695GlyCys: 0.695 ± 0.016	4.032GlyAsp: 4.032 ± 0.047	2.445GlyGlu: 2.445 ± 0.031	1.937GlyPhe: 1.937 ± 0.028	7.173GlyGly: 7.173 ± 0.118	2.351GlyHis: 2.351 ± 0.036	2.379GlyIle: 2.379 ± 0.027	1.845GlyLys: 1.845 ± 0.03	5.653GlyLeu: 5.653 ± 0.052	1.693GlyMet: 1.693 ± 0.035	1.418GlyAsn: 1.418 ± 0.032	4.509GlyPro: 4.509 ± 0.054	2.03GlyGln: 2.03 ± 0.029	4.653GlyArg: 4.653 ± 0.052	5.584GlySer: 5.584 ± 0.068	4.011GlyThr: 4.011 ± 0.04	4.115GlyVal: 4.115 ± 0.044	0.853GlyTrp: 0.853 ± 0.018	1.524GlyTyr: 1.524 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	4.452HisAla: 4.452 ± 0.052	0.284HisCys: 0.284 ± 0.009	1.942HisAsp: 1.942 ± 0.029	1.255HisGlu: 1.255 ± 0.02	0.821HisPhe: 0.821 ± 0.018	2.696HisGly: 2.696 ± 0.048	1.455HisHis: 1.455 ± 0.038	0.892HisIle: 0.892 ± 0.016	0.534HisLys: 0.534 ± 0.014	2.757HisLeu: 2.757 ± 0.032	0.505HisMet: 0.505 ± 0.011	0.51HisAsn: 0.51 ± 0.014	2.504HisPro: 2.504 ± 0.042	1.066HisGln: 1.066 ± 0.019	2.293HisArg: 2.293 ± 0.029	1.367HisSer: 1.367 ± 0.026	1.398HisThr: 1.398 ± 0.022	2.322HisVal: 2.322 ± 0.028	0.326HisTrp: 0.326 ± 0.01	0.624HisTyr: 0.624 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.967IleAla: 3.967 ± 0.039	0.439IleCys: 0.439 ± 0.012	2.102IleAsp: 2.102 ± 0.026	1.796IleGlu: 1.796 ± 0.03	0.975IlePhe: 0.975 ± 0.021	2.055IleGly: 2.055 ± 0.026	0.955IleHis: 0.955 ± 0.017	1.162IleIle: 1.162 ± 0.027	1.231IleLys: 1.231 ± 0.022	2.957IleLeu: 2.957 ± 0.041	0.774IleMet: 0.774 ± 0.018	0.954IleAsn: 0.954 ± 0.02	1.957IlePro: 1.957 ± 0.025	1.37IleGln: 1.37 ± 0.023	2.207IleArg: 2.207 ± 0.03	1.871IleSer: 1.871 ± 0.031	2.017IleThr: 2.017 ± 0.03	2.375IleVal: 2.375 ± 0.036	0.389IleTrp: 0.389 ± 0.011	0.824IleTyr: 0.824 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.123LysAla: 3.123 ± 0.043	0.272LysCys: 0.272 ± 0.009	1.342LysAsp: 1.342 ± 0.023	1.362LysGlu: 1.362 ± 0.027	0.676LysPhe: 0.676 ± 0.016	1.416LysGly: 1.416 ± 0.025	0.766LysHis: 0.766 ± 0.015	1.162LysIle: 1.162 ± 0.024	1.379LysLys: 1.379 ± 0.035	2.468LysLeu: 2.468 ± 0.04	0.595LysMet: 0.595 ± 0.014	0.806LysAsn: 0.806 ± 0.02	1.835LysPro: 1.835 ± 0.029	1.241LysGln: 1.241 ± 0.024	2.265LysArg: 2.265 ± 0.031	1.674LysSer: 1.674 ± 0.029	1.862LysThr: 1.862 ± 0.025	1.451LysVal: 1.451 ± 0.024	0.305LysTrp: 0.305 ± 0.01	0.717LysTyr: 0.717 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	12.136LeuAla: 12.136 ± 0.087	1.127LeuCys: 1.127 ± 0.023	5.148LeuAsp: 5.148 ± 0.042	4.294LeuGlu: 4.294 ± 0.057	2.73LeuPhe: 2.73 ± 0.04	5.4LeuGly: 5.4 ± 0.046	2.64LeuHis: 2.64 ± 0.029	2.937LeuIle: 2.937 ± 0.036	2.677LeuLys: 2.677 ± 0.036	8.876LeuLeu: 8.876 ± 0.09	2.062LeuMet: 2.062 ± 0.029	2.132LeuAsn: 2.132 ± 0.032	6.67LeuPro: 6.67 ± 0.059	3.883LeuGln: 3.883 ± 0.047	6.677LeuArg: 6.677 ± 0.06	6.33LeuSer: 6.33 ± 0.052	5.397LeuThr: 5.397 ± 0.041	6.098LeuVal: 6.098 ± 0.052	1.13LeuTrp: 1.13 ± 0.022	1.937LeuTyr: 1.937 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	3.447MetAla: 3.447 ± 0.038	0.189MetCys: 0.189 ± 0.008	1.267MetAsp: 1.267 ± 0.021	0.9MetGlu: 0.9 ± 0.017	0.48MetPhe: 0.48 ± 0.012	1.489MetGly: 1.489 ± 0.024	0.601MetHis: 0.601 ± 0.016	0.728MetIle: 0.728 ± 0.016	0.594MetLys: 0.594 ± 0.014	2.059MetLeu: 2.059 ± 0.028	0.562MetMet: 0.562 ± 0.014	0.608MetAsn: 0.608 ± 0.014	1.895MetPro: 1.895 ± 0.03	0.868MetGln: 0.868 ± 0.019	1.405MetArg: 1.405 ± 0.02	1.506MetSer: 1.506 ± 0.024	1.625MetThr: 1.625 ± 0.022	1.278MetVal: 1.278 ± 0.022	0.209MetTrp: 0.209 ± 0.007	0.372MetTyr: 0.372 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.848AsnAla: 2.848 ± 0.031	0.218AsnCys: 0.218 ± 0.008	1.382AsnAsp: 1.382 ± 0.028	1.079AsnGlu: 1.079 ± 0.018	0.629AsnPhe: 0.629 ± 0.015	1.687AsnGly: 1.687 ± 0.028	0.601AsnHis: 0.601 ± 0.011	0.856AsnIle: 0.856 ± 0.021	0.701AsnLys: 0.701 ± 0.016	1.917AsnLeu: 1.917 ± 0.031	0.518AsnMet: 0.518 ± 0.014	0.63AsnAsn: 0.63 ± 0.016	1.484AsnPro: 1.484 ± 0.023	0.787AsnGln: 0.787 ± 0.015	1.325AsnArg: 1.325 ± 0.022	1.103AsnSer: 1.103 ± 0.022	1.211AsnThr: 1.211 ± 0.023	1.435AsnVal: 1.435 ± 0.022	0.26AsnTrp: 0.26 ± 0.011	0.555AsnTyr: 0.555 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	12.043ProAla: 12.043 ± 0.119	0.608ProCys: 0.608 ± 0.016	3.631ProAsp: 3.631 ± 0.034	2.983ProGlu: 2.983 ± 0.03	1.858ProPhe: 1.858 ± 0.025	4.614ProGly: 4.614 ± 0.058	2.141ProHis: 2.141 ± 0.042	1.949ProIle: 1.949 ± 0.028	1.515ProLys: 1.515 ± 0.026	6.447ProLeu: 6.447 ± 0.059	1.541ProMet: 1.541 ± 0.029	1.314ProAsn: 1.314 ± 0.025	10.115ProPro: 10.115 ± 0.177	2.167ProGln: 2.167 ± 0.034	5.197ProArg: 5.197 ± 0.062	8.223ProSer: 8.223 ± 0.093	5.225ProThr: 5.225 ± 0.049	4.566ProVal: 4.566 ± 0.049	0.912ProTrp: 0.912 ± 0.017	1.296ProTyr: 1.296 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.529GlnAla: 4.529 ± 0.062	0.435GlnCys: 0.435 ± 0.012	1.583GlnAsp: 1.583 ± 0.025	1.468GlnGlu: 1.468 ± 0.029	1.042GlnPhe: 1.042 ± 0.017	1.797GlnGly: 1.797 ± 0.029	1.359GlnHis: 1.359 ± 0.026	1.584GlnIle: 1.584 ± 0.023	1.072GlnLys: 1.072 ± 0.022	4.11GlnLeu: 4.11 ± 0.052	0.801GlnMet: 0.801 ± 0.018	0.905GlnAsn: 0.905 ± 0.016	2.412GlnPro: 2.412 ± 0.034	3.195GlnGln: 3.195 ± 0.119	3.319GlnArg: 3.319 ± 0.042	2.205GlnSer: 2.205 ± 0.029	2.339GlnThr: 2.339 ± 0.03	1.886GlnVal: 1.886 ± 0.029	0.519GlnTrp: 0.519 ± 0.014	0.896GlnTyr: 0.896 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	8.298ArgAla: 8.298 ± 0.075	0.82ArgCys: 0.82 ± 0.017	4.059ArgAsp: 4.059 ± 0.044	3.226ArgGlu: 3.226 ± 0.043	2.104ArgPhe: 2.104 ± 0.027	4.629ArgGly: 4.629 ± 0.057	2.77ArgHis: 2.77 ± 0.034	2.443ArgIle: 2.443 ± 0.031	1.824ArgLys: 1.824 ± 0.027	7.045ArgLeu: 7.045 ± 0.05	1.47ArgMet: 1.47 ± 0.02	1.333ArgAsn: 1.333 ± 0.021	5.322ArgPro: 5.322 ± 0.062	2.904ArgGln: 2.904 ± 0.038	7.321ArgArg: 7.321 ± 0.089	4.999ArgSer: 4.999 ± 0.058	3.428ArgThr: 3.428 ± 0.032	4.17ArgVal: 4.17 ± 0.041	1.003ArgTrp: 1.003 ± 0.019	1.576ArgTyr: 1.576 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	10.847SerAla: 10.847 ± 0.106	0.614SerCys: 0.614 ± 0.017	4.074SerAsp: 4.074 ± 0.047	2.919SerGlu: 2.919 ± 0.033	1.711SerPhe: 1.711 ± 0.027	5.593SerGly: 5.593 ± 0.073	2.143SerHis: 2.143 ± 0.039	2.048SerIle: 2.048 ± 0.033	1.842SerLys: 1.842 ± 0.032	6.308SerLeu: 6.308 ± 0.055	1.629SerMet: 1.629 ± 0.027	1.463SerAsn: 1.463 ± 0.024	7.015SerPro: 7.015 ± 0.098	2.483SerGln: 2.483 ± 0.035	4.976SerArg: 4.976 ± 0.053	7.845SerSer: 7.845 ± 0.119	4.875SerThr: 4.875 ± 0.048	4.086SerVal: 4.086 ± 0.041	0.75SerTrp: 0.75 ± 0.016	1.251SerTyr: 1.251 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	10.225ThrAla: 10.225 ± 0.085	0.69ThrCys: 0.69 ± 0.018	3.012ThrAsp: 3.012 ± 0.033	2.282ThrGlu: 2.282 ± 0.031	1.654ThrPhe: 1.654 ± 0.027	3.952ThrGly: 3.952 ± 0.043	1.581ThrHis: 1.581 ± 0.024	2.04ThrIle: 2.04 ± 0.032	1.517ThrLys: 1.517 ± 0.026	5.755ThrLeu: 5.755 ± 0.052	1.284ThrMet: 1.284 ± 0.019	1.192ThrAsn: 1.192 ± 0.021	5.864ThrPro: 5.864 ± 0.055	2.03ThrGln: 2.03 ± 0.034	3.766ThrArg: 3.766 ± 0.038	4.794ThrSer: 4.794 ± 0.047	5.675ThrThr: 5.675 ± 0.126	3.809ThrVal: 3.809 ± 0.041	0.821ThrTrp: 0.821 ± 0.016	1.225ThrTyr: 1.225 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	9.024ValAla: 9.024 ± 0.066	0.803ValCys: 0.803 ± 0.017	3.629ValAsp: 3.629 ± 0.035	2.684ValGlu: 2.684 ± 0.036	1.876ValPhe: 1.876 ± 0.026	3.794ValGly: 3.794 ± 0.042	1.748ValHis: 1.748 ± 0.024	2.082ValIle: 2.082 ± 0.031	1.769ValLys: 1.769 ± 0.029	6.208ValLeu: 6.208 ± 0.053	1.502ValMet: 1.502 ± 0.023	1.402ValAsn: 1.402 ± 0.025	4.707ValPro: 4.707 ± 0.048	2.247ValGln: 2.247 ± 0.03	4.089ValArg: 4.089 ± 0.038	4.239ValSer: 4.239 ± 0.035	3.816ValThr: 3.816 ± 0.037	4.739ValVal: 4.739 ± 0.047	0.866ValTrp: 0.866 ± 0.016	1.421ValTyr: 1.421 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.178TrpAla: 1.178 ± 0.019	0.191TrpCys: 0.191 ± 0.007	0.717TrpAsp: 0.717 ± 0.016	0.499TrpGlu: 0.499 ± 0.012	0.383TrpPhe: 0.383 ± 0.011	0.573TrpGly: 0.573 ± 0.017	0.42TrpHis: 0.42 ± 0.013	0.534TrpIle: 0.534 ± 0.014	0.377TrpLys: 0.377 ± 0.011	1.237TrpLeu: 1.237 ± 0.02	0.325TrpMet: 0.325 ± 0.01	0.375TrpAsn: 0.375 ± 0.011	0.812TrpPro: 0.812 ± 0.017	0.604TrpGln: 0.604 ± 0.014	1.066TrpArg: 1.066 ± 0.019	0.956TrpSer: 0.956 ± 0.017	0.87TrpThr: 0.87 ± 0.016	0.71TrpVal: 0.71 ± 0.015	0.215TrpTrp: 0.215 ± 0.008	0.31TrpTyr: 0.31 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.421TyrAla: 2.421 ± 0.031	0.273TyrCys: 0.273 ± 0.009	1.376TyrAsp: 1.376 ± 0.025	1.094TyrGlu: 1.094 ± 0.019	0.693TyrPhe: 0.693 ± 0.016	1.628TyrGly: 1.628 ± 0.032	0.717TyrHis: 0.717 ± 0.015	0.75TyrIle: 0.75 ± 0.015	0.588TyrLys: 0.588 ± 0.014	2.086TyrLeu: 2.086 ± 0.03	0.464TyrMet: 0.464 ± 0.012	0.609TyrAsn: 0.609 ± 0.017	1.13TyrPro: 1.13 ± 0.026	0.808TyrGln: 0.808 ± 0.017	1.533TyrArg: 1.533 ± 0.024	0.943TyrSer: 0.943 ± 0.022	1.232TyrThr: 1.232 ± 0.021	1.44TyrVal: 1.44 ± 0.021	0.271TyrTrp: 0.271 ± 0.009	0.622TyrTyr: 0.622 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6161 proteins (3431561 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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