Human immunodeficiency virus type 1 04CD.FR.KZS

Taxonomy: Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus; Human immunodeficiency virus 1; HIV-1 unknown group

Average proteome isoelectric point is 7.03

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A8E122|A8E122_9HIV1 Envelope glycoprotein gp160 OS=Human immunodeficiency virus type 1 04CD.FR.KZS OX=467353 GN=env PE=3 SV=1
MM1 pKa = 7.72ISLKK5 pKa = 9.8TISIAALIVAFLIVVVVWTIVYY27 pKa = 9.69IEE29 pKa = 3.97YY30 pKa = 10.52RR31 pKa = 11.84KK32 pKa = 10.05LLRR35 pKa = 11.84QKK37 pKa = 10.76RR38 pKa = 11.84IDD40 pKa = 3.48RR41 pKa = 11.84LLEE44 pKa = 4.34RR45 pKa = 11.84IRR47 pKa = 11.84EE48 pKa = 4.0RR49 pKa = 11.84AEE51 pKa = 4.06DD52 pKa = 3.71SGNEE56 pKa = 3.97SDD58 pKa = 5.73GDD60 pKa = 3.95TEE62 pKa = 3.92EE63 pKa = 4.23LARR66 pKa = 11.84LVEE69 pKa = 4.44MGPHH73 pKa = 7.34DD74 pKa = 5.45LGNDD78 pKa = 3.2NDD80 pKa = 4.0LL81 pKa = 4.24

Molecular weight: 9.31 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A8E120|A8E120_9HIV1 Protein Vpr OS=Human immunodeficiency virus type 1 04CD.FR.KZS OX=467353 GN=vpr PE=3 SV=1
MM1 pKa = 7.33EE2 pKa = 5.2NRR4 pKa = 11.84WQGMIVWQVDD14 pKa = 3.16RR15 pKa = 11.84MRR17 pKa = 11.84INAWKK22 pKa = 10.6SLVKK26 pKa = 10.53YY27 pKa = 10.42HH28 pKa = 5.16MHH30 pKa = 6.83KK31 pKa = 10.47SKK33 pKa = 10.58KK34 pKa = 9.6AKK36 pKa = 7.97GWHH39 pKa = 5.51YY40 pKa = 9.32RR41 pKa = 11.84HH42 pKa = 6.89HH43 pKa = 7.26YY44 pKa = 9.88DD45 pKa = 2.99SHH47 pKa = 7.19HH48 pKa = 6.79PKK50 pKa = 10.0ISSEE54 pKa = 3.93VHH56 pKa = 5.76IPLGDD61 pKa = 3.82AEE63 pKa = 4.91LVVTTYY69 pKa = 10.06WGLQTGEE76 pKa = 4.37RR77 pKa = 11.84DD78 pKa = 2.83WHH80 pKa = 6.36LGQGVSIEE88 pKa = 4.03WRR90 pKa = 11.84LKK92 pKa = 9.93RR93 pKa = 11.84YY94 pKa = 7.58RR95 pKa = 11.84TQVDD99 pKa = 3.43PGLADD104 pKa = 3.48QLIHH108 pKa = 6.48IHH110 pKa = 6.15YY111 pKa = 9.18FDD113 pKa = 5.15CFSEE117 pKa = 4.35SAIRR121 pKa = 11.84KK122 pKa = 9.18AILGYY127 pKa = 9.95RR128 pKa = 11.84VSPRR132 pKa = 11.84CDD134 pKa = 3.06YY135 pKa = 10.81PAGHH139 pKa = 6.13NQVGSLQYY147 pKa = 10.85LALTALITPKK157 pKa = 10.15KK158 pKa = 9.37IKK160 pKa = 10.01PSLPSVRR167 pKa = 11.84KK168 pKa = 8.55LTEE171 pKa = 4.09DD172 pKa = 3.21RR173 pKa = 11.84WNKK176 pKa = 7.28PQKK179 pKa = 9.38TRR181 pKa = 11.84GHH183 pKa = 6.69RR184 pKa = 11.84EE185 pKa = 3.72NQTMNGQQ192 pKa = 3.29

Molecular weight: 22.59 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2936

81

1001

419.4

47.63

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.403 ± 0.432

1.737 ± 0.363

4.223 ± 0.521

7.119 ± 0.655

2.725 ± 0.231

7.221 ± 0.22

2.384 ± 0.528

7.016 ± 0.903

6.812 ± 0.901

8.481 ± 0.486

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.112 ± 0.401

4.939 ± 0.932

5.075 ± 0.785

5.688 ± 0.535

5.722 ± 0.664

5.007 ± 0.414

5.722 ± 0.781

6.063 ± 0.453

2.997 ± 0.266

2.554 ± 0.323
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski